Die Interviews - Ergebnisse aus 20 Großstädten Deutschlands DFG-Forschungsprojekt "Stadträume in Spannungsfeldern"

DIE INTERVIEWS - ERGEBNISSE AUS 20 GROSSSTÄDTEN DEUTSCHLANDS DFG-FORSCHUNGSPROJEKT "STADTRÄUME IN SPANNUNGSFELDERN" Stars-Materialien (Rights reserved) (-) IssueTeil 01 Das Forschungsprojekt - Eine Kurzdokumentation des DFG-Forschungsprojektes "Stadträume in Spannungsfeldern" (Rights reserved) ( - ) IssueTeil 02 Die Fallstudien - Ergebnisse aus Leipzig, Hannover und Aachen DFG-Forschungsprojekt "Stadträume in Spannungsfeldern" (Rights reserved) ( - ) IssueTeil 03 Die Interviews - Ergebnisse aus 20 Großstädten Deutschlands DFG-Forschungsprojekt "Stadträume in Spannungsfeldern" (Rights reserved) ( -

Die Fallstudien - Ergebnisse aus Leipzig, Hannover und Aachen DFG-Forschungsprojekt "Stadträume in Spannungsfeldern"

DIE FALLSTUDIEN - ERGEBNISSE AUS LEIPZIG, HANNOVER UND AACHEN DFG-FORSCHUNGSPROJEKT "STADTRÄUME IN SPANNUNGSFELDERN" Stars-Materialien (Rights reserved) (-) IssueTeil 01 Das Forschungsprojekt - Eine Kurzdokumentation des DFG-Forschungsprojektes "Stadträume in Spannungsfeldern" (Rights reserved) ( - ) IssueTeil 02 Die Fallstudien - Ergebnisse aus Leipzig, Hannover und Aachen DFG-Forschungsprojekt "Stadträume in Spannungsfeldern" (Rights reserved) ( - ) IssueTeil 03 Die Interviews - Ergebnisse aus 20 Großstädten Deutschlands DFG-Forschungsprojekt "Stadträume in Spannungsfeldern" (Rights reserved) ( -

The Seventeenth Data Release of the Sloan Digital Sky Surveys: Complete Release of MaNGA, MaStar and APOGEE-2 Data

This paper documents the seventeenth data release (DR17) from the Sloan Digital Sky Surveys; the fifth and final release from the fourth phase (SDSS-IV). DR17 contains the complete release of the Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey, which reached its goal of surveying over 10,000 nearby galaxies. The complete release of the MaNGA Stellar Library (MaStar) accompanies this data, providing observations of almost 30,000 stars through the MaNGA instrument during bright time. DR17 also contains the complete release of the Apache Point Observatory Galactic Evolution Experiment 2 (APOGEE-2) survey which publicly releases infra-red spectra of over 650,000 stars. The main sample from the Extended Baryon Oscillation Spectroscopic Survey (eBOSS), as well as the sub-survey Time Domain Spectroscopic Survey (TDSS) data were fully released in DR16. New single-fiber optical spectroscopy released in DR17 is from the SPectroscipic IDentification of ERosita Survey (SPIDERS) sub-survey and the eBOSS-RM program. Along with the primary data sets, DR17 includes 25 new or updated Value Added Catalogs (VACs). This paper concludes the release of SDSS-IV survey data. SDSS continues into its fifth phase with observations already underway for the Milky Way Mapper (MWM), Local Volume Mapper (LVM) and Black Hole Mapper (BHM) surveys

Effectiveness and safety of opicapone in Parkinson’s disease patients with motor fluctuations: the OPTIPARK open-label study

Background The efficacy and safety of opicapone, a once-daily catechol-O-methyltransferase inhibitor, have been established in two large randomized, placebo-controlled, multinational pivotal trials. Still, clinical evidence from routine practice is needed to complement the data from the pivotal trials. Methods OPTIPARK (NCT02847442) was a prospective, open-label, single-arm trial conducted in Germany and the UK under clinical practice conditions. Patients with Parkinson’s disease and motor fluctuations were treated with opicapone 50 mg for 3 (Germany) or 6 (UK) months in addition to their current levodopa and other antiparkinsonian treatments. The primary endpoint was the Clinician’s Global Impression of Change (CGI-C) after 3 months. Secondary assessments included Patient Global Impressions of Change (PGI-C), the Unified Parkinson’s Disease Rating Scale (UPDRS), Parkinson’s Disease Questionnaire (PDQ-8), and the Non-Motor Symptoms Scale (NMSS). Safety assessments included evaluation of treatment-emergent adverse events (TEAEs) and serious adverse events (SAEs). Results Of the 506 patients enrolled, 495 (97.8%) took at least one dose of opicapone. Of these, 393 (79.4%) patients completed 3 months of treatment. Overall, 71.3 and 76.9% of patients experienced any improvement on CGI-C and PGI-C after 3 months, respectively (full analysis set). At 6 months, for UK subgroup only (n = 95), 85.3% of patients were judged by investigators as improved since commencing treatment. UPDRS scores at 3 months showed statistically significant improvements in activities of daily living during OFF (mean ± SD change from baseline: − 3.0 ± 4.6, p < 0.0001) and motor scores during ON (− 4.6 ± 8.1, p < 0.0001). The mean ± SD improvements of − 3.4 ± 12.8 points for PDQ-8 and -6.8 ± 19.7 points for NMSS were statistically significant versus baseline (both p < 0.0001). Most of TEAEs (94.8% of events) were of mild or moderate intensity. TEAEs considered to be at least possibly related to opicapone were reported for 45.1% of patients, with dyskinesia (11.5%) and dry mouth (6.5%) being the most frequently reported. Serious TEAEs considered at least possibly related to opicapone were reported for 1.4% of patients. Conclusions Opicapone 50 mg was effective and generally well-tolerated in PD patients with motor fluctuations treated in clinical practice. Trial registration Registered in July 2016 at clinicaltrials.gov (NCT02847442)

Training für Bio-Inspekteure zum Thema Tierwohl - AWARE

This project shall develop a harmonized inspection approach for animal welfare in organic farming and corresponding training concepts for organic inspectors. Such an approach does not exist in the European Union up to now. The focus on animal-related indicators is an innovative audit solution which supports best – according to recent European research and development projects – a good life of farm animals. The training concept shall use a blended learning approach, consisting of the use of an E-learning-Platform, lectures and practical exercises on organic farms to ensure the learning success of the participants. The training shall involve specialists from different EU member states. The output of the project applied for may not only be used by organic inspectors, but also by official animal welfare inspectors in future. As animal welfare inspections require specific audit methodology, particular observational skills of organic inspectors with regard to animal related indicators and a different documentation methodology (descriptive part of the inspection report instead of checklists, photo documentation), this project tackles a new and innovative inspection methodology with regard to animal welfare which shall be included into the inspection toolbox developed within the project IRM-Organic