Project Half Double Current Results of Phase 1 and Phase 2, December 2017

The Half Double mission: Project Half Double has a clear mission. We want to succeed in finding a project methodology that can increase the success rate of our projects while increasing the development speed of new products and services. We are convinced that by doing so we can strengthen Denmark’s competitiveness and play an important role in the battle for jobs and future welfare. The overall goal is to deliver “Projects in half the time with double the impact” where projects in half the time should be understood as half the time to impact (benefit realization, effect is achieved) and not as half the time for project execution. The Half Double project journey: It all began in May 2013 when we asked ourselves: How do we create a new and radical project paradigm that can create successful projects? Today the movement includes hundreds of passionate project people, and it grows larger by the day. The formal part of Project Half Double was initiated in June 2015. It is a two-phase project: phase 1 took place from June 2015 to June 2016 with seven pilot projects, and phase 2 is in progress from July 2016 to July 2018 with 10 pilot projects.The Half Double consortium: Implement Consulting Group is the project leader establishing and managing the collaboration with the pilot project companies in terms of methodology. Aarhus University and the Technical University of Denmark will evaluate the impact of the pilot projects and legitimize the methodology in academia.The Danish Industry Foundation, an independent philanthropic foundation, is contributing to the project financially with DKK 13.8 million.About this report: This report focuses on phase 2 pilot projects documenting their development and further consolidates results from the phase 1 pilot projects. This is the third report about Project Half Double (Svejvig et al. 2016, Svejvig et al. 2017). This report’s target group inludes practitioners in Danish industry and society in general. The editorial team from Aarhus University prepared the report from October 2017 to December 2017, which means that data about pilot projects from December 2017 is not included

Miljøvennlig drift av sykkelveinettet i Oslo Miljøeffekter av formiatbaserte avisningsmidler – Resultater fra vannkjemiske og biologiske undersøkelser vinteren 2018.

Hvert år brukes det omtrent 7000 tonn vegsalt (MgCl2 og NaCl) på kommunale veger i Oslo. På grunn av de negative effektene som vegsalt kan ha, og med bakgrunn i bystyrevedtak fra 2012 om at Oslo kommune skal erstatte vegsalt med mer miljøvennlige alternativer, ønsker Bymiljøetaten å teste ut alternative miljøvennlige avisningsmidler på veg- og sykkelvegnettet. Fra februar 2018 ble natriumformiat benyttet som avisningsmiddel på Eterveien og en del av Østensjøveien langs Østensjøvannet i Oslo. Innløpsbekkene til innsjøen ble overvåket gjennom testperioden. Formiat forbruker oksygen ved nedbrytning, men ut fra sesongens resultater er det ingenting som tyder på at tilførsel av formiat har forårsaket oksygenmangel, hverken i sidebekkene eller i Østensjøvannet. Effektene av formiat på vegetasjon er vanskelig å si noe konkret om da det ble brukt vanlig vegsalt og formiat samme sesong. Systematiske undersøkelser av saltskader på vegetasjon gjennom vinteren, hyppigere prøvetaking i bekkene, samt kontinuerlig overvåking ved utløpet til Østesjøvannet er noen av tiltakene som foreslås for videreføringen av prosjektet vinteren 2018/2019.publishedVersio

Project Half Double: results of phase 1 and phase 2 - June 2019

The purpose of this report in a series of reports from Project Half Double is to present the final overall results from phase 1 and phase 2 of Project Half Double as well as to describe the nine pilot projects from phase 2 in detail

Correlation between gene expression and MRI STIR signals in patients with chronic low back pain and Modic changes indicates immune involvement

Disability and distress caused by chronic low back pain (LBP) lacking clear pathoanatomical explanations cause huge problems both for patients and society. A subgroup of patients has Modic changes (MC), identifiable by MRI as vertebral bone marrow lesions. The cause of such changes and their relationship to pain are not yet understood. We explored the pathobiology of these lesions using profiling of gene expression in blood, coupled with an edema-sensitive MRI technique known as short tau inversion recovery (STIR) imaging. STIR images and total RNA from blood were collected from 96 patients with chronic LBP and MC type I, the most inflammatory MC state. We found the expression of 37 genes significantly associated with STIR signal volume, ten genes with edema abundancy (a constructed combination of STIR signal volume, height, and intensity), and one gene with expression levels significantly associated with maximum STIR signal intensity. Gene sets related to interferon signaling, mitochondrial metabolism and defense response to virus were identified as significantly enriched among the upregulated genes in all three analyses. Our results point to inflammation and immunological defense as important players in MC biology in patients with chronic LBP.publishedVersio

Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors

Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.Peer reviewe