Implementation of the Hydrographic Data Acquisition and Processing System (HDAPS) in the NOAA Fleet

The U.S. National Oceanic and Atmospheric Administration (NOAA) has developed an automated system for acquiring and processing hydrographic field data in support of its charting mission. The Hydrographic Data Acquisition and Processing System (HDAPS) addresses NOAA’s broad requirement to conduct hydrographic surveys in the coastal waters of the U.S. Systems have been successfully deployed on ships, launches, and small boats. Two types of HDAPS data acquisition systems (DAS) are presented. The first system, based on Hewlett-Packard (HP) hardware, is deployed on ships and launches. The second type is a small boat, 24-volt system, based on 1BM-PC compatible hardware. Both types of DAS are capable of conducting echo sounding and side scan sonar surveys. Data acquired by both systems are processed on an HP-based data processing system

Design of a multi-purpose building "to zero energy consumption" according to european directive 2010/31/ce: Architectural and plant solutions

Considering the significant impact that the residential sector has on energy consumption, it is particularly important to implement policies aimed at improving energy efficiency in buildings for saving primary energy, and also to spread the concept of sustainable development through the use of appropriate technology and proper project criteria for new constructions. For these reasons the Municipality of Città della Pieve promoted the creation of a "Renewable Energy Park" in a deprived area of its territory, so that there were the main technologies for the production of green energy. In this context, it could not be lacking an educational/demonstrative "zero energy consumption" building for multifunctional activities realized with the most innovative techniques to save energy. The building will exemplify the optimization of the benefits derived from improved energy efficiency in synergy with systems of energy production from renewable sources, such as to make possible the transition from "passive" building to get to "active" building. In this paper we describe the technical solutions adopted both in the building envelope and the system concept for the project of that "zero energy consumption" building according to Directive 2010/31/CE. In order to validate the proposed solutions, it has also been carried out a simulation of the behaviour of the building in summer and winter so that it is possible to assess the actual benefits obtained both in terms of energy and in economic terms following the adoption of the proposed solutions

Activation of a non-neuronal cholinergic system in visceral white adipose tissue of obese mice and humans

Background and objectives: Since white adipose tissue (WAT) lacks parasympathetic cholinergic innervation, the source of the acetylcholine (ACh) acting on white adipocyte cholinergic receptors is unknown. This study was designed to identify ACh-producing cells in mouse and human visceral WAT and to determine whether a non-neuronal cholinergic system becomes activated in obese inflamed WAT. Methods: Mouse epididymal WAT (eWAT) and human omental fat were studied in normal and obese subjects. The expression of the key molecules involved in cholinergic signaling was evaluated by qRT-PCR and western blotting whereas their tissue distribution and cellular localization were investigated by immunohistochemistry, confocal microscopy and in situ hybridization. ACh levels were measured by liquid chromatography/tandem mass spectrometry. The cellular effects of ACh were assessed in cultured human multipotent adipose-derived stem cell (hMADS) adipocytes. Results: In mouse eWAT, diet-induced obesity modulated the expression of key cholinergic molecular components and, especially, raised the expression of choline acetyltransferase (ChAT), the ACh-synthesizing enzyme, which was chiefly detected in interstitial macrophages, in macrophages forming crown-like structures (CLSs), and in multinucleated giant cells (MGCs). The stromal vascular fraction of obese mouse eWAT contained significantly higher ACh and choline levels than that of control mice. ChAT was undetectable in omental fat from healthy subjects, whereas it was expressed in a number of interstitial macrophages, CLSs, and MGCs from some obese individuals. In hMADS adipocytes stressed with tumor necrosis factor a, ACh, alone or combined with rivastigmine, significantly blunted monocyte chemoattractant protein 1 and interleukin 6 expression, it partially but significantly, restored adiponectin and GLUT4 expression, and promoted glucose uptake. Conclusions: In mouse and human visceral WAT, obesity induces activation of a macrophage-dependent non-neuronal cholinergic system that is capable of exerting anti-inflammatory and insulin-sensitizing effects on white adipocytes. (c) 2023 The Author(s). Published by Elsevier GmbH. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)

Evolution of brightness and magnetic features of young solar-type stars – I. The young G star HIP 89829

The evolution in latitude of sunspots is a key feature of the cyclic solar dynamo. Here, we present the results of a spectroscopic and spectropolarimetric monitoring campaign on the young (~20 Myr old) early G star HIP 89829, in order to investigate potential evolution in the distribution of the star's spots and magnetic features. Our analysis of this G5V star spans eight epochs, from June 2010 to August 2015. The techniques of Doppler imaging and Zeeman-Doppler imaging were used to create brightness maps for each epoch and magnetic maps for two epochs. The brightness images show the star to have stable spot features with two main spot latitudes - a polar spot, often seen on young rapidly rotating stars such as this, and another highly unusual group of large spot features around the 20° and 30° latitudes. These lower spot latitudes appear to be rather stable over the 5 yr of observations. We included a solar-type differential rotation law into the imaging process and measured near-solid-body rotation for epochs where sufficient data exist for this analysis. The magnetic features show a dominant poloidal and a weaker toroidal magnetic field for both Stokes V epochs, which is unusual for a star with a rapid rotation period of 0.57 d. We conclude that HIP 89829 is an active young solar-type star with long-lived spots and near-solid-body rotation

Which executive functioning deficits are associated with AD/HD, ODD/CD and comorbid AD/HD+ODD/CD?

Item does not contain fulltextThis study investigated (1) whether attention deficit/hyperactivity disorder (AD/HD) is associated with executive functioning (EF) deficits while controlling for oppositional defiant disorder/conduct disorder (ODD/CD), (2) whether ODD/CD is associated with EF deficits while controlling for AD/HD, and (3)~whether a combination of AD/HD and ODD/CD is associated with EF deficits (and the possibility that there is no association between EF deficits and AD/HD or ODD/CD in isolation). Subjects were 99~children ages 6–12 years. Three putative domains of EF were investigated using well-validated tests: verbal fluency, working memory, and planning. Independent of ODD/CD, AD/HD was associated with deficits in planning and working memory, but not in verbal fluency. Only teacher rated AD/HD, but not parent rated AD/HD, significantly contributed to the prediction of EF task performance. No EF deficits were associated with ODD/CD. The presence of comorbid AD/HD accounts for the EF deficits in children with comorbid AD/HD+ODD/CD. These results suggest that EF deficits are unique to AD/HD and support the model proposed by R. A. Barkley (1997).17 p

Photostability of commercial sunscreens upon sun exposure and irradiation by ultraviolet lamps

BACKGROUND: Sunscreens are being widely used to reduce exposure to harmful ultraviolet (UV) radiation. The fact that some sunscreens are photounstable has been known for many years. Since the UV-absorbing ingredients of sunscreens may be photounstable, especially in the long wavelength region, it is of great interest to determine their degradation during exposure to UV radiation. Our aim was to investigate the photostability of seven commercial sunscreen products after natural UV exposure (UVnat) and artificial UV exposure (UVart). METHODS: Seven commercial sunscreens were studied with absorption spectroscopy. Sunscreen product, 0.5 mg/cm(2), was placed between plates of silica. The area under the curve (AUC) in the spectrum was calculated for UVA (320–400 nm), UVA1 (340–400 nm), UVA2 (320–340 nm) and UVB (290–320 nm) before (AUC(before)) and after (AUC(after)) UVart (980 kJ/m(2 )UVA and 12 kJ/m(2 )of UVB) and before and after UVnat. If theAUC Index (AUCI), defined as AUCI = AUC(after)/AUC(before), was > 0.80, the sunscreen was considered photostable. RESULTS: Three sunscreens were unstable after 90 min of UVnat; in the UVA range the AUCI was between 0.41 and 0.76. In the UVB range one of these sunscreens was unstable with an AUCI of 0.75 after 90 min. Three sunscreens were photostable after 120 min of UVnat; in the UVA range the AUCI was between 0.85 and 0.99 and in the UVB range between 0.92 and 1.0. One sunscreen showed in the UVA range an AUCI of 0.87 after UVnat but an AUCI of 0.72 after UVart. Five of the sunscreens were stable in the UVB region. CONCLUSION: The present study shows that several sunscreens are photounstable in the UVA range after UVnat and UVart. There is a need for a standardized method to measure photostability, and the photostability should be marked on the sunscreen product

Investigating cooperation with robotic peers

We explored how people establish cooperation with robotic peers, by giving participants the chance to choose whether to cooperate or not with a more/less selfish robot, as well as a more or less interactive, in a more or less critical environment. We measured the participants' tendency to cooperate with the robot as well as their perception of anthropomorphism, trust and credibility through questionnaires. We found that cooperation in Human-Robot Interaction (HRI) follows the same rule of Human-Human Interaction (HHI), participants rewarded cooperation with cooperation, and punished selfishness with selfishness. We also discovered two specific robotic profiles capable of increasing cooperation, related to the payoff. A mute and non-interactive robot is preferred with a high payoff, while participants preferred a more human-behaving robot in conditions of low payoff. Taken together, these results suggest that proper cooperation in HRI is possible but is related to the complexity of the task

A new panel of epitope mapped monoclonal antibodies recognising the prototypical tetraspanin CD81

Background: Tetraspanins are small transmembrane proteins, found in all higher eukaryotes, that compartmentalize cellular membranes through interactions with partner proteins. CD81 is a prototypical tetraspanin and contributes to numerous physiological and pathological processes, including acting as a critical entry receptor for hepatitis C virus (HCV). Antibody engagement of tetraspanins can induce a variety of effects, including actin cytoskeletal rearrangements, activation of MAPK-ERK signaling and cell migration. However, the epitope specificity of most anti-tetraspanin antibodies is not known, limiting mechanistic interpretation of these studies. Methods: We generated a panel of monoclonal antibodies (mAbs) specific for CD81 second extracellular domain (EC2) and performed detailed epitope mapping with a panel of CD81 mutants. All mAbs were screened for their ability to inhibit HCV infection and E2-CD81 association. Nanoscale distribution of cell surface CD81 was investigated by scanning electron microscopy. Results: The antibodies were classified in two epitope groups targeting opposing sides of EC2. We observed a wide range of anti-HCV potencies that were independent of their epitope grouping, but associated with their relative affinity for cell-surface expressed CD81. Scanning electron microscopy identified at least two populations of CD81; monodisperse and higher-order assemblies, consistent with tetraspanin-enriched microdomains. Conclusions: These novel antibodies provide well-characterised tools to investigate CD81 function, including HCV entry, and have the potential to provide insights into tetraspanin biology in general

magma mixing history and dynamics of an eruption trigger

The most violent and catastrophic volcanic eruptions on Earth have been triggered by the refilling of a felsic volcanic magma chamber by a hotter more mafic magma. Examples include Vesuvius 79 AD, Krakatau 1883, Pinatubo 1991, and Eyjafjallajokull 2010. Since the first hypothesis, plenty of evidence of magma mixing processes, in all tectonic environments, has accumulated in the literature allowing this natural process to be defined as fundamental petrological processes playing a role in triggering volcanic eruptions, and in the generation of the compositional variability of igneous rocks. Combined with petrographic, mineral chemistry and geochemical investigations, isotopic analyses on volcanic rocks have revealed compositional variations at different length scales pointing to a complex interplay of fractional crystallization, mixing/mingling and crustal contamination during the evolution of several magmatic feeding systems. But to fully understand the dynamics of mixing and mingling processes, that are impossible to observe directly, at a realistically large scale, it is necessary to resort to numerical simulations of the complex interaction dynamics between chemically different magmas