Análisis de los indicadores de calidad en la modalidad e-learning desde la perspectiva pedagógica

La expansión de internet en países desarrollados ha influido en muchos sectores. La educación, y en especial la formación, no ha quedado al margen. La modalidad e-learning, o teleformación, en apenas una década ha experimentado un crecimiento notable. Algunas organizaciones se han adaptado a esta modalidad, y otras, incluso se han creado a partir de la aparición de la misma. Este rápido crecimiento tecnológico no siempre ha sido acompañado de una adaptación pedagógica adecuada. La calidad de las acciones formativas, en esta modalidad, en ocasiones obedece más a las innovaciones tecnológicas que a las pedagógicas, tal y como se puede apreciar en los resultados de esta investigación. La implantación de la evaluación de la calidad de esta modalidad no sólo mejorará la confianza, sino que además puede convertirse en una fuente de información esencial para la mejora de los procesos pedagógicos. Analizamos, la opinión de los profesionales de algunos indicadores de calidad relacionados con la modalidad e-learning o teleformación.The expansion of the Internet in developed countries has influenced many sectors. Education, and particularly training, has not been left out. E-learning format, or long distance learning, in just a decade has seen remarkable growth. Some organizations have adapted to this mode, and others, have even been created from the appearance of it. This rapid technological growth has not always been accompanied by adequate pedagogical adaptation. The quality of the training, in this mode, sometimes due more to technological innovations rather than teaching, as can be seen in the results of thisresearch. The implementation of the quality of evaluation of this type not only improves confidence, but can also become a source of information for improving educational processes. We analyze the professional opinion of some quality indicators related to e-learning or long distance learning

Analysis of quality indicators in e-learning from a pedagogical perspective

La expansión de internet en países desarrollados ha influido en muchos sectores. La educación, y en especial la formación, no ha quedado al margen. La modalidad e-learning, o teleformación, en apenas una década ha experimentado un crecimiento notable. Algunas organizaciones se han adaptado a esta modalidad, y otras, incluso se han creado a partir de la aparición de la misma. Este rápido crecimiento tecnológico no siempre ha sido acompañado de una adaptación pedagógica adecuada. La calidad de las acciones formativas, en esta modalidad, en ocasiones obedece más a las innovaciones tecnológicas que a las pedagógicas, tal y como se puede apreciar en los resultados de esta investigación. La implantación de la evaluación de la calidad de esta modalidad no sólo mejorará la confianza, sino que además puede convertirse en una fuente de información esencial para la mejora de los procesos pedagógicos. Analizamos, la opinión de los profesionales de algunos indicadores de calidad relacionados con la modalidad e-learning o teleformación.The expansion of the Internet in developed countries has influenced many sectors. Education, and particularly training, has not been left out. E-learning format, or long distance learning, in just a decade has seen remarkable growth. Some organizations have adapted to this mode, and others, have even been created from the appearance of it. This rapid technological growth has not always been accompanied by adequate pedagogical adaptation. The quality of the training, in this mode, sometimes due more to technological innovations rather than teaching, as can be seen in the results of thisresearch. The implementation of the quality of evaluation of this type not only improves confidence, but can also become a source of information for improving educational processes. We analyze the professional opinion of some quality indicators related to e-learning or long distance learning

Postcopulatory sexual selection favors fertilization success of restocking hybrid quails over native Common quails (Coturnix coturnix)

Postcopulatory sexual selection plays an important role in the reproductive success of males in many species. Differences in fertilization success could affect rates of admixture and genetic introgression between divergent lineages. We investigated sperm precedence in matings in captivity involving Common quails (Coturnix coturnix) and farm quails of hybrid origin (C. coturnix × domestic Japanese quail, C. japonica), the last used in restocking practices to increase hunting bags. These inter-specific matings in natural conditions are claimed to represent an important threat to the conservation of native Common quail populations. Results showed that fertilization success of each male depended on (1) the time it spent with the female, (2) the presence of sperm from a previous male in the female oviduct, (3) the time that the previous partner had been copulating with the female, and, most importantly, (4) the genetic origin of the male (wild or farm). Farm hybrid males showed higher fertilization success than wild Common males, and they required less time with the female to fertilize the same proportion of eggs. The presence of sperm from another male in the female oviduct reduced the percentage of fertilized eggs by a male. However, this reduction was higher for wild males when the precedent mate was a farm male. In summary, the sperm of farm hybrid males may outcompete the sperm of native males and this could be favoring the introgression of domestic Japanese alleles into the Common quail population, thus constituting a severe conservation threat to wild Common quail populations

Lupus Eritematoso Sistémico: generalidades sobre su fisiopatología, clínica, abordaje diagnóstico y terapéutico

El Lupus Eritematoso Sistémico (LES) es uno de los prototipos de las enfermedades autoinmunes, compromete principalmente al sexo femenino, con una proporción 9:1 mujer-hombre. Se caracteriza por la formación de autoanticuerpos con la participación de la inmunidad adaptativa e innata, en interacción con los factores genéticos y medioambientales. Estos autoanticuerpos son parte central de la fisiopatología de la enfermedad, causando desde compromiso orgánico leve hasta compromiso multisistémico grave. El diagnóstico es clínico, orientado por una anamnesis detallada, un examen físico exhaustivo y los marcadores de autoinmunidad; eventualmente podría apoyarse en criterios clasificatorios de algunas sociedades científicas. La actual revisión pretende destacar las generalidades sobre la enfermedad, haciendo énfasis en su fisiopatología, presentación clínica, y su abordaje diagnóstico y terapéutico, sirviendo de apoyo para la formación médica integral en beneficio de los pacientes

Effects of intracoronary antithrombotics on ventricular function: A comparison of tenecteplase versus abciximab during primary percutaneous intervention in myocardial infarction

Adjunctive medical therapy during primary percutaneous coronary intervention (PPCI) is based on anticoagulation and antiplatelet drugs. Additionally, the glycoprotein IIb/IIIa inhibitor (GPI) abciximab has been shown to reduce infarct size in some clinical trials [1]. However, the role of intracoronary fibrinolysis has not been well established during PPCI. We sought to explore the hypothesis that a locally administered fibrinolytic could be more effective in dissolving coronary thrombus at the macro and microvasculature than adding a third antiplatelet drug in patients already receiving double antiplatelet therapy, and therefore improve myocardial perfusion and left ventricular function

Efficacy of novel indoor residual spraying methods targeting pyrethroid-resistant aedes aegypti within experimental houses

Challenges in maintaining high effectiveness of classic vector control in urban areas has renewed the interest in indoor residual spraying (IRS) as a promising approach for Aedes-borne disease prevention. While IRS has many benefits, application time and intrusive indoor applications make its scalability in urban areas difficult. Modifying IRS to account for Ae. aegypti resting behavior, named targeted IRS (TIRS, spraying walls below 1.5 m and under furniture) can reduce application time; however, an untested assumption is that modifications to IRS will not negatively impact entomological efficacy. We conducted a comparative experimental study evaluating the residual efficacy of classically-applied IRS (as developed for malaria control) compared to two TIRS application methods using a carbamate insecticide against a pyrethroid-resistant, field-derived Ae. aegypti strain. We performed our study within a novel experimental house setting (n = 9 houses) located in Merida (Mexico), with similar layouts and standardized contents. Classic IRS application (insecti-cide applied to full walls and under furniture) was compared to: a) TIRS: insecticide applied to walls below 1.5 m and under furniture, and b) Resting Site TIRS (RS-TIRS): insecticide applied only under furniture. Mosquito mortality was measured eight times post-application (out to six months post-application) by releasing 100 Ae. aegypti females/house and collecting live and dead individuals after 24 hrs exposure. Compared to Classic IRS, TIRS and RS-TIRS took less time to apply (31% and 82% reduction, respectively) and used less insecticide (38% and 85% reduction, respectively). Mortality of pyrethroid-resistant Ae. aegypti did not significantly differ among the three IRS application methods up to two months post application, and did not significantly differ between Classic IRS and TIRS up to four months post application. These data illustrate that optimizing IRS to more efficiently target Ae. aegypti

Massive and effective acorn dispersal into agroforestry systems byan overlooked vector, the Eurasian magpie (Pica pica)

Oak regeneration and the expansion of forested sites in Eurasia rely on acorn dispersal by animals,especially the Eurasian jay (Garrulus glandarius). However, in open agroforestry systems where jaysare absent, such as old fields far from acorn sources, oak recruitment still occurs. We hypothesize that theEurasian magpie (Pica pica), an abundant corvid in this system, substitutes the jay in its seed dispersal function.By ringing 169 magpies, video recording >7500 acorn removal events with trail cameras, and radiotagging337 acorns, we quantified that (1) magpies cached 41&#-56% of the annual acorn production of Quercusilex trees in single caches on the ground; (2) breeding pairs, and especially males, were the main acorndispersers; (3) each breeding magpie cached 169&#-1372 acorns in 6 weeks; and (4) the effectiveness of dispersal(percentage of cached acorns resulting in seedlings) was 0.6&-2.4%, which (5) yielded a high densityof emerged seedlings (56&-439 seedlings/ha). We evidence that magpie could be a key species in the regenerationof oak agroforestry mosaics because they massively and effectively dispersed acorns. However, inour particular study site, effectiveness was low probably due to herbivory and summer drought stress (i.e.,a context limitation rather than an intrinsic limitation of the disperser). As the distributions of magpies andoaks overlap widely in Eurasia, effective acorn dispersal by magpies could have a significant role in largescaleoak forest recovery in strongly fragmented landscapes.Ministerio de Ciencia y TecnologíaREMEDINALUniversidad de AlcaláMinisterio de Ciencia, Innovación y Universidade

Comprehensive characterization of a novel, oncogenic and targetable SEPTIN6::ABL2 fusion in T-ALL

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Detection of novel fusion-transcripts by RNA-Seq in T-cell lymphoblastic lymphoma

Fusions transcripts have been proven to be strong drivers for neoplasia-associated mutations, although their incidence in T-cell lymphoblastic lymphoma needs to be determined yet. Using RNA-Seq we have selected 55 fusion transcripts identified by at least two of three detection methods in the same tumour. We confirmed the existence of 24 predicted novel fusions that had not been described in cancer or normal tissues yet, indicating the accuracy of the prediction. Of note, one of them involves the proto oncogene TAL1. Other confirmed fusions could explain the overexpression of driver genes such as COMMD3-BMI1, LMO1 or JAK3. Five fusions found exclusively in tumour samples could be considered pathogenic (NFYG-TAL1, RIC3-TCRBC2, SLC35A3-HIAT1, PICALM MLLT10 and MLLT10-PICALM). However, other fusions detected simultaneously in normal and tumour samples (JAK3-INSL3, KANSL1-ARL17A/B and TFG-ADGRG7) could be germ-line fusions genes involved in tumour-maintaining tasks. Notably, some fusions were confirmed in more tumour samples than predicted, indicating that the detection methods underestimated the real number of existing fusions. Our results highlight the potential of RNA-Seq to identify new cryptic fusions, which could be drivers or tumour-maintaining passenger genes. Such novel findings shed light on the searching for new T-LBL biomarkers in these haematological disorders.The authors would like to thank the Spanish Biobanks integrated in the Spanish Hospital Biobanks Network (RetBioH; www.redbiobancos.es) for providing us with the necessary T-LBL samples to elaborate this work. We thank all patients who were willing to donate their samples without their support the research work would not be possible. And to Isabel Sastre for her technical support. This work was supported by the Spanish Ministry of Economy and Competitiveness (SAF2015-70561-R; MINECO/FEDER, EU); the Autonomous Community of Madrid, Spain (B2017/BMD-3778; LINFOMAS-CM) and the Spanish Association Against Cancer (AECC, 2018; PROYE18054PIRI). Institutional grants from the Fundación Ramón Areces and Banco de Santander are also acknowledged.S

Circulating levels of specific members of chromosome 19 microRNA cluster are associated with preeclampsia development

Purpose: To perform serum microRNA expression profiling to identify members of chromosome 19 miRNA cluster involved in preeclampsia development. Methods: Serum chromosome 19 miRNA cluster microRNA expression profiling was evaluated at 12, 16, and 20 gestational weeks and at the time of preeclampsia diagnosis, in women who developed preeclampsia (WWD-PE; n = 16) and controls (n = 18) using TaqMan low density array plates. Results: A total of 51 chromosome 19 microRNA cluster members were evaluated. The circulating hsa-miRs 512-3p, 518f3p, 520c-3p, and 520d-3p, were differentially expressed between groups (P < 0.05). Compared with controls, serum levels of hsa-miR-518f-3p at 20 GW were useful for identifying WWD-Mild-PE (P = 0.035) and WWD-Severe-PE(P = 0.007). Conclusions: Serum hsa-miRs 512-3p, 518f-3p, 520c-3p, and 520d-3p, are differentially expressed between WWD-PE and controls and their role in the development of preeclampsia should be investigated further