2,487 research outputs found
Determination and quantification of carotenoids in sea sponges Raspaciona aculeata and Dictyonella marsilii present in the Ganzirri Lake (Messina), Italy
Considering the crucial role of carotenoids exploitable both as nutraceuticals and also as dyes in food industry, there are many efforts in seeking for new sources of these pigments, especially in the marine world. In this study, for the first time, we extracted carotenoids from sea sponges Raspaciona aculeata and Dictyonella marsilii taken from Ganzirri Lake Messina (Italy). The determination and quantification of carotenoids was made by UPLC-PDA-MS. Remarkable results concern renieratene content in R. aculeate found to be over 2570 ppm
Properties of a new food supplement containing actinia equina extract
Marine species represent a great source of biologically active substances; Actinia equina (AE),
an Anthozoa Cnidaria belonging to the Actinidiae family, have been proposed as original food and have
already been included in several cooking recipes in local Mediterranean shores, and endowed with
excellent nutraceutical potential. The aim of this study was to investigate some unexplored features
of AE, through analytical screening and an in-vitro and in-vivo model. An in-vitro study, made on
RAW 264.7 stimulated with H2O2, showed that the pre-treatment with AE exerted an antioxidant
action, reducing lipid peroxidation and up-regulating antioxidant enzymes. On the other hand,
the in-vivo study over murine model demonstrated that the administration of AE extracts is able
to reduce the carrageenan (CAR)-induced paw edema. Furthermore, the histological damage due
to the neutrophil infiltration is prevented, and this highlights precious anti-inflammatory features
of the interesting food-stu. Moreover, it was assessed that AE extract modulated nuclear factor
kappa-light-chain-enhancer of activated B cells (NF-kB) and The nuclear factor erythroid 2–related
factor 2 (Nrf-2) pathways. In conclusion, our data demonstrated that thanks to the antioxidant and
anti-inflammatory properties, AE extract could be used as a new food supplement for inflammatory
pathology prevention
Estudio paramétrico de la eficacia de disipadores friccionales para protección antisísmica de edificios
Este trabajo trata sobre la simulación numérica del comportamiento dinámico de edificios de varias plantas equipados con dispositivos disipadores de energía cuyo funcionamiento se basa en la fricción seca. Los edificios se modelan como pórticos planos (un grado de libertad por planta). El comportamiento dinámico de estas estructuras se describe por un modelo numérico no lineal desarrollado por los autores. Éste consiste en un algoritmo de integración temporal paso a paso basado en el método de Newmark. Se supone que la fuerza de fricción que actúa en cada disipador sigue la ley de rozamiento seco de Coulomb. Los resultados obtenidos con el algoritmo propuesto se comparan con los proporcionados por el programa comercial ADINA; la concordancia es satisfactoria. Además, los primeros resultados hallados (preliminares) muestran que los disipadores de fricción reducen sustancialmente la respuesta.Peer ReviewedPostprint (published version
Evidence for the role of EPHX2 gene variants in anorexia nervosa.
Anorexia nervosa (AN) and related eating disorders are complex, multifactorial neuropsychiatric conditions with likely rare and common genetic and environmental determinants. To identify genetic variants associated with AN, we pursued a series of sequencing and genotyping studies focusing on the coding regions and upstream sequence of 152 candidate genes in a total of 1205 AN cases and 1948 controls. We identified individual variant associations in the Estrogen Receptor-ß (ESR2) gene, as well as a set of rare and common variants in the Epoxide Hydrolase 2 (EPHX2) gene, in an initial sequencing study of 261 early-onset severe AN cases and 73 controls (P=0.0004). The association of EPHX2 variants was further delineated in: (1) a pooling-based replication study involving an additional 500 AN patients and 500 controls (replication set P=0.00000016); (2) single-locus studies in a cohort of 386 previously genotyped broadly defined AN cases and 295 female population controls from the Bogalusa Heart Study (BHS) and a cohort of 58 individuals with self-reported eating disturbances and 851 controls (combined smallest single locus P<0.01). As EPHX2 is known to influence cholesterol metabolism, and AN is often associated with elevated cholesterol levels, we also investigated the association of EPHX2 variants and longitudinal body mass index (BMI) and cholesterol in BHS female and male subjects (N=229) and found evidence for a modifying effect of a subset of variants on the relationship between cholesterol and BMI (P<0.01). These findings suggest a novel association of gene variants within EPHX2 to susceptibility to AN and provide a foundation for future study of this important yet poorly understood condition
Brechas de género y generación : documento de trabajo
Desde el Estado peruano se han generado dos importantes herramientas que permiten un combate directo a la existencia y permanencia de las brechas de género. En una primera instancia tenemos la Política Nacional de Igualdad de Género , cuyo foco de acción es la discriminación estructural de las mujeres como fuente de desigualdad; y, en un segundo lugar, la Política Nacional de la Juventud, que expone como problema público “la desigualdad en alcanzar el desarrollo integral de la población joven que afecta su participación en la sociedad”. Para el abordaje del problema público, la Política Nacional de Juventud integra el enfoque de género como transversal, ya que considera que es una herramienta de análisis que permite examinar las desigualdades en el ejercicio del poder, las cuales son complementadas con una mirada desde la perspectiva del ciclo de vida, que permite reconocer a las y los jóvenes en sus diferencias y particularidades, identificando las brechas existentes en la sociedad que dificultan sus oportunidades de acceso al desarrollo integral
Work-life balance in the police: the development of a self-management competency framework
Purpose Addressing a gap in the current work–life balance (WLB) literature regarding individual-focused approaches to inform interventions, we elicited behaviors used to self-manage WLB to draw up a competency-based WLB framework for relevant learnable knowledge, skills, and abilities (KSAs; Hoffmann, Eur J Ind Train 23:275–285, 1999) and mapping this against extant WLB frameworks. Design/Methodology/Approach Our participants were from a major UK police force, which faces particular challenges to the work–life interface through job demands and organizational cutbacks, covering a range of operational job roles, including uniformed officers and civilian staff. We took a mixed methods approach starting with semi-structured interviews to elicit 134 distinct behaviors (n = 20) and used a subsequent card sort task (n = 10) to group these into categories into 12 behavioral themes; and finally undertook an online survey (n = 356) for an initial validation. Findings Item and content analysis reduced the behaviors to 58, which we analyzed further. A framework of eight competencies fits the data best; covering a range of strategies, including Boundary Management, Managing Flexibility, and Managing Expectations. Implications The WLB self-management KSAs elicited consist of a range of solution-focused behaviors and strategies, which could inform future WLB-focused interventions, showing how individuals may negotiate borders effectively in a specific environment. Originality/Value A competence-based approach to WLB self-management is new, and may extend existing frameworks such as Border Theory, highlighting a proactive and solution-focused element of effective behaviors
Measurement of the B0-anti-B0-Oscillation Frequency with Inclusive Dilepton Events
The - oscillation frequency has been measured with a sample of
23 million \B\bar B pairs collected with the BABAR detector at the PEP-II
asymmetric B Factory at SLAC. In this sample, we select events in which both B
mesons decay semileptonically and use the charge of the leptons to identify the
flavor of each B meson. A simultaneous fit to the decay time difference
distributions for opposite- and same-sign dilepton events gives ps.Comment: 7 pages, 1 figure, submitted to Physical Review Letter
Observation of two new baryon resonances
Two structures are observed close to the kinematic threshold in the mass spectrum in a sample of proton-proton collision data, corresponding
to an integrated luminosity of 3.0 fb recorded by the LHCb experiment.
In the quark model, two baryonic resonances with quark content are
expected in this mass region: the spin-parity and
states, denoted and .
Interpreting the structures as these resonances, we measure the mass
differences and the width of the heavier state to be
MeV,
MeV,
MeV, where the first and second
uncertainties are statistical and systematic, respectively. The width of the
lighter state is consistent with zero, and we place an upper limit of
MeV at 95% confidence level. Relative
production rates of these states are also reported.Comment: 17 pages, 2 figure
Measurement of the Branching Fraction for B- --> D0 K*-
We present a measurement of the branching fraction for the decay B- --> D0
K*- using a sample of approximately 86 million BBbar pairs collected by the
BaBar detector from e+e- collisions near the Y(4S) resonance. The D0 is
detected through its decays to K- pi+, K- pi+ pi0 and K- pi+ pi- pi+, and the
K*- through its decay to K0S pi-. We measure the branching fraction to be
B.F.(B- --> D0 K*-)= (6.3 +/- 0.7(stat.) +/- 0.5(syst.)) x 10^{-4}.Comment: 7 pages, 1 postscript figure, submitted to Phys. Rev. D (Rapid
Communications
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