55 research outputs found
Economic Damage and Host Preference of Lepidopterous Pests of Major Warm Season Turfgrasses of Hawaii
The four major lepidopterous pests of turfgrasses of Hawaii are the grass webworm, Herpetogramma licarisalis (Walker), (GWW); lawn armyworm, Spodoptera mauritia (Boisduval), (LAW); black cutworm, Agrostis ipsilon (Hufnagle), (BCW); and fiery skipper, Hylephila phylaeus (Drury), (FS). The effects of different densities of larvae of these four insects on development of feeding injury to 'Sunturf’ bermudagrass, Cynodon magennisii (Hurcombe), were determined in 12.7 cm diameter pots in a glasshouse. Effects of diets of different turfgrasses on larval development and survival of the GWW and FS were determined in the laboratory. Complete consumption of ‘Sunturf’ bermudagrass occurred in 6-7 days with populations of greater than 3 LAW, 4 BCW, 10 FS. and 12 GWW. All population levels of LAW and BCW caused serious injury (greater than 20% of turf consumed) 4-5 days after adding third instar larvae to pots. One FS and one or two GWW larvae per pot caused only slight feeding injury. Developmental rate and survival of the GWW were poorest on 'Tifgreen’ and common bermudagrass. FS larvae developed more slowly when fed Zoysia matrella (L.) and centipedegrass, Eremochloa ophiuroides ((Munro.) Hack). All FS larvae fed St. Augustinegrass, Stenotaphrum secundatum ((Walt.) Kuntz.), died after 7-8 days
Secreted frizzled-related protein disrupts PCP in eye lens fiber cells that have polarised primary cilia
AbstractPlanar cell polarity (PCP) signaling polarises cells along tissue axes. Although pathways involved are becoming better understood, outstanding issues include; (i) existence/identity of cues that orchestrate global polarisation in tissues, and (ii) the generality of the link between polarisation of primary cilia and asymmetric localisation of PCP proteins. Mammalian lenses are mainly comprised of epithelial-derived fiber cells. Concentrically arranged fibers are precisely aligned as they elongate along the anterior–posterior axis and orientate towards lens poles where they meet fibers from other segments to form characteristic sutures. We show that lens exhibits PCP, with each fiber cell having an apically situated cilium and in most cases this is polarised towards the anterior pole. Frizzled and other PCP proteins are also asymmetrically localised along the equatorial–anterior axis. Mutations in core PCP genes Van Gogh-like 2 and Celsr1 perturb oriented fiber alignment and suture formation. Suppression of the PCP pathway by overexpressing Sfrp2 shows that whilst local groups of fibers are often similarly oriented, they lack global orientation; consequently when local groups of fibers with different orientations meet they form multiple, small, ectopic suture-like configurations. This indicates that this extracellular inhibitor disrupts a global polarising signal that utilises a PCP-mediated mechanism to coordinate the global alignment and orientation of fibers to lens poles
Reforming Watershed Restoration: Science in Need of Application and Applications in Need of Science
Research priorities in prehabilitation for patients undergoing cancer surgery: an international Delphi study
Background
Recently, the number of prehabilitation trials has increased significantly. The identification of key research priorities is vital in guiding future research directions. Thus, the aim of this collaborative study was to define key research priorities in prehabilitation for patients undergoing cancer surgery.
Methods
The Delphi methodology was implemented over three rounds of surveys distributed to prehabilitation experts from across multiple specialties, tumour streams and countries via a secure online platform. In the first round, participants were asked to provide baseline demographics and to identify five top prehabilitation research priorities. In successive rounds, participants were asked to rank research priorities on a 5-point Likert scale. Consensus was considered if > 70% of participants indicated agreement on each research priority.
Results
A total of 165 prehabilitation experts participated, including medical doctors, physiotherapists, dieticians, nurses, and academics across four continents. The first round identified 446 research priorities, collated within 75 unique research questions. Over two successive rounds, a list of 10 research priorities reached international consensus of importance. These included the efficacy of prehabilitation on varied postoperative outcomes, benefit to specific patient groups, ideal programme composition, cost efficacy, enhancing compliance and adherence, effect during neoadjuvant therapies, and modes of delivery.
Conclusions
This collaborative international study identified the top 10 research priorities in prehabilitation for patients undergoing cancer surgery. The identified priorities inform research strategies, provide future directions for prehabilitation research, support resource allocation and enhance the prehabilitation evidence base in cancer patients undergoing surgery
Photon beam asymmetry Sigma for eta and eta ' photoproduction from the proton
Measurements of the linearly-polarized photon beam asymmetry for
photoproduction from the proton of and mesons are
reported. A linearly-polarized tagged photon beam produced by coherent
bremsstrahlung was incident on a cryogenic hydrogen target within the CEBAF
Large Acceptance Spectrometer. Results are presented for the reaction for incident photon energies from 1.070 to 1.876 GeV, and from
1.516 to 1.836 GeV for the reaction. For , the data reported here considerably extend the range of
measurements to higher energies, and are consistent with the few previously
published measurements for this observable near threshold. For , the results obtained are consistent with the few previously
published measurements for this observable near threshold, but also greatly
expand the incident photon energy coverage for that reaction. Initial analysis
of the data reported here with the Bonn-Gatchina model strengthens the evidence
for four nucleon resonances -- the , ,
and resonances -- which presently lack the
"four-star" status in the current Particle Data Group compilation, providing
examples of how these new measurements help refine models of the
photoproduction process.Comment: 10 pages, 3 figure
Factors Associated with Revision Surgery after Internal Fixation of Hip Fractures
Background: Femoral neck fractures are associated with high rates of revision surgery after management with internal fixation. Using data from the Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) trial evaluating methods of internal fixation in patients with femoral neck fractures, we investigated associations between baseline and surgical factors and the need for revision surgery to promote healing, relieve pain, treat infection or improve function over 24 months postsurgery. Additionally, we investigated factors associated with (1) hardware removal and (2) implant exchange from cancellous screws (CS) or sliding hip screw (SHS) to total hip arthroplasty, hemiarthroplasty, or another internal fixation device. Methods: We identified 15 potential factors a priori that may be associated with revision surgery, 7 with hardware removal, and 14 with implant exchange. We used multivariable Cox proportional hazards analyses in our investigation. Results: Factors associated with increased risk of revision surgery included: female sex, [hazard ratio (HR) 1.79, 95% confidence interval (CI) 1.25-2.50; P = 0.001], higher body mass index (fo
Whole-genome sequencing reveals host factors underlying critical COVID-19
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
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