Near-infrared reddening of extra-galactic GMCs in a face-on geometry

[Abridged] We describe the near-infrared reddening signature of giant molecular clouds (GMCs) in external galaxies. In particular, we examine the E(J-H) and E(H-K) color-excesses, and the effective extinction law observed in discrete GMC regions. We also study the effect of the relative scale height of the GMC distribution to the color-excesses, and to the observed mass function of GMCs. We perform Monte Carlo radiative transfer simulations with 3D models of stellar radiation and clumpy dust distributions, resembling a face-on geometry. The scattered light is included in the models, and near-infrared color maps are calculated from the simulated data. The effective near-infrared reddening law, i.e. the ratio E(J-H)/E(H-K), has a value close to unity in GMC regions. The ratio depends on the relative scale height of GMCs, xi, and for xi values 0.1...0.75 we find the typical ratios of 0.6...1.1. The effective extinction law turns out to be very flat in GMC regions. We find the ratios of apparent extinctions of A(H)/A(K)=1.35...1.55 and A(J)/A(H)=1.15. The effect of the scattered flux on the effective reddening law, as well as on the effective extinction law, is significant. Regarding the GMC mass function, we find no correlation between the input and observed slopes of the mass functions. Rather, the observed slope reflects the parameter $\xi$ and the dynamical range of the mass function. We estimate that only a fraction of 10...20 % of the total mass of GMCs is recovered, if the observed color-excess values are transformed to masses using the Galactic reddening law. In the case of individual clouds the fraction can vary between ~0...50 %.Comment: 8 pages, 10 figures, accepted for publication in A&A. Added missing histograms in Fig.

Knockout of latrophilin-3 in Sprague-Dawley rats causes hyperactivity, hyper-reactivity, under-response to amphetamine, and disrupted dopamine markers

Attention deficit hyperactivity disorder is a pervasive developmental disorder characterized by inattention, impulsivity, and hyperactivity and is 75–90% heritable. Latrophilin-3 (LPHN3; or ADGRL(3)) is associated with a subtype of ADHD, but how it translates to symptoms is unknown. LPHN3 is a synaptic adhesion G protein coupled receptor that binds to fibronectin leucine rich transmembrane protein 3 and teneurin-3 (FLRT3 and TEN-3). We created a null mutation of Lphn3 (KO) in Sprague-Dawley rats using CRISPR/Cas9 to delete exon-3. The KO rats had no effects on reproduction or survival but reduced growth. KO females showed catch-up weight gain whereas KO males did not. We tested WT and KO littermates for home-cage activity, anxiety-like behavior, acoustic startle response, and activity after amphetamine challenge. Expression of Lphn3-related genes, monoamines, and receptors were determined. Lphn3 KO rats showed persistent hyperactivity, increased acoustic startle, reduced activity in response to amphetamine relative to baseline, and female-specific reduced anxiety-like behavior. Expression of Lphn1, Lphn2, and Flrt3 by qPCR and their protein products by western-blot analysis showed no compensatory upregulation. Striatal tyrosine hydroxylase, aromatic L-amino acid decarboxylase (AADC), and the dopamine transporter were increased and dopamine D1 receptor (DRD1) and dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32) decreased with no changes in DRD2, DRD4, vesicular monoamine transporter-2, N-methyl-d-aspartate (NMDA)-NR1, -NR2A, or -NR2B. LPHN3 is expressed in many brain regions but its function is largely unknown. Data from human, mouse, zebrafish, Drosophila and our new Lphn3 KO rat data collectively show that its disruption is significantly correlated with hyperactivity and associated striatal changes in dopamine markers

Mathematical modelling of a liver hollow fibre bioreactor

A mathematical model has been developed to assist with the development of a hollow fibre bioreactor (HFB) for hepatotoxicity testing of xenobiotics; specifically, to inform the HFB operating set-up, interpret data from HFB outputs and aid in optimizing HFB design to mimic certain hepatic physiological conditions. Additionally, the mathematical model has been used to identify the key HFB and compound parameters that will affect xenobiotic clearance. The analysis of this model has produced novel results that allow the operating set-up to be calculated, and predictions of compound clearance to be generated. The mathematical model predicts the inlet oxygen concentration and volumetric flow rate that gives a physiological oxygen gradient in the HFB to mimic a liver sinusoid. It has also been used to predict the concentration gradients and clearance of a test drug and paradigm hepatotoxin, paracetamol (APAP). The effect of altering the HFB dimensions and fibre properties on APAP clearance under the condition of a physiological oxygen gradient is analysed. These theoretical predictions can be used to design the most appropriate experimental set up and data analysis to quantitatively compare the functionality of cell types that are cultured within the HFB to those in other systems

Lifetime determination of excited states in Cd-106

Two separate experiments using the Differential Decay Curve Method have been performed to extract mean lifetimes of excited states in 106 Cd. The inedium-spin states of interest were populated by the Mo-98(C-12, 4n) Cd-106 reaction performed at the Wright Nuclear Structure Lab., Yale University. From this experiment, two isomeric state mean lifetimes have been deduced. The low-lying states were populated by the Mo-96(C-13, 3n)Cd-106 reaction performed at the Institut fur Kernphysik, Universitat zu Koln. The mean lifetime of the I-pi = 2(1)(+) state was deduced, tentatively, as 16.4(9) ps. This value differs from the previously accepted literature value from Coulomb excitation of 10.43(9) ps

Comparative effectiveness study of patient‐reported outcomes after proton therapy or intensity‐modulated radiotherapy for prostate cancer

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106701/1/cncr28536.pd

A morphological comparison between the central region in AGN and normal galaxies using HST data

We study the morphology of the central region of a sample of Active Galactic Nuclei (AGN) and a ``control'' sample of normal galaxies using archival observations of the WFPC2 instrument onboard the Hubble Space Telescope (HST). We use the ellipse fitting technique in order to get a good description of the inner ``smooth'' light distribution of the galaxy. We then divide the observed galaxy image by the artificial image from the fitted ellipses in order to detect morphological signatures in the central region around the nucleus of the galaxy. We perform quantitative comparisons of different subgroups of our sample of galaxies (according to the Hubble type and the nuclear activity of the galaxies) by calculating the average amplitude of the structures that are revealed with the ellipse fitting technique. Our main conclusions are as follows: 1) All AGNs show significant structure in their inner 100 pc and 1 kpc regions whose amplitude is similar in all of them, independent of the Hubble type of the host galaxy. 2) When considering early-type galaxies, non-AGN galaxies show no structure at all, contrary to what we find for AGN. 3) When considering late-type galaxies, both AGN and non-AGN galaxies show significant structure in their central region. Our results are consistent with the hypothesis that all early-type galaxies host a supermassive black hole, but only those that have enough material in the central regions to fuel it show an active nucleus. The situation is more complicated in late-type galaxies. Either not all of them host a central black hole, or, in some of them, the material inside the innermost 100 pc region is not transported to the scales of the central engine for some reason, or the large amount of gas and dust hides the active nucleus from our sight.Comment: Accepted for publication in A&A. A gziped ps file with high resolution figures is available at http://armonia.physics.uoc.gr/~xilouris/publications/pub.htm

Dietary garlic and hip osteoarthritis: evidence of a protective effect and putative mechanism of action

Background Patterns of food intake and prevalent osteoarthritis of the hand, hip, and knee were studied using the twin design to limit the effect of confounding factors. Compounds found in associated food groups were further studied in vitro. Methods Cross-sectional study conducted in a large population-based volunteer cohort of twins. Food intake was evaluated using the Food Frequency Questionnaire; OA was determined using plain radiographs. Analyses were adjusted for age, BMI and physical activity. Subsequent in vitro studies examined the effects of allium-derived compounds on the expression of matrix-degrading proteases in SW1353 chondrosarcoma cells. Results Data were available, depending on phenotype, for 654-1082 of 1086 female twins (median age 58.9 years; range 46-77). Trends in dietary analysis revealed a specific pattern of dietary intake, that high in fruit and vegetables, showed an inverse association with hip OA (p = 0.022). Consumption of 'non-citrus fruit' (p = 0.015) and 'alliums' (p = 0.029) had the strongest protective effect. Alliums contain diallyl disulphide which was shown to abrogate cytokine-induced matrix metalloproteinase expression. Conclusions Studies of diet are notorious for their confounding by lifestyle effects. While taking account of BMI, the data show an independent effect of a diet high in fruit and vegetables, suggesting it to be protective against radiographic hip OA. Furthermore, diallyl disulphide, a compound found in garlic and other alliums, represses the expression of matrix-degrading proteases in chondrocyte-like cells, providing a potential mechanism of action