Valuation monotonicity, fairness and stability in assignment problems [WP]

In this paper, we investigate the possibility of having stable rules for twosided markets with transferable utility, that satisfy some valuation monotonicity and fairness axioms. Valuation fairness requires that changing the valuation of a buyer for the object of a seller leads to equal changes in the payoffs of this buyer and seller. This is satisfied by the Shapley value, but is incompatible with stability. A main goal in this paper is to weaken valuation fairness in such a way that it is compatible with stability. It turns out that requiring equal changes only for buyers and sellers that are matched to each other before as well as after the change, is compatible with stability. In fact, we show that the only stable rule that satisfies weak valuation fairness is the well-known fair division rule which is obtained as the average of the buyers-optimal and the sellersoptimal payoff vectors. Our second goal is to characterize these two extreme rules by valuation monotonicity axioms. We show that the buyers-optimal (respectively sellersoptimal) stable rule is char- acterized as the only stable rule that satisfies buyervaluation monotonicity which requires that a buyer cannot be better off by weakly decreasing his/her valuations for all objects, as long as he is assigned the same object as before (respectively object-valuation antimonotonicity which requires that a buyer cannot be worse off when all buyers weakly decrease their valuations for the object that is assigned to this specific buyer, as long as this buyer is assigned the same object as before). Finally, adding a consistency axiom, the two optimal rules are characterized in the general domain of allocation rules for two-sided assignment markets with a variable population

A utilização de estudos de caso na pesquisa em administração

This article aims to discuss to what extent the use of the case study method of research has been appropriately used in the field of business administration studies. To achieve this aim all articles based on the case study method presented in the XXVI Encontro Nacional de Pós-graduação em Administração (EnAnpad) were closely examined. The results show that the case study method has been used in almost all investigations within the field of business administration studies. Among the most critical aspects regarding this use is reference to very few different sources of evidence and also lack of accuracy in the analytical procedures. Only a few articles showed evidence of thorough analytical procedures. There is enough empirical evidence to suggest that researchers do require more specific background as for advantages and limitations in using the case study method, mainly in business administration master programs. Key words: business administration, research, case studies.Este estudo tem como objetivo analisar criticamente a utilização do estudo de caso como delineamento de pesquisa no campo da Administração. Para sua realização, procedeu-se à análise dos trabalhos apresentados no XXVI Encontro Nacional de Pós-Graduação em Administração (ENANPAD) que puderam ser caracterizados como estudos de caso. Constatou-se que os estudos de caso vêm sendo utilizados para investigação em praticamente todas as áreas da Administração. Os aspectos mais críticos relativos aos resultados obtidos referem-se à utilização de poucas fontes de evidência na maioria das pesquisas e à falta de clareza nos procedimentos analíticos. Poucos são os trabalhos caracterizados pela aplicação de procedimentos rigorosos. Conclui-se pela necessidade de maior atenção na preparação dos pesquisadores quanto às vantagens e limitações do estudo de caso, sobretudo nos programas de mestrado em Administração. Palavras-chave: administração, pesquisa, estudos de caso

Case study method in business administration research

Este estudo tem como objetivo analisar criticamente a utilização do estudo de caso como delineamento de pesquisa no campo da Administração. Para sua realização, procedeu-se à análise dos trabalhos apresentados no XXVI Encontro Nacional de Pós-Graduação em Administração (ENANPAD) que puderam ser caracterizados como estudos de caso. Constatou-se que os estudos de caso vêm sendo utilizados para investigação em praticamente todas as áreas da Administração. Os aspectos mais críticos relativos aos resultados obtidos referem-se à utilização de poucas fontes de evidência na maioria das pesquisas e à falta de clareza nos procedimentos analíticos. Poucos são os trabalhos caracterizados pela aplicação de procedimentos rigorosos. Conclui-se pela necessidade de maior atenção na preparação dos pesquisadores quanto às vantagens e limitações do estudo de caso, sobretudo nos programas de mestrado em Administração. Palavras-chave: administração, pesquisa, estudos de caso.This article aims to discuss to what extent the use of the case study method of research has been appropriately used in the field of business administration studies. To achieve this aim all articles based on the case study method presented in the XXVI Encontro Nacional de Pós-graduação em Administração (EnAnpad) were closely examined. The results show that the case study method has been used in almost all investigations within the field of business administration studies. Among the most critical aspects regarding this use is reference to very few different sources of evidence and also lack of accuracy in the analytical procedures. Only a few articles showed evidence of thorough analytical procedures. There is enough empirical evidence to suggest that researchers do require more specific background as for advantages and limitations in using the case study method, mainly in business administration master programs. Key words: business administration, research, case studies

Joyero engastador

Se presenta el diseño didáctico de la especialidad en joyería así como los bloques modulares, módulos instruccionales, objetivos, requisitos, operaciones y contenidos.The didactic design of the specialty in jewelry is presented as well as the modular blocks, instructional modules, objectives, requirements, operations and contents.Armado por moldeo -- Cadenerìa manual -- Engaste al grano -- Proceso de la cera perdida -- Armado especial -- Gestion empresarialna182 página

Dominant influenza A(H3N2) and B/Yamagata virus circulation in EU/EEA, 2016/17 and 2017/18 seasons, respectively

We use surveillance data to describe influenza A and B virus circulation over two consecutive seasons with excess all-cause mortality in Europe, especially in people aged 60 years and older. Influenza A(H3N2) virus dominated in 2016/17 and B/Yamagata in 2017/18. The latter season was prolonged with positivity rates above 50% among sentinel detections for at least 12 weeks. With a current west-east geographical spread, high influenza activity might still be expected in eastern Europe.S

MÉTODO Y SISTEMA DE HABILIDADES DE LA QUÍMICA INORGÁNICA Y ANALÍTICA PARA AGRONOMÍA CON ENFOQUE HOLÍSTICO – CONFIGURACIONAL

In terms of contributing to the solution of the insufficiencies in the dedication to study that the students of Agronomy’s Course at Granma's University present; applied the  Holistic Configurationally Model of the Dynamics of the Higher Education, to precision and fundamentation of the instructive educational developer method and over himself the system of abilities of Inorganic and Analytical Chemistry; what must contribute to a better structuring, organization and development the dynamics of the themes of the subject of study. This work constitutes a result of the thesis of mastery of the principal authoress. In the realization and of the same they used empiric methods (observation of the teaching educational process, interviews, opinion polls, revision of documents, particularly the programs of the discipline from the previous at plan of study A to the study program to the present time) and theoretic methods (historic logician, analysis – synthesis, modulation and systemic structural functional).En función de contribuir a la solución de las insuficiencias en la dedicación al estudio que presentan los estudiantes de la carrera de Agronomía en la Universidad de Granma; se aplicó el Modelo Holístico Configuracional de la Dinámica de la Educación Superior, a la precisión y fundamentación del método instructivo-educativo-desarrollador y el sistema de habilidades de la Química Inorgánica y Analítica; lo que debe contribuir a una mejor estructuración, organización y desarrollo la dinámica de los temas de la asignatura. Este trabajo constituye un resultado de la tesis de maestría de la autora principal y en la realización del mismo se emplearon métodos empíricos (observación del proceso docente-educativo, entrevistas, encuestas, revisión de documentos, particularmente los programas de la disciplina desde los anteriores al plan de estudio A hasta la actualidad) y métodos teóricos (histórico-lógico, análisis– síntesis, modelación y sistémico-estructural-funcional)

Comparación de la colecistectomía laparoscópica frente a la convencional en la colecistitis aguda

A comparison of laparoscopic cholecystectomy versus conventional cholecystectomy with the objective of comparing costs, morbidity and mortality between the two declared procedures, level I of evidence studies were taken as reference. It was performed a bibliographic search in medical databases on acute cholecystitis with level I of evidence, there were included results of complications, costs and mortality as comparison indexes between the procedures in acute cholecystectomy through a lineal logistic regression model and it was defined the level of statistical significance 95 %. It was verified that although direct costs could be higher in laparoscopic cholecystectomy, total costs are higher in conventional cholecystectomy including more complications possibilities and mortality. It was concluded that laparoscopic surgery brings economic and health benefits in relation with conventional surgery in cases of acute cholecystitis.Se realizó una comparación entre la colecistectomía laparoscópica frente a la colecistectomía convencional con el objetivo de comparar los costos, morbilidad y mortalidad entre los dos procederes, se tomaron como referencia estudios publicados con nivel de evidencia l. Se realizó una búsqueda bibliográfica en bases de datos médicas de estudios sobre colecistitis aguda con nivel de evidencia l, se incluyeron los resultados de las complicaciones, costos y mortalidad como índices de comparación entre ambos procederes en la colecistitis aguda, a través de una regresión logística lineal, se definieron los niveles de significación estadística en un 95 %. Se comprobó que aunque los costos directos pudieran ser superiores en la colecistectomía laparoscópica, los costos totales son mayores en la cirugía abierta, esta última con mayor posibilidad de complicaciones y mortalidad. Se concluye que la cirugía laparoscópica trae aparejados beneficios económicos y de salud en relación a la cirugía abierta en casos con colecistitis aguda

A wearable low-power and low-cost electromyographic sensor for arm prosthesis

Abstract— This work presents the design considerations for an electromyographic (EMG) sensor destined to be integrated in a low-cost robotic arm prosthetic for below-elbow amputation, which is being developed in Paraguay by a multidisciplinary teamwork. The design exposed on this paper is addressed to optimize the embedded 14 bits ADC of the MSP432P401R microcontroller. It achieves the amplification and filtering of EMG signals with an input-referred noise of 1.35 μVRMS, and a CMRR greater than 95 dB, with a very low quiescent current consumption of 40 μA. The sensor also includes a common-mode feedback circuit that drives a reference electrode.Este trabajo presenta las consideraciones de diseño para un sensor de señales de electromíograma (EMG), diseñado para ser integrado en una prótesis robótica de bajo costo, para amputaciones bajo codo, que está siendo desarrollada en Paraguay por un equipo de trabajo multidisciplinario. El diseño presentado está dirigido a optimizar el rango dinámico del ADC embebido en el microcontrolador MSP432P401R de Texas Instruments. El sensor efectúa la amplificación y el filtrado de las señales de EMG con un ruido referido a la entrada de 1.35 μVRMS, un CMRR mayor a 95 dB y un muy bajo consumo de corriente, menor a 40 μA. Este también incluye un circuito de realimentación de modo común.Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señale

Characterization of Drosophila ATPsynC mutants as a new model of mitochondrial ATP synthase disorders

Mitochondrial disorders associated with genetic defects of the ATP synthase are among the most deleterious diseases of the neuromuscular system that primarily manifest in newborns. Nevertheless, the number of established animal models for the elucidation of the molecular mechanisms behind such pathologies is limited. In this paper, we target the Drosophila melanogaster gene encoding for the ATP synthase subunit c, ATPsynC, in order to create a fruit fly model for investigating defects in mitochondrial bioenergetics and to better understand the comprehensive pathological spectrum associated with mitochondrial ATP synthase dysfunctions. Using P-element and EMS mutagenesis, we isolated a set of mutations showing a wide range of effects, from larval lethality to complex pleiotropic phenotypes encompassing developmental delay, early adult lethality, hypoactivity, sterility, hypofertility, aberrant male courtship behavior, locomotor defects and aberrant gonadogenesis. ATPsynC mutations impair ATP synthesis and mitochondrial morphology, and represent a powerful toolkit for the screening of genetic modifiers that can lead to potential therapeutic solutions. Furthermore, the molecular characterization of ATPsynC mutations allowed us to better understand the genetics of the ATPsynC locus and to define three broad pathological consequences of mutations affecting the mitochondrial ATP synthase functionality in Drosophila: i) pre-adult lethality; ii) multi-trait pathology accompanied by early adult lethality; iii) multi-trait adult pathology. We finally predict plausible parallelisms with genetic defects of mitochondrial ATP synthase in humans.This work was supported by grants from Ministero dell’Istruzione, dell’Università e della Ricerca (MIUR) to C.C. and University of Bari D.R. n. 12939 to D.P

Schlafen 12 restricts HIV-1 latency reversal by a codon-usage dependent post-transcriptional block in CD4+ T cells

Latency is a major barrier towards virus elimination in HIV-1-infected individuals. Yet, the mechanisms that contribute to the maintenance of HIV-1 latency are incompletely understood. Here we describe the Schlafen 12 protein (SLFN12) as an HIV-1 restriction factor that establishes a post-transcriptional block in HIV-1-infected cells and thereby inhibits HIV-1 replication and virus reactivation from latently infected cells. The inhibitory activity is dependent on the HIV-1 codon usage and on the SLFN12 RNase active sites. Within HIV-1-infected individuals, SLFN12 expression in PBMCs correlated with HIV-1 plasma viral loads and proviral loads suggesting a link with the general activation of the immune system. Using an RNA FISH-Flow HIV-1 reactivation assay, we demonstrate that SLFN12 expression is enriched in infected cells positive for HIV-1 transcripts but negative for HIV-1 proteins. Thus, codon-usage dependent translation inhibition of HIV-1 proteins participates in HIV-1 latency and can restrict the amount of virus release after latency reversal.We thank Drs Yingying Li, Feng Gao and Beatrice H. Hahn for providing codon-optimized HIV-1 Gag expression vector, Drs James Hoxie and Susan Zolla-Pazner for supplying anti-Nef and -p24 antibodies, respectively through the NIH AIDS reagent program. We also thank Dr Song Gao for providing SLFN13-tRNA structure information, and Dr Maria-Eugenia Gas Lopez and Dr Ester Gea-Mallorquí for advise. This work was supported by following grants: M.K.I., JSPS Oversea Research Fellowship and Takeda Science Foundation; A.E.C., PT17/0009/0019 (ISCIII/MINECO and FEDER); M.J.B., RTI2018-101082-B-I00 and PID2021-123321OB-I00 [MINECO/FEDER]), and the Miguel Servet program by ISCIII (CP17/00179 and CPII22/00005); C.B., M.R.R., C.D.C., European Union’s Horizon 2020 research and innovation program under grant agreement 681137-EAVI2020 and NIH grant P01-AI131568; J.D., the Spanish Ministry of Science and Innovation (PID2019106959RB-I00/AEI/10.13039/501100011033); A.M., the Spanish Ministry of Science and Innovation (PID2019-106323RB-I00 AEI//10.13039/501100011033) and the institutional “María de Maeztu” Programme for Units of Excellence in R&D (CEX2018-000792-M).info:eu-repo/semantics/publishedVersio