485 research outputs found
Ammonites from the Apoderoceras beds (Early Pliensbachian) in SĂŁo Pedro de Muel (Lusitanian Basin, Portugal)
NN Scattering: Chiral Predictions for Asymptotic Observables
We assume that the nuclear potential for distances larger than 2.5 fm is
given just by the exchanges of one and two pions and, for the latter, we adopt
a model based on chiral symmetry and subthreshold pion-nucleon amplitudes,
which contains no free parameters. The predictions produced by this model for
nucleon-nucleon observables are calculated and shown to agree well with both
experiment and those due to phenomenological potentials.Comment: 16 pages, 12 PS figures included, to appear in Physical Review
Biostratigraphic sequence of Portuguese West-basin. Differentiation during the Lias and Dogger.
Depto. de GeodinĂĄmica, EstratigrafĂa y PaleontologĂaFac. de Ciencias GeolĂłgicasTRUEpu
Topological Charged Black Holes in High Dimensional Spacetimes and Their Formation from Gravitational Collapse of a Type II Fluid
Topological charged black holes coupled with a cosmological constant in
spacetimes are studied, where is an Einstein
space of the form . The global structure for
the four-dimensional spacetimes with is investigated systematically.
The most general solutions that represent a Type fluid in such a high
dimensional spacetime are found, and showed that topological charged black
holes can be formed from the gravitational collapse of such a fluid. When the
spacetime is (asymptotically) self-similar, the collapse always forms black
holes for , in contrast to the case , where it can form
either balck holes or naked singularities.Comment: 14 figures, to appear in Phys. Rev.
Quark Condensate in the Deuteron
We study the changes produced by the deuteron on the QCD quark condensate by
means the Feynman-Hellmann theorem and find that the pion mass dependence of
the pion-nucleon coupling could play an important role. We also discuss the
relation between the many body effect of the condensate and the meson exchange
currents, as seen by photons and pions. For pion probes, the many-body term in
the physical amplitude differs significantly from that of soft pions, the one
linked to the condensate. Thus no information about the many-body term of the
condensate can be extracted from the pion-deuteron scattering length. On the
other hand, in the Compton amplitude, the relationship with the condensate is a
more direct one.Comment: to appear in Physics Review C (19 pages, 3 figures
Downregulation Of 14q32 Micrornas In Primary Human Desmoplastic Medulloblastoma
Medulloblastoma (MB) is one of the most common pediatric cancers, likely originating from abnormal development of cerebellar progenitor neurons. MicroRNA (miRNA) has been shown to play an important role in the development of the central nervous system. Microarray analysis was used to investigate miRNA expression in desmoplastic MB from patients diagnosed at a young age (1 or 2 years old). Normal fetal or newborn cerebellum was used as control. A total of 84 differentially expressed miRNAs (64 downregulated and 20 upregulated) were found. Most downregulated miRNAs (32/64) were found to belong to the cluster of miRNAs at the 14q32 locus, suggesting that this miRNA locus is regulated as a module in MB. Possible mechanisms of 14q32 miRNAs downregulation were investigated by the analysis of publicly available gene expression data sets. First, expression of estrogen-related receptor-Îł (ESRRG), a reported positive transcriptional regulator of some 14q32 miRNAs, was found downregulated in desmoplastic MB. Second, expression of the parentally imprinted gene MEG3 was lower in MB in comparison to normal cerebellum, suggesting a possible epigenetic silencing of the 14q32 locus. miR-129-5p (11p11.2/7q32.1), miR-206 (6p12.2), and miR-323-3p (14q32.2), were chosen for functional studies in DAOY cells. Overexpression of miR-129-5p using mimics decreased DAOY proliferation. No effect was found with miR-206 or miR-323 mimics. © 2013 Lucon, Rocha, Craveiro, Dilloo, Cardinalli, Cavalcanti, Aguiar, Maurer-Morelli and Yunes.3 SEPEllison, D., Classifying the medulloblastoma: insights from morphology and molecular genetics (2002) Neuropathol Appl Neurobiol, 28, pp. 257-282. , doi:10.1046/j.1365-2990.2002.00419.xGulino, A., Di Marcotullio, L., Ferretti, E., De Smaele, E., Screpanti, I., Hedgehog signaling pathway in neural development and disease (2007) Psychoneuroendocrinology, 32, pp. S25-56. , doi:10.1016/j.psyneuen.2007.03.017Kool, M., Koster, J., Bunt, J., Hasselt, N.E., Lakeman, A., van Sluis, P., Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features (2008) PLoS ONE, 3, pp. e3088. , doi:10.1371/journal.pone.0003088Northcott, P.A., Korshunov, A., Witt, H., Hielscher, T., Eberhart, C.G., Mack, S., Medulloblastoma comprises four distinct molecular variants (2010) J Clin 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doi:10.1038/emboj.2008.172Venkataraman, S., Alimova, I., Fan, R., Harris, P., Foreman, N., Vibhakar, R., MicroRNA 128a increases intracellular ROS level by targeting Bmi-1 and inhibits medulloblastoma cancer cell growth by promoting senescence (2010) PLoS ONE, 5 (6), pp. e10748. , doi:10.1371/journal.pone.0010748Genovesi, L.A., Carter, K.W., Gottardo, N.G., Giles, K.M., Dallas, P.B., Integrated analysis of miRNA and mRNA expression in childhood medulloblastoma compared with neural stem cells (2011) PLoS ONE, 6 (9), pp. e23935. , doi:10.1371/journal.pone.0023935Weeraratne, S.D., Amani, V., Neiss, A., Teider, N., Scott, D.K., Pomeroy, S.L., miR-34a confers chemosensitivity through modulation of MAGE-A and p53 in medulloblastoma (2011) Neuro Oncol, 13 (2), pp. 165-175. , doi:10.1093/neuonc/noq179Lv, S.Q., Kim, Y.H., Giulio, F., Shalaby, T., Nobusawa, S., Yang, H., Genetic alterations in MicroRNAs in medulloblastomas (2012) Brain Pathol, 22, pp. 230-239. , 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pp. 1918-1928. , doi:10.1074/jbc.M112.396762Wei, L., Yan-hua, G., Teng-fei, C., Xiao-zhong, P., Jian-gang, Y., Zhen-yu, M., Identification of differentially expressed microRNAs by microarray: a possible role for microRNAs gene in medulloblastomas (2009) Chin Med J, 122 (20), pp. 2405-241
CHIRAL BACKGROUND FOR THE TWO PION EXCHANGE NUCLEAR POTENTIAL: A PARAMETRIZED VERSION
We argue that the minimal chiral background for the two-pion exchange
nucleon-nucleon interaction has nowadays a rather firm conceptual basis, which
entitles it to become a standard ingredient of any modern potential. In order
to facilitate applications, we present a parametrized version of a
configuration space potential derived previously. We then use it to assess the
phenomenological contents of some existing NN potentials.Comment: REVTEX style, 16 pages, 5 PostScript figures compressed, tarred and
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Planck intermediate results. VIII. Filaments between interacting clusters
About half of the baryons of the Universe are expected to be in the form of
filaments of hot and low density intergalactic medium. Most of these baryons
remain undetected even by the most advanced X-ray observatories which are
limited in sensitivity to the diffuse low density medium. The Planck satellite
has provided hundreds of detections of the hot gas in clusters of galaxies via
the thermal Sunyaev-Zel'dovich (tSZ) effect and is an ideal instrument for
studying extended low density media through the tSZ effect. In this paper we
use the Planck data to search for signatures of a fraction of these missing
baryons between pairs of galaxy clusters. Cluster pairs are good candidates for
searching for the hotter and denser phase of the intergalactic medium (which is
more easily observed through the SZ effect). Using an X-ray catalogue of
clusters and the Planck data, we select physical pairs of clusters as
candidates. Using the Planck data we construct a local map of the tSZ effect
centered on each pair of galaxy clusters. ROSAT data is used to construct X-ray
maps of these pairs. After having modelled and subtracted the tSZ effect and
X-ray emission for each cluster in the pair we study the residuals on both the
SZ and X-ray maps. For the merging cluster pair A399-A401 we observe a
significant tSZ effect signal in the intercluster region beyond the virial
radii of the clusters. A joint X-ray SZ analysis allows us to constrain the
temperature and density of this intercluster medium. We obtain a temperature of
kT = 7.1 +- 0.9, keV (consistent with previous estimates) and a baryon density
of (3.7 +- 0.2)x10^-4, cm^-3. The Planck satellite mission has provided the
first SZ detection of the hot and diffuse intercluster gas.Comment: Accepted by A&
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