Transhumanist habitat for the elderly people

Actualmente vivimos en una era donde la superpoblación esta envejeciendo, dando como resultado adultos con menos instrumentos para cuidarse durante su vejez, pero gracias a la evolución de la tecnología, se han creado instrumentos, que sirven para facilitar las cosas en contraste con sus predecesores, la unión de estos fenómenos es en donde se plantea un hábitat, donde el adulto mayor pueda vivir dignamente, un espacio que les de la opción a la población abandonada de vivir en una comunidad, apoyada en la sostenibilidad y la tecnología domótica y urbótica.We currently live in an era where overpopulation is aging, resulting in adults with fewer tools to take care of themselves during their old age, but thanks to the evolution of technology, tools have been created, which serve to facilitate things in contrast to their predecessors, the union of these phenomena is where a habitat is proposed, where the elderly can live with dignity, a space that gives the abandoned population the option of living in a community, supported by sustainability and home automation and urban technology.Arquitecto (a)Pregrad

Determinantes de la Tasa de Cambio Nominal: Verificación Empírica del Modelo de Precios Rígidos en la Economía Colombiana, 1995:I–2006:I

En este artículo se exponen en primera instancia, las características relevantes de los diversos modelos que se han desarrollado a través de la historia con el objetivo de explicar el comportamiento que presenta la tasa de cambio nominal, y en segundo lugar, se realiza la aplicación empírica del modelo de precios rígidos de determinación de la tasa de cambio para la economía colombiana mediante la técnica econométrica de cointegración. De la aplicación econométrica se destaca que las variables relevantes en el modelo de precios rígidos forman una relación estable de largo plazo, y que los signos de las elasticidades estimadas son conformes a lo planteado por el modelo.First at all, this paper shows the relevant characteristics of different models that are been created throughout the history in order to explain the nominal exchange rate’s behavior. Second, it is done an econometric exercise of the sticky–price nominal exchange rate model on the Colombian economic, through the cointegration technique. From the empirical exercise is found that the relevant variables implied in the sticky–price nominal exchange rate model form a stable long term relationship and the estimated elasticities’ sing confirm the model

Verificación empírica del modelo de precios rígidos en la economía colombiana, 1995:I–2006:I

En este artículo se contrasta empíricamente la validez del enfoque monetario de precios rígidos para la determinación de la tasa de cambio en la economía colombiana para el período 1995-2006 a través de la técnica econométrica de cointegración. Se encuentra que las variables relevantes en el modelo forman una relación estable de largo plazo, y que los signos de las elasticidades estimadas son conformes a lo planteado por la teoría

Verificación empírica del modelo de precios rígidos en la economía colombiana, 1995:I–2006:I

En este artículo se contrasta empíricamente la validez del enfoque monetario de precios rígidos para la determinación de la tasa de cambio en la economía colombiana para el período 1995-2006 a través de la técnica econométrica de cointegración. Se encuentra que las variables relevantes en el modelo forman una relación estable de largo plazo, y que los signos de las elasticidades estimadas son conformes a lo planteado por la teoría

The impact of associated tenotomies on the outcome of incomplete phalangeal osteotomies for lesser toe deformities

Partial or incomplete osteotomy (IO) of the phalanx is recently described in the literature. However, the clinical outcome and the rate of complications when applied to lesser toe deformities (LTD) have been never addressed. This study aims to find out if the association of tenotomies to incomplete or partial phalanx osteotomies has a significant impact on the clinical outcomes, the occurrence of complications, and the recovery time after surgery. Methods: A retrospective review of two cohorts of cases operated in our institution for hallux abductus valgus (HAV) and associated LTD from 2008 to 2014 was carried out. The surgical correction of both HAV and the associated LTD was always performed by minimally invasive techniques. The study included a total of 223 patients (723 IO in 556 toes). In 129 cases, the IO for LTD correction was performed without tenotomies, and in 94, the procedure was combined with flexor and/or extensor tenotomies. Patients were assessed with the American Orthopaedic Foot and Ankle Society (AOFAS) questionnaire before surgery and at 6- and 12-month follow-up. Results: The mean preoperative AOFAS score before surgery was similar in both cohorts. At 12-month follow-up, the cohort without tenotomies showed better recovery (95.7 ± 2.8 versus 92.5 ± 6.8; p < 0.01). AOFAS scores decreased as the number of associated LTD increased (r = − 0.814; p < 0.001). Cases operated on by PO + tenotomy showed a high rate of complications such as delayed union of the osteotomy (p < 0.01), hypertrophic callus (p < 0.01), phalangeal fracture at the osteotomy site (p < 0.01), and lack of correction (p < 0.05). The overall occurrence of adverse events was 38.6% in cases operated by PO + tenotomy and 13.9% in cases receiving PO alone (p < 0.0001). Cases operated on without tenotomy showed a shorter time to complete recovery for daily life activities (37.4 ± 2.3 versus 43.0 ± 1.7 days; p < 0.01). Conclusion: The performance of associated tenotomies to incomplete phalanx osteotomies provides worse clinical outcomes, higher complication rates, and longer recovery time as compared to similar forefoot surgeries without tenotomies.Podologí

Lo glocal y el turismo. Nuevos paradigmas de interpretación.

El estudio del turismo se realiza desde múltiples escalas y enfoques, este libro aborda muchos temas que es necesario discutir desde diversas perspectivas; es el caso de la reflexión sobre la propia disciplina y sus conceptos, así como los asuntos específicos referidos al impacto territorial, los tipos de turismo, las cuestiones ambientales, el tema de la pobreza, la competitividad, las políticas públicas, el papel de las universidades, las áreas naturales protegidas, la sustentabilidad, la cultura, el desarrollo, la seguridad, todos temas centrales documentados y expuestos con originalidad y dominio del asunto. Lo multiescalar es básico para la comprensión del sistema turístico, sistema formado de procesos globales, regionales y locales. El eje de discusión del libro es lo glocal, esa interacción entre lo nacional y local con lo global

Memorias del Primer Simposio Internacional: Formación Humana y Transformación Social.

El documento completo no se encuentra disponible en acceso abierto (disponible portada y tabla de contenido)

Memorias del Primer Simposio Internacional: Formación Humana y Transformación Social.

El documento completo no se encuentra disponible en acceso abierto (disponible portada y tabla de contenido)

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Role of age and comorbidities in mortality of patients with infective endocarditis

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group