61 research outputs found
Sales and Exchanges of Capital Assets for Deferred Payment Obligations
- Author
- Publication venue
- Case Western Reserve University School of Law Scholarly Commons
- Publication date
- 01/01/1976
- Field of study
Sales and Exchanges of Capital Assets for Deferred Payment Obligations
- Author
- Publication venue
- Case Western Reserve University School of Law Scholarly Commons
- Publication date
- 01/01/1976
- Field of study
Children must be protected from the tobacco industry's marketing tactics.
- Author
- Abdallah Said
- Absalom Gareth
- Adams Nick
- Adeboyeku David
- Agate Rowan
- Agrawal Sanjay
- Ahmed Liju
- Allen Bev
- Anderson Paul
- Anwar Sadia
- Arabnia Gilda
- Ayres Jon
- Badman Ros
- Bafadhel Mona
- Baker Emma
- Banerjee Tushar
- Barker Jack
- Barnes Peter
- Barnett Emma
- Barnham Kate
- Barr Laura
- Barry Simon
- Bartoszewicz Charlotte
- Beasley Victoria
- Berry Matthew
- Bhowmik Angshu
- Bingham Lyn
- Bintcliffe Oliver
- Bloch Susannah
- Boland Alison
- Bolton Charlotte
- Booth Andrew
- Booton Richard
- Bothamley Graham
- Bott Julia
- Bourke Stephen
- Bradley Bethia
- Breen Ronan
- Brennan Amanda
- Bridges Diana
- Britton John
- Brown Joanna
- Brown Louise
- Brown Sarah
- Browne Emma
- Brunet Martin
- Burge Sherwood
- Burgin Karen
- Burke Hannah
- Bush Andrew
- Butcher Jane
- Buttery Robert
- Buxton Maria
- Calverley Peter
- Campbell Colin
- Campbell Ian
- Capstick Toby
- Carlin Chris
- Casswell Georgina
- Chaudhry Nauman
- Chavasse Richard
- Christensen Anne
- Christopher Anne
- Chua Felix
- Clarke Sarah
- Clive Amelia
- Colin Campbell
- Collett Anne
- Collins Andrea
- Collins Nicola
- Connell David
- Connellan Stephen
- Connelly Carol
- Connett Gary
- Connolly Bronwen
- Cookson John
- Cooper Angela
- Cooper David
- Costello Carol Ann
- Coutts Ian
- Cowie Calvin
- Cox Nicola
- Crawfurd Laura
- Creagh-Brown Ben
- Crooks Gillian
- Crooks Gillian
- Crooks Stephen
- Crossingham Iain
- Cullen Kathy
- Cummings Natalie
- Curry Denise
- Curtis Katrina
- Daniels Tracey
- Davey Claire
- Davidson Philip
- Davies Carol-Anne
- Davies Lisa
- Davies Peter
- Davies Sarah
- Davison John
- Davison Tony
- Dayer Mark
- Deegan Paul
- Denniston Sarah
- Deveson Pete
- Dewar Maria
- Diana Bridges
- Dobson Lee
- Docherty Marianne
- Dodd James
- Doe Simon
- Dow Claire
- Downs Janis
- Dowson Lee
- Durham Stephen
- Durrington Hannah
- Dutta P
- Dwarakanath Akshay
- Eaden James
- Edwards Adrian
- Edwards Catherine
- Edwards John
- Edwards Sheila
- Edwina Wooler
- Elizabeth Ringrose
- Elkin Sarah
- Elston Will
- Emerson Peter
- English Peter
- Esterbrook Georgina
- Everett Caroline
- Farmer Ray
- Feary Johanna
- Fern Karen
- Fleming Louise
- Fletcher Tim
- Ford David
- Ford Kate
- Forrest Ian
- Forster Georgia
- Fowler Robert William
- Fowler Stephen
- Fraser Una
- Freeman Debbie
- Fuld Jonathan
- Furness John
- Gaduzo Stephen
- Gardiner Karen
- Georgiadi Adamantia
- Ghosh Dipansu
- Gibson John
- Gill Alison
- Goldman Jon
- Goode Chris
- Graham Alison
- Graham Annika
- Graves Jennifer
- Gray Barry
- Gray Linda
- Greenhalgh Trish
- Greening Neil
- Griffiths Mark
- Griffiths Paul
- Griffiths Valerie
- Grove Alison
- Guadagno Alison
- Guyatt Fran
- Hailes Karen
- Haja Mydin Helmy
- Haney Sarah
- Hankinson Jenny
- Haqqee Raana
- Harle Amelie
- Harrison Brian
- Harrris Ann
- Hart Nicholas
- Harvey John
- Haslam Patricia L
- Heslop Karen
- Hewitt Lee
- Hickman Katherine
- Hicks Alex
- Higgins Bernard
- Hilton Kay
- Hoadley Jacky
- Hodgson Luke
- Hodson Matthew
- Holden Emma
- Holmes Steve
- Hopkinson Nicholas
- Hosker Harold
- Hough Alexandra
- Houghton Catherine
- Howell Tim
- Hughes John
- Hutchinson John
- Hynes Gareth
- Iftikhar Ahsan
- Iles Peter
- Ioakim Shona
- Janes Sam
- Jennings David
- Jha Akhilesh
- John Edwards
- Johnston Carol
- Jolley Caroline
- Jones Helen
- Kaul Sundeep
- Keaney Niall
- Keilty Sarah
- Kemp Samuel
- Ketchell Robert Ian
- Khan Katie
- Kim Randall
- Kowal Julia
- Kumar Sanjay
- Lacy-Colson Amruta
- Lane Amber
- Lane Ian
- Lebus Jenny
- Lenney Warren
- Lenney Warren
- Leonard Andrew
- Leonard Helen
- Lightbody Darren
- Lipman Marc
- Lithgow Anna
- Lloyd Jananee
- Lloyd Julie
- Lock Sara
- Lomas Dean David
- Long Alex
- Lord Victoria
- Lordan James
- Lowe Lesley
- Lyall Rebecca
- Lyons Elizabeth
- Lytton Stephen
- MacBean Vicky
- Macdonald Ian
- Mackenzie Nesta
- Mackinlay Carolyn
- Macmillan Alison Bennett
- Maddocks Matthew
- Majeed Azeem
- Malin Adam
- Mallia-Milanes Brendan
- Malone Sarah
- Man William
- Maqsood Usman
- Marsden Paul
- Marshall Robert
- Martin Katharine
- Martin Sarah
- Matthew Hodson
- Matusiewicz Simon
- Maxwell David
- McAuley Danny
- McCarvill Iona
- McHugh Martin
- McKee Martin
- McNicholl Diarmuid
- Meadows Chris
- Merritt Simon
- Milburn Heather
- Miller Joy
- Miller Lauren
- Mir Misbah
- Mitchell Sally
- Mitchelmore Philip
- Mohd Noh Mohd Shahrin
- Molloy Alanna
- Monaghan Valerie
- Montgomery Hugh
- Montgomery Mary
- Moore Caroline
- Moore-Gillon John
- Morgan David
- Morrison Douglas
- Moxham John
- Munday Maureen
- Mungall Sarah
- Murray Clare
- Mustfa Naveed
- Myerson James
- Narasimhan Divya
- Naveed Shams-un-nisa
- Nelson Christopher
- Newey Alison
- Nicholl David
- Nickol Annabel
- Nicoll Debby
- Nikolic Marko
- Nyman Cyril
- O'Callaghan Una
- O'Connor Sally
- O'Driscoll Ronan
- O'Hara Doreen
- O'Kane Cecilia
- Ohri Chandra
- Olive Sandra
- Olivier Sharon
- Olley Amy
- Ong Yee Ean
- Ormerod Lawrence
- Padmanaban Vijay
- Parker Samuel
- Parkes Marilyn
- Parmar Sonia
- Parry Diane
- Partridge Martyn
- Partridge Samuel
- Patel Anant
- Patel Irem
- Paterson Ian
- Paton James Y
- Pawulska Barbara
- Peedell Clive
- Pengo Martino
- Phitidis Elpida
- Pieri-Davies Sue
- Pillai Anilkumar
- Powell Helen
- Powrie Duncan
- Primhak Robert
- Prowse Keith
- Prowse Keith
- Purcell Helen
- Puthucheary Zudin
- Pye Kathy
- Quint Jennifer
- Radnan Paul
- Rafferty Gerrard
- Rajhan Ashwin
- Raju Raghu
- Ramsay Michelle
- Range Simon
- Redington Anthony
- Reilly Jacqui
- Restrick Louise
- Ridyard John
- Rigge Lucy
- Ringrose Elizabeth
- Robinson Grace
- Robinson Louise
- Rodman Anne
- Roots Debbie
- Roots Debbie
- Rosalind Backham
- Ross David
- Round Jonathan
- Ruiz Gary
- Russell Richard
- Ryan Helen
- Safavi Shahideh
- Saini Sarvesh
- Sapey Elizabeth
- Satia Imran
- Satkunam Karnan
- Scaffardi Anthony
- Scheele Kate
- Seaton Douglas
- Serlin Matthew
- Seymour John
- Shaheen Fizah
- Sharkey Emma
- Sharp Charles
- Sherrington Rebecca
- Shields Michael
- Shribman Jonathan
- Shrikrishna Dinesh
- Simon Ward
- Simonds Anita
- Simpson John
- Sloper Katherine
- Smith David
- Smith Peter
- Spencer Charlotte
- Spencer David
- Spiro Stephen
- Stableforth David
- Stanton Andrew
- Starren Elizabeth
- Steel Mark
- Steier Joerg
- Stern Myra
- Stewart Tara
- Stockley Robert
- Stocks Janet
- Stratford- Martin James
- Sturney Sharon
- Suh Eui-Sik
- Summers Geoffrey
- Sumner Helen
- Sutherland Tim
- Sylvester Karl
- Szram Joanna
- Tate Paul
- Taylor Amy
- Templeton-Wright Suzanne
- Thomas Ajit
- Thomas Angela
- Thomas Matt
- Thomson Fiona
- Thomson Neil
- Tilbrook Sean
- Timlett Amber
- Towns Rebecca
- Tracey Mathieson
- Treharne Jo
- Tunnicliffe Georgia
- Turner Sally
- Turner Steve
- Vaughan Sophie
- Voase Nia
- Walker Paul
- Walker Woolf
- Wallis Colin
- Walmsley Sandy
- Walters Nicola
- Ward Ann
- Ward Simon
- Warner John
- Warwick Geoffrey
- Watson John
- Wedzicha Wisia
- Wheatley Iain
- White John
- Whitfield Ruth
- Wicker Jacquelyne
- Wieboldt Jason
- Williams Ruth
- Williamson Kathryn
- Wilson Patrick
- Wilson Robert
- Winter Barbara
- Winter Robert
- Winter-Burke Alice
- Wood Fraser
- Wood Marion
- Woodcock Ashley
- Woodhead Mark
- Wooler Edwina
- Woolhouse Ian
- Wright Joanne
- Yasso Razouqi
- Zoumot Zaid
- Zurek Andrew
- Publication venue
- 'BMJ'
- Publication date
- 01/01/2013
- Field of study
Act now against new NHS competition regulations: an open letter to the BMA and the Academy of Medical Royal Colleges calls on them to make a joint public statement of opposition to the amended section 75 regulations.
- Author
- Anson James
- Applebee Jackie
- Arnold Natasha
- Awsare Ninaad
- Bambra Clare
- Banks Ian
- Bareford David
- Basarab Adriana
- Beadsworth Mike
- Beer Naomi
- Bell David
- Bell David
- Bennett-Richards Phillip
- Bhatti Osman
- Boomla Kambiz
- Bossano David
- Bostock David
- Boswell John P
- Bratty Catherine
- Brearey Steve
- Brown Kirsten
- Brown Raymond
- Buhrs Ernst
- Burgess-Allen Jilla
- Bury Bob
- Buttivant Helen
- Caan Woody
- Cabot Kate
- Camilleri-Ferrante Corinne
- Carter Lucy
- Chamberlain MA
- Chandy Rajiv
- Cheeroth Sheila
- Clark Leon
- Clarke Aileen
- Clarke Edward
- Coates Jonathan
- Cole Jim
- Coleman Michel
- Colvin Deborah
- Cook Derek
- Cripwell Michael
- Crome Peter
- Cullinan Paul
- Currie Jonny
- Daley Helen
- Danby Jude
- Darling Jonathan
- Davies David
- Davies Gerry
- Davis Jacky
- Deveson Pete
- Dickinson Jane
- Dickson Harriet
- Domizio Paola
- Duncan John AT
- Edwards Mark
- Edwards Martin
- Ehrhardt Peter
- Eisner Maggie
- Erskine Jonathan
- Etherington Robert
- Evans David
- Evans-Jones John
- Farrelly George
- Feder Gene
- Feehally John
- Fell Henry
- Fellows Griffith
- Fielding Richard
- Finer Nick
- Finer Sarah
- Fisher Brian
- Fitchett Mike
- Fitzgerald Richard
- Fleming Peter
- Fleming Peter
- Fluxman Jonathan
- Folb Jonathan
- Folb Jonathan
- Ford Amy
- Ford Steven
- Franks Andrea
- Freud Kathy McAdam
- Gawler Jeff
- Gibbs John
- Gill Alison
- Godfrey Peter
- Goodger V
- Gore Jonathan
- Gould Derek A
- Greenhalgh Trisha
- Griffiths Alun
- Grunewald Richard
- Gurling Hugh
- Hall Alyson
- Hall Peter
- Hamlyn Adrian N
- Hawkins David
- Highton Clare
- Hirst Julie
- Hobson Esther
- Holland Walter
- Holt Kim
- Holt Victoria J
- Hopkinson Nicholas
- Hotchkiss Julie
- Hughes Richard
- Ingrams Grant
- Ireland Maggie
- Irvine Louise
- Irving William L
- Jacobson Bobbie
- Jeffreys Anne
- Jenner David
- Jenner David
- Johnson Guy
- Johnston Sally
- Johnstone Chris
- Jones Anna
- Jones Coral
- Jones Phil
- Kendall Bryony
- Kinmonth Ann-Louise
- Kirwin Simon
- Klonin Hilary
- Knight David
- Koperski M
- Kraemer Sebastian
- Landers Aileen
- Lau Alice
- Lawrence David
- Lee Alan
- Lefevre Dianne
- Leigh Martha
- Lewis David
- Lewis David
- Lewis Geoffrey
- Livingstone Anna
- Lockwood Kate
- Logan Jane
- Logan Mary
- Logan Stuart
- Lowes Simon
- Lyttelton Laura
- Ma Richard
- Macfarlane Alison
- Macgibbon Robert
- Macklon AF
- Maclennan Iain
- Macpherson Jamie
- Main John
- Mann Nick
- Marlowe Gary
- Marmot Saul
- Martin P
- Maryon-Davis Alan
- Mason Rebecca
- McCartney Margaret
- McCoy David
- McEewen J
- McElderry Elisabeth
- McKee Martin
- McPherson Klim
- Michael Benedict
- Middleton John
- Miller Jo
- Mindell Jennifer
- Mitchel Sarah
- Mitchison Sally
- Moore Robert
- Morrison Richard
- Mullen Paul
- Munday Pat
- Murphy E
- Newell Jo
- Nixon Jonathan
- Noor R
- Nsutebu Emmanuel
- Ormerod Julian
- Ormerod Oliver
- Paintin David
- Patel Anita
- Paul Ashish
- Peedell Clive
- Pollock Alyson
- Pride Neil
- Puntis John
- Rainbow Daniel
- Rawaf Salman
- Reeve Joanne
- Reissman Gerard
- Ross Wendy
- Rossiter Brian
- Salim Asad
- Savage Wendy
- Sayer Mel
- Schweiger Martin
- Scott Brian
- Scott-Samuel Alex
- Sharma Ajay
- Sharp Deborah J
- Sharvill John
- Sikorski Jim
- Silverman Ruth
- Singer Ron
- Singh G
- Singh Surinder
- Smailes Alison
- Smyth Alan
- Souza Richard de
- Stevenson Nicola
- Stobbart Kate
- Suckling Ruth
- Tallis Ray
- Tebboth Louise
- Timmis Alison
- Timms Philip
- Tomlinson Jonathon
- Tomlinson Laurie
- Tomson D
- Tomson Mike
- Torabi Payam
- Tulloch Alex
- Turner Gill
- Venning Helen
- Walker Jonathan
- Waterston Tony
- Wesby Barbara
- West Andrew
- West Robert
- West Robert
- Whincup Peter
- Wolfe Ingrid
- Wortley Pam
- Wrigley David
- Young Gail
- Young Jane
- Yudkin John S
- Zinkin Pam
- Publication venue
- 'BMJ'
- Publication date
- 20/03/2013
- Field of study
International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways.
- Author
- Abigail Hynes
- Aditya Mandal
- Adrian Barnardo
- Aftab Ala
- Agostino Colli
- Alan Shepherd
- Alan Watson
- Alastair McNair
- Alberto Mattalia
- Alexandra McKay
- Alice Wright
- Alison Brind
- Alison Loftus
- Alison Paton
- Alistair King
- Allister Grant
- Altaf Palegwala
- Amir Shah
- Amit Singhal
- Ana Lleo
- Andrea Broad
- Andrea Crosignani
- Andrea Galli
- Andrew Austin
- Andrew Bathgate
- Andrew Bell
- Andrew Burroughs
- Andrew Chilton
- Andrew Davis
- Andrew Douds
- Andrew Douglass
- Andrew Fraser
- Andrew Gibbins
- Andrew Higham
- Andrew L Mason
- Andrzej Piotrowicz
- Andy Li
- Angelo Andriulli
- Anna Fouracres
- Annarosa Floreani
- Anne Eastick
- Anton Gunasekera
- Antonio Benedetti
- Antonio Picciotto
- Aruna Dias
- Ashis Mukhopadhya
- Ashley Brown
- Asifabbas Naqvi
- Athar Saeed
- Bal Shinder
- Barbara Coco
- Barbara Foglieni
- Barbara Hoeroldt
- Becky Holbrook
- Beverley Longhurst
- Bob Grover
- Brian D. Juran
- Bridget Bird
- Bridget Gunson
- Bronwen Williams
- Bruce R Bacon
- Caradog Thomas
- Carl A. Anderson
- Carlo Ferrari
- Carly Brown
- Carmela Cursaro
- Carol Thomas
- Carole Collins
- Carole Foale
- Caroline Cowley
- Caroline Hamilton
- Caroline Lawlor
- Caroline Mulvaney-Jones
- Caroline Palmer
- Carolyn MacNicol
- Caron Innes
- Casey S. Greene
- Catherine Gray
- Catherine Vincent
- Charles Grimley
- Charles Millson
- Chin Lye Ch'ng
- Chris Evans
- Chris Ford
- Christine Dickson
- Christopher Healey
- Christopher Hovell
- Christopher I. Amos
- Christopher Macdonald
- Christopher Shallcross
- Christopher Shorrock
- Claire Duggan
- Claudio Tiribelli
- Craig Lammert
- Cristina Barlassina
- Cynthia Levy
- D Williams
- Dakai Zhu
- Daniel Forton
- Daniele Cusi
- Daniele Prati
- Darren Clement
- David C. Qian
- David Elphick
- David Gorard
- David Jones
- David Neal
- David Ramanaden
- David Tyrer
- Dawn Sirdefield
- Deb Ghosh
- Debashis Das
- Delyth Braim
- Denise Gocher
- Denise O'Donnell
- Dermot Gleeson
- Diane Simpson
- Domenico Alvaro
- Donna Cotterill
- Douglas Thorburn
- Earl Williams
- Eileen Marshall
- Eleanor Dungca
- Elizabeth J Atkinson
- Elizabeth Tanqueray
- Elva Wilhelmsen
- Emily Archer
- Emma Durant
- Emma Grieve
- Emma Gunter
- Erik M Schlicht
- Ervin Shpuza
- Estelle Nambela
- Esther Unitt
- Fabio Macaluso
- Fabio Marra
- Faiz Ali
- Federica Malinverno
- Filomena Morisco
- Fiona Gordon
- Fiona Wright
- Floriano Rosina
- Florin Muscariu
- Frances Hines
- Francesca Bernuzzi
- Gang Xie
- Gary Bray
- Gayle Clifford
- Geeta Prasad
- George Abouda
- George Bird
- George F. Mells
- George Lipscomb
- George MacFaul
- Giancarlo Spinzi
- Gianfranco Elia
- Gideon M. Hirschfield
- Gill Watts
- Giovanni Casella
- Glynis Stansfield
- Gordon Wood
- Graeme Alexander
- Graham Butcher
- Graham Foster
- Grazia A Niro
- Gregory Whatley
- Greta Van Duyvenvoorde
- Guan Lim
- Gwen Baxter
- Hannah Dewhurst
- Harriet Gordon
- Harriet Mitchison
- Heather J. Cordell
- Helen Doyle
- Helen Fairlamb
- Helen Sweeting
- Helen Wooldridge
- Hemant Gupta
- Henry C Bodenheimer Jr
- Hilary Pateman
- Howard Curtis
- Howard Klass
- Hyder Hussaini
- Hye-Jeong Lee
- Ian Drake
- Ian Gee
- Ian Gooding
- Ian Rees
- Ilaria Bianchi
- Ilaria Sogno
- Imran Patanwala
- Imroz Salam
- Isobel Amey
- Jaber Gasem
- Jacky Orpe
- Jacqueline Brighton
- James A. B. Floyd
- James Featherstone
- James Gotto
- James Neuberger
- Jane Bowles
- Jane Collier
- Jane Gitahi
- Jane Maiden
- Jane Metcalf
- Janeane Hails
- Janette Curtis
- Janie Keggans
- Janine Musselwhite
- Javaid Subhani
- Jayne Jones
- Jean Kordula
- Jeff Butterworth
- Jennie Kendall
- Jennifer Morrison
- Jeremy Shearman
- Jeremy Tibble
- Jessica Whiteman
- Jia Qu
- Jill Conder
- Jinyi Zhang
- Jo Ridpath
- Joanna Allison
- Joanna Sayer
- Jocelyn Fraser
- John Dillon
- John Mclindon
- John Ramage
- Jonathan Booth
- Jonathan Brown
- Joseph A Odin
- Joy Sadeghian
- Joy Wilkins
- Julia Maltby
- Julie Browning
- Julie Colley
- Julie Tregonning
- Juliette Verheyden
- Kapil Kapur
- Karen Hogben
- Karen Warner
- Karin Young
- Kate Martin
- Kate Ocker
- Katharine Pollock
- Katherine A. Siminovitch
- Katherine I. Morley
- Kathryn Houghton
- Katie Seward
- Katie Spurdle
- Keith Elliott
- Keith George
- Kelly Amor
- Kerenza Boulton
- Kerry Flahive
- Kevin Yoong
- Kimberley Netherton
- Kirsten Walker
- Kirsty Martin
- Konrad Koss
- Konstantinos N. Lazaridis
- LaiTing Tan
- Landon L Chan
- Leonie Grellier
- Linda Jones
- Linda Kent
- Linda March
- Lisa Morgan
- Liz Farrington
- Lizzie Stafford
- Lola Dali-kemmery
- Lorenzo Morini
- Lorraine Hankey
- Lory Saveria Crocè
- Louise Winter
- Lourdes Cumlat
- Luca Fabris
- Lucie Hobson
- Luigi Muratori
- Lyn Graves
- Lynn Currie
- Lynn O'Donohoe
- M. Eric Gershwin
- Maggie Hughes
- Mandy Carnahan
- Marco Carbone
- Marco Marzioni
- Marek Czajkowski
- Maria Consiglia Bragazzi
- Maria Francesca Donato
- Maria Hamilton
- Maria Hayes
- Maria Vinci
- Mariam Nasseri
- Marie Green
- Marie Quinn
- Marina Leoni
- Mario Strazzabosco
- Marisa Mills
- Mariza de Andrade
- Mark Ainsworth
- Mark Aldersley
- Mark Cox
- Mark Narain
- Mark Wilkinson
- Mark Wright
- Markus Gess
- Marta Spreafico
- Martin Lombard
- Martin Prince
- Martyn Carter
- Mary Crossey
- Mary Ninkovic
- Massimo Colombo
- Massimo Zuin
- Matthew Brookes
- Matthew Cowan
- Matthew Cramp
- Matthew Foxton
- Maurizia Brunetto
- Mauro Podda
- Maxton Pitcher
- Mazn Karmo
- Mcdonald Mupudzi
- Melanie Harrison
- Melanie Kent
- Mervyn Davies
- Mesbah Rahman
- Metod Oblak
- Michael F. Seldin
- Michael Heneghan
- Mike Mendall
- Minesh Patel
- Mirko Tarocchi
- Mohamed Dawwas
- Mousa Hani S
- Natalie Taylor
- Natalie Wheatley
- Neil Fisher
- Nicholas Sharer
- Nicola Lancaster
- Nikki White
- Noma Ncube
- null null
- null null
- null null
- Nurani Sivaramakrishnan
- Oza Chirag
- Paolo Muratori
- Parizade Raymode
- Patrick Goggin
- Paul Banim
- Paul Kitchen
- Paul Richardson
- Paul Southern
- Paula Townshend
- Peter Bramley
- Peter K Gregersen
- Peter Mills
- Phillipa Desousa
- Pier Maria Battezzati
- Pierluigi Toniutto
- Piero L Almasio
- Piero Portincasa
- Pietro Andreone
- Pietro Invernizzi
- Piotr Milkiewicz
- Pradeep Sanghi
- Pranab Gyawali
- PuiChing Chan
- Purushothaman Premchand
- Rachel Abrahams
- Raj Srirajaskanthan
- Ray Mathew
- Ray Shidrawi
- Rebecca Bishop
- Rebecca Casey
- Rebecca Cloudsdale
- Rebecca Jones
- Renzo Montanari
- Reuben Ayres
- Richard Aspinall
- Richard Evans
- Richard Marley
- Richard Miller
- Richard N. Sandford
- Richard Sturgess
- Robert P Myers
- Robert Przemioslo
- Roberta Lazzari
- Roger McCorry
- Roland Ede
- Roman Galaska
- Rory Harvey
- Rosanna Fontana
- Rose Damant
- Rupert Ransford
- Ruth Penn
- Saket Singhal
- Sally Batham
- Sally-Ann Rolls
- Sallyanne Pearson
- Samantha Ducker
- Sambit Sen
- Samir Vyas
- Sandra Greer
- Sanjiv Jain
- Sarah Besley
- Sarah Jones
- Sarah Thornthwaite
- Sass Levi
- Savino Bruno
- Senayon Desmennu
- Sharat Misra
- Sherill Tripoli
- Silvia Colombo
- Simon Dyer
- Simon Panter
- Simon Rushbrook
- Simon Taylor-Robinson
- Simon Whalley
- Simon Williams
- Sonia Rossi
- Sonia Tarallo
- Sophie Holder
- Stephen D Ryder
- Steve Pereira
- Steven Mann
- Stewart Campbell
- Subramaniam Ramakrishnan
- Subrata Saha
- Sue Glenn
- Sue Walsh
- Sunil Dolwani
- Susan Congreave
- Susan Gallagher
- Susan Jones
- Susan Lord
- Susan Slininger
- Sushma Saksena
- Suzie Marriott
- Syed Shaukat
- Talal Valliani
- Theodore Ngatchu
- Thiriloganathan Mathialahan
- Tim Harding
- Tobias Balschun
- Toby Delahooke
- Tom Lee
- Tom Yapp
- Tracey Shewan
- Udi Shmueli
- Valentina Liakina
- Valeria Silvestre
- Velimir A Luketic
- Victoria Lambourne
- Vincenzo O Palmieri
- Vincenzo Ronca
- Voi Shim Wong
- William Stableforth
- Yafang Li
- Yeng Ang
- Yolanda Baird
- Younghun Han
- Publication venue
- Nat Commun
- Publication date
- 01/01/2015
- Field of study
Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in an independent cohort (n=3,716 cases and 4,261 controls). We discover and validate six previously unknown risk loci for PBC (Pcombined<5 × 10(-8)) and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine-cytokine pathways, for which relevant therapies exist
The impact of immediate breast reconstruction on the time to delivery of adjuvant therapy: the iBRA-2 study
- Author
- Abdullah Nassreen
- Accurso Antonello
- Accurso Antonello
- Achuthan Raj
- Adam Rahma
- Adelekan Matthew
- Adwani Asha
- Aertssen Anna
- Agrawal Amit
- Agrawal Avi
- Ain Quratul
- Ainsworth Rachel
- Akerlund Malin
- Akolekar Deepika
- Alder Louise
- Alexander Susanna
- Ali Deedar
- Ali Rozina
- Allan Anna
- Allum William
- Aloraifi Fatima
- Amin Khalid
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- Arif Tahera
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- Asgeirsson Kristjan
- Athanasiou Irene
- Audisio Riccardo
- Azmy Iman
- Bache Sarah
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- Collis Nick
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- Dave Rajiv
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- Dordea Matei
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- Gill Emma
- Goh Steven
- Govindarajulu Sasirekha
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- Grp iBRA-2 Steering
- Guest Francesca
- Gui Gerald
- Gutteridge Eleanor
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- Jiwa Natasha
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- O'Brien Ciara
- O'Brien James
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- Taghizadeh Rieka
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- Taylor Lauren
- Tebbal Sally
- Tevlin Ruth
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- Thomas Rachel Bright
- Thomson Simon
- Thorne Amanda
- Thrush Steven
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- To Natalie
- Tomlins Abigail
- Trapszo Pawel
- Trickey Adam
- Turton Philip
- Udayasankar S
- Valassiadou Kalliope
- Verjee Liaquat S
- Vidya Raghavan
- Vigneswaran Natali
- Vinayagam Raman
- Vollermere Angela J
- Walker Philip
- Weiler-Mithoff Eva
- Weston-Petrides Gina
- Whisker Lisa
- Wilkins Alex
- Williamson Paula
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- Wilson Sherif
- Windle Rebecca
- Wintrip Dorothy
- Wood Simon
- Wooler Brendan
- Woollard Alex
- Woollard Alexander
- Yoshimura Ryo
- Young Oliver
- Younis Ibby
- Youssef Mina
- Zechmeister Katalin
- Zeidan Bashar
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
Background:
Immediate breast reconstruction (IBR) is routinely offered to improve quality-of-life for women requiring mastectomy, but there are concerns that more complex surgery may delay adjuvant oncological treatments and compromise long-term outcomes. High-quality evidence is lacking. The iBRA-2 study aimed to investigate the impact of IBR on time to adjuvant therapy.
Methods:
Consecutive women undergoing mastectomy ± IBR for breast cancer July–December, 2016 were included. Patient demographics, operative, oncological and complication data were collected. Time from last definitive cancer surgery to first adjuvant treatment for patients undergoing mastectomy ± IBR were compared and risk factors associated with delays explored.
Results:
A total of 2540 patients were recruited from 76 centres; 1008 (39.7%) underwent IBR (implant-only [n = 675, 26.6%]; pedicled flaps [n = 105,4.1%] and free-flaps [n = 228, 8.9%]). Complications requiring re-admission or re-operation were significantly more common in patients undergoing IBR than those receiving mastectomy. Adjuvant chemotherapy or radiotherapy was required by 1235 (48.6%) patients. No clinically significant differences were seen in time to adjuvant therapy between patient groups but major complications irrespective of surgery received were significantly associated with treatment delays.
Conclusions:
IBR does not result in clinically significant delays to adjuvant therapy, but post-operative complications are associated with treatment delays. Strategies to minimise complications, including careful patient selection, are required to improve outcomes for patients
AI is a viable alternative to high throughput screening: a 318-target study
- Author
- Abaffy Tatjana
- Abraham Elena Theres
- Abrahão Jônatas Santos
- Abramyan Tigran M.
- Agianian Bogos
- Agogo-Mawuli Percy
- Agoulnik Alexander I.
- Agrawal Rajendra K.
- Aguilera Elena
- Ahmed Mostafa
- Akk Gustav
- Akopian Tatos
- Al-Yozbaki Minnatallah
- Aldhamen Yasser Ali
- Alkan Cigdem
- Alramadhani Dina
- Alteen Matthew G.
- Alvarez Guzmán
- Ammendola Serena
- Anastasio Noelle C.
- Anderson Brandon M.
- Anderson Deborah H.
- Andricopulo Adriano D.
- Angell Richard M.
- Anthis Nicholas J.
- Antonelli Lorenzo
- Apfel Athena Marie
- Arias Juan Antonio Sanchez
- Arozarena Imanol
- Arrigoni Cristina
- Artía Zoraima
- Ashkar Shireen R.
- Ashton Mark R.
- Austin Richard C.
- Ayachi Aicha Gharbi
- Azeem Syeda Maryam
- Bailey-Elkin Ben A.
- Balakrishnan Bijina
- Balaña-Fouce Rafael
- Ballatore Carlo
- Banerjee Sourav
- Banerji Versha
- Banjo Toshihiro
- Barghash Marim M.
- Batey Robert A.
- Battistoni Andrea
- Baumann Ulrich
- Bdira Fredj Ben
- Bedi Mel
- Ben-Johny Manu
- Bergman Bastiaan
- Bernard Denzil
- Berti Andrew
- Bharambe Nikhil
- Bishop Ozlem Tastan
- Blanchet Xavier
- Blelloch Robert
- Blumenthal Robert M.
- Bognár Gabriella
- Bogomolovas Julijus
- Bon Carlotta
- Boorman Jacob
- Borowska Anna
- Borriello Francesco
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- Buckner Frederick S.
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- Sorenson Jon M.
- Stafford Kate
- Stahl Andreas
- Statsyuk Alexander V.
- Stec Natalia
- Stecula Adrian
- Stetefeld Joerg
- Strauss Erick
- Stuchbury Grant David
- Su Leila
- Su Tong
- Su Zhengchen
- Sugamori Kim S.
- Sun Ying
- Suterwala Shabbir
- Svensson Fredrik
- Sverzhinsky Aleksandr
- Swart Tarryn
- Taglialatela Angelo
- Tam Heng-Keat
- Tandon Vasudha
- Tang Weiping
- Tang Young
- Tanner John J.
- Taylor Richard E.
- Teixeira Thaiz Rodrigues
- Teramoto Tadahisa
- Thai Van Chi
- Thayer Desiree
- Thomas Bill
- Thompson Erik W.
- Tilford Hannah
- Tiwari Rakesh Kumar
- Toh Alan Kie Leong
- Tomilov Alexey
- Toogood Peter
- Torner Carles
- Trabocchi Andrea
- Trader Darci J.
- Trakhtenberg Ephraim F.
- Trinh Nguyen Mai
- Truong Ha
- Tse-Dinh Yuk-Ching
- Tsimbalyuk Sofiya
- Tumes Damon J.
- Tye Mark A.
- Uribe Ruben Vazquez
- Valli Marilia
- van den Akker Focco
- van den Bedem Henry
- Van Doren Steven R.
- Van Grack Tessa
- Van Hung Le Vuong
- Van Pelt Natascha
- Van Remmen Holly
- Van Voorhis Wesley C.
- Vandenberg Robert J.
- Veit Guido
- Verhamme Ingrid M.
- Verma Rajkumar
- Viola Ronald E.
- Virtanen Anniina
- Vizeacoumar Franco J.
- Vizeacoumar Frederick S.
- Vleminckx Margot
- von Hundelshausen Philipp
- Voss Jan Hendrik
- Vrielink Alice
- Waggoner Stephen N.
- Walensky Loren D.
- Wallach Izhar
- Wang Feng
- Wang Jianghai
- Wang Jun
- Wang Xingyou
- Wang Zhenghe
- Warrington Jeffrey M.
- Watkins Joshua
- Wazir Sarah
- Weber Christian
- Welsbie Derek S.
- Wentworth Kelly L.
- Wert-Lamas Leon
- White Andrew
- White Simon J.
- Whitesell Luke
- Williams Tiffany
- Wilson Cornelia M.
- Wilson Mark A.
- Windisch Marc P.
- Wong Keith S.
- Woods Virgil A.
- Worley Brad
- Wu Pengpeng
- Wu Xiaoyang
- Wulff Heike
- Xiang Fei
- Xu Hongyang
- Xu Jiake
- Xu Jingyi
- Xu Sophia Q.
- Xu Xin
- Yan Riqiang
- Yang Chao-Yie
- Yen Yun
- Young Matthew A.
- Yu Fang
- Yu Xinfang
- Yuan Haynes
- Yuan Xinrui
- Zahler Stefan
- Zeina Christina M.
- Zelinskaya Natalia
- Zhang Dingqiang
- Zhang Gang
- Zhang Wenjun
- Zhang Xu
- Zhang Yan Jessie
- Zhang Zhiguo
- Zhao Jinshi
- Zhou Han
- Zhou Hui
- Zhou Jia
- Zhou Pei
- Zhou Shan
- Zhu Jiaqi
- Zhu Siran
- Zhu Yini
- Zhuo Ling
- Zochodne Douglas William
- Publication venue
- Publication date
- 01/01/2024
- Field of study
: High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNet® model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. Our empirical results suggest that computational methods can substantially replace HTS as the first step of small-molecule drug discovery
International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways
- Author
- 94
- Abigail Hynes 159
- Aditya Mandal
- Adrian Barnardo 182
- Aftab Ala 138
- Agostino Colli 45
- Alan Shepherd 213
- Alan Watson 81
- Alastair McNair 175
- Alberto Mattalia 54
- Alexandra McKay 132
- Alice Wright 245
- Alison Brind 294
- Alison Loftus 91
- Alison Paton 119
- Alistair King
- Allister Grant
- Almasio 33 Piero L.
- Altaf Palegwala 98
- Amir Shah 189
- Amit Singhal
- Amos 2 Christopher I.
- Ana Lleo 12
- Anderson 8 Carl A.
- Andrea Broad 139
- Andrea Crosignani 39
- Andrew Austin 119
- Andrew Bell 305
- Andrew Burroughs 249
- Andrew Chilton 166
- Andrew Douds 243
- Andrew Gibbins 122
- Andrew Higham 293
- Andrew Bathgate
- Andrew Davis
- Andrew Douglass
- Andrew Fraser
- Andrzej Piotrowicz
- Andy Li 303
- Angelo Andriulli 37
- Anna Fouracres 247
- Annarosa Floreani 51
- Anne Eastick
- Anton Gunasekera
- Antonio Benedetti 40
- Antonio Picciotto 59
- Aruna Dias 82
- Ashis Mukhopadhya
- Ashley Brown
- Asifabbas Naqvi
- Athar Saeed 139
- Atkinson 19 Elizabeth J.
- Bacon 28 Bruce R.
- Bal Shinder 258
- Barbara Coco 43
- Barbara Foglieni 11
- Barbara Hoeroldt 244
- Becky Holbrook 222
- Beverley Longhurst 240
- Bob Grover 151
- Bodenheimer Jr 29 Henry C.
- Bridget Bird 191
- Bridget Gunson 287
- Bronwen Williams
- Caradog Thomas
- Carlo Ferrari 49
- Carly Brown 270
- Carmela Cursaro 36
- Carol Thomas 156
- Carole Collins 300
- Carole Foale 138
- Caroline Cowley 182
- Caroline Mulvaney Jones
- Caroline Hamilton
- Caroline Lawlor
- Caroline Palmer
- Carolyn MacNicol 163
- Caron Innes
- Catherine Vincent 31
- Catherine Gray
- Chan 19 Landon L.
- Charles Grimley
- Charles Millson
- Chin Lye Ch’
- Chris Evans 190
- Chris Ford
- Christine Dickson 239
- Christopher Healey 71
- Christopher Hovell 122
- Christopher Shorrock 90
- Christopher Shallcross
- Claire Duggan 159
- Claudio Tiribelli 48
- Cordell Heather J.
- Craig Lammert 7
- Cristina Barlassina 38
- Cynthia Levy 32
- Dakai Zhu 2
- Daniel Forton 275
- Daniele Prati 11
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- Darren Clement 294
- David Elphick 106
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- Diane Simpson 239
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- Douglas Thorburn 249
- Earl Williams 246
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- Eleanor Dungca 107
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- Emma Durant
- Eric Gershwin 15 M.
- Ervin Shpuza
- Estelle Nambela
- Esther Unitt 289
- Fabio Macaluso 34
- Faiz Ali 156
- Federica Malinverno 46
- Filomena Morisco 57
- Fiona Gordon 288
- Fiona Wright 189
- Floriano Rosina 60
- Florin Muscariu
- Floyd James A. B.
- Frances Hines
- Francesca Bernuzzi 41
- Galli Andrea
- Gang Xie
- Gary Bray 272
- Gayle Clifford 270
- Geeta Prasad 285
- George Lipscomb 91
- George MacFaul 187
- George Abouda
- George Bird
- Giancarlo Spinzi 61
- Gianfranco Elia 49
- Gill Watts 285
- Giovanni Casella 44
- Glynis Stansfield 163
- Gordon Wood 140
- Graeme Alexander 101
- Graham Foster 80
- Graham Butcher
- Greene Casey S.
- Gregersen Peter K.
- Gregory Whatley 280
- Greta Van Duyvenvoorde 90
- Guan Lim 135
- Gwen Baxter 191
- Hannah Dewhurst 246
- Harriet Gordon 145
- Harriet Mitchison 107
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- Helen Fairlamb
- Helen Sweeting
- Hemant Gupta
- Hilary Pateman
- Hirschfield Gideon M.
- Howard Curtis
- Howard Klass
- Hyder Hussaini 247
- Hye Jeong Lee 167
- Ian Gooding 108
- Ian Rees 157
- Ian Drake
- Ian Gee
- Ilaria Bianchi 41
- Ilaria Sogno 41
- Imran Patanwala 252
- Imroz Salam 158
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- Juran 7 Brian D.
- Kapil Kapur 79
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- Karen Warner
- Karin Young 196
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- Kirsty Martin
- Konrad Koss 126
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- Lazaridis 7 Konstantinos N.
- Leonie Grellier 164
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- Lorenzo Morini 56
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- Lory Saveria Croce ` 48
- Louise Winter 312
- Lourdes Cumlat 306
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- Lucie Hobson
- Luigi Muratori 36
- Luketic 27 Velimir A.
- Lyn Graves 247
- Lynn Currie
- Lynn O’
- Maggie Hughes
- Mandy Carnahan
- Marco Carbone 101
- Marco Marzioni 40
- Marek Czajkowski
- Maria Consiglia Bragazzi 42
- Maria Francesca Donato 46
- Maria Hayes 240
- Maria Vinci 65
- Maria Hamilton
- Mariam Nasseri 151
- Marie Green 254
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- Marina Leoni 249
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- Mary Ninkovic
- Mason 21 Andrew L.
- Massimo Colombo 46
- Massimo Zuin
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- Mauro Podda 41
- Maxton Pitcher
- Mazn Karmo 109
- Mcdonald Mupudzi 286
- Melanie Harrison 70
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- Mells George F.
- Mervyn Davies
- Mesbah Rahman 68
- Metod Oblak 300
- Michael Heneghan 167
- Mike Mendall
- Minesh Patel
- Mohamed Dawwas 101
- Morley Katherine I.
- Mousa Hani S. 41
- Myers 22 Robert P.
- Natalie Taylor 265
- Natalie Wheatley 108
- Neil Fisher 123
- Nicholas Sharer 239
- Nicola Lancaster
- Nikki White
- Niro 37 Grazia A.
- Noma Ncube
- Nurani Sivaramakrishnan 186
- Odin 26 Joseph A.
- Oza Chirag
- Palmieri 58 Vincenzo O.
- Paolo Muratori 36
- Parizade Raymode 166
- Patrick Goggin 240
- Paul Banim 165
- Paul Kitchen 182
- Paul Richardson 252
- Paul Southern 92
- Paula Townshend
- Peter Bramley
- Peter Mills
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- Pier Maria Battezzati 39
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- Pietro Invernizzi
- Piotr Milkiewicz 24
- Pradeep Sanghi
- Pranab Gyawali 77
- PuiChing Chan 296
- Purushothaman Premchand 78
- Qian 2 David C.
- Rachel Abrahams 117
- Raj Srirajaskanthan 176
- Ray Shidrawi 153
- Ray Mathew
- Rebecca Bishop
- Rebecca Casey
- Rebecca Cloudsdale
- Rebecca Jones
- Renzo Montanari 55
- Reuben Ayres 248
- Richard Aspinall 240
- Richard Evans 88
- Richard Marley 80
- Richard Miller 183
- Richard Sturgess 70
- Robert Przemioslo 216 Christopher Macdonald
- Roberta Lazzari 51
- Roger McCorry 85
- Roland Ede
- Roman Galaska 71
- Rory Harvey 84
- Rosanna Fontana 37
- Rose Damant 98
- Rupert Ransford 313
- Ruth Penn
- Ryder Stephen D.
- Saket Singhal 258
- Sally Ann Rolls 156
- Sally Batham
- Sallyanne Pearson 244
- Samantha Ducker 188
- Sambit Sen 179
- Samir Vyas 257
- Sandford Richard N.
- Sandra Greer 312
- Sanjiv Jain 283
- Sarah Jones 159
- Sarah Besley
- Sarah Thornthwaite
- Sass Levi
- Savino Bruno 41
- Schlicht 7 Erik M.
- Seldin 15 Michael F.
- Senayon Desmennu
- Sharat Misra
- Sherill Tripoli
- Silvia Colombo 47
- Siminovitch Katherine A.
- Simon Panter 270
- Simon Rushbrook 215
- Simon Taylor Robinson 162
- Simon Williams 163
- Simon Dyer
- Simon Whalley
- Sonia Rossi 41
- Sonia Tarallo 60
- Sophie Holder
- Steve Pereira 284
- Steven Mann
- Stewart Campbell
- Subramaniam Ramakrishnan 296
- Subrata Saha 191
- Sue Glenn 106
- Sue Walsh 280
- Sunil Dolwani
- Susan Gallagher 294
- Susan Lord 118
- Susan Congreave
- Susan Jones
- Susan Slininger
- Sushma Saksena
- Suzie Marriott 248
- Syed Shaukat 152
- Talal Valliani 216
- Tarocchi Mirko
- Theodore Ngatchu
- Thiriloganathan Mathialahan 89
- Tim Harding
- Tobias Balschun 20
- Toby Delahooke
- Tom Yapp 69
- Tom Lee
- Tracey Shewan 279
- Udi Shmueli 221
- Valentina Liakina 30
- Valeria Silvestre 105
- Victoria Lambourne 253
- Vincenzo Ronca 41
- Voi Shim Wong 306
- William Stableforth 247
- Williams 197 D.
- Yafang Li
- Yeng Ang 312
- Yolanda Baird 304
- Younghun Han
- Publication venue
- Publication date
- 01/01/2015
- Field of study
The James Webb Space Telescope Mission
- Author
- Abbott Randy
- Abell James S.
- Abernathy Mark
- Abney Faith E.
- Abraham John G.
- Abraham Roberto
- Abul-Huda Yasin M.
- Acton Scott
- Adams Cynthia K.
- Adams Evan
- Adler David S.
- Adriaensen Maarten
- Aguilar Jonathan Albert
- Ahmed Mansoor
- Ahmed Nasif S.
- Ahmed Tanjira
- Alarcon Rafael Ramos
- Albat Rüdeger
- Albert Loïc
- Alberts Stacey
- Aldridge David
- Allen Mary Marsha
- Allen Shaune S.
- Altenburg Martin
- Altunc Serhat
- Alvarez Jose Lorenzo
- Ambrose Leslie L.
- Anandakrishnan Satya M.
- Andersen Gregory C.
- Anderson Harry James
- Anderson Jay
- Anderson Kristen
- Anderson Sara M.
- Aprea Julio
- Archer Benita J.
- Arenberg Jonathan W.
- Argyriou Ioannis
- Arribas Santiago
- Artigau Étienne
- Arvai Amanda Rose
- Atcheson Paul
- Atkinson Charles B.
- Averbukh Jesse
- Aymergen Cagatay
- Bacinski John J.
- Baggett Wayne E.
- Bagnasco Giorgio
- Baker Lynn L.
- Balzano Vicki Ann
- Banks Kimberly A.
- Baran David A.
- Barker Elizabeth A.
- Barrett Larry K.
- Barringer Bruce O.
- Barto Allison
- Bast William
- Baudoz Pierre
- Baum Stefi
- Beatty Thomas G.
- Beaulieu Mathilde
- Bechtold Kathryn
- Beck Tracy
- Beddard Megan M.
- Beichman Charles
- Bellagama Larry
- Bely Pierre
- Berger Timothy W.
- Bergeron Louis E.
- Bertch Maria D.
- Beskow Charlotte
- Betz Laura E.
- Biagetti Carl P.
- Birkmann Stephan
- Bjorklund Kurt F.
- Blackwood James D.
- Blazek Ronald Paul
- Blossfeld Stephen
- Bluth Marcel
- Boccaletti Anthony
- Boegner Jr. Martin E.
- Bohlin Ralph C.
- Boia John Joseph
- Bonaventura N.
- Bond Nicholas A.
- Bosley Kari Ann
- Boucarut Rene A.
- Bouchet Patrice
- Bouwman Jeroen
- Bower Gary
- Bowers Ariel S.
- Bowers Charles W.
- Boyce Leslye A.
- Boyer Christine T.
- Boyer Martha L.
- Boyer Michael
- Boyer Robert
- Bradley Larry D.
- Brady Gregory R.
- Brandl Bernhard R.
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- Breda David
- Bremmer Harold G.
- Brennan David
- Bresnahan Pamela A.
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- Bromenschenkel Asa
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- Bunker A. J.
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- Böker Torsten
- Cabaud Olivier
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- Coulais Alain
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- Dailey Christopher T.
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- de Chambure Daniel
- de Jong Pauline
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- Deschenes Jeremy
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- Douglas Jr. Robert E.
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- Dupuis Jean
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- Engesser Michael
- Espinoza Néstor
- Etienne Odessa
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- Illingworth Garth
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- Jeffers Basil S.
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- Kaltenegger Lisa
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- Östlin Göran
- Publication venue
- Publication date
- 10/04/2023
- Field of study
Twenty-six years ago a small committee report, building on earlier studies,
expounded a compelling and poetic vision for the future of astronomy, calling
for an infrared-optimized space telescope with an aperture of at least 4m.
With the support of their governments in the US, Europe, and Canada, 20,000
people realized that vision as the 6.5m James Webb Space Telescope. A
generation of astronomers will celebrate their accomplishments for the life of
the mission, potentially as long as 20 years, and beyond. This report and the
scientific discoveries that follow are extended thank-you notes to the 20,000
team members. The telescope is working perfectly, with much better image
quality than expected. In this and accompanying papers, we give a brief
history, describe the observatory, outline its objectives and current observing
program, and discuss the inventions and people who made it possible. We cite
detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space
Telescope Overview, 29 pages, 4 figure
Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study
- Author
- Abel K
- Adamali H.
- Adeloye D
- Adeyemi Oluwaseun
- Adrego Rita
- Aguilar Jimenez Laura A.
- Ahmad Haider N
- Ahmad Shanaz
- Ahmed R
- Ahwireng Nyarko
- Ainsworth Mark
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- Alamoudi Asma
- Alfaro-Almagro Fidel
- Ali Mariam
- Aljaroof M
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- Allen R J
- Allerton Lisa
- Allsop Lynne
- Allt Ann Marie
- Almeida Paula
- Altmann Danny
- Alvarez Corral Maria
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- Zawia Amira
- Zeidan Lisa
- Zhao Bang
- Zheng Bang
- Zongo O.
- Publication venue
- Elsevier
- Publication date
- 22/09/2023
- Field of study
Introduction:
The multiorgan impact of moderate to severe coronavirus infections in the post-acute phase is still poorly understood. We aimed to evaluate the excess burden of multiorgan abnormalities after hospitalisation with COVID-19, evaluate their determinants, and explore associations with patient-related outcome measures.
Methods:
In a prospective, UK-wide, multicentre MRI follow-up study (C-MORE), adults (aged ≥18 years) discharged from hospital following COVID-19 who were included in Tier 2 of the Post-hospitalisation COVID-19 study (PHOSP-COVID) and contemporary controls with no evidence of previous COVID-19 (SARS-CoV-2 nucleocapsid antibody negative) underwent multiorgan MRI (lungs, heart, brain, liver, and kidneys) with quantitative and qualitative assessment of images and clinical adjudication when relevant. Individuals with end-stage renal failure or contraindications to MRI were excluded. Participants also underwent detailed recording of symptoms, and physiological and biochemical tests. The primary outcome was the excess burden of multiorgan abnormalities (two or more organs) relative to controls, with further adjustments for potential confounders. The C-MORE study is ongoing and is registered with ClinicalTrials.gov, NCT04510025.
Findings:
Of 2710 participants in Tier 2 of PHOSP-COVID, 531 were recruited across 13 UK-wide C-MORE sites. After exclusions, 259 C-MORE patients (mean age 57 years [SD 12]; 158 [61%] male and 101 [39%] female) who were discharged from hospital with PCR-confirmed or clinically diagnosed COVID-19 between March 1, 2020, and Nov 1, 2021, and 52 non-COVID-19 controls from the community (mean age 49 years [SD 14]; 30 [58%] male and 22 [42%] female) were included in the analysis. Patients were assessed at a median of 5·0 months (IQR 4·2–6·3) after hospital discharge. Compared with non-COVID-19 controls, patients were older, living with more obesity, and had more comorbidities. Multiorgan abnormalities on MRI were more frequent in patients than in controls (157 [61%] of 259 vs 14 [27%] of 52; p<0·0001) and independently associated with COVID-19 status (odds ratio [OR] 2·9 [95% CI 1·5–5·8]; padjusted=0·0023) after adjusting for relevant confounders. Compared with controls, patients were more likely to have MRI evidence of lung abnormalities (p=0·0001; parenchymal abnormalities), brain abnormalities (p<0·0001; more white matter hyperintensities and regional brain volume reduction), and kidney abnormalities (p=0·014; lower medullary T1 and loss of corticomedullary differentiation), whereas cardiac and liver MRI abnormalities were similar between patients and controls. Patients with multiorgan abnormalities were older (difference in mean age 7 years [95% CI 4–10]; mean age of 59·8 years [SD 11·7] with multiorgan abnormalities vs mean age of 52·8 years [11·9] without multiorgan abnormalities; p<0·0001), more likely to have three or more comorbidities (OR 2·47 [1·32–4·82]; padjusted=0·0059), and more likely to have a more severe acute infection (acute CRP >5mg/L, OR 3·55 [1·23–11·88]; padjusted=0·025) than those without multiorgan abnormalities. Presence of lung MRI abnormalities was associated with a two-fold higher risk of chest tightness, and multiorgan MRI abnormalities were associated with severe and very severe persistent physical and mental health impairment (PHOSP-COVID symptom clusters) after hospitalisation.
Interpretation:
After hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings emphasise the need for proactive multidisciplinary care pathways, with the potential for imaging to guide surveillance frequency and therapeutic stratification
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