Molecular dynamics simulations of the evaporation of particle-laden droplets

We use molecular dynamics simulations to study the evaporation of particle-laden droplets on a heated surface. The droplets are composed of a Lennard-Jones fluid containing rigid particles which are spherical sections of an atomic lattice, and heating is controlled through the temperature of an atomistic substrate. We observe that sufficiently large (but still nano-sized) particle-laden drops exhibit contact line pinning, measure the outward fluid flow field which advects particle to the drop rim, and find that the structure of the resulting aggregate varies with inter-particle interactions. In addition, the profile of the evaporative fluid flux is measured with and without particles present, and is also found to be in qualitative agreement with earlier theory. The compatibility of simple nanoscale calculations and micron-scale experiments indicates that molecular simulation may be used to predict aggregate structure in evaporative growth processes

CSF lactate dehydrogenase activity in patients with Creutzfeldt-Jakob disease exceeds that in other dementias

The diagnosis of Creutzfeldt- Jakob disease (CJD) is still made by exclusion of other dementias. We now evaluated lactate dehydrogenase (LDH) in the cerebrospinal fluid (CSF) as a possible additional diagnostic tool. CSF LDH levels of patients with CJD ( n = 26) were compared with those in other dementias ( n = 28). LDH isoenzymes were determined in a subset ( n = 9). Total LDH and isoenzyme LDH-1 were significantly higher, whereas the fractions of LDH-2 and LDH-3 were significantly lower in CJD patients. We conclude that in addition to established CSF parameters, LDH and its isoenzymes might serve as a further help to discriminate between CJD and other dementias. Copyright (C) 2004 S. Karger AG, Basel

Which solar EUV indices are best for reconstructing the solar EUV irradiance ?

The solar EUV irradiance is of key importance for space weather. Most of the time, however, surrogate quantities such as EUV indices have to be used by lack of continuous and spectrally resolved measurements of the irradiance. The ability of such proxies to reproduce the irradiance from different solar atmospheric layers is usually investigated by comparing patterns of temporal correlations. We consider instead a statistical approach. The TIMED/SEE experiment, which has been continuously operating since Feb. 2002, allows for the first time to compare in a statistical manner the EUV spectral irradiance to five EUV proxies: the sunspot number, the f10.7, Ca K, and Mg II indices, and the He I equivalent width. Using multivariate statistical methods such as multidimensional scaling, we represent in a single graph the measure of relatedness between these indices and various strong spectral lines. The ability of each index to reproduce the EUV irradiance is discussed; it is shown why so few lines can be effectively reconstructed from them. All indices exhibit comparable performance, apart from the sunspot number, which is the least appropriate. No single index can satisfactorily describe both the level of variability on time scales beyond 27 days, and relative changes of irradiance on shorter time scales.Comment: 6 figures, to appear in Adv. Space. Re

Mitochondrial Homeostasis Mediates Lipotoxicity in the Failing Myocardium

Heart failure remains the most common cause of death in the industrialized world. In spite of new therapeutic interventions that are constantly being developed, it is still not possible to completely protect against heart failure development and progression. This shows how much more research is necessary to understand the underlying mechanisms of this process. In this review, we give a detailed overview of the contribution of impaired mitochondrial dynamics and energy homeostasis during heart failure progression. In particular, we focus on the regulation of fatty acid metabolism and the effects of fatty acid accumulation on mitochondrial structural and functional homeostasis

Relating agent prominence to discourse prominence: DO-clefts in German

The article investigates the hypothesis that prominence phenomena on different levels of linguistic structure are systematically related to each other. More specifically, it is hypothesized that prominence relations in morphosyntax reflect, and contribute to, prominence management in discourse. This hypothesis is empirically based on the phenomenon of agentivity clines, i.e. the observation that the relevance of agentivity features such as volition or sentience is variable across different constructions. While some constructions, including German DO-clefts, show a strong preference for highly agentive verbs, other constructions, including German basic active constructions, have no particular requirements regarding the agentivity of the verb, except that at least one agentivity feature should be present. Our hypothesis predicts that this variable relevance of agentivity features is related to the discourse constraints on the felicitous use of a given construction, which in turn, of course, requires an explicit statement of such constraints. We propose an original account of the discourse constraints on DO-clefts in German using the ‘Question Under Discussion’ framework. Here, we hypothesize that DO-clefts render prominent one implicit question from a set of alternative questions available at a particular point in the developing discourse. This then yields a prominent question-answer pair that changes the thematic structure of the discourse. We conclude with some observations on the possibility of relating morphosyntactic prominence (high agentivity) to discourse prominence (making a Question Under Discussion prominent by way of clefting)

A balancing act: Evidence for a strong subdominant d-wave pairing channel in Ba0.6K0.4Fe2As2{\rm Ba_{0.6}K_{0.4}Fe_2As_2}

We present an analysis of the Raman spectra of optimally doped ${\rm Ba_{0.6}K_{0.4}Fe_2As_2}$ based on LDA band structure calculations and the subsequent estimation of effective Raman vertices. Experimentally a narrow, emergent mode appears in the $B_{1g}$ ($d_{x^2-y^2}$) Raman spectra only below $T_c$, well into the superconducting state and at an energy below twice the energy gap on the electron Fermi surface sheets. The Raman spectra can be reproduced quantitatively with estimates for the magnitude and momentum space structure of the s$_{+-}$ pairing gap on different Fermi surface sheets, as well as the identification of the emergent sharp feature as a Bardasis-Schrieffer exciton, formed as a Cooper pair bound state in a subdominant $d_{x^2-y^2}$ channel. The binding energy of the exciton relative to the gap edge shows that the coupling strength in this subdominant $d_{x^2-y^2}$ channel is as strong as 60% of that in the dominant $s_{+-}$ channel. This result suggests that $d_{x^2-y^2}$ may be the dominant pairing symmetry in Fe-based sperconductors which lack central hole bands.Comment: 10 pages, 6 Figure

Impact of food and water-borne diseases on European population health

Composite health measures are increasingly applied in studies aiming at describing the burden of diseases, and food and water-borne diseases (FWDs) are no exception. The Burden of Communicable Diseases in Europe (BCoDE) is a project led and funded by the European Centre for Disease Prevention and Control (ECDC) with the purpose of encouraging and empowering public health experts in the estimation of the impact of communicable diseases expressed in Disability Adjusted Life Years (DALYs). Calculation of DALYs and a critical assessment of burden of disease outputs require a thorough consideration of a number of methodological and epidemiological decisions ranging from modelling (e.g. incidence versus prevalence), disease model parameters (e.g. risks of developing complications or death) and the data feeding the number of cases.Burden of disease studies produce useful results for public health decision-making, in particular when they aim at informing preventive strategies. For this purpose, we attributed FWDs results from the BCoDE 2015 study to different exposure routes. We discuss these in the more general perspective of generating burden of disease evidence for planning and prioritisation, including the potentials and limitations of its methodology

The Relationship of Functional Movement Patterns and Health-Related Quality of Life

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Клинические, гемодинамические и биохимические эффекты рамиприла у больных сахарным диабетом 2-го типа и артериальной гипертензией

Изучены клинические, гемодинамические и биохимические эффекты рамиприла у больных сахарным диабетом 2−го типа и артериальной гипертензией.Вивчено клінічні, гемодинамічні та біохімічні ефекти раміприлу у хворих на цукровий діабет 2−го типу та артеріальну гіпертензію.Clinical, hemodynamic, and biochemical effects of Ramipril were investigated in patients with type 2 diabetes mellitus and arterial hypertension