Characteristics and outcomes of adult patients in the PETHEMA registry with relapsed or refractory FLT3-ITD mutation-positive acute myeloid leukemia

This retrospective study investigated outcomes of 404 patients with relapsed/refractory (R/R) FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) acute myeloid leukemia (AML) enrolled in the PETHEMA registry, pre-approval of tyrosine kinase inhibitors. Most patients (63%) had received first-line intensive therapy with 3 + 7. Subsequently, patients received salvage with intensive therapy (n = 261), non-intensive therapy (n = 63) or supportive care only (n = 80). Active salvage therapy (i.e., intensive or non-intensive therapy) resulted in a complete remission (CR) or CR without hematological recovery (CRi) rate of 42%. More patients achieved a CR/CRi with intensive (48%) compared with non-intensive (19%) salvage therapy (p < 0.001). In the overall population, median overall survival (OS) was 5.5 months; 1- and 5-year OS rates were 25% and 7%. OS was significantly (p < 0.001) prolonged with intensive or non-intensive salvage therapy compared with supportive therapy, and in those achieving CR/CRi versus no responders. Of 280 evaluable patients, 61 (22%) had an allogeneic stem-cell transplant after they had achieved CR/CRi. In conclusion, in this large cohort study, salvage treatment approaches for patients with FLT3-ITD mutated R/R AML were heterogeneous. Median OS was poor with both non-intensive and intensive salvage therapy, with best long-term outcomes obtained in patients who achieved CR/CRi and subsequently underwent allogeneic stem-cell transplant.This study was supported by Centro de Investigación Biomédica en Red Cáncer (CIBERONC), Valencia, Spain [CB16/12/00284]

Internal Marketing Orientation: an empirical research in hotel sector

The study has three aims. First, to measure internal market orientation second, to analyze the relation-ships between IMO and two organizational consequences: job satisfaction and commitment; and third,to incorporate a new sub-dimension work/family balance. Empirical research has been done in a sampleof Spanish hotels. Results show that IMO is a strategic determinant of both job satisfaction and employeecommitment

Genetically predicted telomere length and Alzheimer’s disease endophenotypes: a Mendelian randomization study

Telomere length (TL) is associated with biological aging, consequently influencing the risk of age-related diseases such as Alzheimer's disease (AD). We aimed to evaluate the potential causal role of TL in AD endophenotypes (i.e., cognitive performance, N = 2233; brain age and AD-related signatures, N = 1134; and cerebrospinal fluid biomarkers (CSF) of AD and neurodegeneration, N = 304) through a Mendelian randomization (MR) analysis. Our analysis was conducted in the context of the ALFA (ALzheimer and FAmilies) study, a population of cognitively healthy individuals at risk of AD. A total of 20 single nucleotide polymorphisms associated with TL were used to determine the effect of TL on AD endophenotypes. Analyses were adjusted by age, sex, and years of education. Stratified analyses by APOE-epsilon 4 status and polygenic risk score of AD were conducted. MR analysis revealed significant associations between genetically predicted longer TL and lower levels of CSF A beta and higher levels of CSF NfL only in APOE-epsilon 4 non-carriers. Moreover, inheriting longer TL was associated with greater cortical thickness in age and AD-related brain signatures and lower levels of CSF p-tau among individuals at a high genetic predisposition to AD. Further observational analyses are warranted to better understand these associations

Una comunidad de práctica para el desarrollo de la iniciativa, búsqueda e integración de la información y el trabajo en equipo

Durante el curso 2009-2010, ante el contexto de incertidumbre económica que reflejaban continuamente los medios de comunicación cuyas dimensiones y posibles consecuencias eran desconocidas, decidimos formar una Comunidad de Práctica en la asignatura Política Económica de tercer curso de la doble Licenciatura en Economía y Administración y Dirección de Empresas, y aprender juntos lo que estaba ocurriendo a nuestro alrededor. Esto exigió por parte de todos los integrantes una búsqueda exhaustiva de información, que compartíamos entre todos, para así incrementar el conocimiento dentro del grupo; esta búsqueda requirió de iniciativa a la hora de identificar los problemas objeto de estudio y de un trabajo en equipo de los alumnos coordinado por la profesora. El desarrollo de estas competencias dentro de la Comunidad de Práctica nos llevó en una fase posterior, a querer investigar el conocimiento que tenían otros jóvenes universitarios a través de la elaboración por parte de la Comunidad de Práctica de un cuestionario sobre temas de actualidad económica que estaban teniendo una gran difusión en los medios de comunicación, con el objetivo de valorar si los estudiantes de titulaciones afines al área de empresa tenían un mayor conocimiento de esos temas que otros jóvenes universitarios.SIN FINANCIACIÓNNo data 2011UE

Dossier de prensa

SIN FINANCIACIÓNNo data 2010UE

El papel de los inmigrantes en el mercado de la vivienda (Especial referencia a la Comunidad de Madrid)

Opinión doctrinal sobre la interrelación existente entre el crecimiento del precio de la vivienda y el incremento de inmigrantes residentes en nuestro país, con independencia de factores adyacentes centrado en la Comunidad de Madrid.No data (2008)UE

Inteligencia emocional vs inteligencia general: aspectos a considerar en la docencia

SIN FINANCIACIÓNNo data 201

Let's make people management visible

“Let’s make people management visible” is an innovation project that was run in all 2nd year groups for the Managing People courses, within the Social Science Faculty. The project involved all the teachers who taught this course, and was organized around cooperative learning. The objective of this project was the students to understand and learn, in a playful way, the basics of People Management. To this end, students organized in teams, created a video documentary and a business case that should reflect one of the following areas of knowledge contained in the syllabus: job design, recruitment and selection, training, performance appraisal and motivation. To prepare the content for the video, students used bibliographic and audiovisual resources and they worked with the role- playing technique. After the videos were finished, students shared their acquired knowledge by putting in common their work and by solving the business cases developed by the other groups. The competencies developed were: teamwork, empathy, tolerance, decision making, responsibility and creativity. Thirty videos were submitted to the contest and published in the V Seminar on Human Resources, "Talentum."SIN FINANCIACIÓNNo data 2010UE

Emotional intelligence vs. General intelligence: Aspects to consider in teaching

Para el desarrollo de esta investigación, se suministraron dos cuestionarios a estudiantes de la Universidad Europea de Madrid. Concretamente, los estudiantes cumplimentaron el cuestionario TEIQue (Trait Emotional Intelligence Questionnaire) para la medición de la Inteligencia emocional y la escala R del Test PMA (Primary Mental Abilities) para la valoración del factor de razonamiento. Los resultados de esta investigación, aunque no han permitido establecer una vinculación clara entre Inteligencia Emocional e Inteligencia General, han permitido vislumbrar algunas tendencias que relacionan las subescalas del cuestionario TEIQue con el factor razonamiento de los estudiantes. A través de esta relación, se han podido establecer perfiles y, a partir de ellos, se han identificado las metodologías docentes más adecuadas para mejorar los resultados académicos de los estudiantes.In order to carry out this research, two questionnaires were administered to students from the Universidad Europea de Madrid. Specifically, students completed the TEIQue (Trait Emotional Intelligence Questionnaire), which measures emotional intelligence, and the PMA (Primary Mental Abilities) Test in its R scale, which measures the reasoning factor. Although the results of this research failed to establish a clear link between Emotional Intelligence and General Intelligence, they have shown some trends that relate the TEIQue subscales with the reasoning factor in students. Through this relationship, it has been possible to establish profiles and, from them, to identify the most appropriate teaching methodologies in order to improve the students’ academic performance.SIN FINANCIACIÓNNo data 2014UE

Effect of oral nitrates on pulse pressure and arterial elasticity in patients aged over 65 years with refractory isolated systolic hypertension: study protocol for a randomized controlled trial

BACKGROUND: Isolated systolic hypertension is a highly prevalent disease among the elderly. The little available evidence on the efficacy of nitrates for treating the disease is based on small experimental studies. METHODS/DESIGN: We performed a multicenter, randomized, double-blind, phase III, placebo-controlled trial in 154 patients aged over 65 years with refractory isolated systolic hypertension. Patients were randomized to placebo or 40 mg/day of extended-release isosorbide mononitrate added to standard therapy and titrated to 60 mg/day at week 6 if blood pressure exceeded 140/90 mmHg.The primary objective was to assess the effect on clinical pulse pressure of extended-release isosorbide mononitrate added to standard therapy in patients aged over 65 years with refractory isolated systolic hypertension after 3 months of treatment.The secondary objectives were as follows: to quantify the effect of adding the study drug on central blood pressure and vascular compliance using the augmentation index and pulse wave velocity; to evaluate the safety profile by recording adverse effects (frequency, type, severity) and the percentage of patients who had to withdraw from the trial because of adverse events; to quantify the percentage of patients who reach a clinical systolic blood pressure <140 mmHg or <130 mmHg measured by ambulatory blood pressure monitoring; and to quantify the change in pulse pressure measured by ambulatory blood pressure monitoring. DISCUSSION: Few clinical trials have been carried out to test the effect of oral nitrates on isolated systolic hypertension, even though these agents seem to be effective. Treatment with extended-release isosorbide mononitrate could improve control of systolic blood pressure without severe side effects, thus helping to reduce the morbidity and mortality of the disease. TRIAL REGISTRATION: EUDRACT Number: 2012-002988-10.Funding for the trial was provided by the Ministry of Health, Social Services and Equality (call for the development of independent clinical research, Exp Nº EC11-111).S