24 research outputs found
A community-based validation study of the short-form 36 version 2 philippines (tagalog) in two cities in the philippines
- Author
- Allan Wilbert G. Gumatay
- CA McHorney
- CL Go
- D Child
- E. Shyong Tai
- Elmer Jasper B. Llanes
- EO Laumann
- ES Tai
- Felicidad V. Velandria
- Felix Eduardo R. Punzalan
- Hwee-Lin Wee
- J Thumboo
- JE Jr Ware
- JE Jr. Ware
- LL Lim
- LT Hu
- Mary Lenore Grefal
- Nina T. Castillo-Carandang
- Noel Christopher Barengo
- Oliver C. Alix
- Olivia T. Sison
- Paul Ferdinand M. Reganit
- R Birn
- Rody G. Sy
- S Fukuhara
- SV Navarra
- W Rigby
- Y Suzukamo
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 26/12/2013
- Field of study
10.1371/journal.pone.0083794PLoS ONE812-POLN
Climate resilience in agriculture: Key concepts for community-based adaptation
- Author
- Baconguis Rowena
- Barbon Wilson J.
- Bernales Lorna L.
- Dalusag Joanna
- Gonsalves Julian
- Jordan Jonna
- Joven Bernadette
- Lorenzo Maria Cristina
- Mendez Kharla Vianca
- Monville-Oro Emilita
- Narte Julieta
- Narte Russel
- Navarra Eduardo V
- Puno Arnel
- Rosales Belina
- Rosimo Maggie
- Sebastian Leocadio S.
- Servano Gonzalo
- Tolentino Caress
- Vidallo Rene
- Publication venue
- Publication date
- 28/01/2017
- Field of study
These primer was produced for a project under CCAFs, jointly implemented by the
International Institute of Rural Reconstruction (IIRR), Philippines and the World
Agroforestry Center (ICRAF), Vietnam Country Office.
CCAFS Project No.: P55-FPI-SEA-ICRA
Identification of regulatory variants associated with genetic susceptibility to meningococcal disease
- Author
- Abdulla A.
- Abelake Eugenia
- Adeel A.O.A.
- Aebi C.
- Agapow P.
- Agbeko R.
- Agyeman P.
- Anderson S.
- Antonio M.
- Arpe V.
- Ausserer B.
- Baer W.
- Barham H.
- Barral-Arca Ruth
- Barrios X.G.
- Bartlett M.
- Beckmann R.
- Beiroa A.G.
- Bellos E.
- Bensch J.
- Berger C.
- Berger T.
- Bernhard-Stirnemann S.
- Binder A.
- Bindl L.
- Bittrich H.J.
- Boeddha N.P.
- Bojang K.
- Bokhandi S.
- Borghini L.
- Brangenberg R.
- Breuer H.A.
- Breukels M.A.
- Brinkman D.M.C.
- Brió Sanagustín Sonia
- Broede H.
- Bruckner R.
- Calle I.R.
- Carreras Eduardo
- Carrol E.D.
- Carter S.
- Cebey-López M.
- Coin L.J.
- Cole F.
- Contreras J.R.
- Cratev L.
- Cremer M.
- Curras-Tuala M.J.
- Davies P.
- Davila S.
- de Groot R.
- de Korte C.C.M.M.
- de Vries E.
- de Waal W.J.
- Deeg K.H.
- Deep A.
- Dekkers R.
- Diab G.
- Dilch A.
- Dings-Lammertink A.
- Doedens R.A.
- Donker A.E.
- Dousma M.
- Driessen G.J.A.
- Eitelberger F.
- Eleftherohorinou H.
- Emonts M.
- Evert W.
- Faber T.E.
- Faust S.
- Fedlmaier M.
- Fernández R.
- Fernández S.S.
- Fink C.
- Forte M.S.
- Fortune P.M.
- Frederick H.
- Fucik P.
- Fusch C.
- Förster K.M.
- Gabriel Markwart
- Galassini R.
- García N.
- Geishofer G.
- Gerrits G.P.J.M.
- Gerver J.A.M.
- Giannoni E.
- González F.Á.
- Gormley S.
- Grande A.J.
- Gribbin A.
- Groneck P.
- Grube R.
- Gruber A.
- Gröblacher-Roth H.
- Guillén S.
- Gómez-Carballa A.
- Göpel W.
- Görke W.
- Hamilton S.
- Hammer J.
- Hardy K.
- Hasters P.
- Hauser E.
- Hautz J.
- Hazelzet J.
- Heidema J.
- Heininger U.
- Heininger U.
- Hennenberger A.
- Herberg J.
- Herrmann J.
- Herting E.
- Hibberd M.L.
- Hofmann T.
- Hoggart C.
- Homan-van der Veen J.
- Hourmat B.
- Hudnott P.
- Huemer C.
- Hüseman D.
- Iglesias P.L.
- Inwald D.
- Jacobs M.A.M.
- Jansen N.J.G.
- Jennings R.
- Johnston J.
- Kaforou M.
- Kahlert C.
- Kalhoff H.
- Kasper J.M.
- Kawczynski P.
- Kebbeh N.
- Kenwright R.
- Klinge J.
- Klobassa D.
- Klucovska K.
- Knaufer-Schiefer S.
- Kneyber M.C.J.
- Koch H.
- Koch R.
- Koopman-Keemink Y.
- Kronberger M.
- Kuijpers T.W.
- Kumlien B.
- Kunze W.
- Kurnik P.
- König M.
- Langenhorst V.J.
- Lenz K.
- Leusink J.
- Levin M.
- León M.C.L.
- Lischka A.
- Loranth K.
- Loza B.F.
- Lozano M.J.
- Luigs P.
- Lässig W.
- Maak B.
- Mahler K.
- Markart M.
- Martin M.
- Martinon-Torres F.
- Martinón-Torres N.
- Mashbat M.
- McCorkell J.
- McCready S.
- Meier P.
- Meissl M.
- Menikou S.
- Merth I.T.
- Miedema C.J.
- Miething R.
- Mingorance Á.N.
- Mitter H.
- Moreno D.
- Moser R.
- Mustafa S.
- Müller H.
- Nadel S.
- Navarra H.
- Navarro M.
- Neeleman C.
- Neth O.
- Nicolai T.h.
- Niederer-Loher A.
- Noordzij J.G.
- Nossal R.
- Nsirim E.
- O'Neill L.
- Obihara C.C.
- Pacheco P.O.
- Padilla M.d.C.M.
- Pajkrt D.
- Paky F.
- Palacios A.
- Pardo-Seco J.
- Patel R.
- Patel S.
- Pathan N.
- Paulus S.
- Penzien J.M.
- Pernice W.
- Peters J.
- Peters M.
- Pfau E.
- Pfurtscheller K.
- Philipsen H.L.A.
- Pinnock E.
- Pischedda S.
- Png E.
- Pollard A.J.
- Poortman G.H.
- Posfay-Barbe K.M.
- Potgieter S.T.
- Potjewijd J.
- Power S.
- Pérez B.M.
- Quietzach J.
- Rahman R.
- Ramaiah R.
- Redondo-Collazo L.
- Reiter H.L.
- Reiter K.
- Relly C.
- Reyes S.B.
- Rial J.G.
- Ridout J.
- Rodríguez-Tenreiro C.
- Rojo P.
- Rosias P.P.R.
- Royad C.
- Runge K.
- Rödl S.
- Saidykhan M.
- Salas Antonio
- Salzer H.R.
- Sancho-Shimizu V.
- Sanders E.A.M.
- Santos A.E.M.
- Sarr I.
- Schaller G.
- Scheibenpflug C.
- Schermann P.
- Schimmel U.
- Schlapbach L.J.
- Schmidt A.
- Schulz D.
- Schwarick J.
- Schwarz R.
- Schweitzer-Krantz S.
- Schürmann R.
- Secka F.
- Seidenberg J.
- Seidler E.
- Seitz C.
- Sey G.
- Sillaber U.
- Silva M.d.S.P.
- Silveira L.F.
- Simic-Schleicher G.
- Simma B.
- Sitzmann F.C.
- Sontheimer D.
- Sperl W.
- Sprong T.
- Standing F.
- Stocker M.
- Straßer F.
- Streif W.
- Sánchez F.G.
- Sánchez J.M.M.
- Ta V.H.
- Tato L.M.P.
- ten Tussher G.W.
- Thakker C.
- Thio B.J.
- Thomas G.
- Thurston S.
- Tillmann R.
- Torre A.C.
- Tramper-Stranders G.A.
- Tuffrey C.
- Töpke B.
- Universitat Autònoma de Barcelona
- van de Beek D.
- van der Ende A.
- van der Flier M.
- van der Flier M.
- van der Meer H.
- van Deuren M.
- van Furth A.M.T.
- van Kuppevelt A.J.M.
- van Overbeek-van Gils A.L.T.
- van Wermeskerken A.M.
- Varnholt V.
- Vega A.
- Vergara E.O.
- Verwijs W.A.
- Vicente L.G.
- Vivanco A.
- von der Wense A.
- Walcher W.
- Weigand N.
- Weikmann E.
- Weiss U.
- White D.
- White S.
- Willis L.
- Wocko L.
- Wolfs T.F.W.
- Wright Victoria
- Young Z.
- Zenz W.
- Zobel G.
- Zwiauer K.
- Zöhrer B.
- Álvarez C.Á.
- Publication venue
- Publication date
- 01/01/2019
- Field of study
Non-coding genetic variants play an important role in driving susceptibility to complex diseases but their characterization remains challenging. Here, we employed a novel approach to interrogate the genetic risk of such polymorphisms in a more systematic way by targeting specific regulatory regions relevant for the phenotype studied. We applied this method to meningococcal disease susceptibility, using the DNA binding pattern of RELA - a NF-kB subunit, master regulator of the response to infection - under bacterial stimuli in nasopharyngeal epithelial cells. We designed a custom panel to cover these RELA binding sites and used it for targeted sequencing in cases and controls. Variant calling and association analysis were performed followed by validation of candidate polymorphisms by genotyping in three independent cohorts. We identified two new polymorphisms, rs4823231 and rs11913168, showing signs of association with meningococcal disease susceptibility. In addition, using our genomic data as well as publicly available resources, we found evidences for these SNPs to have potential regulatory effects on ATXN10 and LIF genes respectively. The variants and related candidate genes are relevant for infectious diseases and may have important contribution for meningococcal disease pathology. Finally, we described a novel genetic association approach that could be applied to other phenotypes
Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study
- Author
- Abad Ricardo Diaz
- Abe Toshikazu
- Abroug Fekri
- Adams John C.
- Adamsson Richard O.
- Adolfsson Anne
- Aguilar Ronald Zumaran
- Aguirre Janet S.
- Aguirre-Bermeo Hernan
- Aisa Tharwat M.
- Aisiku Imo
- Ajetunmobi Olaitan O.
- Aker Mustafa
- Akyol Onat O.
- Al Dorzi Hasan M.
- Al Jabbary Ahmed S.
- Albaiceta Guillermo M.
- Albarrak Mohamad M.
- Albiero Daniela
- Alda Rosa S.
- Alejandro Risso V.
- Alexander Peter
- Algaba Ángela
- Aliaga Felipe A.
- Alisasis Alain U.
- Allan Russell M.
- Allue Raquel Montoiro
- Almekhlafi Ghaleb
- Alonso Javier G.
- Altaf Wahid
- Alvarez António M.
- Alvarez Javier
- Amin Pravin
- Amir Fahd
- Amor Abdellatif Benslama Mourad
- An Youzhong
- Andersen Finn H.
- Andoh Kohkichi
- Andruszkiewicz Pawel
- Aneman Anders
- Antonelli Massimo M.
- Antônio Ana Carolina P.
- Aoki Nobumasa
- Appelberg Henrik
- Arabi Yaasen
- Arabi Yaseen M.
- Araujo Ana M.
- Arizmendi Alfons
- Arnal Jean-Michel
- Artiga Maria Jose D.
- Artigas Antonio
- Ascoli Aline
- Au Siu-Ming
- Avila Luis E.
- Azad Raman
- Azevedo Luciano Cesar
- Baboi Loredana
- Badie Julio C.
- Bailey Irene M.
- Bailey Mathew B.
- Bajwa Ed
- Balkhi Hicham
- Baltus Thomas
- Banner-Goodspeed Valerie M.
- Barberet Guillaume
- Baron Rebecca M.
- Baronia Arvind K.
- Barratt-Due Andreas
- Barros Filipa M.
- Barros Nelson C.
- Batra Hitesh
- Battle Ceri E.
- Bauer Philippe R.
- Beck Eduardo
- Beck Oliver
- Bedreag Ovidiu H.
- Beegle Scott H.
- Beitler Jeremy R.
- Bellani Giacomo
- Bellani Giacomo
- Beloncle Francois
- Beraldo Daniel O.
- Berghe Caroline
- Berkelmans Frantz
- Besset Sebastien L.
- Bettini Lisandro R.
- Beuret Pascal
- Bezzi Marco G.
- Bhardwaj Vallish K.
- Bhowmick Kaushik
- Biehler Jerome
- Bigot Charlene
- Bihari Shailesh
- Biondi Rodrigo S.
- Biscione Roberto R.
- Bisso Mariano Carboni
- Black Colin S.
- Blakeman Thomas C.
- Bolon Stefan
- Borello Silvina A.
- Borotto Erika E.
- Botteri Marco
- Bouchoucha Slaheddine
- Boukhazna Messabi
- Bouw Maria J.
- Boyd Owen
- Bramall Jon
- Braschi Antonio
- Brazzi Luca
- Breen Dorothy M.
- Briquet Anais
- Brito Vania A.
- Brizuela Matias
- Brochard Laurent
- Brochard Laurent
- Broman Lars M.
- Brown Samuel M.
- Browne Troy S.
- Bruhn Alejandro R.
- Brunettini Barbara
- Bruns Monique M.
- Buensuseso Juan A.
- Bugedo Guillermo
- Buise Marc P.
- Bulpa Pierre A.
- Bumbasierevic Vesna
- Bumbasirevic Vesna
- Burtenshaw Andrew J.
- Burtin Philippe
- Buzancais Gautier
- Béduneau Gaetan
- Camsooksai Julie
- Canestrini Sergio
- Cani Alma
- Carbayo-Gorriz Cecilia
- Cardonnet Luis P.
- Careless Jon P.
- Carpentier Dorothée
- Carreño Nicolás G.
- Carteaux Guillaume
- Casalena Paolo
- Casement Jonathan
- Castro Alejandro G.
- Castro Silvia
- Catorze Nuno T.
- Cazorla-Barranquero Francisca G.
- Ceniceros-Barros Alexandra
- Cereijo Enrique
- Cerny Vladimir
- Cerrato Valeria I.
- Cervantes Mavy Ramirez
- Cesar Palazon Sanchez
- Ceunen Helga
- Ceylan Ilkay
- Chabanne Russell
- Chapman Rhiannon
- Chau Simon K.
- Chelly Jonathan
- Chen Kai
- Chena Ariel
- Cheng Meisy Perez
- Chiche Jean-Daniel
- Chouchene Imed
- Choudry Shazia
- Christiansen Aage
- Cimic Nedim
- Cinnella Gilda
- Cirone Rob
- Citalán Johanna E.
- Claraco-Vega Luis M.
- Clarkson Kevin
- Clarkson Kevin P.
- Claverias Laura
- Cohen Jason E.
- Cole Jade M.
- Collins Daniel V.
- Collyer Thomas
- Colombo Riccardo
- Combaux Daniele M.
- Combes Alain
- Cooper Raphael
- Coppadoro Andrea
- Corneci Dan E.
- Cortegiani Andrea
- Cortez Cesar A.
- Coxo Cristina M.
- Cracchiolo Andrea N.
- Cranshaw Julius H.
- Crapelli Giulia
- Crouch Daniel R.
- Crova Philippe J.
- Csabi Peter
- Curley Gerard
- Curto Elena Gallego
- Daldin Julio
- Dangers Laurence
- Danin Pierre-Eric
- Daubin C. dric
- Daviaud Fabrice
- Davies Kyle G.
- Dawson Heidi
- de Cima-Iglesias Sara
- de Gordoa Laura Ortiz-Ruiz
- de Haro Candelaria
- de Pablo Raul
- de Prost Nicolas
- Dean Michael N.
- Declercq Pierre-Louis M.
- Dector Dulce
- Dector Dulce M.
- Deicas Alberto
- del Carmen Lorente Maria
- Dellamonica Jean
- Dellera Christian
- Delsing Angela
- Demirkiran Oktay
- Demoule Alexandre
- Dempsey Ged
- Dendane Tarek
- Depuydt P.
- Depuydt Pieter
- Derman Suleyman S.
- di Tomasso Nora N.
- di Yu D.
- Diaz-Rodriguez Esther
- Dive Alain M.
- Dixit Subhal B.
- Do Vale Fernandes Antero
- Dolva Merete S.
- Donnelly Adrian
- Dowling Anna T.
- Doyen Denis
- Dres Martin
- Dreyer Kyle R.
- Dunne Eimhin S.
- Dupont Herve
- Duranteau Jacques
- Dwyer Rory
- Démpaire Gabriel
- Ebeid Alejandro
- Elatrous Souheil
- Elisabet Garcia M.
- Elkhayari Mina
- Ellis Helen E.
- Elmasri Mary
- Erbabacan Emre
- Eriksson Karin E.
- Esteban Andres
- Estenssoro Elisa
- Esteve Francisco
- Estilita Joana M.
- Estrella Claudia R.
- Ezzouine Hanane
- Fan Eddy
- Fan Eddy
- Fartoukh Muriel
- Farías Pamela A.
- Fawkes Danielle A.
- Ferguson Andrew
- Ferguson Niall D.
- Fernandez Adriana M.
- Fernandez Ruben O.
- Fierro Jonathan M.
- Floris Leda
- Follin Arnaud
- Fontenele Danielle C.
- Formenti Paolo
- Forteza Catalina
- Fossali Tommaso
- Foti Giuseppe
- Franco Nieves
- França Ana G.
- Frati Elena
- Frendl Gyorgy
- Frigyik Aniko D.
- Fusari Maurizio
- Futami Satoru
- Gally Josette
- Ganesan Deeban
- Gao Yan
- Gao Yuan N.
- Garcia Patricio H.
- Gattinoni Luciano
- Gazenkampf Andrey A.
- Gelée Bruno
- George Fernando G.
- Ghazi Mohammed
- Gianinetto Hernan
- Giarratano Antonino
- Gillis Sarah
- Girgin Nermin Kelebek
- Gjedsted Jakob
- Glietsch Rita
- Goldgran-Toledano Dany
- Goligher Ewan C.
- Gomaa Dina
- Gomes Rui M.
- Gomez Pablo E.
- Gomez-Flores Saira S.
- Gonz Á Lez Raquel Montiel
- Gonzalez Daniel R.
- Gonzalez Marcos
- González Rojas Manuel A.
- González-Salamanca Ángela
- Gonçalves Claudio H.
- Goodson Jennifer C.
- Gordo Federico
- Gosselin Ryan J.
- Goubaux Bernard
- Graziani Romano
- Grelon Fabien
- Griffin Ruth O.
- Grigoriev Evgeny
- Grijalba Carolina Quintana
- Grissom Colin K.
- Gritsan Alexey I.
- Grubissich Nicolas
- Gueret Renaud M.
- Gurjar Mohan
- Guttormsen Anne B.
- Guérin Claude
- Gómez Pilar Ricart Aroa
- Hacking Danielle J.
- Haddad Youssef
- Hadfield Dan
- Hagan Samantha J.
- Han Hui
- Han Yi
- Hang Ai Y.
- Hanlon Gabrielle C.
- Harasawa Tomofumi
- Harrois Anatole
- Hashemian S. M.
- Hashemian Seyed Mohammadreza
- Hashida Tomoaki
- He Zhenyang
- Hedlund Lars
- Heidari Farshad
- Heines Serge J.
- Helleberg Johan
- Henderson Galen
- Herbrecht Jean-Etienne
- Hermosa Cecilia
- Hessell Robert J.
- Heunks Leo M.
- Higashijima Ushio
- Hirata Akira
- Holzgraefe Bernhard
- Honda Hiroyuki
- Honrubia Teresa
- Hopf Hans-Bernd F.
- Hopkins Phil
- Hormis Anil P.
- Hou Peter C.
- Hou Sen-Kuang
- Hraiech Sami
- Hua Ma X.
- Huang Qing Q.
- Huang Xiao B.
- Huerta Francisco P.
- Huff Nidhi G.
- Humphreys Sally K.
- Hunt Anna
- Hurtado Javier
- Hutchison Robyn A.
- Hutton Paula J.
- Ibañez-Santacruz Marcos
- Ichikado Kazuya
- Ilutovich Santiago
- Imai Hiroshi
- Imma Vallverdu P.
- Imperio María C.
- Insaurralde Carolina S.
- Inskip Deborah M.
- Ioannou Nicholas
- Iotti Giorgio A.
- Irvine Donald A.
- Ismail Dina
- Ismail Mehvish
- Ito Fumihito
- Izawa Masayo
- Jaafar Rola F.
- Jakubowska Karina
- Jamaati Hamidreza
- Jarquin-Badiola Yves D.
- Jassal Mandeep
- Javeed Areej
- Javier-Blanco
- Jhamatthew Thomas Rajeev R.
- Jiang Liangyan
- Jibaja Manuel
- Jimenez Antonio G.
- Jochmans S. bastien
- Jog Sameer A.
- Jovanovic Bojan
- Judy Claine
- Jurado M. . Teresa
- Kadaba Varsha
- Kajtor Istvan
- Kakar Vivek
- Kalaitzis Evangelos
- Kalkoff Michael
- Kamel Ghassan
- Kameyama Yoshinobu
- Kamoun Salma
- Kander Thomas
- Kannan Santhana G.
- Kansuke-Koyama
- Kashiwa Yozo
- Kedelv Hans
- Kennedy Barry
- Khebbeb Samy
- Kheir Fayez
- Kheir Fayez M.
- Kimura Hiroyasu
- Kiourtzieva Ellada V.
- Kitch Barrett T.
- Knapman Karl M.
- Knoll Jenny
- Knowles Serena
- Kol Mark R.
- Kong Jing
- Kraßler Jens
- Krstevski Amanda
- Kulkarni Shreedhar
- Kumar Alek
- Kurahashi Kiyoyasu
- Kusumoto Kohei
- Laake Jon H.
- Laake Jon Henrik
- Labarca Eduardo F.
- Laffey John
- Laffey John G.
- Laffey John G.
- Lamb Keith D.
- Lanspa Michael J.
- Larsson Anders
- Larsson Niklas
- le Moal Charlene
- Lebbinck Herve
- Lee Jarone
- Leemann-Refondini Corinne
- Lemiale Virginie
- Lemus Jordana S.
- Leon Yoshido Hector H.
- Li Bin
- Li Qingdong
- Li Qiong J.
- Li Wenwen
- Li Xiao L.
- Li Xinyu
- Li Yimin
- Li Yuan Y.
- Li-Xin Zhou
- Liew Kong Y.
- Ling Long L.
- Liu Haitao
- Liu Jian
- Liu Jing L.
- Liu Ling
- Llano Miguel
- Llinares Moya David D.
- Lohner Ralph
- Loiacono Flavia A.
- Lombardo Andrea
- Lopez Esther Bermejo
- Lopez-Delgado Juan C.
- Lora Fredy S.
- Lora Pilar
- Lorente Jose A.
- Losada Elena Perez
- Lovazzano Pablo
- Lu Weihua
- Lu Yuanhua
- Luis Palazon Sanchez Eugenio
- Luo Xiaoming
- Lynch Joan M.
- López-Messa Juan B.
- Maazouzi Wajdi
- MacFadyen Rosaleen
- MacFie Caroline C.
- Madotto Fabiana
- Maeyama Hiroki N.
- Maghrabi Khalid A.
- Magret Monica
- Mahto Heera L.
- Mancebo Jordi
- Manoharan Venika
- Marcos Diego Pastor
- Marcu Alexandra
- Maria Villa
- Marin Julien
- Marin Maria C.
- Martinez Felipe T.
- Martinho Aurelia M.
- Marum Susan M.
- Massa Eleni V.
- Mataloun Sergio
- Matamis Dimitrios
- Matsumoto Shuhei
- Mattei Alessia
- May Martin M.
- McArthur Colin
- McAuley Daniel F.
- McAuley Daniel F.
- McAuley Danny
- McCalman Katie H.
- McKechnie Stuart
- McKee Raymond
- McKenna Toni E.
- McLeod Alex
- McNamee Lia
- McNicholas Bairbre
- Meaney Edel A.
- Meco Basak Ceyda
- Meersseman Philippe
- Mehta Sangeeta
- Mejia Francisco Javier Flores
- Mellis Clare
- Memon Mohammedfaruk
- Mercat Alain
- Mesar Tomaz
- Messias António M.
- Messika Jonathan
- Meybohm Patrick
- Michel Philippe
- Millar Rebecca T.
- Miller Jennene J.
- Miller Russel R.
- Mirabella Lucia
- Miryam-Prieto-González
- Mizuguchi Ichiko
- Mochizuki Katsunori
- Mohr Nicholas M.
- Mojoli Francesco
- Moles Silvia Iglesias
- Molin Alexandre
- Montanha Gustavo M.
- Monteiro Jorge M.
- Montero Laura Alvarez
- Montes Oscanoa Fredy A.
- Monti Giacomo
- Montini Luca M.
- Moock Marcelo
- Morin Anna-Karin
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- Watt Philip
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- Yu Rongguo
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- Yumha Jacob S.
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- Zacharas Giannis A.
- Zacharowski Kai D.
- Zani Gianluca
- Zantua Kim S.
- Zazu Alan
- Zeggwagh Amine Ali
- Zein Salem Ould
- Zender Hervé O.
- Zhai Zhe
- Zhang Fan
- Zhang Xing Y.
- Zhao Huiying
- Zhao Jun
- Zhao Xian Y.
- Zheng Ruiqiang
- Zhou Fa C.
- Zhou Suming
- Zhu Bao H.
- Zhu Wei H.
- Zogheib Elie H.
- Ñamendys-Silva Silvio A.
- Ünal Necmettin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe
Plasma lipid profiles discriminate bacterial from viral infection in febrile children
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- Abdulla A. (Amina)
- Abelake E. (Eugenia)
- Adeel A.O.A. (A. O.A.)
- Aebi C. (Christoph)
- Aebi C. (Christoph)
- Agapow P. (Paul)
- Agbeko R. (Rachel)
- Agyeman P. (Philipp)
- Anderson S. (Suzanne)
- Antonio M. (Martin)
- Baer W. (Walter)
- Barham H. (Heather)
- Barral-Arca R. (Ruth)
- Barrios X.G. (Xavier Gabaldó)
- Bartlett M. (Maeve)
- Baumgart H. (Hinrich)
- Baumgartner M. (Markus)
- Behrends U. (Uta)
- Beiroa A.G. (Andrea Grela)
- Bellos E. (Evangelos)
- Berger C. (Christoph)
- Berger C. (Christoph)
- Bernhard-Stirnemann S. (Sara)
- Biebl A. (Ariane)
- Binder A. (Alexander)
- Birnbacher R. (Robert)
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/12/2019
- Field of study
Fever is the most common reason that children present to Emergency Departments. Clinical signs and symptoms suggestive of bacterial infection ar
Immunocompromised patients with acute respiratory distress syndrome : Secondary analysis of the LUNG SAFE database
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- Abad R.D.
- Abe Toshikazu
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- Antonelli Massimo
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- Universitat Autònoma de Barcelona
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- Zhao Jun
- Zhao Xian Y.
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- Zhu Wei H.
- Zogheib Elie
- Zumaran Aguilar Ronald
- Ñamendys-Silva S.A.
- ünal Necmettin
- Publication venue
- Publication date
- 01/01/2018
- Field of study
The aim of this study was to describe data on epidemiology, ventilatory management, and outcome of acute respiratory distress syndrome (ARDS) in immunocompromised patients. Methods: We performed a post hoc analysis on the cohort of immunocompromised patients enrolled in the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) study. The LUNG SAFE study was an international, prospective study including hypoxemic patients in 459 ICUs from 50 countries across 5 continents. Results: Of 2813 patients with ARDS, 584 (20.8%) were immunocompromised, 38.9% of whom had an unspecified cause. Pneumonia, nonpulmonary sepsis, and noncardiogenic shock were their most common risk factors for ARDS. Hospital mortality was higher in immunocompromised than in immunocompetent patients (52.4% vs 36.2%; p < 0.0001), despite similar severity of ARDS. Decisions regarding limiting life-sustaining measures were significantly more frequent in immunocompromised patients (27.1% vs 18.6%; p < 0.0001). Use of noninvasive ventilation (NIV) as first-line treatment was higher in immunocompromised patients (20.9% vs 15.9%; p = 0.0048), and immunodeficiency remained independently associated with the use of NIV after adjustment for confounders. Forty-eight percent of the patients treated with NIV were intubated, and their mortality was not different from that of the patients invasively ventilated ab initio. Conclusions: Immunosuppression is frequent in patients with ARDS, and infections are the main risk factors for ARDS in these immunocompromised patients. Their management differs from that of immunocompetent patients, particularly the greater use of NIV as first-line ventilation strategy. Compared with immunocompetent subjects, they have higher mortality regardless of ARDS severity as well as a higher frequency of limitation of life-sustaining measures. Nonetheless, nearly half of these patients survive to hospital discharge. Trial registration: ClinicalTrials.gov, NCT02010073. Registered on 12 December 2013
Immunocompromised patients with acute respiratory distress syndrome: Secondary analysis of the LUNG SAFE database
- Author
- Abad Ricardo Diaz
- Abe Toshikazu
- Abroug Fekri
- Adams John C.
- Adamsson Richard
- Adolfsson Anne
- Aguilar Ronald Zumaran
- Aguirre Janet S.
- Aguirre-Bermeo Hernan
- Aisa Tharwat
- Aisiku Imo
- Ajetunmobi Olaitan
- Aker Mustafa
- Akyol Onat
- Al Dorzi Hasan M.
- Al Jabbary Ahmed
- Albaiceta Guillermo
- Albarrak Mohamad M.
- Albiero Daniela
- Alda Rosa S.
- Alejandro Risso V.
- Alexander Peter
- Alfonso Alec A. Tallet
- Algaba Ángela
- Aliaga Felipe A.
- Alisasis Alain
- Allan Russell
- Allue Raquel Montoiro
- Almekhlafi Ghaleb
- Alonso Javier
- Altaf Wahid
- Alvarez António
- Alvarez Javier
- Amin Pravin
- Amir Fahd
- Amor Mourad
- An Youzhong
- Andersen Finn
- Andoh Kohkichi
- Andruszkiewicz Pawel
- Aneman Anders
- Antonelli Massimo
- Antonelli Massimo
- Antônio Ana Carolina P.
- Aoki Nobumasa
- Appelberg Henrik
- Arabi Yaasen
- Arabi Yaseen M.
- Araujo Ana
- Arizmendi Alfons
- Arnal Jean-Michel
- Artiga Maria Jose D.
- Artigas Antonio
- Ascoli Aline
- Au Siu-Ming
- Avila Luis
- Azad Raman
- Azevedo Luciano Cesar
- Baboi Loredana
- Badie Julio
- Bailey Irene M.
- Bailey Mathew B.
- Bajwa Ed
- Balkhi Hicham
- Baltus Thomas
- Banner-Goodspeed Valerie
- Barberet Guillaume
- Baron Rebecca
- Baronia Arvind K.
- Barratt-Due Andreas
- Barros Filipa
- Barros Nelson C.
- Batra Hitesh
- Battle Ceri
- Bauer Philippe
- Beck Eduardo
- Beck Oliver
- Bedreag Ovidiu
- Beegle Scott H.
- Beitler Jeremy R.
- Bellani Giacomo
- Beloncle Francois
- Benslama Abdellatif
- Beraldo Daniel O.
- Berghe Caroline
- Berkelmans Frantz
- Besset Sebastien
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- Villamagua Boris
- Villar Veronica
- Vinzio Mauricio
- Virgilio Corcoles G.
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- Wang Chunting
- Wang Hua
- Wang Shou H.
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- Watanabe Eizo
- Watt Philip
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- Wenham Tim
- Wessbergh Joanna
- Whitehead Christina
- Willett Emma L.
- Williams Alexandra J.
- Williams Karen E.
- Wise Matt
- Wittebole Xavier
- Wong Helen S.
- Woods Paul W.
- Wrathall David
- Wrigge Hermann
- Wu Ya
- Xin-Hua Qiang
- Xu Yonghao
- Yamaguchi Osamu
- Yamaji Yoshihiro
- Yao Qingchun
- Ye Zheng L.
- Yeatts Dale
- Yu Rongguo
- Yu Tao
- Yu Wenkui
- Yumha Jacob S.
- Yuste Luis J.
- Zacharas Giannis
- Zacharowski Kai
- Zani Gianluca
- Zantua Kim
- Zazu Alan
- Zeggwagh Amine Ali
- Zein Salem Ould
- Zender Hervé
- Zhai Zhe
- Zhang Fan
- Zhang Xing Y.
- Zhao Huiying
- Zhao Jun
- Zhao Xian Y.
- Zheng Ruiqiang
- Zhou Fa C.
- Zhou Suming
- Zhu Bao
- Zhu Wei H.
- Zogheib Elie
- Ñamendys-Silva Silvio A.
- ünal Necmettin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Background: The aim of this study was to describe data on epidemiology, ventilatory management, and outcome of acute respiratory distress syndrome (ARDS) in immunocompromised patients. Methods: We performed a post hoc analysis on the cohort of immunocompromised patients enrolled in the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) study. The LUNG SAFE study was an international, prospective study including hypoxemic patients in 459 ICUs from 50 countries across 5 continents. Results: Of 2813 patients with ARDS, 584 (20.8%) were immunocompromised, 38.9% of whom had an unspecified cause. Pneumonia, nonpulmonary sepsis, and noncardiogenic shock were their most common risk factors for ARDS. Hospital mortality was higher in immunocompromised than in immunocompetent patients (52.4% vs 36.2%; p < 0.0001), despite similar severity of ARDS. Decisions regarding limiting life-sustaining measures were significantly more frequent in immunocompromised patients (27.1% vs 18.6%; p < 0.0001). Use of noninvasive ventilation (NIV) as first-line treatment was higher in immunocompromised patients (20.9% vs 15.9%; p = 0.0048), and immunodeficiency remained independently associated with the use of NIV after adjustment for confounders. Forty-eight percent of the patients treated with NIV were intubated, and their mortality was not different from that of the patients invasively ventilated ab initio. Conclusions: Immunosuppression is frequent in patients with ARDS, and infections are the main risk factors for ARDS in these immunocompromised patients. Their management differs from that of immunocompetent patients, particularly the greater use of NIV as first-line ventilation strategy. Compared with immunocompetent subjects, they have higher mortality regardless of ARDS severity as well as a higher frequency of limitation of life-sustaining measures. Nonetheless, nearly half of these patients survive to hospital discharge. Trial registration: ClinicalTrials.gov, NCT02010073. Registered on 12 December 2013
Effects Of Different Cavity Disinfectants On Shear Bond Strength Of A Silorane-Based Resin Composite
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- Publication venue
- 'Jaypee Brothers Medical Publishing'
- Publication date
- 01/01/2011
- Field of study
Scopu
Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study
- Author
- ??lvaro Ortega Guerrero
- Aaron Lerner
- Aarti Sarwal
- Ainhoa Serrano
- Alba Gonzalo Mill??n
- Alberto Noto
- Alejandro Ruiz Perea
- Alejandro Suarez-de-la-Rica
- Alexis Ferr??
- Alice Santos
- Amaia Quintano Rodero
- Ana Montero Feijoo
- Ana Vallejo de la Cueva
- Andr??s Pujol
- Andrew R. Vogel
- Anna Bar?? Serra
- Anna Estermann
- Anna Teresa Mazzeo
- Annachiara Marra
- Anselmo Caricato
- Antonio Ram??rez-Palma
- Ariadna Bell??s
- Aris P??rez Lucendo
- Aur??lien Mazeraud
- Beata-Gabriela K Simpson
- Beatriz Del Moral Barbudo
- Beatriz Garc??a G??ngora
- Berta Gallego Rodr??guez
- Berta Monle??n
- Blanca Fern??ndez Tom??s
- Blanca Furquet
- Borja Hinojal Olmedillo
- Brenda T Pun
- Bruno Gon??alves
- C. Adrian Austin
- C??sar Rodriguez Nu??ez
- Carla Margarida Teixeira
- Carlos A. Calvo
- Carlos Mu??oz De Cabo
- Carmen Andrea Sanchis-Veryser
- Carolina Ferrer G??mez
- Catherine M. Kuza
- Chiara Maria Concetta Massaro
- Chiara Robba
- Christine Harb
- Christopher Berkey
- Cristina ??lvarez
- Cristina Delgado Palacios
- Cristina Fuster
- Cristina Granja
- Cristina Murcia Gubianas
- Daniel A Godoy Torres
- David A Bennett
- David D??az Mu??oz
- David Mart??nez-Gascue??a
- David Pesta??a Lagunas
- Denise Battaglini
- Diana Gil-Castillejos
- Dulce Morales
- E Wesley Ely
- Eduardo Tobar
- Elena Abril Palomares
- Elena Gallego Curto
- Elena Gonz??lez Gonz??lez
- Eleonora Stival
- Elisa Govea Bogossian
- Ellis Morgan
- Eloisa Sofia Tanzarella
- Emilio del Campo Molina
- Emilio Maseda
- Emily Sanders
- Enver Rodriguez-Mart??nez
- Erik Roman-Pognuz
- Esteban Morcillo
- Estefan??a Carvajal Revuelta
- Eva ??lvarez Torres
- Fabio Silvio Taccone
- Felipe Gonz??lez-Seguel
- Fernando Higuero
- Figen Esen
- Filadelfo Bustos Molina
- Francisco Javier Mor??n Gallego
- Francisco Luis P??rez Caballero
- Frank Rasulo
- G??nseli Orhun
- Gabriel Heras La Calle
- Gabriele Pintaudi
- Gemma Gom?? Fern??ndez
- Gen??s Carrasco G??mez
- Giuseppe Servillo
- Guillaume Lacave
- Guillem Navarra-Ventura
- Hilde Woien
- Hollis R O'Neal
- Ignacio Baeza G??mez
- Ignacio Catal??n-Monz??n
- Ignacio Garutti
- Imen Ben Saida
- In??s P??rez Francisco
- Irene Paredes Borrachero
- Irene Patricia Bar??n Barrera
- Irene Torres
- Isabel de la Calle Gil
- Isabel Jesus Pereira
- Isabel Pe??a Luna
- Isabel Reyes Garc??a
- Itziar Insausti
- Jacques Creteur
- Jaume Puig
- Jes??s Caballero
- Jo??o Silva
- Jordi Morillas P??rez
- Jorge Rubio
- Jose Garc??a Cantos
- Juan Romeu Prieto
- Karen Herrera-Davis
- Karen Shephard
- Karla N????ez V??zquez
- Katie M. Vance
- Kelly Drumright
- Kiran Devulapally
- Kristine Nelson
- Laura Galarza
- Laura Gonz??lez Cubillo
- Laura Labrador Romero
- Laura Lizama
- Lisa Smit
- Lorenzo Peluso
- Lucia Chowdhury
- M??nica Garc??a Sim??n
- Mandeep Sing
- Mar??a Cruz Mart??n Delgado
- Mar??a de las Nieves Noci Moreno
- Mar??a Elena Mart??nez Quintana
- Mar??a Esther Rodriguez Delgado
- Mar??a Jes??s M??rmol Cubillo
- Mar??a Jes??s Montero
- Mar??a Jos?? S??nchez Carretero
- Mar??a Luisa Garc??a P??rez
- Mar??a Pilar Vicente-Fern??ndez
- Mar??a Rosa Sanchis-Martin
- Maria Claudia Gim??nez Santamarina
- Mario Dalorzo Gonz??lez
- Marta Mart??n Mart??nez
- Martin Siegemund
- Mathieu van der Jagt
- Matilde Gonz??lez Serrano
- Mattia Marchesi
- Meri Martin Cerezuela
- Michael Kenes
- Michelle Woodham
- Miguel Valente
- Milagros Calizaya Vargas
- Mohamed Boussarsar
- Morgan H. Tandy
- Muhammed Elhadi
- Myrto Tzimou
- N??ria Zellweger
- Nathan E Brummel
- Nekane Romero
- Nerea Aretxabala Cortajarena
- Nihal Patel
- Onur M Orun
- Oriol Plans Galv??n
- Pablo Carre??o-Montenegro
- Pablo Garc??a Domelo
- Pablo T. Aznar
- Paloma LaTorre Andreu
- Paola Valls
- Paolo Pelosi
- Patricia Pi??eiro Otero
- Patricia Rodr??guez Villamizar
- Paula Castello-Mora
- Paula Ram??rez
- Perihan Ergin ??zcan
- Pilar Leal Sanz
- Pratik P Pandharipande
- Rafael Badenes
- Rafael Zaragoza
- Rameela Raman
- Ricard Molina Latorre
- Rita Pereia
- Robert A Balk
- Robert C Hyzy
- Robert E. Hosse
- Rosa Mar??a P??rez Manrique
- Rosal??a Navarro Casado
- Salvatore Lucio Cutuli
- Sameep Sehgal
- Sara C. LaHue
- Sara Torrico S??nchez
- Sarah Cohen
- Sarah J Peterson
- Sergio Llorente Damas
- Sheila Moya Guti??rrez
- Silvia Beretta
- Silvia Garc??a de Castrill??n i Ramal
- Sol Fernandez-Gonzalo
- Spencer Roberson
- St??phane Legriel
- Stephanie Wilson-Linville
- Susana Gallardo S??nchez
- Theresa Olasveengen
- Thomas Godet
- Timothy D Girard
- Ugo Fraisse
- Vanja C. Douglas
- Ver??nica Rojas
- Viviane Hidalgo-Calibin
- Wencong Chen
- Xavier Andorr?? Sunyer
- Yago Garc??a Blanco-Traba
- Yolanda Poveda Hern??ndez
- Publication venue
- Publication date
- 01/01/2021
- Field of study
Mechanical ventilation in patients with cardiogenic pulmonary edema : a sub-analysis of the LUNG SAFE study
- Author
- Abad R.D.
- Abe Toshikazu
- Abroug Fekri
- Adams J.C.
- Adamsson R.O.
- Adolfsson A.
- Aguilar R.Z.
- Aguirre J.S.
- Aguirre-Bermeo Hernan
- Aisa T.M.
- Aisiku Imoigele P.
- Ajetunmobi O.O.
- Aker M.
- Akyol O.O.
- Al Dorzi H.M.
- Albaiceta G.M.
- Albaiceta Guillermo M.
- Albarrak M.M.
- Albiero D.
- Alda R.S.
- Alejandro Risso V.
- Alexander P.
- Alfonso A.A.T.
- Algaba Á.
- Aliaga Felipe A.
- Alisasis A.U.
- AlJabbary A.S.
- Allan R.M.
- Allue R.M.
- Almekhlafi G.
- Alonso J.G.
- Altaf W.
- Alvarez A.M.
- Alvarez Javier
- Amado-Rodríguez Laura
- Amin Pravin
- Amir F.
- Amor M.
- An Youzhong
- Andersen F.H.
- Andoh K.
- Andruszkiewicz P.
- Aneman Anders
- Antonelli M.M.
- Antônio Ana Carolina P.
- Aoki N.
- Appelberg H.
- Arabi Yaasen.
- Araujo A.M.
- Arizmendi A.
- Arnal J.M.
- Artiga M.J.D.
- Artigas A.
- Ascoli Aline
- Avila L.E.
- Azad Raman
- Azevedo Luciano Cesar
- Baboi L.
- Badie J.C.
- Bailey Irene M.
- Bailey M.B.
- Bajwa Ed
- Balkhi H.
- Baltus T.
- BannerGoodspeed V.M.
- Barberet G.
- Baro R.M.
- Baronia A.K.
- Barratt-Due A.
- Barros F.M.
- Barros N.C.
- Batra H.
- Battle C.E.
- Bauer P.R.
- Beck E.
- Beck O.
- Bedreag O.H.
- Beegle S.H.
- Beitler J.R.
- Beloncle Francois
- Benslama A.
- Beraldo Daniel O.
- Berghe Caroline
- Berkelmans F.
- Besset S.L.
- Bettini Lisandro R.
- Beuret P.
- Bezzi Marco G.
- Bhardwaj V.K.
- Bhowmick K.
- Biehler J.
- Bigot C.
- Bihari Shailesh
- BinHJAbul Wahab Ahmad Yazid
- Biondi Rodrigo S.
- Biscione R.R.
- Bisso Mariano Carboni
- Black C.S.
- Blakeman T.C.
- Blanco J.
- Bolon S.
- Borello Silvina A.
- Borotto E.E.
- Botteri M.
- Bouchoucha S.
- Boukhazna M.
- Bouw M.J.
- Boyd O.
- Bramall J.
- Braschi A.
- Brazzi L.
- Breen D.M.
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- Brochard L.
- Broman L.M.
- Brown S.M.
- Browne T.S.
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- Brunettini B.
- Bruns M.M.
- Buensuseso J.A.
- Bugedo Guillermo
- Buise M.P.
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- Canestrini Sergio
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- Vargas M.P.
- Vascotto E.R.
- Vasquez Daniela N.
- Vega Luis D.
- Venti A.
- Vercueil A.
- Vermassen Joris
- Verstraete Rik
- Villagomez A.J.
- Villagomez Asisclo
- Villamagua B.G.
- Villar Veronica
- Vinzio Mauricio
- Virgilio C.G.
- Vitale M.N.
- Volta C.A.
- Wang C.
- Wang Hua X.
- Wang S.H.
- Wang Wei
- Warren J.
- Watanabe E.
- Watt P.
- Welters I.D.
- Wenham T.
- Wessbergh J.
- Whitehead Christina
- Willett E.L.
- Williams A.J.
- Williams K.E.
- Wittebole Xavier
- Wong Helen S.
- Woods Paul W.
- Wrathall D.W.
- Wrigge Hermann
- Wrigge Hermann
- Wu Ya Q.
- Xin-Hua Q.
- Xu Y.
- Yamaguchi O.
- Yamaji Y.
- Yao Q.
- Ye Zheng L.
- Yeatts D.J.
- Yu R.
- Yu Tao
- Yu Wenkui
- Yumha Jacob S.
- Yuste L.J.
- Zacharas Giannis A
- Zacharowski Kai
- Zani G.
- Zantua C.K.S.
- Zazu Alan
- Zeggwagh Amine Ali
- Zein Salem Ould
- Zender Hervé O
- Zhai Zhe
- Zhang Fan
- Zhang X.Y.
- Zhao Huiying
- Zhao Jun
- Zhao X.Y.
- Zheng Ruiqiang
- Zhou Fa C.
- Zhou S.
- Zhu Bao H.
- Zhu W.H.
- Zogheib Elie
- Ñamendys-Silva S.A.
- Ünal N.
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Patients with acute respiratory failure caused by cardiogenic pulmonary edema (CPE) may require mechanical ventilation that can cause further lung damage. Our aim was to determine the impact of ventilatory settings on CPE mortality. Patients from the LUNG SAFE cohort, a multicenter prospective cohort study of patients undergoing mechanical ventilation, were studied. Relationships between ventilatory parameters and outcomes (ICU discharge/hospital mortality) were assessed using latent mixture analysis and a marginal structural model. From 4499 patients, 391 meeting CPE criteria (median age 70 [interquartile range 59-78], 40% female) were included. ICU and hospital mortality were 34% and 40%, respectively. ICU survivors were younger (67 [57-77] vs 74 [64-80] years, p < 0.001) and had lower driving (12 [8-16] vs 15 [11-17] cmHO, p < 0.001), plateau (20 [15-23] vs 22 [19-26] cmHO, p < 0.001) and peak (21 [17-27] vs 26 [20-32] cmHO, p < 0.001) pressures. Latent mixture analysis of patients receiving invasive mechanical ventilation on ICU day 1 revealed a subgroup ventilated with high pressures with lower probability of being discharged alive from the ICU (hazard ratio [HR] 0.79 [95% confidence interval 0.60-1.05], p = 0.103) and increased hospital mortality (HR 1.65 [1.16-2.36], p = 0.005). In a marginal structural model, driving pressures in the first week (HR 1.12 [1.06-1.18], p < 0.001) and tidal volume after day 7 (HR 0.69 [0.52-0.93], p = 0.015) were related to survival. Higher airway pressures in invasively ventilated patients with CPE are related to mortality. These patients may be exposed to an increased risk of ventilator-induced lung injury. Trial registration Clinicaltrials.gov NCT02010073