Larval dispersion along a straight coast with tidal currents: Complex distribution patterns from a simple model

Copyright © 1995 Inter-Research.The majority of marine species have a complex life cycle where the adult phase is preceded by a pelagic larval phase. The dynamics of the more obvious adult phase may be strongly influenced by the distribution and abundance of larvae. Field experiments have been unable to give a complete picture of the spatial-temporal dynamics of the larval phase. This is due to the extremely small size of the individual larvae and the environment in which they live. Here we present a mathematical model of the dispersal of larvae into a region consisting of a straight coastline and a current dominated by tidal effects. Spawning is near the coast from a well-defined site the size of a small jetty or reef and the larvae have a relatively short pelagic lifetime. The model is based on the advection-diffusion-mortality equation. Using a new analytic solution to the model, we examine the effect of processes such as the current structure, mortality, and the duration and rate at which larvae are released, on dispersal. The model is relatively simple but produces surprisingly complex patterns of dispersal. This has implications for attempts to produce more complex models of dispersal and the way in which field data of larval densities should be interpreted.S. A. Richards, H. P. Possingham, B. J. Noy

Secukinumab, a human anti-interleukin-17A monoclonal antibody, in patients with psoriatic arthritis (FUTURE 2): a randomised, double-blind, placebo-controlled, phase 3 trial

Background: Interleukin 17A is a proinflammatory cytokine that is implicated in the pathogenesis of psoriatic arthritis. We assessed the efficacy and safety of subcutaneous secukinumab, a human anti-interleukin-17A monoclonal antibody, in patients with psoriatic arthritis. Methods: In this phase 3, double-blind, placebo-controlled study undertaken at 76 centres in Asia, Australia, Canada, Europe, and the USA, adults (aged ≥18 years old) with active psoriatic arthritis were randomly allocated in a 1:1:1:1 ratio with computer-generated blocks to receive subcutaneous placebo or secukinumab 300 mg, 150 mg, or 75 mg once a week from baseline and then every 4 weeks from week 4. Patients and investigators were masked to treatment assignment. The primary endpoint was the proportion of patients achieving at least 20% improvement in the American College of Rheumatology response criteria (ACR20) at week 24. Analysis was by intention to treat. This study is registered with ClinicalTrials.gov, number NCT01752634. Findings: Between April 14, and Nov 25, 2013, 397 patients were randomly assigned to receive secukinumab 300 mg (n=100), 150 mg (n=100), 75 mg (n=99), or placebo (n=98). A significantly higher proportion of patients achieved an ACR20 at week 24 with secukinumab 300 mg (54 [54%] patients; odds ratio versus placebo 6·81, 95% CI 3·42–13·56; p<0·0001), 150 mg (51 [51%] patients; 6·52, 3·25–13·08; p<0·0001), and 75 mg (29 [29%] patients; 2·32, 1·14–4·73; p=0·0399) versus placebo (15 [15%] patients). Up to week 16, the most common adverse events were upper respiratory tract infections (four [4%], eight [8%], ten [10%], and seven [7%] with secukinumab 300 mg, 150 mg, 75 mg, and placebo, respectively) and nasopharyngitis (six [6%], four [4%], six [6%], and eight [8%], respectively). Serious adverse events were reported by five (5%), one (1%), and four (4%) patients in the secukinumab 300 mg, 150 mg, and 75 mg groups, respectively, compared with two (2%) in the placebo group. No deaths were reported. Interpretation: Subcutaneous secukinumab 300 mg and 150 mg improved the signs and symptoms of psoriatic arthritis, suggesting that secukinumab is a potential future treatment option for patients with this disorder

Short-term serotonergic but not noradrenergic antidepressant administration reduces attentional vigilance to threat in healthy volunteers

Anxiety is associated with threat-related biases in information processing such as heightened attentional vigilance to potential threat. Such biases are an important focus of psychological treatments for anxiety disorders. Selective serotonin reuptake inhibitors (SSRIs) are effective in the treatment of a range of anxiety disorders. The aim of this study was to assess the effect of an SSRI on the processing of threat in healthy volunteers. A selective noradrenergic reuptake inhibitor (SNRI), which is not generally used in the treatment of anxiety, was used as a contrast to assess the specificity of SSRI effects on threat processing. Forty-two healthy volunteers were randomly assigned to 7 d double-blind intervention with the SSRI citalopram (20 mg/d), the SNRI reboxetine (8 mg/d), or placebo. On the final day, attentional and interpretative bias to threat was assessed using the attentional probe and the homograph primed lexical decision tasks. Citalopram reduced attentional vigilance towards fearful faces but did not affect the interpretation of ambiguous homographs as threatening. Reboxetine had no significant effect on either of these measures. Citalopram reduces attentional orienting to threatening stimuli, which is potentially relevant to its clinical use in the treatment of anxiety disorders. This finding supports a growing literature suggesting that an important mechanism through which pharmacological agents may exert their effects on mood is by reversing the cognitive biases that characterize the disorders that they treat. Future studies are needed to clarify the neural mechanisms through which these effects on threat processing are mediated

An Observational Determination of the Bolometric Quasar Luminosity Function

We combine a large set of quasar luminosity function (QLF) measurements from the rest-frame optical, soft and hard X-ray, and near- and mid-infrared bands to determine the bolometric QLF in the redshift interval z=0-6. Accounting for the observed distributions of quasar column densities and variation of spectral energy distribution (SED) shapes, and their dependence on luminosity, makes it possible to integrate the observations in a reliable manner and provides a baseline in redshift and luminosity larger than that of any individual survey. We infer the QLF break luminosity and faint-end slope out to z~4.5 and confirm at high significance (>10sigma) previous claims of a flattening in both the faint- and bright-end slopes with redshift. With the best-fit estimates of the column density distribution and quasar SED, which both depend on luminosity, a single bolometric QLF self-consistently reproduces the observed QLFs in all bands and at all redshifts for which we compile measurements. Ignoring this luminosity dependence does not yield a self-consistent bolometric QLF and there is no evidence for any additional dependence on redshift. We calculate the expected relic black hole mass function and mass density, cosmic X-ray background, and ionization rate as a function of redshift and find they are consistent with existing measurements. The peak in the total quasar luminosity density is well-constrained at z=2.15+/-0.05. We provide a number of fitting functions to the bolometric QLF and its manifestations in various bands, and a script to return the QLF at arbitrary frequency and redshift from these fits, as the most simple inferences from the QLF measured in a single band can be misleading.Comment: 24 pages, 11 figures. Submitted to ApJ. A routine to return the QLF from the fits herein is available at http://www.cfa.harvard.edu/~phopkins/Site/qlf.htm

Modeling payback from research into the efficacy of left-ventricular assist devices as destination therapy

Objectives: Ongoing developments in design have improved the outlook for left-ventricular assist device (LVAD) implantation as a therapy in end-stage heart failure. Nevertheless, early cost-effectiveness assessments, based on first-generation devices, have not been encouraging. Against this background, we set out (i) to examine the survival benefit that LVADs would need to generate before they could be deemed cost-effective; (ii) to provide insight into the likelihood that this benefit will be achieved; and (iii) from the perspective of a healthcare provider, to assess the value of discovering the actual size of this benefit by means of a Bayesian value of information analysis. Methods: Cost-effectiveness assessments are made from the perspective of the healthcare provider, using current UK norms for the value of a quality-adjusted life-year (QALY). The treatment model is grounded in published analyses of the Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart Failure (REMATCH) trial of first-generation LVADs, translated into a UK cost setting. The prospects for patient survival with second-generation devices is assessed using Bayesian prior distributions, elicited from a group of leading clinicians in the field. Results: Using established thresholds, cost-effectiveness probabilities under these priors are found to be low (.2 percent) for devices costing as much as £60,000. Sensitivity of the conclusions to both device cost and QALY valuation is examined. Conclusions: In the event that the price of the device in use would reduce to £40,000, the value of the survival information can readily justify investment in further trials

Plant species or flower colour diversity? Identifying the drivers of public and invertebrate response to designed annual meadows

© 2018 The Authors There is increasing evidence of the benefits of introducing urban meadows as an alternative to amenity mown grass in public greenspaces, both for biodiversity, and human wellbeing. Developing a better understanding of the meadow characteristics driving human and wildlife response is therefore critical. We addressed this by assessing public and invertebrate response to eight different annual meadow mixes defined by two levels of plant species diversity and two levels of colour diversity, sown in an urban park in Luton, UK, in April 2015. On-site questionnaires with the visiting public were conducted in July, August and September 2015. Invertebrate responses were assessed via contemporaneous visual surveys and one sweep net survey (August 2015). Flower colour diversity had effects on human aesthetic response and the response of pollinators such as bumblebees and hoverflies. Plant species diversity, however, was not a driver of human response with evidence that people used colour diversity as a cue to assessing species diversity. Plant species diversity did affect some invertebrates, with higher abundances of certain taxa in low species diversity meadows. Our findings indicate that if the priority for sown meadows is to maximise human aesthetic enjoyment and the abundance and diversity of observable invertebrates, particularly pollinators, managers of urban green infrastructure should prioritise high flower colour diversity mixes over those of high plant species diversity. Incorporating late-flowering non-native species such as Coreopsis tinctoria (plains coreopsis) can prolong the attractiveness of the meadows for people and availability of resources for pollinators and would therefore be beneficial

Dust Reddening in SDSS Quasars

We explore the form of extragalactic reddening toward quasars using a sample of 9566 quasars with redshifts 0<z<2.2, and accurate optical colors from the Sloan Digital Sky Survey (SDSS). We confirm that dust reddening is the primary explanation for the red ``tail'' of the color distribution of SDSS quasars. Our fitting to 5-band photometry normalized by the modal quasar color as a function of redshift shows that this ``tail'' is well described by SMC-like reddening but not by LMC-like, Galactic, or Gaskell et al. (2004) reddening. Extension to longer wavelengths using a subset of 1886 SDSS-2MASS matches confirms these results at high significance. We carry out Monte-Carlo simulations that match the observed distribution of quasar spectral energy distributions using a Lorentzian dust reddening distribution; 2% of quasars selected by the main SDSS targeting algorithm (i.e., which are not extincted out of the sample) have E_{B-V} > 0.1; less than 1% have E_{B-V} > 0.2, where the extinction is relative to quasars with modal colors. Reddening is uncorrelated with the presence of intervening narrow-line absorption systems, but reddened quasars are much more likely to show narrow absorption at the redshift of the quasar than are unreddened quasars. Thus the reddening towards quasars is dominated by SMC-like dust at the quasar redshift.Comment: 29 pages including 8 figures. AJ, September 2004 issu

Hadronic Resonances from Lattice QCD

The determination of the pattern of hadronic resonances as predicted by Quantum Chromodynamics requires the use of non-perturbative techniques. Lattice QCD has emerged as the dominant tool for such calculations, and has produced many QCD predictions which can be directly compared to experiment. The concepts underlying lattice QCD are outlined, methods for calculating excited states are discussed, and results from an exploratory Nucleon and Delta baryon spectrum study are presented.Comment: 8 pages, VII Latin American Symposium on Nuclear Physics and Application

Results and Frontiers in Lattice Baryon Spectroscopy

The Lattice Hadron Physics Collaboration (LHPC) baryon spectroscopy effort is reviewed. To date the LHPC has performed exploratory Lattice QCD calculations of the low-lying spectrum of Nucleon and Delta baryons. These calculations demonstrate the effectiveness of our method by obtaining the masses of an unprecedented number of excited states with definite quantum numbers. Future work of the project is outlined.Comment: To appear in the proceedings for the VII Latin American Symposium of Nuclear Physics and Application