14 research outputs found
Role of a BRICS Bank in a multipolar world : is China establishing a new international organization to change the international order or to legitimize Chinese FDI?
- Publication venue
- The University of Hong Kong (Pokfulam, Hong Kong)
- Publication date
- 01/01/2015
- Field of study
published_or_final_versionInternational and Public AffairsMasterMaster of International and Public Affair
Continuous glucose monitoring in pregnant women with type 1 diabetes (CONCEPTT): a multicentre international randomised controlled trial.
- Author
- Adelantado Juan María
- Adib Sapida
- Amiel Stephanie A
- Asztalos Elizabeth
- Babington Gayna
- Banerjee Anita
- Barrett Jon F R
- Baxendale Darlene
- Baxter Janet
- Bertuzzi Federico
- Bilous Rudy
- Bonomo Matteo
- Booth John
- Brackenridge Anna
- Breen Adriana
- Briley Annette
- Byrne Carolyn
- Canciani Gioia
- Carty David
- Castorino Kristin
- Chilton Sharon
- Chlost Martyna
- Cleave Barbara
- Conway Sharon
- Coolen Jill
- Corcoy Rosa
- Crawford Isobel
- Cutts Terri
- Daigle Sylvie
- Daniela Giuseppina
- Davenport Katy
- de Leiva Alberto
- Donovan Lois E
- Dougherty Frances
- Dover Anna
- Dunne Fidelma
- Egan Aoife
- Endersby Del
- Feig Denice S
- Forbes Jane
- Fowler Duncan
- Frase Donna
- Godbout Ariane
- Gougeon Claire
- Green Louisa
- Grisoni Jeannie
- Halperin Ilana
- Heller Simon
- Henry Kathy
- Hewapathirana Niranjala
- Hod Moshe
- Holt Richard
- Houlden Robyn
- Hudson Sue
- Hunt Katharine F
- Hutton Eileen K
- Isabel Chico Ana
- Jackson Margaret
- Johnston Susan
- Jones Nia
- Jovanovic Lois
- Kearney Gretta
- Keely Erin
- Kirwin Collette
- Kollman Craig
- Kudirka Anne
- Lindsay Robert
- Lou Olivia
- Lowe Julia
- Lubina Alexandra
- MacDougall Malcolm
- Mackenzie Fiona
- Malcolm Janine
- Mansell Peter
- Maresh Michael
- Martin Nicki
- McInnes Natalia
- McManus Ruth
- McSorley Therese
- Meek Claire L
- Mion Elena
- Mitchell Susan
- Morris Damian
- Morris Juliet
- Mukhtar Rasha
- Murphy Helen R
- Murphy Kellie E
- Murray Lynne
- Neoh Sandra
- Newstead-Angel Jill
- Nisbet Chloe
- Novodorsky Peter
- O'Brien Robert
- Oldford Carolyn
- Paul Emma
- Perkins Michelle
- Philip Sam
- Pintaudi Basilio
- Piper Leanne
- Pragnell Marlon
- Quinn Susan
- Ransom Thomas
- Rayman Gerry
- Reid Anna
- Rogers Helen
- Rogowsky Anna
- Rosier Josephine
- Rossi Benedetta
- Ruedy Katrina
- Sanchez J Johanna
- Scott Eleanor
- Singh Claire
- Smith Ada
- Spick Dawn
- Stanton Irene
- Stewart Zoe A
- Strom Michelle
- Taylor Julie
- Tazzeo Tracy
- Temple Rosemary
- Tomlinson George
- Tundidor Diana
- Turner Jeremy
- Walbridge Fiona
- Watson Margaret
- Weisnagel John
- Wysocki Tim
- Young Catherine
- Publication venue
- Lancet
- Publication date
- 01/11/2017
- Field of study
BACKGROUND: Pregnant women with type 1 diabetes are a high-risk population who are recommended to strive for optimal glucose control, but neonatal outcomes attributed to maternal hyperglycaemia remain suboptimal. Our aim was to examine the effectiveness of continuous glucose monitoring (CGM) on maternal glucose control and obstetric and neonatal health outcomes. METHODS: In this multicentre, open-label, randomised controlled trial, we recruited women aged 18-40 years with type 1 diabetes for a minimum of 12 months who were receiving intensive insulin therapy. Participants were pregnant (≤13 weeks and 6 days' gestation) or planning pregnancy from 31 hospitals in Canada, England, Scotland, Spain, Italy, Ireland, and the USA. We ran two trials in parallel for pregnant participants and for participants planning pregnancy. In both trials, participants were randomly assigned to either CGM in addition to capillary glucose monitoring or capillary glucose monitoring alone. Randomisation was stratified by insulin delivery (pump or injections) and baseline glycated haemoglobin (HbA1c). The primary outcome was change in HbA1c from randomisation to 34 weeks' gestation in pregnant women and to 24 weeks or conception in women planning pregnancy, and was assessed in all randomised participants with baseline assessments. Secondary outcomes included obstetric and neonatal health outcomes, assessed with all available data without imputation. This trial is registered with ClinicalTrials.gov, number NCT01788527. FINDINGS: Between March 25, 2013, and March 22, 2016, we randomly assigned 325 women (215 pregnant, 110 planning pregnancy) to capillary glucose monitoring with CGM (108 pregnant and 53 planning pregnancy) or without (107 pregnant and 57 planning pregnancy). We found a small difference in HbA1c in pregnant women using CGM (mean difference -0·19%; 95% CI -0·34 to -0·03; p=0·0207). Pregnant CGM users spent more time in target (68% vs 61%; p=0·0034) and less time hyperglycaemic (27% vs 32%; p=0·0279) than did pregnant control participants, with comparable severe hypoglycaemia episodes (18 CGM and 21 control) and time spent hypoglycaemic (3% vs 4%; p=0·10). Neonatal health outcomes were significantly improved, with lower incidence of large for gestational age (odds ratio 0·51, 95% CI 0·28 to 0·90; p=0·0210), fewer neonatal intensive care admissions lasting more than 24 h (0·48; 0·26 to 0·86; p=0·0157), fewer incidences of neonatal hypoglycaemia (0·45; 0·22 to 0·89; p=0·0250), and 1-day shorter length of hospital stay (p=0·0091). We found no apparent benefit of CGM in women planning pregnancy. Adverse events occurred in 51 (48%) of CGM participants and 43 (40%) of control participants in the pregnancy trial, and in 12 (27%) of CGM participants and 21 (37%) of control participants in the planning pregnancy trial. Serious adverse events occurred in 13 (6%) participants in the pregnancy trial (eight [7%] CGM, five [5%] control) and in three (3%) participants in the planning pregnancy trial (two [4%] CGM and one [2%] control). The most common adverse events were skin reactions occurring in 49 (48%) of 103 CGM participants and eight (8%) of 104 control participants during pregnancy and in 23 (44%) of 52 CGM participants and five (9%) of 57 control participants in the planning pregnancy trial. The most common serious adverse events were gastrointestinal (nausea and vomiting in four participants during pregnancy and three participants planning pregnancy). INTERPRETATION: Use of CGM during pregnancy in patients with type 1 diabetes is associated with improved neonatal outcomes, which are likely to be attributed to reduced exposure to maternal hyperglycaemia. CGM should be offered to all pregnant women with type 1 diabetes using intensive insulin therapy. This study is the first to indicate potential for improvements in non-glycaemic health outcomes from CGM use. FUNDING: Juvenile Diabetes Research Foundation, Canadian Clinical Trials Network, and National Institute for Health Research
World Congress Integrative Medicine & Health 2017: Part one
- Author
- Aarva Paulina
- Abanades Sergio
- Abbadey Miznah
- Abbadey Miznah
- Adam Daniela
- Adams Jon
- Adams Jon
- Adams Jon
- Agdal Rita
- Ahnoumy Shafekah
- Alamoudi Omer
- AlBedah Abdullah
- Alorizi Seyed M E
- Alræk Terje
- Amarell Catharina
- Amarell Catherina
- Amarell Catherina
- Amarell Catherina
- Amini Fatemeh
- Ammendola Aldo
- Amri Hakima
- Amunni Gianni
- An Ruopeng
- Andermo Susanne
- Anderson Belinda
- Anheyer Dennis
- Anheyer Dennis
- Anheyer Dennis
- Anheyer Melanie
- Anheyer Melanie
- Annese Christine
- Arau Annemarie
- Arimitsu Junsuke
- Arman Maria
- Arnon Zahi
- Arnon Zahi
- Arye Eran
- Arye Eran
- Atarzadeh Fatemeh
- Attias Samuel
- Aval Shapour B
- Avidan Benjamin
- Avshalomov David
- Azari Masoumeh A
- Azizi Hamideh
- Azizi Hamideh
- Azizi Hoda
- Azizi Hoda
- Baars Erik
- Baccetti Sonia
- Baccetti Sonia
- Bai Chen
- Balneaves Lynda
- Bandelin Lena
- Barth Jürgen
- Barth Jürgen
- Bashtian Maryam H
- Baumann Klaus
- Beccia Ariel
- Bedregal Paula
- Beissner Florian
- Beissner Florian
- Beljanski Sylvie
- Belland Laura
- Benson Herbert
- Bentner Martina
- Berberat Pascal O
- Berger Bettina
- Berger Bettina
- Berger Bettina
- Berger Bettina
- Beyer Jörg
- Bhasin Manoj
- Biffi Sauro
- Binstock Maxwell
- Binting Sylvia
- Binting Sylvia
- Binting Sylvia
- Binting Sylvia
- Bishop Felicity
- Bishop Felicity
- Bishop Felicity
- Blanco Mar
- Blonde Clara
- Blonde Clara
- Bocci Chiara
- Boers Inge
- Boers Inge
- Bogani Patrizia
- Bonin D
- Bonucci Massimo
- Boon Heather
- Boon Heather
- Boon Heather
- Boothroyd Clare
- Boulanger Karen
- Bradbury Katherine
- Bradbury Katherine
- Bradley Ryan
- Brand Bernhard
- Breen Jenny
- Breitkreuz Thomas
- Briggs Josephine P
- Brinkhaus Benno
- Brinkhaus Benno
- Brinkhaus Benno
- Brinkhaus Benno
- Brinkhaus Benno
- Brinkhaus Benno
- Brodzky Marc
- Bronfort Gert
- Brooks Audrey
- Broom Alex
- Bruin Anja
- Bruset Stig
- Bu Xiangwei
- Bucuras Petru
- Bugarcic Andrea
- Buleu Florina
- Burnstock Geoffrey
- Busch Martine
- Buttó Ludovica
- Büssing Arndt
- Büssing Arndt
- Büssing Arndt
- Büssing Arndt
- Büssing Arndt
- Caldwell Christine
- Canella Claudia
- Cao Hui-juan
- Capler Rielle
- Carnes Dawn
- Carnes Dawn
- Castillo Noelia
- Chang Jessica
- Chang Mayling
- Chang Yinhui
- Chapman Michael
- Chen Bingzhong
- Cheon Chunhoo
- Cheshire Anna
- Ching Jessica Y L
- Cho Hyun J
- Cho Yumin
- Choi Da
- Choi Soo J
- Chouping Han
- Christodorescu Ruxandra
- Chuang Elisabeth
- Chung Vincent C H
- Coakley Amanda
- Cooley Kieran
- Cooper Cyrus
- Cotton Sian
- Cotton Sian
- Courneene Brendan
- Cramer Holger
- Cramer Holger
- Cramer Holger
- Cramer Holger
- Cramer Holger
- Cramer Holger
- Cree Margit
- Cysarz Dirk
- Dagnelie Pieter
- Daher Michel
- Daneshfard Babak
- Daneshfard Babak
- Daneshfard Babak
- Demerdash Abdulrahman
- Denninger John
- Derk Gwendolyn
- Dicen Demijon
- Diez Camino
- Dieze Helene
- Diezel Helene
- Diezel Helene
- Dimitrov Borislav
- Dimitrov Borislav
- Dobos Gustav
- Dobos Gustav
- Dobos Gustav
- Dobos Gustav
- Dobos Gustav
- Dobos Gustav
- Dong Fei
- Dong Fei
- Dongen Martien
- Dragan Simona
- Dräger Kilian
- Dubois Julie
- Dunlap Corina
- Dusek Jeffrey
- Eckert Marion
- Eckert Marion
- Eckert Marion
- Eckert Marion
- Edelhäuser Friedrich
- Edelhäuser Friedrich
- Eisenberg David
- Elyakim Rami
- Empoliti Joanne
- Esmaily Habibollah
- Esmaily Habibollah
- Esmaily Habibollah
- Esmel Neus
- Espinosa Stéphane
- Estiri Nazanin
- Evans Roni
- Evans Roni
- Evans Roni
- Fahey Paul
- Falkenberg Torkel
- Falkenberg Torkel
- Falkenberg Torkel
- Fan Xueyi
- Fang T.
- Fani Renato
- Fattahi Mohammad R
- Fawkes Carol
- Fawkes Carol
- Fei Yu-Tong
- Fei Yu-Tong
- Feng Xue
- Ferreri Rosaria
- Firenzuoli Fabio
- Firenzuoli Fabio
- Firenzuoli Fabio
- Fischer Isabell
- Fisher Peter
- Fisher Peter
- Flanagan Jane
- Flower Andrew
- Flower Andrew
- Flower Andrew
- Flower Andrew
- Fogerite Susan
- Foote Trevor R
- Foster Jo
- Foster Jo
- Fox Kealoha
- Frawley Jane
- Fricchione Gregory
- Fricchione Gregory L
- Frick Eckhard
- Fuente Francisca
- Fuente Francisca G
- Fønnebø Vinjar
- Fønnebø Vinjar
- Gafer Nahla
- Gallo Eugenia
- Gamus Dorit
- Gao Zishan
- Goldblatt Elisabeth
- Gomez Olga
- Grabenhenrich Linus
- Gramminger Harsha
- Graz Bertrand
- Gruber Harald
- Gruber Harald
- Gräßel Elmar
- Grünther Ralph-Achim
- Gu Xiaohong
- Gu Xiaohong
- Gu Xiaohong
- Guckenberger Matthias
- Guendling Nadine
- Guendling Peter W
- Guerrero Fanny
- Guffi Marta
- Gupta Hedwig H
- Gupta S. N
- Gutiérrez Soledad
- Haas Mitch
- Hablas Mohamed
- Hahn Eckhard
- Haller Dirk
- Haller Heidemarie
- Hamme Gesa-Meyer
- Han Dongwoon
- Han Dongwoon
- Haramati Aviad
- Haramati Aviad
- Haramati Aviad
- Haramati Aviad
- Haramati Aviad
- Hassanzadeh Malihe
- He Luzhu
- He Y.
- Heinrich Michael
- Heinrich Michael
- Helin Kaija
- Henriksson Roger
- Herrera Maria
- Heusser Peter
- Hilgard Dörte
- Ho Robin S T
- Hoff Evelyn
- Hohmann Christoph D
- Holmes Michelle
- Holtermann Christoph
- Horin Shomron
- Horneber Markus
- Hoseini Leila
- Hu Xiao-Yang
- Hu Xiao-Yang
- Huang Ching W
- Hueber Carly
- Hughes John
- Hughes John
- Hummelsberger Josef
- Hwang Ula
- Högl Manuel
- Icke Katja
- Ijaz Nadine
- Ijaz Nadine
- Im Hyea B
- Irnich Dominik
- Ivaldi Giovanni B
- Jacobs Christoph
- Jaladat Amir M
- Jan Sae B
- Jang Bo H
- Jang Eun H
- Jeitler Michael
- Jeitler Mika
- Jenewein Josef
- Jian Pei
- Jimenez José I
- Jin Li
- Jocham Alexandra
- Johnson Neil
- Jong Mats
- Jong Mats
- Jong Miek
- Jong Miek
- Jong Miek
- Jong Miek
- Jong Miek
- Joos Stefanie
- Joos Stefanie
- Jung Sonny
- Jung Young S
- Jäger Sven F
- Kaimiklotis John
- Kao Lan
- Kaplan Gary
- Kebudi Rejin
- Kemper Kathi
- Kerckhoff Annette
- Kern Alexandra
- Kessler Christian
- Kessler Christian
- Kessler Christian S
- Kessler Christian S
- Khadem Nayereh
- Khadivzadeh Talat
- Khalil Mohamed
- Kienle Gunver S
- Kim Eun S
- Kim Ha Y
- Kim Jihye
- Kim Keun H
- Kim Rana
- Klafke Nadja
- Klein Hedda
- Kligler Ben
- Kligler Ben
- Kligler Ben
- Kligler Benjamin
- Klocke Carina
- Klose Petra
- Ko Seong G
- Ko Youme
- Koch Sabine
- Kopylov Uri
- Kortum Ria
- Koshak Abdulrahman
- Koshak Emad
- Kostanjsek Nenad
- Kotlyanskaya Lucy
- Kraemer Kristen
- Kraft Karin
- Krantz Barbara
- Kreitzer Mary J
- Kreitzer Mary J
- Kristoffersen Agnete
- Kroez Matthias
- Kruse Sigrid
- Kröz Matthias
- Kröz Matthias
- Kuchta Kenny
- Lacey Sheryl
- LaForce Cathryn
- Lahat Adi
- Lai Lily Y
- Lai Lily Y
- Lang Alon
- Lang Anna-Lena
- Lange Silke
- Langhorst Jost
- Langhorst Jost
- Langhorst Jost
- Langley Julia
- Latif Abdul
- Lauche Romy
- Lauche Romy
- Lauche Romy
- Lauche Romy
- Lauche Romy
- Leach Matthew
- Lebensohn Patricia
- Lee Myeong S
- Lefeber Donald
- Leininger Brent
- Leininger Brent
- Leung Brenda
- Lewith George
- Lewith George
- Lewith George
- Lewith George
- Lewith George
- Lewith George
- Lewith George
- Lewith George
- Li Jin-gen
- Liang Fanrong
- Liang Ning
- Liang Ning
- Libermann Towia
- Lill JR
- Linde Klaus
- Linde Klaus
- Linka Esther
- Little Paul
- Liu Bin
- Liu Jian-Ping
- Liu Jian-Ping
- Liu Jian-ping
- Liu Jian-ping
- Liu Tiegang
- Liu Tiegang
- Liu Tiegang
- Liu Xugang
- Loerch Ronny
- Logue Martin
- Logue Martin
- Lotfalizadeh Marzieh
- Lotz Fabian
- Lotz Fabian
- Luberto Christina M
- Luberto Christina M
- Luberto Christina M
- Lumpkin Michael
- Luttenberger Katharina
- Lynen Andreas
- Lyttleton Jane
- Lötzke Désirée
- Lötzke Désirée
- Lüthi Sebastian
- Ma Jiaju
- Ma Xueyan
- Ma Xueyan
- MacPherson Hugh
- MacPherson Hugh
- Maggini Valentina
- Mahler Cornelia
- Mao Jun J
- Mao Xiaosong
- Marantz Paul
- Martin David
- Martin David
- Martin David D
- Martin Lily
- Masetti Morgana
- Masllorens Laia
- Matthes Harald
- Matthes Harald
- Matthes Harald
- McKee Melissa D
- Meaglia Ilaria
- Meissner Karin
- Meng Fengxian
- Mengoni Alessio
- Miceli Elisangela
- Michalsen Andreas
- Michalsen Andreas
- Michalsen Andreas
- Michalsen Andreas
- Michalsen Andreas
- Michalsen Andreas
- Michalsen Andres
- Mikolasek Michael
- Mittwede Martin
- Mohme Wiebke
- Monechi Maria V
- Monechi Maria V
- Moore Michael
- Moore Michael
- Motoo Yoshiharu
- Mudd Lanay M
- Mueller Andreas
- Mujkanovic Edin
- Munk Niki
- Murakozy Henriette
- Musial Frauke
- Muñoz Luis
- Naafs Marianne
- Neri Isabella
- NG Siew
- Nimri Omar
- Nimrouzi Majid
- Nimrouzi Majid
- Noi Ofir
- Nordberg Johanna H
- Nordberg Johanna H
- Ogal Mercedes
- Ogal Mercedes
- Ogawa Keiko
- Ogawa Masao
- Oritz Miriam
- Ortiz Miriam
- Ortiz Miriam
- Ortiz Miriam
- Ortiz Miriam
- Ostermann Thomas
- Ostermann Thomas
- Ots Thomas
- Otto Fabius
- Pach Daniel
- Paeizi Reza
- Paetow Arion
- Pah Ana M
- Pammer Patricia
- Panagioti Maria
- Paolini Marina
- Park Elyse
- Paske William
- Passi Alvaro
- Pasura Laura
- Paul Friedemann
- Pendergrass Anna
- Peters David
- Petrescu Marius
- Philpotts Lisa
- Ping Liu
- Pohlmann Urs
- Ponstein Anne
- Popovici Roxana
- Porcu Patrizia
- Preibisch Christine
- Puigmartí Carolina
- Pushparaj Peter
- Qutub Majdy
- Ralston Rick
- Rangitakatu Melisa
- Ratcliffe Julie
- Ratner Emily
- Razaq Samaher
- Recchia Daniela R
- Reinhold Thomas
- Reinhold Thomas
- Reisenberger Birgit
- Reisenberger Birgit
- Reyes Laura
- Rezaeizadeh Hossein
- Ridge Damien
- Riebau Robert
- Riva John J
- Robens Sibylle
- Roberts Lisa
- Roberts Lisa
- Rodondi Pierre-Yves
- Rodriguez Lourdes D
- Rodriguez Lourdes D
- Rodríguez Alfredo
- Roll Stephanie
- Roll Stephanie
- Román Keyla
- Román Keyla
- Rosenecker Joseph
- Rosenstiel Alexandra
- Rossi Elio
- Rossi Elio
- Rossi Elio
- Rostock Matthias
- Rotter Gabriele
- Rotter Gabriele
- Rotter Gabriele
- Ruiz Jonatan
- Ruiz Jonatan
- Rütz Michaela
- Saad Bashar
- Saez Gualberto
- Saghebi Seyed A
- Saha Felix J
- Sala Roser
- Salamonsen Anita
- Salehi Alireza
- Salomon Nir
- Samuels Noah
- Sanaye Mohammad R
- Sanaye Mohammad R
- Sasaki Yui
- Sceidt Christel
- Schad Friedemann
- Schaible Hans-Georg
- Scheffer Christian
- Schiff Elad
- Schiff Elad
- Schloss Janet
- Schläppi Marc
- Schnabel Katharina
- Schneeweiß Andreas
- Schneider Antonius
- Schröder Sven
- Schröer Beate
- Schröer Beate
- Schulz Craig
- Schumann Dania
- Schwartze Sophia
- Schwarz Silke
- Schömitz Meike
- Schönauer Annette
- Schönauer Annette
- Sears Richard
- Segantini Sergio
- Seifert Georg
- Sela Gil
- Sethe Dominik
- Shabestari Mahmoud M
- Shafto Kate
- Sharp Lena
- Shen Z.
- Shi Xuemin
- Shimizu Genki
- Shinday Nina
- Sibbritt David
- Silbermann Michael
- Simmons Laura
- Simon Chantal
- Simon Patrick
- Six Claudia
- Smith Caroline
- Sorsa Minna
- Stange Rainer
- Stange Rainer
- Stankewitz Josephin
- Steckhan Nico
- Steckhan Nico
- Steel Amie
- Steel Amie
- Steel Amie
- Steel Amie
- Stefano Mariella
- Stefano Mariella
- Steinberg Lois
- Stoichescu Gheorghe
- Stoll Sarah
- Stoltenberg Anna
- Strobl Judit
- Stuart Beth
- Stuart Beth
- Stub Trine
- Stub Trine
- Stupp Roger
- Stöckigt Barbara
- Stör Wolfram
- Suhr Ralf
- Sundberg Tobias
- Sundberg Tobias
- Szecsenyi Joachim
- Tafazoli Vahid
- Taghanaki Hamidreza
- Takeda Wendy
- Tauschel Diethard
- Tauschel Diethard
- Tavassoli Fatemeh
- Teut Michael
- Teut Michael
- Theorell Töres
- Thijs Carel
- Tissing Wim
- Tjaden Bram
- Trapp Barbara
- Tremel Nadine
- Tröger Wilfried
- Tucek Gerhard
- Uhlmann Lorenz
- Ullmann Alexander
- Vahle Maik
- Vega Miguel
- Villanueva Irene
- Vlieger Arine
- Vliet Marja
- Vliet Marja
- Voiß Petra
- Voller Fabio
- von Hagens Cornelia
- Vuolanto Pia
- Wali Siraj
- Wan Yuxiang
- Wan Yuxiang
- Wan Yuxiang
- Wang Dali
- Wang J.
- Wang Li-qiong
- Wang Xuan
- Wang Ying
- Ward Lesley
- Wardle Jon
- Wardle Jon
- Wardle Jon
- Wartner Eva
- Wasson Rachel
- Watanabe Kenji
- Wayne Peter
- Weber Wendy
- Weidenhammer Wolfgang
- Wen Grace Y G
- Wenzel Claudia
- White Shelley
- Wie Li
- Wieland Lisa S
- Wieland Lisa S
- Wiesener Solveig
- Wietmarschen Herman
- Willcox Merlin
- Willcox Merlin
- Willich Stefan N
- Witt Clauda
- Witt Claudia
- Witt Claudia
- Witt Claudia
- Witt Claudia
- Witt Claudia M
- Witt Claudia M
- Wode Kathrin
- Wong Hoi L C
- Wong Lisa M
- Wong Wendy
- Wu Darong
- Wu Justin
- Wu Justin
- Wu Justin C Y
- Wu Liqun
- Wu Ruo-Han
- Wu Ruo-Han
- Wu Xin Y
- Wullinger Michael
- Wüst Ana P
- Xu Jingnan
- Yan Liyi
- Yan Liyi
- Yan Xianzhong
- Yang Yufei
- Yardley Lucy
- Yardley Lucy
- Yardley Lucy
- Yeh Gloria
- ying Yang
- Yu He
- Yu He
- Yu He
- Yu Shuguang
- Zabihi Reza
- Zabihi Reza
- Zakeresfahani Arash
- Zalpour Christoff
- Zarshenas Mohammad M
- Zhang X.
- Zhang Yuqing
- Zhang Zhengju
- Zhen Jianhua
- Zheng Zian
- Zheng Zian
- Zheng Zian
- Zieger Anja
- Zillgen Hannah
- Zoderer Iris
- Zwickey Heather
- Özbe Dominik
- Öztürk Ali Ö
- Öztürk Gizemnur
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes
- Author
- Aarsland Dag
- Aarsland Dag
- Abdelnour Carla
- Abraham Richard
- Abraham Richard
- Adarmes-Gómez A.D.
- Adarmes-Gómez Ad
- Aguilera N.
- Aguilera Nuria
- Ahmad Shahzad
- Al-Chalabi Ammar
- Al-Chalabi Ammar
- Alarcon E.
- Alarcón-Martín E.
- Alarcón-Martín Emilio
- Alcolea Daniel
- Alegret M.
- Alegret Montserrat
- Alonso M.D.
- Alvarez Ignacio
- Alvarez Victoria
- Ambati Aditya
- Amer-Ferrer G.
- Amin Najaf
- Amouyel Philippe
- Amouyel Philippe
- Amouyel Phillippe
- Anastasiou Anna
- Anastasiou Costas
- Andrade Victor
- Andreassen Ole A.
- Andreassen Ole A.
- Andreassen Ole A.
- Andreoni Simona
- Annuar Azlina Ahmad
- Antequera M.
- Anthoula Tsolaki
- Antikainen Riitta
- Antonell Anna
- Antúnez C.
- Appollonio Ildebrando
- Arcaro Marina
- Archetti Silvana
- Arfan Ikram M.
- Arias Pastor Alfonso
- Ariel Prestia Federico
- Armstrong Nicola J.
- Arosio Beatrice
- Arosio Beatrice
- Assogna Francesca
- Athanasiu Lavinia
- Athanasiu Lavinia
- Au Wing-Lok
- Bahrami Shahram
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- Luckcuck Lauren
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- Moebus Susanne
- Moebus Susanne
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- Mok Shi Qi
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- Papenberg Goran
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- Parnetti Lucilla
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- Parveen Kayenat
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- Pasquier Florence
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- Thalamuthu Anbupalam
- Thomas Charlene
- Thomas Tegos
- Thomassen Jesper Qvist
- Thonberg Håkan
- Toda Tatsushi
- Todd Stephen
- Todd Stephen
- Traykov Latchezar
- Tremolizzo Lucio
- Tremolizzo Lucio
- Tsolaki Magda
- Tsolaki Magda
- Tuomilehto Jaakko
- Turton James
- Tybjærg-Hansen Anne
- Tzourio Christophe
- Táarraga L.
- Tárraga Lluís
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- Ulstein Ingun
- Ulstein Ingun
- Uphill James
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- Valero S.
- Valero S.
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- Van Broeckhoven Christine
- van der Flier Wiesje
- van der Flier Wiesje M.
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- van der Lugt Aad
- Van Dongen Jasper
- van Duijn Cornelia M.
- Van Duin Cornelia
- van Rooij Jeroen
- van Swieten John
- van Swieten John
- Vandenberghe Rik
- Vardy Emma
- Vargas L.
- Vargas Liliana
- Verhey Frans
- Verhey Frans
- Vicente M.P.
- Vidal Jean-Sébastien
- Vigo-Ortega R.
- Vigo-Ortega R.
- Vivancos L.
- Vogelgsang Jonathan
- Vyhnalek Martin
- Vyhnalek Martin
- Waern Margda
- Wagner Michael
- Wallon David
- Wallon David
- Warden Donald
- Warner Nick
- Warren Jason D.
- Weber Heike
- Weinhold Leonie
- Wichmann H-Erich
- Wilcock Gordon
- Williams Amy
- Williams Julie
- Williams Julie
- Williams Julie
- Wiltfang Jens
- Wiltfang Jens
- Wiltfang Jens
- Windle Gill
- Woods Bob
- Wu Yih-Ru
- Xu Renshi
- Xu Yu-ming
- Yan Yaping
- Yang Jing
- Yannakoulia Mary
- Yaqub Amber
- Yogeshwar Selina Maria
- Yonkova Mihova Kalina
- Yu Eric
- Zetterberg Henrik
- Zettergren Anna
- Zhang Jing
- Zulaica Miren
- Álvarez I.
- Álvarez V.
- Álvarez Victoria
- Publication venue
- National Academy of Sciences
- Publication date
- 29/08/2023
- Field of study
Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues
Ofatumumab versus Teriflunomide in Multiple Sclerosis
- Author
- Aaron Carlson
- Achim Berthele
- Adaeze Onuoha
- Adam Wolff
- Adnan Subei
- Agnes Koves
- Ahmad Ata
- Aiden Haghikia
- Aimee Borazanci
- Akram Dastagir
- Albert Saiz Hinarejos
- Alberto Vasquez
- Alena Martinkova
- Alfredo Rodriguez Antigüedad
- Alina Sergeevna Agafina
- Alison Brooke Allen
- Alla Shifrin
- Amit Bar-Or
- Ana Martins Da Silva
- Ana Voldsgaard Jensen
- Andrejs Millers
- Andrew Gale
- Andrew P Keegan
- Andrzej Wiak
- Angel Carrasco
- Angel R Chinea Martinez
- Angela Timoteo
- Angelica Carbajal Ramirez
- Ann Bass
- Anna Naumovna Belova
- Anne Cross
- Annette Okai
- Anselm Kornhuber
- Anshu Rohatgi
- Anton Vladic
- Antonio Uccelli
- Antonio Vasco Salgado
- April Erwin
- Ariel Antezana-Antezana
- Arnfin Bergmann
- Arnon Karni
- Astrid Edland
- Ayse Nur Yuceyar
- Aysun Soysal
- Bar-Or A.
- Barbara Green
- Barbara Willekens
- Bart Van Wijmeersch
- Bartosz Karaszewski
- Beatrijs Wokke
- Belgin Petek Balci
- Ben Turner
- Benedikt Frank
- Bharathy E Sundaram
- Bhupendra Khatri
- Bhupesh Dihenia
- Birte Elias-Hamp
- Bjoern Tackenberg
- Bob W Van Oosten
- Bogdan Gheorghiu
- Bonaventura Casanova Estruch
- Brian Costell
- Brian Steingo
- Brigitte Wildemann
- Bruce L Hughes
- Bruno Brochet
- Carlo Pozzilli
- Carlos Ballario
- Carlos Capela
- Carlos Veira
- Carrie M Hersh
- Cavit Boz
- Celia Oreja-Guevara
- Celine Louapre
- Cesar Castaneda
- Chiara Zecca
- Chris Retief
- Christian Calvo Vildoso
- Christine Lebrun-Frenay
- Christopher Laganke
- Christopher Luzzio
- Cohen J. A.
- Comi G.
- Corey Ford
- Correale J.
- Coyle P. K.
- Craig Edward Herrman
- Craig Senzon
- Cross A. H.
- Csilla Rozsa
- Cynthia Huffman
- Dalia Mickeviciene
- Daniel R Wynn
- David Axel Laplaud
- David Barnes
- David D O Bear
- David H Mattson
- David Lesch
- David Paling
- David Weisman
- de Seze J.
- Deborah A Burke
- Denis Viktorovich Sazonov
- Dennis W Dietrich
- Deren Huang
- Derrick Robertson
- Dheeraj Khurana
- Djamchid Lotfi
- Dmitry Pokhabov
- Don Joseph Alfonso
- Dusan Stefoski
- Edward J Fox
- Egon Kurca
- Ekaterina Igorevna Kairbekova
- Elena Gennadievna Arefieva
- Eli Silber
- Elzbieta Jasinska
- Emily Pharr
- Enrique Alvarez
- Erik Strauss
- Eugen Schlegel
- Eva Meluzinova
- Eva-Maria Maida
- Evanthia Bernitsas
- Faria Amjad
- Farit Axatovich Khabirov
- Filipe Correia
- Florian Then Bergh
- Francesco Sacca
- Francois Emond
- Francois Grandmaison
- Francois Jacques
- Fredrik Piehl
- Fritz Leutmezer
- Gabriel Pardo
- Garry R Cutter
- Gemma Reig Rosello
- Geoffrey Eubank
- Georgi Krastev
- Gerald Mcintosh
- Gereon Nelles
- Giacomo Lus
- Giancarlo Comi
- Giles F Crowell
- Gilles Edan
- Giovanni Castelnovo
- Girolama Alessandra Marfia
- Goodyear A.
- Guntis Karelis
- Guy Laureys
- Halina Bartosik Psujek
- Hana Bokun
- Hans-Peter Hartung
- Haring D. A.
- Hauser S. L.
- Hayrettin Tumani
- Heinz Wiendl
- Helle Hvilsted Nielsen
- Hemanth Rao
- Husnu Efendi
- Igor Antoncic
- Igor Stolyarov
- Igor Vyacheslavovich Litvinenko
- Irina Aleksandrovna Sokolova
- Israel Steiner
- Ivan Milanov
- Ivana Stetkarova
- Ivaylo Tarnev
- Iwona Jastrzebska
- J Michael Hemphill
- Jack H Florin
- Jacqueline Nicholas
- James Napier
- James Overell
- James Scott
- Jan Lycke
- Jan Mares
- Jaroslaw Slawek
- Jason M Silversteen
- Javier Vasallo
- Jean-Raphael Schneider
- Jeanette Wendt
- Jeannette Lechner-Scott
- Jeffrey A Cohen
- Jeffrey Cohen
- Jeffrey Gross
- Jeffrey Groves
- Jeffrey Kaplan
- Jerome de Seze
- Jerry S Wolinsky
- Jessica Stulc
- Jeyaraj Durai Pandian
- Jo Caekebeke
- Joanna A Cooper
- Joao Cerqueira
- Joao De Sa
- John Foley
- John Parratt
- John Scagnelli
- Jolana Markova
- Jolanta Kalnina
- Jonathan C Calkwood
- Jorge Correale
- Jorge Gustavo Jose
- Jose Carlos Alvarez Cermeño
- Jose Martinez Rodriguez
- Jose Meca Lallana
- Jose Pizarro Otero
- Jose Rafecas
- Joshua Katz
- Joy Dev Mukherji
- Juan Antonio Garcia Merino
- Juan Jose Lopez Prieto
- Juha Pekka Eralinna
- Juliette S Saad
- Julio Perez
- Kakarieka A.
- Kappos L.
- Karine Geens
- Karl-Otto Sigel
- Katherine Standley
- Katrin Gross-Paju
- Keith Edwards
- Kenneth Sharlin
- Kerloeguen C.
- Khurram Bashir
- Kimberly Wagner
- Konstantinos Kilidireas
- Konstantinos Voumvourakis
- Kore Liow
- Kristina Svendsen
- Krisztina Kovacs
- Krzysztof Selmaj
- Larisa Ivanovna Volkova
- Larry Lee Blankenship Jr
- Laszlo Mate
- Laszlo Vecsei
- Laura Brambilla
- Lekha Pandit
- Leppert D.
- Li B.
- Liesly Lee
- Liliana Montoya
- Livia De Sousa
- Lluis Ramio Torrenta
- Lon D Lynn
- Lucia Forero Diaz
- Lucienne Costa Frossard Franca
- Ludo Vanopdenbosch
- Ludwig Kappos
- Luis Querol Gutierrez
- Lyubomir Haralanov
- M Mateo Paz Soldan
- Maciej Maciejowski
- Mads Ravnborg
- Marc Debouverie
- Marco Salvetti
- Maria Manova Slavova
- Maria Nikolaevna Zaharova
- Maria Vafaevna Davydovskaya
- Marie Sarah Gagne Brosseau
- Marija Bosnjak Pasic
- Mario Habek
- Marja-Liisa Sumelahti
- Mark Agius
- Mark Allan Goldstein
- Mark Cascione
- Mark Freedman
- Mark Janicki
- Marta Vachova
- Martin Cloutier
- Martin Gavidia
- Martin R Bialow
- Martin Stangel
- Martin Valis
- Mary Denise Hughes
- Massimo Filippi
- Matthew Craner
- Matthew J Baker
- Matthias Boehringer
- Mauro Zaffaroni
- Meena Angamuthu Kanikannan
- Merschhemke M.
- Michael Isaacs
- Michaela Tyblova
- Michal Dufek
- Michelle Apperson
- Michelle B Kuczma
- Mirela Cerghet
- Miroslav Brozman
- Miroslaw Dziki
- Monika Adamczyk Sowa
- Montalban X.
- Murat Terzi
- Nadezhda Alekseevna Malkova
- Natalia Agafonovna Totolyan
- Nathaniel Robb Whaley
- Nikolaos Fakas
- Nikolaos Grigoriadis
- Nikolay Vasilievich Dorogov
- Norma Haydee Deri
- Olaf Martin Hoffmann
- Olivier Deryck
- Ondrej Skoda
- Pahari Ghosh
- Paolo Gallo
- Patricia K Coyle
- Patrick Oschmann
- Patrick Vermersch
- Paul K Winner
- Pavel Hradilek
- Pavle Repovic
- Pedro Serrano Castro
- Penko Shotekov
- Per Soelberg Sørensen
- Peter Koleda
- Peter Turcani
- Peter Valkovic
- Peter Van Domburg
- Peter Vestergaard Rasmussen
- Pierre Clavelou
- Pierre Labauge
- Pingili R.
- Praful Kelkar
- Radi Shahien
- Rafael Arroyo Gonzalez
- Rahul Chakor
- Rahul Kulkarni
- Ramanathan K.
- Randall Trudell
- Raquel Gouveia
- Rasa Kizlaitiene
- Raymond Hupperts
- Reinhard Hohlfeld
- Ricardo Ayala
- Richard Sater
- Robert Bonek
- Robert Carruthers
- Robert Fairborn Armstrong
- Robert Naismith
- Robert Thomas Nahouraii
- Rogier Q Hintzen
- Romero Rekha Pillai
- Ron Milo
- Ronald S Murray
- Roopkumar Gursahani
- Samuel Hunter
- Sangeeta Ravat
- Sara Eichau Madueño
- Sara Qureshi
- Sarah Morrow
- Satori Maria
- Selmaj K.
- Sergio Martinez Yelamos
- Serhan Sevim
- Serkan Ozakbas
- Sharon Lynch
- Sibyl Wray
- Silke Walter
- Silva Butkovic Soldo
- Silvia R Delgado
- Silvia Rossi
- Simona Bonavita
- Somsak Tiamkao
- Srinivasa Rangasetty
- Stacy Donlon
- Stanley Cohan
- Stanya Smith
- Stella Anatolievna Sivertseva
- Stephen C Reingold
- Stephen L Hauser
- Stuart James Shafer
- Sulev Haldre
- Suresh Kumar
- Susan Azalone
- Susan Hibbs
- Susana Liwacki
- Suzanne Hodgkinson
- Sylvia Menck
- Tamara A Miller
- Tamara Castillo Trivino
- Thomas Doerner
- Thomas Giancarlo
- Thy-Sheng Lin
- Till Sprenger
- Tjalf Ziemssen
- Tobias Derfuss
- Tomic D.
- Troy Desai
- Valeria Studer
- Valerie Delvaux
- Varun K Saxena
- Veit Ulrich Becker
- Vera Straeten
- Viera Hancinova
- Vincent Van Pesch
- Virgina Meca Lallana
- Virginia Simnad
- Vladimir Donath
- Vladimira Vuletic
- Waldemar Fryze
- Wiendl H.
- Willi R.
- William David Honeycutt
- William E McElveen
- William Logan
- William Wagner
- Xavier Montalban
- Xaviere Montalban Gairin
- Yves Lapierre
- Zita Biro
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2020
- Field of study
BACKGROUND: Ofatumumab, a subcutaneous anti-CD20 monoclonal antibody, selectively depletes B cells. Teriflunomide, an oral inhibitor of pyrimidine synthesis, reduces T-cell and B-cell activation. The relative effects of these two drugs in patients with multiple sclerosis are not known. METHODS: In two double-blind, double-dummy, phase 3 trials, we randomly assigned patients with relapsing multiple sclerosis to receive subcutaneous ofatumumab (20 mg every 4 weeks after 20-mg loading doses at days 1, 7, and 14) or oral teriflunomide (14 mg daily) for up to 30 months. The primary end point was the annualized relapse rate. Secondary end points included disability worsening confirmed at 3 months or 6 months, disability improvement confirmed at 6 months, the number of gadolinium-enhancing lesions per T1-weighted magnetic resonance imaging (MRI) scan, the annualized rate of new or enlarging lesions on T2-weighted MRI, serum neurofilament light chain levels at month 3, and change in brain volume. RESULTS: Overall, 946 patients were assigned to receive ofatumumab and 936 to receive teriflunomide; the median follow-up was 1.6 years. The annualized relapse rates in the ofatumumab and teriflunomide groups were 0.11 and 0.22, respectively, in trial 1 (difference, -0.11; 95% confidence interval [CI], -0.16 to -0.06; P<0.001) and 0.10 and 0.25 in trial 2 (difference, -0.15; 95% CI, -0.20 to -0.09; P<0.001). In the pooled trials, the percentage of patients with disability worsening confirmed at 3 months was 10.9% with ofatumumab and 15.0% with teriflunomide (hazard ratio, 0.66; P = 0.002); the percentage with disability worsening confirmed at 6 months was 8.1% and 12.0%, respectively (hazard ratio, 0.68; P = 0.01); and the percentage with disability improvement confirmed at 6 months was 11.0% and 8.1% (hazard ratio, 1.35; P = 0.09). The number of gadolinium-enhancing lesions per T1-weighted MRI scan, the annualized rate of lesions on T2-weighted MRI, and serum neurofilament light chain levels, but not the change in brain volume, were in the same direction as the primary end point. Injection-related reactions occurred in 20.2% in the ofatumumab group and in 15.0% in the teriflunomide group (placebo injections). Serious infections occurred in 2.5% and 1.8% of the patients in the respective groups. CONCLUSIONS: Among patients with multiple sclerosis, ofatumumab was associated with lower annualized relapse rates than teriflunomide. (Funded by Novartis; ASCLEPIOS I and II ClinicalTrials.gov numbers, NCT02792218 and NCT02792231.)
New insights into the genetic etiology of Alzheimer's disease and related dementias.
- Author
- Aarsland Dag
- Abdelnour Carla
- ADGC
- Ahmad Shahzad
- Alarcón-Martín Emilio
- Alcolea Daniel
- Alegret Montserrat
- Allende Irene Rosas
- Alvarez Ignacio
- Amin Najaf
- Amouyel Philippe
- Andrade Victor
- Andreassen Ole A
- Antúnez Carmen
- Appollonio Ildebrando
- Arcaro Marina
- Archetti Silvana
- Armstrong Nicola J
- Arosio Beatrice
- Athanasiu Lavinia
- Bailly Henri
- Banaj Nerisa
- Baquero Miquel
- Barral Sandra
- Beiser Alexa
- Bellenguez Céline
- Below Jennifer E
- Benchek Penelope
- Benussi Luisa
- Berr Claudine
- Besse Céline
- Bessi Valentina
- Biessels Geert Jan
- Binetti Giuliano
- Bis Joshua C
- Bizarro Alessandra
- Blesa Rafael
- Boada Mercè
- Boerwinkle Eric
- Boland Anne
- Borroni Barbara
- Boschi Silvia
- Bossù Paola
- Bresner Catherine
- Bressler Jan
- Brodaty Henry
- Broeckhoven Christine Van
- Brookes Keeley J
- Brusco Luis Ignacio
- Bråthen Geir
- Buiza-Rueda Dolores
- Bullido María J
- Burholt Vanessa
- Bush William S
- Bûrger Katharina
- Calero Miguel
- Campos-Martin Rafael
- Cantwell Laura B
- Carracedo Ángel
- Cecchetti Roberta
- Cervera-Carles Laura
- Chapuis Julien
- Charbonnier Camille
- CHARGE
- Chen Hung-Hsin
- Chene Geneviève
- Chillotti Caterina
- Chung Jaeyoon
- Ciccone Simona
- Claassen Jurgen AHR
- Clarimon Jordi
- Clark Christopher
- Conti Elisa
- Corma-Gómez Anaïs
- Costa Marcos R
- Costantini Emanuele
- Cuccaro Michael L
- Custodero Carlo
- Daian Delphine
- Dalmasso Maria Carolina
- Damotte Vincent
- Daniele Antonio
- Dardiotis Efthimios
- Dartigues Jean-François
- de Deyn Peter Paul
- de Mendonça Alexandre
- de Munain Adolfo Lopez
- de Paiva Lopes Katia
- de Rojas Itziar
- de Witte Lot D
- Debette Stéphanie
- Deckert Jürgen
- DEGESCO
- Del Ser Teodoro
- Deleuze Jean-François
- Demgene
- Denning Nicola
- DeStefano Anita
- Dichgans Martin
- Diehl-Schmid Janine
- Diez-Fairen Mónica
- Djurovic Srdjan
- Dongen Jasper Van
- Dufouil Carole
- Duron Emmanuelle
- Düzel Emrah
- EADB
- EADI
- Eiriksdottir Gudny
- Engelborghs Sebastiaan
- Escott-Price Valentina
- Espinosa Ana
- Ewers Michael
- Faber Kelley M
- Fabrizio Tagliavini
- Fardo David W
- Farotti Lucia
- Farrer Lindsay A
- Fenoglio Chiara
- Fernández-Fuertes Marta
- Ferrari Raffaele
- Ferreira Catarina B
- Ferri Evelyn
- Fin Bertrand
- FinnGen
- Fischer Peter
- Fladby Tormod
- Fließbach Klaus
- Fongang Bernard
- Fornage Myriam
- Foroud Tatiana M
- Fortea Juan
- Fostinelli Silvia
- Fox Nick C
- Franco-Macías Emlio
- Frank-García Ana
- Frikke-Schmidt Ruth
- Froelich Lutz
- Fulton-Howard Brian
- Galimberti Daniela
- Garcia-Gonzalez Pablo
- Garcia-Madrona Sebastian
- Garcia-Ribas Guillermo
- García-Alberca Jose Maria
- García-González Pablo
- GERAD
- Ghanbari Mohsen
- Ghidoni Roberta
- Giedraitis Vilmantas
- Giegling Ina
- Giorgio Giaccone
- Goate Alison M
- Goldhardt Oliver
- Gomez-Fonseca Duber
- González-Pérez Antonio
- GR@ACE
- Graff Caroline
- Grande Giulia
- Green Emma
- Grenier-Boley Benjamin
- Grimmer Timo
- Grunin Michelle
- Grünblatt Edna
- Gudnason Vilmundur
- Guetta-Baranes Tamar
- Haapasalo Annakaisa
- Hadjigeorgiou Georgios
- Haines Jonathan L
- Hamilton-Nelson Kara L
- Hampel Harald
- Hanon Olivier
- Hardy John
- Hartmann Annette M
- Harwood Janet
- Hausner Lucrezia
- Heilmann-Heimbach Stefanie
- Helisalmi Seppo
- Heneka Michael T
- Hernández Isabel
- Herrmann Martin J
- Hiltunen Mikko
- Hoffmann Per
- Holmans Peter A
- Holmes Clive
- Holstege Henne
- Hort Jakub
- Hulsman Marc
- Humphrey Jack
- Ikram M Arfan
- Ingelsson Martin
- Jansen Iris E
- Jessen Frank
- Jian Xueqiu
- Johansson Charlotte
- Juan Pascual Sánchez
- Jun Gyungah R
- Kastumata Yuriko
- Kauwe John
- Kehoe Patrick G
- Kilander Lena
- Kivipelto Miia
- Kleineidam Luca
- Koivisto Anne
- Kornhuber Johannes
- Kosmidis Mary H
- Kuksa Pavel P
- Kukull Walter A
- Kunkle Brian W
- Kuulasmaa Teemu
- Kuzma Amanda B
- Küçükali Fahri
- Lage Carmen
- Lambert Jean-Charles
- Laukka Erika J
- Launer Lenore
- Lauria Alessandra
- Lee Chien-Yueh
- Lehtisalo Jenni
- Lerch Ondrej
- Lleó Alberto
- Longstreth William
- Lopez Oscar
- Love Seth
- Luckcuck Lauren
- Lunetta Kathryn L
- Löwemark Malin
- Ma Yiyi
- MacLeod Catherine A
- Macías Juan
- Maier Wolfgang
- Mangialasche Francesca
- Marquié Marta
- Marshall Rachel
- Martin Eden R
- Masullo Carlo
- Mather Karen
- Mayeux Richard
- Mead Simon
- Mecocci Patrizia
- Medina Miguel
- Meggy Alun
- Mehrabian Shima
- Mendoza Silvia
- Menéndez-González Manuel
- Mir Pablo
- Moebus Susanne
- Mol Merel
- Molina-Porcel Laura
- Montes Angel Martín
- Montrreal Laura
- Morelli Laura
- Moreno Fermin
- Moreno-Grau Sonia
- Morgan Kevin
- Mosley Thomas
- Muchnik Carolina
- Mukherjee Shubhabrata
- Nacmias Benedetta
- Naj Adam C
- Ngandu Tiia
- Nicolas Gael
- Nielsen Sune Fallgaard
- Nordestgaard Børge G
- Nöthen Markus M
- Olaso Robert
- Orellana Adelina
- Orsini Michela
- Ortega Gemma
- Padovani Alessandro
- Paolo Caffarra
- Papenberg Goran
- Parnetti Lucilla
- Pasquier Florence
- Pastor Alfonso Arias
- Pastor Ana Belén
- Pastor Pau
- Peloso Gina
- Pericak-Vance Margaret A
- Pericard Pierre
- Peters Oliver
- Pijnenburg Yolande AL
- Pineda Juan A
- Pisanu Claudia
- Piñol-Ripoll Gerard
- Polak Thomas
- Popp Julius
- Posthuma Danielle
- Priller Josef
- Prokic Ivana
- Psaty Bruce M
- Puerta Raquel
- Pérez-Cordón Alba
- Pérez-Tur Jordi
- Quenez Olivier
- Quintela Inés
- Rainero Innocenzo
- Raj Towfique
- Rajabli Farid
- Ramakers Inez
- Ramirez Alfredo
- Real Luis M
- Reinders Marcel JT
- Reitz Christiane
- Reyes-Dumeyer Dolly
- Ridge Perry
- Riedel-Heller Steffi
- Riederer Peter
- Roberto Natalia
- Rodriguez-Rodriguez Eloy
- Rodríguez Carmen Martínez
- Rongve Arvid
- Rosende-Roca Maitée
- Rossi Giacomina
- Rossi Paolo Dionigi
- Royo Jose Luis
- Rubino Elisa
- Ruiz Agustín
- Rujescu Dan
- Rábano Alberto
- Sachdev Perminder
- Sakka Paraskevi
- Saltvedt Ingvild
- Sanabria Ángela
- Sanchez-Garcia Florentino
- Sando Sigrid B
- Sarnowski Chloé
- Satizabal Claudia L
- Scamosci Michela
- Scarmeas Nikolaos
- Scarpini Elio
- Schellenberg Gerard D
- Scheltens Philip
- Scherbaum Norbert
- Scherer Martin
- Schmid Matthias
- Schneider Anja
- Schott Jonathan M
- Selbæk Geir
- Seripa Davide
- Serrano Manuel
- Seshadri Sudha
- Sha Jin
- Shadrin Alexey A
- Sims Rebecca
- Skrobot Olivia
- Sleegers Kristel
- Slifer Susan
- Snijders Gijsje JL
- Soininen Hilkka
- Solfrizzi Vincenzo
- Solomon Alina
- Song Yeunjoo
- Sorbi Sandro
- Sotolongo-Grau Oscar
- Spallazzi Marco
- Spalletta Gianfranco
- Spottke Annika
- Squassina Alessio
- Stordal Eystein
- Ståhlbom Anne Kinhult
- Sáez María Eugenia
- Sánchez-Arjona María Bernal
- Sánchez-Valle Raquel
- Tartan Juan Pablo
- Tesí Niccolo
- Thalamuthu Anbupalam
- Thomas Tegos
- Thomassen Jesper Qvist
- Tosto Giuseppe
- Traykov Latchezar
- Tremolizzo Lucio
- Tsolaki Anthoula
- Tsolaki Magda
- Tybjærg-Hansen Anne
- Tárraga Lluís
- Uitterlinden Andre
- Ullgren Abbe
- Ulstein Ingun
- Valero Sergi
- Valladares Otto
- van der Flier Wiesje M
- van der Lee Sven J
- van der Lugt Aad
- van Duijn Cornelia M
- van Rooij Jeroen
- van Swieten John
- Vance Jeffery
- Vandenberghe Rik
- Vardarajan Badri N
- Verhey Frans
- Vidal Jean-Sébastien
- Vilas Raquel Huerto
- Vogelgsang Jonathan
- Vyhnalek Martin
- Wagner Michael
- Wallon David
- Wang Li-San
- Wang Ruiqi
- Weinhold Leonie
- Williams Julie
- Wiltfang Jens
- Windle Gill
- Woods Bob
- Yang Qiong
- Yannakoulia Mary
- Yaqub Amber
- Zare Habil
- Zhang Xiaoling
- Zhao Yi
- Zhu Congcong
- Zulaica Miren
- Álvarez Victoria
- Publication venue
- Nat Genet
- Publication date
- 01/01/2022
- Field of study
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele
New insights into the genetic etiology of Alzheimer's disease and related dementias
- Author
- Aarsland Dag
- Abdelnour Carla
- Ahmad Shahzad
- Alarcón-Martín Emilio
- Alcolea Daniel
- Alegret Montserrat
- Allende Irene Rosas
- Alvarez Ignacio
- Amin Najaf
- Amouyel Philippe
- Andrade Victor
- Andreassen Ole
- Antúnez Carmen
- Appollonio Ildebrando
- Arcaro Marina
- Archetti Silvana
- Armstrong Nicola J.
- Arosio Beatrice
- Athanasiu Lavinia
- Bailly Henri
- Banaj Nerisa
- Baquero Miquel
- Barral Sandra
- Beiser Alexa
- Bellenguez Céline
- Below Jennifer E.
- Benchek Penelope
- Benussi Luisa
- Berr Claudine
- Besse Céline
- Bessi Valentina
- Biessels Geert Jan
- Binetti Giuliano
- Bis Joshua C.
- Bizarro Alessandra
- Blesa Rafael
- Boada Mercè
- Boerwinkle Eric
- Boland Anne
- Borroni Barbara
- Boschi Silvia
- Bossù Paola
- Bresner Catherine
- Bressler Jan
- Brodaty Henry
- Broeckhoven Christine Van
- Brookes Keeley J.
- Brusco Luis Ignacio
- Bråthen Geir
- Buiza-Rueda Dolores
- Bullido María J
- Burholt Vanessa
- Bush William S.
- Bûrger Katharina
- Calero Miguel
- Campos-Martin Rafael
- Cantwell Laura B.
- Carracedo Ángel
- Cecchetti Roberta
- Cervera-Carles Laura
- Chapuis Julien
- Charbonnier Camille
- Chen Hung-Hsin
- Chene Geneviève
- Chillotti Caterina
- Chung Jaeyoon
- Ciccone Simona
- Claassen Jurgen A H R
- Clarimon Jordi
- Clark Christopher
- Conti Elisa
- Corma-Gómez Anaïs
- Costa Marcos R.
- Costantini Emanuele
- Cuccaro Michael L.
- Custodero Carlo
- Daian Delphine
- Dalmasso Maria Carolina
- Damotte Vincent
- Daniele Antonio
- Dardiotis Efthimios
- Dartigues Jean-François
- de Deyn Peter Paul
- de Mendonça Alexandre
- de Munain Adolfo Lopez
- de Paiva Lopes Katia
- de Rojas Itziar
- de Witte Lot D.
- Debette Stéphanie
- Deckert Jürgen
- Del Ser Teodoro
- Deleuze Jean-François
- Denning Nicola
- DeStefano Anita
- Dichgans Martin
- Diehl-Schmid Janine
- Diez-Fairen Mónica
- Djurovic Srdjan
- Dongen Jasper Van
- Dufouil Carole
- Duron Emmanuelle
- Düzel Emrah
- Eiriksdottir Gudny
- Engelborghs Sebastiaan
- Escott-Price Valentina
- Espinosa Ana
- Ewers Michael
- Faber Kelley M.
- Fabrizio Tagliavini
- Fardo David W.
- Farotti Lucia
- Farrer Lindsay A.
- Fenoglio Chiara
- Fernández-Fuertes Marta
- Ferrari Raffaele
- Ferreira Catarina B.
- Ferri Evelyn
- Fin Bertrand
- Fischer Peter
- Fladby Tormod
- Fließbach Klaus
- Fongang Bernard
- Fornage Myriam
- Foroud Tatiana M.
- Fortea Juan
- Fostinelli Silvia
- Fox Nick C.
- Franco-Macías Emlio
- Frank-García Ana
- Frikke-Schmidt Ruth
- Froelich Lutz
- Fulton-Howard Brian
- Galimberti Daniela
- Garcia-Gonzalez Pablo
- Garcia-Madrona Sebastian
- Garcia-Ribas Guillermo
- García-Alberca Jose Maria
- García-González Pablo
- Ghanbari Mohsen
- Ghidoni Roberta
- Giedraitis Vilmantas
- Giegling Ina
- Giorgio Giaccone
- Goate Alison M.
- Goldhardt Oliver
- Gomez-Fonseca Duber
- González-Pérez Antonio
- Graff Caroline
- Grande Giulia
- Green Emma
- Grenier-Boley Benjamin
- Grimmer Timo
- Grunin Michelle
- Grünblatt Edna
- Gudnason Vilmundur
- Guetta-Baranes Tamar
- Haapasalo Annakaisa
- Hadjigeorgiou Georgios
- Haines Jonathan L.
- Hamilton-Nelson Kara L.
- Hampel Harald
- Hanon Olivier
- Hardy John
- Hartmann Annette M.
- Harwood Janet
- Hausner Lucrezia
- Heilmann-Heimbach Stefanie
- Helisalmi Seppo
- Heneka Michael T.
- Hernández Isabel
- Herrmann Martin J.
- Hiltunen Mikko
- Hoffmann Per
- Holmans Peter A.
- Holmes Clive
- Holstege Henne
- Hort Jakub
- Hulsman Marc
- Humphrey Jack
- Ikram M Arfan
- Ingelsson Martin
- Jansen Iris E.
- Jessen Frank
- Jian Xueqiu
- Johansson Charlotte
- Juan Pascual Sánchez
- Jun Gyungah R.
- Kastumata Yuriko
- Kauwe John
- Kehoe Patrick G.
- Kilander Lena
- Kivipelto Miia
- Kleineidam Luca
- Koivisto Anne
- Kornhuber Johannes
- Kosmidis Mary H.
- Kuksa Pavel P.
- Kukull Walter A.
- Kunkle Brian W.
- Kuulasmaa Teemu
- Kuzma Amanda B.
- Küçükali Fahri
- Lage Carmen
- Lambert Jean-Charles
- Laukka Erika J.
- Launer Lenore
- Lauria Alessandra
- Lee Chien-Yueh
- Lehtisalo Jenni
- Lerch Ondrej
- Lleó Alberto
- Longstreth William
- Lopez Oscar
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- Lunetta Kathryn L.
- Löwemark Malin
- Ma Yiyi
- MacLeod Catherine A.
- Macías Juan
- Maier Wolfgang
- Mangialasche Francesca
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- Marshall Rachel
- Martin Eden R.
- Masullo Carlo
- Mather Karen
- Mayeux Richard
- Mead Simon
- Mecocci Patrizia
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- Meggy Alun
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- Mendoza Silvia
- Menéndez-González Manuel
- Mir Pablo
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- Mol Merel
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- Montrreal Laura
- Morelli Laura
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- Morgan Kevin
- Mosley Thomas
- Muchnik Carolina
- Mukherjee Shubhabrata
- Nacmias Benedetta
- Naj Adam C.
- Ngandu Tiia
- Nicolas Gael
- Nielsen Sune Fallgaard
- Nordestgaard Børge G
- Nöthen Markus M.
- Olaso Robert
- Orellana Adelina
- Orsini Michela
- Ortega Gemma
- Padovani Alessandro
- Paolo Caffarra
- Papenberg Goran
- Parnetti Lucilla
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- Pastor Alfonso Arias
- Pastor Ana Belén
- Pastor Pau
- Peloso Gina
- Pericak-Vance Margaret A.
- Pericard Pierre
- Peters Oliver
- Pijnenburg Yolande A L
- Pineda Juan A.
- Pisanu Claudia
- Piñol-Ripoll Gerard
- Polak Thomas
- Popp Julius
- Posthuma Danielle
- Priller Josef
- Prokic Ivana
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- Puerta Raquel
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- Pérez-Tur Jordi
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- Quintela Inés
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- Rajabli Farid
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- Ramirez Alfredo
- Real Luis M.
- Reinders Marcel J T
- Reitz Christiane
- Reyes-Dumeyer Dolly
- Ridge Perry
- Riedel-Heller Steffi
- Riederer Peter
- Roberto Natalia
- Rodriguez-Rodriguez Eloy
- Rodríguez Carmen Martínez
- Rongve Arvid
- Rosende-Roca Maitée
- Rossi Giacomina
- Rossi Paolo Dionigi
- Royo Jose Luis
- Rubino Elisa
- Ruiz Agustín
- Rujescu Dan
- Rábano Alberto
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- Sakka Paraskevi
- Saltvedt Ingvild
- Sanabria Ángela
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- Sando Sigrid Botne
- Sarnowski Chloé
- Satizabal Claudia L.
- Scamosci Michela
- Scarmeas Nikolaos
- Scarpini Elio
- Schellenberg Gerard D.
- Scheltens Philip
- Scherbaum Norbert
- Scherer Martin
- Schmid Matthias
- Schneider Anja
- Schott Jonathan M.
- Selbæk Geir
- Seripa Davide
- Serrano Manuel
- Seshadri Sudha
- Sha Jin
- Shadrin Alexey
- Sims Rebecca
- Skrobot Olivia
- Sleegers Kristel
- Slifer Susan
- Snijders Gijsje J L
- Soininen Hilkka
- Solfrizzi Vincenzo
- Solomon Alina
- Song Yeunjoo
- Sorbi Sandro
- Sotolongo-Grau Oscar
- Spallazzi Marco
- Spalletta Gianfranco
- Spottke Annika
- Squassina Alessio
- Stordal Eystein
- Ståhlbom Anne Kinhult
- Sáez María Eugenia
- Sánchez-Arjona María Bernal
- Sánchez-Valle Raquel
- Tartan Juan Pablo
- Tesí Niccolo
- Thalamuthu Anbupalam
- Thomas Tegos
- Thomassen Jesper Qvist
- Tosto Giuseppe
- Traykov Latchezar
- Tremolizzo Lucio
- Tsolaki Anthoula
- Tsolaki Magda
- Tybjærg-Hansen Anne
- Tárraga Lluís
- Uitterlinden Andre
- Ullgren Abbe
- Ulstein Ingun
- Valero Sergi
- Valladares Otto
- van der Flier Wiesje M.
- van der Lee Sven J.
- van der Lugt Aad
- van Duijn Cornelia M.
- van Rooij Jeroen
- van Swieten John
- Vance Jeffery
- Vandenberghe Rik
- Vardarajan Badri N.
- Verhey Frans
- Vidal Jean-Sébastien
- Vilas Raquel Huerto
- Vogelgsang Jonathan
- Vyhnalek Martin
- Wagner Michael
- Wallon David
- Wang Li-San
- Wang Ruiqi
- Weinhold Leonie
- Williams Julie
- Wiltfang Jens
- Windle Gill
- Woods Bob
- Yang Qiong
- Yannakoulia Mary
- Yaqub Amber
- Zare Habil
- Zhang Xiaoling
- Zhao Yi
- Zhu Congcong
- Zulaica Miren
- Álvarez Victoria
- Publication venue
- 'Nature Research Society'
- Publication date
- 01/01/2022
- Field of study
Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele
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- Author
- Abma Joyce
- Acock Alan
- Acs Gregory
- Adams Michele
- Adams Ryan
- Adler Marina A.
- Adler-Baeder Francesca
- Ainsworth James W.
- Amin Sajeda
- Anderson Kathryn
- Anderson Kristin
- Anderson Peter
- Anderson Siwan
- Angel Jacqueline
- Ann Powell Mary
- Arnet Connidis Ingrid
- Arrighi Barbara
- Atkinson Alice M.
- Avellar Sarah
- Babcock Renee
- Baber Kristine
- Bachman Heather
- Badgett M. V. Lee
- Bahr Kathleen S.
- Bahr Stephen
- Baker Paul
- Banerjee Leena
- Baolian Qin Desiree
- Barber Jennifer
- Barker Judith C.
- Barnes Grace M.
- Barnett Rosalind C.
- Barnett Rosemary
- Bartell Denise S.
- Bartfeld Judi
- Bartkowski John
- Bartle-Haring Suzanne
- Bass Brenda L.
- Batson Christie D.
- Baum II Charles L.
- Bauman Karl E.
- Beach Steven
- Beattie Irenee R.
- Beets Gijs
- Belcastro Philip
- Benda Brent B.
- Benin Mary
- Benson Mark
- Berardo Felix M.
- Berger Lawrence M.
- Berger Roni
- Berke Debra L.
- Berry Brent
- Beutel Ann M.
- Biddlecom Ann
- Bielby Denise D.
- Binstock Georgina
- Bjarnason Thoroddur
- Blair Clancy
- Blaisure Karen R.
- Blieszner Rosemary
- Blume Libby
- Bogin Catherine
- Bokker Lon
- Bornstein Marc
- Borsella Angela
- Boss Pauline
- Bouchard Genevieve
- Bouchey Heather
- Bould Sally
- Boxer Paul
- Boyce Rodgers Kathleen
- Bozick Robert
- Bradbury Thomas N.
- Bradley Robert H.
- Brady-Smith Christy
- Bratter Jenifer
- Braun Bonnie
- Brayfield April A.
- Brennom Jennifer M.
- Britto Pia
- Brown B. Bradford
- Brown J. Brian
- Brown Susan L.
- Bryson Alex
- Buchanan Christy
- Budescu David V.
- Bufford Rodger
- Bulanda Jennifer
- Bulanda Ronald
- Bumpass Larry L.
- Bumpus Matt
- Burdette Amy M.
- Burgoyne Carole
- Burr Jeffrey A.
- Butler Amy C.
- Butler Sarah M.
- Bygren Magnus
- Campbell Lori
- Capaldi Deborah
- Carbone-Lopez Kristin
- Carder Paula
- Carini Robert M.
- Carlson Elwood
- Carlson Marcy J.
- Carney Dana R.
- Caron Sandra
- Carpenter Brian
- Carr Steelman Lala
- Carrere Sybil
- Cassidy Margaret L.
- Castle Kathryn
- Cate Rodney M.
- Chan Willaim
- Charles Maria
- Cheal David
- Chen Zeng-yin
- Cheng Simon
- Chesley Noelle
- Chito Childs Erica
- Christensen Andrew
- Christopher F. Scott
- Christopher Karen L.
- Ciabattari Teresa
- Clements Andrea D.
- Clements Mari
- Coatsworth Doug
- Cody Susan
- Cody-Rydzewski Susan R.
- Cognard-Black Andrew
- Cohan Catherine
- Coles Roberta L.
- Coltrane Scott
- Conley Terri
- Cook Cynthia T.
- Cookston Jeff
- Cordova James V.
- Cornelius Tara
- Crawford Duane
- Cready Cynthia M.
- Crosnoe Robert
- Crowder Kyle D.
- Cui Ming
- Curran Sara
- Daly Martin
- David Kevin M.
- Davies Lorraine
- Davis Kelly
- Davis Shannon N.
- Davis-Kean Pamela
- de Oliveira Ebenezer
- de St. Aubin Ed
- de Valk Helga
- De Vos Susan
- Deater-Deckard Kirby
- DeGarmo David
- DeKeseredy Walter
- DeLeire Thomas
- DeLuccie Mary
- Demo David H.
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- DeRose Laurie
- Derscheid Linda E.
- Desai Sonalde
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- Dew Jeffrey
- Dilworth-Anderson Peggye
- Dodoo Francis
- Dodson Lisa
- Doll Kevin
- Dollahite David C.
- Donnelly Brenda W.
- Donnelly Denise A.
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- Duncan Greg J.
- Duncan Karen A.
- Dunham Charlotte
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- Dykstra Pearl
- Ebert Wallace Lora
- Edin Kathryn
- Edwards Mark
- Ehrenberg Marion
- Ehrle Macomber Jennifer L.
- Elliott Wilson Melanie E.
- Elman Cheryl
- Epstein Norman
- Eriksen Shelly
- Erlin Carrie S.
- Evertsson Marie
- Fearnley Shapiro Alyson
- Feinberg Mark
- Felson Richard B.
- Feltey Kathryn
- Fenwick Rudy
- Fernando Rajulton
- Ferrick Margaret
- Few April
- Field Carolyn
- Fingerman Karen L.
- Fischer Tamar
- Fisher Terri
- Fletcher Anne C.
- Fleury-Steiner Ruth E.
- Floyd Kory
- Formoso Diana
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- Fruth Abbey
- Fu Xuanning
- Fulcher Megan
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- Gager Constance T.
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- Gareis Karen
- Garfinkel Irwin
- Gartner Rosemary
- Gartstein Maria
- Gassanov Margaret
- Gaughan Monica M.
- Gavazzi Stephen M.
- Ge Xiaojia
- Gennetian Lisa A.
- Gerard Jean
- Gerris Jan
- Gerteisen Marks Jennifer P.
- Giarrusso Roseann
- Gibson-Davis Christina
- Gierveld Jenny
- Gils Wouter
- Gladstone Jim
- Glaser Karen
- Glenn Norval
- Goldberg Abbie
- Goldberg Wendy
- Golden Lonnie
- Goldscheider Calvin
- Gonzaga Gian
- Good Marie
- Goodnow Jacqueline
- Goodwin Paula Y.
- Gordon Kristina C.
- Gordon Rachel
- Goyette Kim A.
- Gracia Enrique
- Graefe Deborah
- Grant Darlene
- Grasmick Harold
- Green Kerry
- Greenfield Emily A.
- Greenhaus Jeffrey H.
- Greenstein Theodore
- Greve Arent
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- Guo Shenyang
- Guzzo Karen
- Haas Linda
- Haddock Shelley A.
- Hall Scott
- Hamby Sherry
- Hango Darcy W.
- Hans Jason D.
- Hardesty Constance
- Harknett Kristen
- Harpel Tammy
- Harris Shanette M.
- Harwood Jake
- Hawkins Daniel
- Haworth-Hoeppner Susan
- Heard Holly
- Heaton Tim B.
- Hee Chee Kyong
- Helms Heather
- Hendrix Lewellyn
- Henly Julia R.
- Henry Carolyn
- Herrick Susan C.
- Herting Jerald
- Hertlein Katherine
- Heyman Richard
- Hill E. Jeffrey
- Hiller Harry H.
- Hirschl Thomas
- Hoekstra-Weebers Josette
- Hoelter Lynette F.
- Hoffmann John P.
- Hofsetter C. Richard
- Hogan Dennis
- Hohmann-Marriott Bryndl
- Holman Thomas
- Holtzworth-Munroe Amy
- Honeycutt James M.
- Honn Qualls Sara
- Hook Jennifer
- Horwitz Allan V.
- Hosley Cheryl A.
- Houseknecht Sharon
- Huang Chien-Chung
- Huber Joan
- Humble Aine M.
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- Hwang Sean-Shong
- Iacovou Maria
- Iceland John
- Impett Emily A.
- Ispa Jean
- Jane Brubaker Sarah
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- Janson Gregory R.
- Jasinski Jana
- Jekielek Susan
- Jeng Wei-Shiuan
- Jewkes Rachel
- Jo Hunts Holly
- Joesch Jutta M.
- Johnson Matthew
- Johnson Michael P.
- Johnson Rosalind B.
- Jones Deborah
- Jorgensen Stephen
- Joshi Pamela
- Joyner Kara
- Jung Tony
- Kalil Ariel
- Kamo Yoshinori
- Kamp Dush Claire M.
- Kang Fu Vincent
- Karremans Johan
- Kasturirangan Aarati
- Kaufman Gayle
- Kaukinen Catherine
- Kazura Kerry
- Kelley Michelle L.
- Kemp Candace
- Kerpelman Jennifer
- Kiecolt K. Jill
- Killian Tim
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- Kim Irene J.
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- Kirkpatrick Johnson Monica
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- Langhinrich-Rohling Jennifer
- Lansford Jennifer E.
- Lareau Annette
- Laughlin Lynda L.
- Laurenceau Jean-Philippe
- Lauster Nathanael
- Lavee Yoav
- Lawton Leora
- Lee Gary R.
- Lee Kristen
- Lefkowitz Eva
- Lein Laura
- Leite Randy
- Lempers Jacques D.
- Leon Kim
- Leone Janel
- Letiecq Bethany L.
- Levine Coley Rebekah
- Li Fuzhong
- Lichter Daniel T.
- Liefbroer Aart C.
- Lim Soh-Leong
- Lin I-Fen
- Lincoln Karen
- Linver Miriam
- Linville Deanna C.
- Lloyd Kim
- London Andrew S.
- Longmore Monica
- Lopoo Lenard M.
- Lorenz Frederick O.
- Ludwick Ruth
- Lundquist Jennifer
- Luo Ye
- Lyness Kevin
- Lyons Karen S.
- Maccoby Eleanor
- MacDermid Shelley
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- Macmillan Ross
- Macomber Jennifer
- MacPhee David
- MacTavish Katherine
- Madise Nyovani J.
- Malik Neena
- Manning Wendy D.
- Mansfield DeeAnn
- Manzi Claudia
- Margolin Gayla
- Marks Gary
- Marks Jennifer
- Marks Loren
- Marks Nadine
- Marshall Sheila
- Marsiglio William
- Marteleto Leticia
- Martin Molly A.
- Martin Steven P.
- Mattingly Marybeth J.
- Maume David
- McBride Brent A.
- McElroy Mary
- McGraw Lori
- McGroder Sharon M.
- McHale Susan M.
- McPherson Mervyl J.
- McQuillan Julia
- Mederer Helen J.
- Meekers Dominique A.
- Meinhold Jana
- Melby Janet N.
- Mellott Leanna
- Menjivar Cecilia
- Messner Steven
- Michaels Marcia
- Milkie Melissa A.
- Mirsky Julia
- Mollen Debra
- Monden Christiaan
- Moore David
- Morgan David
- Morgan S. Phillip
- Mosack Katie E.
- Muraco Anna
- Murray Colleen I.
- Murray Susan
- Mustillo Sarah
- Myers Barbara J.
- Myers Scott M.
- Myers-Walls Judith A.
- Najarian Cheryl
- Nelson Margaret
- Ngee Tick
- Nievar Angela
- Nock Steven L.
- Nomaguchi Kei
- O'Brien Marion
- Okun Barbara S.
- Olson Loreen N.
- Openshaw D. Kim
- Oppenheimer Valerie K.
- Oropesa Ralph S.
- Ortiz Steven
- Osborne Cynthia
- Oswald Ramona
- Oyserman Daphna
- Ozer Elizabeth M.
- Pahl Jan
- Parcel Toby L.
- Park Lisa Sun-Hee
- Parker Jennifer
- Pavalko Eliza
- Pearce Lisa
- Perren Sonja
- Perry Yvette V.
- Perry-Jenkins Maureen
- Peters Cheryl L.
- Peterson Brennan
- Philaretou Andreas
- Phua VooChin
- Piercy Kathy
- Pillemer Karl
- Poehlmann Julie
- Pollard Michael
- Porterfield Shirley L.
- Powell Brian
- Prazak Miroslava
- Proulx Christine M.
- Pruchno Rachel
- Pungello Elizabeth
- Punyanunt-Carter Narissra
- Putnam Samuel P.
- Radina M. Elise
- Raley Sara
- Ramu G. N.
- Rao Pamela
- Reed Joanna
- Reese-Weber Marla
- Regnerus Mark
- Reifman Alan S.
- Reiss Ira L.
- Remle Corey
- Reynolds Jeremy
- Rezac Sandra J.
- Richards Solomon Cathy
- Riger Stephanie
- Riggio Heidi R.
- Riley David
- Ripley Jen
- Robinson John P.
- Roche Kathleen
- Rogers Stacy J.
- Romich Jennifer L.
- Rosenbaum Alan
- Rosenblatt Paul C.
- Rossi Peter
- Rovine Michael
- Rubin Donald B.
- Sabatelli Ronald M.
- Salway Sarah
- Sanders Gregory F.
- Sanderson Stephen
- Sano Yoshie
- Sarkisian Natalia A.
- Sassler Sharon L.
- Saunders Daniel G.
- Schaefer Earl
- Scheuble Laurie
- Schmeeckle Maria
- Schmitt David P.
- Schmitz Mark
- Schneider Barbara
- Schoen Robert
- Schoenberg Nancy E.
- Schoppe-Sullivan Sarah J.
- Schumm Walter R.
- Scott Andrea
- Scott Brent
- Scott Ellen K.
- Shackelford Todd K.
- Shah Anisha
- Shanahan Lilly
- Shapiro Adam
- Sharp Elizabeth A.
- Shebloski Barbara
- Sherkat Darren
- Shibley Hyde Janet
- Short Susan
- Shorter-Gooden Kumea
- Shuey Kim
- Shumow Lee
- Sigle-Rushton Wendy
- Silverstein Louise
- Silverstein Merril
- Simons Leslie
- Singla Rashmi
- Smith David
- Smith Suzanne R.
- Smock Pamela J.
- Smulyan Lisa
- Snider Blake
- Snyder Karrie
- Sobolewski Juliana
- Somers Cheryl
- South Scott J.
- Spearin Carrie E.
- Springer Kristin W.
- Staik Athena
- Stanley Scott
- Sterk Claire
- Stern Phyllis
- Stevens Greenberg Jan
- Stevens Daphne
- Stevenson Michelle L.
- Stewart Robert
- Stewart Susan D.
- Stiles Beverly
- Stockard Jean
- Strassmann Beverly
- Strohschein Lisa
- Stum Marlene
- Suitor J. Jill
- Sun Yongmin
- Supple Andrew
- Surra Catherine A.
- Swanberg Jennifer E.
- Sweeney Kathryn
- Sweeney Megan M.
- Sweet Stephen
- Swinford Steven
- Takigiku Susan K.
- Tanfer Koray
- Tayki Baffour K.
- Taylor Tiffany
- Teerawichitchainan Bussarawan P.
- Tein Jenn-Yun
- Temple Jeff
- Thompson Gershoff Elizabeth
- Thomson Elizabeth
- Tiefenthaler Jill
- Tomassini Cecilia
- Torr Berna S.
- Trent Katherine
- Trzcinski Ellen
- Tschann Jeanne M.
- Uhlenberg Peter
- Umana-Taylor Adriana
- Umberson Debra J.
- Updegraff Kimberly
- Usdansky Margaret
- Uttal Lynet
- Van Gaalen Ruben I.
- Vogt Yuan Anastasia
- Vollebergh Wilma
- Volling Brenda
- Voorpostel Marieke
- Votruba-Drzal Elizabeth
- Voydanoff Patricia
- Waite Linda J.
- Waldfogel Jane
- Warner Barbara
- Warren Tracey
- Weeden Kim A.
- Weiting Steve
- Wenger G. Clare
- West Jerry
- Wethington Elaine
- Whitchurch Gail G.
- White James M.
- White-Stephan Cookie
- Whiteman Shawn
- Widmer Eric D.
- Wieting Stephen
- Wilcox W. Bradford
- Wildsmith Elizabeth
- Williams Kristi
- Wills Jeremiah
- Willson Andrea
- Wilmoth Janet
- Wilson John
- Winkler Celia C.
- Winslow Sarah
- Wojtkiewicz Roger A.
- Wolfinger Nicholas H.
- Wright Eric R.
- Yabiku Scott T.
- Yagla Mack Kristin
- Yancey George A.
- Yang Frances
- Yeh Hsin-Chen
- Yeung Wei-Jun Jean
- Yount Kathryn
- Zabin Laurie
- Zhang Zhenmei
- Zuo Jiping
- Zweig Janine
- Publication venue
- Publication date
- 01/12/2005
- Field of study
New insights into the genetic etiology of Alzheimer’s disease and related dementias
- Author
- Aaltonen Lauri
- Aaltonen Vesa
- Aarsland Dag
- Aavikko Mervi
- Abalos Mariana Sanchez
- Abdelnour Carla
- Abner Erin
- Abraham Richard
- Adams Hieab
- Adams Perrie M.
- Adarmes-Gómez Ad
- Adarmes-Gómez Astrid D.
- Aguilera Nuria
- Aguilera Nuria
- Aguirre Alyssa
- Ahmad Shahzad
- Akinyemi Rufus O.
- Al-Chalabi Ammar
- Alarcón-Martín Emilio
- Albert Marilyn S.
- Albin Roger L.
- Alcolea Daniel
- Alegret Montserrat
- Ali Muhammad
- Allen Mariet
- Allende Irene Rosas
- Alonso María Dolores
- Alonso María Dolores
- Alvarez Ignacio
- Alvarez Lisa
- Amer-Ferrer Guillermo
- Amin Najaf
- Amouyel Philippe
- Anastasiou Anna
- Anastasiou Costas
- Andrade Victor
- Andreassen Ole A.
- Andreoni Simona
- Antequera Martirio
- Antikainen Riitta
- Antonell Anna
- Anttonen Vuokko
- Antúnez Carmen
- Aparicio Hugo J.
- Apostolova Liana G.
- Appollonio Ildebrando
- Arcaro Marina
- Archetti Silvana
- Armstrong Nicola
- Armstrong Nicola J.
- Arnold Steven E.
- Arosio Beatrice
- Arvas Mikko
- Assogna Francesca
- Asthana Sanjay
- Athanasiu Lavinia
- Atwood Craig S.
- Auge Franck
- Auranen Annika
- Auvinen Päivi
- Awaisa Ghazal
- Ayres Gayle
- Bacha Juan Ignacio
- Bahadori Maryam
- Bahrami Shahram
- Bailly Henri
- Baldwin Clinton T.
- Banaj Nerisa
- Baquero Miquel
- Barber Robert C.
- Barnes Lisa L.
- Barral Sandra
- Barral Sandra
- Bass Nicholas J.
- Bass Nick
- Bastiani Patrizia
- Bayer Anthony
- Beach Thomas G.
- Becker James T.
- Becker James T.
- Becker Tim
- Beecham Gary W.
- Beekly Duane
- Behrens Tim
- Beiser Alexa
- Belezhanska Diyana
- Bellenguez Céline
- Below Jennifer E.
- Below Jennifer E.
- Ben-Shlomo Yoav
- Benchek Penelope
- Benchek Penelope
- Benitez Bruno A.
- Bennett David
- Benussi Alberto
- Benussi Luisa
- Bergh Sverre
- Bernardo-Harrington Mateus
- Berr Claudine
- Bertelson John
- Besse Céline
- Bessi Valentina
- Betts Jo
- Bhangale Tushar
- Biessels Geert Jan
- Binetti Giuliano
- Bing Nan
- Bird Thomas D.
- Bis Joshua C.
- Biswas Shameek
- Bizarro Alessandra
- Bjerke Maria
- Blacker Deborah
- Blesa Rafael
- Blomster Timo
- Boada Mercè
- Boecker Henning
- Boerwinkle Eric
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- Tuovila Outi
- Turpeinen Miia
- Turton James
- Turunen Joni A.
- Tybjærg-Hansen Anne
- Tzourio Christophe
- Tárraga Lluís
- Uitterlinden Andre
- Ullgren Abbe
- Ulstein Ingun
- Uphill James
- Usiskin Keith
- Uusitalo Hannu
- Uusitalo-Järvinen Hannele
- Vacca Alessandro
- Vainio Seppo
- Valero Sergi
- Valladares Otto
- Valladares Otto
- van Adelsberg Janet
- Van Deerlin Vivianna M.
- van den Bussche Hendrik
- van der Flier Wiesje M.
- van der Lee Sven J.
- van der Lugt Aad
- van Duijn Cornelia M.
- van Eldik Linda J.
- van Lent Debora Melo
- van Rooij Jeroen
- van Swieten John
- Vance Jeffery
- Vandenberghe Rik
- Vardarajan Badri N.
- Vardy Emma
- Vargas Liliana
- Vassar Robert
- Verhey Frans
- Vicente Maria Pilar
- Vidal Jean-Sébastien
- Vigo-Ortega R.
- Vigo-Ortega Rosario
- Vilas Raquel Huerto
- Vinters Harry V.
- Virolainen Petri
- Vivancos Liliana
- Vogelgsang Jonathan
- Vojinovic Dina
- Vonsattel Jean-Paul
- Voutilainen Markku
- Vyhnalek Martin
- Wadhawan Samir
- Wagner Michael
- Wallon David
- Wang Clarence
- Wang Li-San
- Wang Ruiqi
- Wang Yanbing
- Warden Donald
- Waring Jeff
- Waring Jeffrey
- Warner Nick
- Warren Jason D.
- Waterworth Dawn
- Weber Heike
- Weinhold Leonie
- Weinstein Galit
- Weintraub Sandra
- Welsh-Bohmer Kathleen A.
- Whelan Christopher
- Whitehead Patrice L.
- Wichmann H-Erich
- Wigmore Eleonor
- Wijsman Ellen M.
- Wilcock Gordon
- Wilhelmsen Kirk C.
- Williams Amy
- Williams Benjamin
- Williams Dylan
- Williams Julie
- Williamson Jennifer
- Wilms Henrik
- Wiltfang Jens
- Windle Gill
- Wingo Thomas S.
- Wisniewski Thomas
- Wittfeld Katharina
- Woltjer Randall L.
- Wong Regis
- Woods Bob
- Woon Martin
- Wright Clinton B.
- Wu Chuang-Kuo
- Wu Ying
- Xia Tai-he
- Xu Ethan
- Xu Fanli
- Yanek Lisa
- Yang Qiong
- Yang Yunju
- Yannakoulia Mary
- Yaqub Amber
- Younkin Steven G.
- Yu Chang-En
- Yu Lei
- Zare Habil
- Zhang Xiaoling
- Zhang Yuanchao
- Zhao Yi
- Zhao Yi
- Zhou Wei
- Zhu Congcong
- Zhu Xiongwei
- Ziemann Adam
- Zoia Chiara Paola
- Zompo Maria Del
- Zulaica Miren
- Álvarez Victoria
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/04/2022
- Field of study
Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele