La Terminación de las Relaciones Colectivas e Individuales de Trabajo de Luz y Fuerza del Centro como consecuencia del Decreto de Extinción.

El presente trabajo contiene imágenes.En el presente documento se analiza la historia del organismo descentralizado Luz y Fuerza del Centro, su origen, su desarrollo y su posterior extinción, como consecuencia de su desincorporación de la administración pública federal, los hallazgos que derivaron de este último suceso, y cuales han sido los efectos de esta decisión tomada por el ejecutivo federal

Dissecting the microglial response in transgenic models of amyloidogenesis and tauopathy

Amyloid-beta (Abeta) peptide deposits and hyperphosphorylated tau protein (phospho-tau) accumulate in Alzheimer’s disease (AD) brains. These abnormal protein aggregates leads to glial activation, synaptic dysfunction, neuronal loss and cognitive decline. While microglial response has mostly been analyzed in relation to Abeta accumulation, little is still known about inflammatory processes associated with tau pathology. Microglial reactivity and defective glial responses have been involved in these proteinopathies. Our aim is to clarify the effects of Abeta and tau separately, in order to improve the comprehension of their differential contribution to neuroinflammation and neurodegeneration. We compared the progression of these processes in an amyloidogenic AD model (APPSL/PS1M146L) and two different models of tauopathy (ThyTau22 and hP301S) from 2 to 18 months of age. Accumulation of aggregated proteins was assessed using specific anti- Abeta and phospho-tau antibodies. Inflammatory response was studied using a battery of microglial markers (Iba1, CD45, CD68, Trem2 and Gal-3). In the hippocampus of these models, Tau and Abeta pathologies initiated as early as 2 months of age and increased progressively with aging. Neuritic plaques induced a strong microglial activation associated to plaques in APP/PS1 mice. Interestingly, inflammatory markers and microglial reactivity were barely increased in the hippocampus of ThyTau mice in contrast to not only APP/PS1, but also to P301S mice, which displayed a prominent microglial response. Deciphering the specific effects of Abeta, tau and their different toxic species, would indeed enable the development of novel therapeutic strategies and drugs targeting neuroinflammatory pathways related to these proteinopathies.Universidad de Málaga. Campus de excelencia Andalucía-Tech. Supported by PI18/01557 (AG) and PI18/01556 (JV) grants from ISCiii of Spain co-financed by FEDER funds from European Union, and by grant PPIT.UMA.B1.2017/26 (RS-V)

Tau pathology and astroglial reactivity: a comparative study of two mouse models of tauopathy

Objectives: Astrocytes are becoming crucial players in the context of neurodegenerative proteinopathies, such as Alzheimer’s disease (AD). Astroglial response has been mainly analyzed in amyloidogenic scenarios, but less is known about their involvement in tauopathies. Here, we aimed to analyze astroglial reactivity to hyperphosphorylated-tau (ptau) in the hippocampus of two transgenic mouse models of tauopathy, ThyTau22 and P301S (2- to 12/18-months). Methods: Proteinopathy was assessed by western-blotting and immunohistochemistry (AT8). Neuroinflammation was analyzed by qPCR and bright-field immunohistochemistry, glial-ptau relationship by confocal and transmission electron microscopy. Results: P301S mice exhibited an intense reactive astrogliosis, increasing progressively with aging accordingly to a strong ptau accumulation, whereas ThyTau22 model showed slighter astrocytosis related to lesser proteinopathy. P301S astrogliosis correlated with an acute DAM-like microglial activation, not observed in ThyTau22 hippocampus. In both models, reactive astrocytes contained ptau, especially around vessels. Conclusions: Our results support that astrocytes respond to ptau in the absence of Abeta. This reactivity correlates with tau pathology and depends on microglial DAM-like activation. In addition, reactive astrocytes may play a role in the elimination/spreading of ptau species through the brain. Deciphering the mechanisms underlying these processes might allow the development of strategies to slow down the progression of AD and other tauopathies.Supported by Instituto de Salud Carlos III of Spain, co-financed by FEDER funds from European Union, through grants PI18/01557 (to AG),PI18/01556 (to JV), and Junta de Andalucia through Consejería de Economía y Conocimiento grants UMA18-FEDERJA-211 (AG), P18-RT-2233 (AG) and US-1262734 (JV) co-financed by Programa Operativo FEDER 2014-2020. Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Comercio exterior del Perú en el contexto de pre - pandemia y pandemia

Objetivo: Analizar la evolución del comercio exterior del Perú en el contexto de Pre-Pandemia y Pandemia. Métodos: El enfoque de investigación es cuantitativo de tipo descriptivo, longitudinal y documental con información del Comercio Exterior del Perú desde enero 2019 a noviembre de 2021 del Banco Central de Reserva del Perú (BCRP) Resultados: En cuanto a las exportaciones e importaciones de mercancías se encontró una disrupción o cambios significativos de los flujos de exportación e importación de mercancías reflejadas en un coeficiente de asimetría negativa de las variables de estudio. Conclusiones: La significativa disrupción o cambio de los flujos de comercio exterior del Perú se explica por las medidas restrictivas implementadas a escala global, cierre de las fronteras y paralización de sectores económicos con consecuencias en el PBI de los socios comerciales reflejadas en una recesión  sincronizada a nivel mundial principal factor explicativo del comportamiento de las exportaciones respecto a las importaciones las medidas de confinamiento determinó la contracción de la demanda interna y el PBI doméstico

Comparing astroglial reactivity in two transgenic mouse models of tauopathy

Astrocytes are becoming crucial players in the pathology of neurodegenerative disorders, such as Alzheimer’s disease (AD). Astrocyte responses have been mainly analyzed in the context of amyloid-beta (Abeta) pathology, highlighting their role in the development/progression of amyloidosis and their relationship with the microglial response. Regarding tau pathology, some studies have reported that astrocytes respond to hyperphosphorylated tau (phospho-tau) and suggested their implication on tau transmission/elimination. Here, we aimed to analyze the astroglial reactivity to tau pathology in the hippocampus of two transgenic mouse models of tauopathy, ThyTau22 and P301S. Proteinopathy was assessed by western-blotting and immunohistochemistry using phospho-tau antibodies (AT8). Inflammatory markers (GFAP, Iba-1, CD45, TREM2) were analyzed by qPCR and immunohistochemistry for bright-field microscopy; glial-phospho-tau relationship was analyzed under confocal and transmission electron microscopy. P301S mice exhibited an intense reactive astrogliosis, increasing with aging in parallel to a strong phospho-tau pathology. ThyTau22 model showed a slighter astrocyte reactivity accompanied by a lesser accumulation of phospho-tau. Astrogliosis in P301S mice closely correlated with an acute DAM-like microglial activation, not observed in ThyTau22 hippocampus. Confocal and ultrastructural studies revealed that, in both models, astrocytic processes contained phospho-tau, especially those surrounding blood vessels. Our results support that astrocytes respond to tau pathology in the absence of Abeta. This reactivity highly correlates with phospho-tau pathology and markedly depends on microglial activation. Moreover, astrocytes may play a role in the elimination/spreading of phospho-tau species through the brain. Deciphering the mechanisms underlying these processes might help to develop therapies to slow down the progression of AD.Supported by Instituto de Salud Carlos III (ISCiii) of Spain, co-financed by FEDER funds from European Union through grants PI18/01557 (to AG), PI18/01556 (to JV), and by Junta de Andalucia through Consejería de Economía y Conocimiento grants UMA18-FEDERJA-211 (AG), P18-RT-2233 (AG) and US-1262734 (JV) co-financed by Programa Operativo FEDER2014-2020. Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Occult Follicular Thyroid Carcinoma presenting as Primary Breast Tumor with Sternal and Skull Metastasis

Introduction: Follicular thyroid carcinoma (FTC) that initially presented as breast tumor with no previous medical history of malignancy of thyroid gland is relatively rare and may cause diagnostic confusion.Presentation of case: We report a 59-year-old Mexican woman with no prior history of malignant thyroid neoplasm that presents with pain and swelling in the upper outer quadrant of the left breast with a year of evolution. Subsequently, subcutaneous tumor was identified in left parietal region. Clinically it was thought in primary breast tumor metastasis to skull. Furthermore, computerized tomography scan identified a tumor in the deep portion of the left breast, infiltrating the sternum that subsequently was confirmed a follicular carcinoma of the thyroid gland.Conclusion: Metastatic FTC may mimic a primary breast tumor. The combined use of clinical information, histopathology and immunohistochemistry were important to establishing a correct cancer diagnosis

Integración del aprendizaje social (social learning) en las asignatras vinculadas al campo de conocimiento del Derecho del Trabajo y la Seguridad Social

Este proyecto trata de integrar las redes sociales como una herramienta colaborativa en la docencia de las materias relacionadas con el Derecho del Trabajo. De entre los recursos asociados a las plataformas "b-learning", e empleo de las redes sociales permite el intercambio de información en tiempo real. A través de este instrumento, los alumnos, guiados por el profesor, aportan su trabajo activo en relación con la materia seleccionada y poniéndolo en común mediante la herramienta elegida. En este proyecto nos decantamos por el empleo de Facebook. Esta metodología puede ser aplicada en cuantas disciplinas se vean especialmente vinculadas a la realidad económico-social, que por su naturaleza requieran de una permanente actualización. La recepción de esta metodología es evidente en aquellas materias que exijan del alumno un esfuerzo crítico que le permita acercarse en profundidad a los elementos novedosos de la materia

Ratings of Sexual Arousal and Ratings of Genital Sensations: Psychometric properties in Spanish sample

Objective Subjective sexual arousal is the psychological perception of arousal. The Multiple Indicators of Subjective Sexual Arousal (MISSA) is one of the limited self-reported measures to evaluate it in a specific situation. The aim is to adapt and examine the psychometric properties of two scales from the MISSA: Ratings of Sexual Arousal (RSA) and Ratings of Genital Sensations (RGS) in a Spanish sample. Material and method The measures were administered to two independent samples composed by heterosexual young individuals aged from 18 to 30 years old. In the first sample (n = 122) the factorial structure of the RSA was examined, which was later confirmed in a second sample (n = 336) where invariance analysis by sex and validity evidences were also analyzed. Both, the RSA and the RGS, together with other scales measuring similar constructs, were answered by participants from both studies (N = 458) in a laboratory setting in which individuals were exposed to films with neutral content and explicit sexual content. Results The Spanish version of the RSA shows a unidimensional structure with adequate reliability (α = .90). This structure showed to be invariant by sex, thus no significant differences were found between men and women. Scores from both, the RSA and the RGS correlated with higher predisposition to get excited and erotophilia. Conclusions The RSA and RGS are reliable and valid measures to evaluate subjective sexual arousal towards sexual stimuli. Therefore, their use is suitable for both clinical and research areas.Objetivo La excitación sexual subjetiva es la percepción de excitación a nivel psicológico, siendo el Multiple Indicators of Subjective Sexual Arousal (MISSA) uno de los escasos instrumentos para evaluarla de manera situacional. El objetivo es adaptar a población española y examinar las propiedades psicométricas de dos de las escalas del MISSA: Valoración de Excitación Sexual (VES) y Valoración de Sensaciones Genitales (VSG). Material y método Se emplearon dos muestras independientes formadas por jóvenes heterosexuales de 18-30 años de edad. En la primera muestra (n = 122) se examinó la estructura factorial de la escala VES, la cual se puso a prueba en una segunda muestra (n = 336) en la que se examinó la invarianza por sexo. Además, en esta segunda muestra se buscaron evidencias de validez de ambas escalas. Los participantes de ambos estudios (N = 458) contestaron las escalas VES y VSG en una situación experimental de laboratorio en la que eran expuestos a films de contenido neutro y contenido sexual explícito. Resultados La versión española de la escala VES presenta una estructura unidimensional con una adecuada fiabilidad de consistencia interna (α = 0,90). Dicha estructura es invariante en cuanto al sexo, no encontrándose diferencias entre hombres y mujeres. Tanto las puntuaciones de la escala VES como de la VSG correlacionaron con la predisposición a excitarse y con la erotofilia. Conclusiones Las escalas VES y VSG son fiables y válidas para evaluar la excitación sexual subjetiva ante estímulos sexuales, constituyendo instrumentos adecuados para su uso, tanto en el ámbito clínico como en el de la investigación

The effects of mango leaf extract during adolescence and adulthood in a rat model of schizophrenia.

There is evidence that in schizophrenia, imbalances in inflammatory and oxidative processes occur during pregnancy and in the early postnatal period, generating interest in the potential therapeutic efficacy of anti-inflammatory and antioxidant compounds. Mangiferin is a polyphenolic compound abundant in the leaves of Mangifera indica L. that has robust antioxidant and anti-inflammatory properties, making it a potential candidate for preventive or co-adjuvant therapy in schizophrenia. Hence, this study set-out to evaluate the effect of mango leaf extract (MLE) in a model of schizophrenia based on maternal immune activation, in which Poly I:C (4 mg/kg) is administered intravenously to pregnant rats. Young adult (postnatal day 60-70) or adolescent (postnatal day 35-49) male offspring received MLE (50 mg/kg of mangiferin) daily, and the effects of MLE in adolescence were compared to those of risperidone, assessing behavior, brain magnetic resonance imaging (MRI), and oxidative/inflammatory and antioxidant mediators in the adult offspring. MLE treatment in adulthood reversed the deficit in prepulse inhibition (PPI) but it failed to attenuate the sensitivity to amphetamine and the deficit in novel object recognition (NOR) induced. By contrast, adolescent MLE treatment prevented the sensorimotor gating deficit in the PPI test, producing an effect similar to that of risperidone. This MLE treatment also produced a reduction in grooming behavior, but it had no effect on anxiety or novel object recognition memory. MRI studies revealed that adolescent MLE administration partially counteracted the cortical shrinkage, and cerebellum and ventricle enlargement. In addition, MLE administration in adolescence reduced iNOS mediated inflammatory activation and it promoted the expression of biomarkers of compensatory antioxidant activity in the prefrontal cortex and hippocampus, as witnessed through the reduction of Keap1 and the accumulation of NRF2 and HO1. Together, these findings suggest that MLE might be an alternative therapeutic or preventive add-on strategy to improve the clinical expression of schizophrenia in adulthood, while also modifying the time course of this disease at earlier stages in populations at high-risk.EB, JAG-P and ST-S work was supported by the “Fondo Europeo de Desarrollo Regional” (FEDER)-UE “A way to build Europe” from the “Ministerio de Economía y Competitividad” (RTI2018-099778-B-I00); from the “Plan Nacional sobre Drogas, Ministerio de Sanidad, Consumo y Bienestar Social” (2019I041); from the “Ministerio de Salud-Instituto de Salud Carlos III” (PI18/01691); from the “Programa Operativo de Andalucía FEDER, Iniciativa Territorial Integrada ITI 2014-2020 Consejería Salud y Familias, Junta de Andalucía” (PI-0080- 2017, PI-0009-2017), “Consejería de Salud y Familias, Junta de Andalucía” (PI-0134-2018 and PEMP-0008-2020); from the “Consejería de Transformación Económica, Industria, Conocimiento y Universidad, Junta de Andalucía” (P20_00958 and CTS-510); from the CEIMAR (CEIJ-003); from the “Instituto de Investigación e Innovación en Ciencias Biomédicas de Cádiz-INiBICA” (LI19/06IN-CO22; IN-C09); from the “CIBERSAM”: CIBER-Consorcio Centro de Investigación Biomédica en Red- (CB07/09/0033), Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación and from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 955684. CM, LC and MTF-P were supported by the Spanish Ministry of Science and Technology (PID2020- 116229RB-I00) and European Regional Development Fund (ERDF). KM and JCL were supported by the “MICINN” (PID2019-109033RB-I00) and the “CIBERSAM”: CIBERConsorcio Centro de Investigación Biomédica en Red- (CB07/ 09/0026), Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación. MLS-M was supported by the “Ministerio de Ciencia, Innovación, Instituto de Salud Carlos III” (PI17/ 01766, BA21/00030), co-financed by European Regional Development Fund (ERDF), “A way to make Europe”; from the “CIBERSAM”: CIBERConsorcio Centro de Investigación Biomédica en Red- (CB07/09/0031), Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación; from the “Delegación del Gobierno para el Plan Nacional sobre Drogas” (2017/085); from the “Fundación Mapfre” and “Fundación Alicia Koplowitz.” MD work was supported by the “Ministerio de Ciencia e In review 18/ 28 Innovación” (MCIN) and “Instituto de Salud Carlos III” (ISCIII) (PT20/00044); from the “CIBERSAM” CIBERConsorcio Centro de Investigación Biomédica en Red-(CB07/ 09/0031). The CNIC is supported by the ISCIII, the MCIN and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505).S