646 research outputs found
Transmission fiber chromatic dispersion dependence on temperature: implications on 40 Gb/s performance
In this letter we will evaluate the performance degradation of a 40 km high-speed (40 Gb/s) optical System, induced by optical fiber variations of the chromatic dispersion induced by temperature changes. The chromatic dispersion temperature sensitivity will be estimated based on the signal quality parameters
Analysis of antenal sensilla patterns of Rhodnius prolixus from Colombia and Venezuela
Antennal sensilla patterns were used to analyze population variation of domestic Rhodnius prolixus from six departments and states representing three biogeographical regions of Colombia and Venezuela. Discriminant analysis of the patterns of mechanoreceptors and of three types of chemoreceptors on the pedicel and flagellar segments showed clear differentiation between R. prolixus populations east and west of the Andean Cordillera. The distribution of thick and thin-walled trichoids on the second flagellar segment also showed correlation with latitude, but this was not seen in the patterns of other sensilla. The results of the sensilla patterns appear to be reflecting biogeographic features or population isolation rather than characters associated with different habitats and lend support to the idea that domestic R. prolixus originated in the eastern region of the Andes.Fil: Esteban, Lyda. Universidad Industrial de Santander; ColombiaFil: Angulo, VĂctor Manuel. Universidad Industrial de Santander; ColombiaFil: Dora Feliciangeli, M.. Universidad de Carabobo; VenezuelaFil: Catala, Silvia Susana. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro Regional de Investigaciones CientĂficas y Transferencia TecnolĂłgica de La Rioja. - Universidad Nacional de La Rioja. Centro Regional de Investigaciones CientĂficas y Transferencia TecnolĂłgica de La Rioja. - Universidad Nacional de Catamarca. Centro Regional de Investigaciones CientĂficas y Transferencia TecnolĂłgica de La Rioja. - SecretarĂa de Industria y MinerĂa. Servicio GeolĂłgico Minero Argentino. Centro Regional de Investigaciones CientĂficas y Transferencia TecnolĂłgica de La Rioja. - Provincia de La Rioja. Centro Regional de Investigaciones CientĂficas y Transferencia TecnolĂłgica de La Rioja; Argentin
TGF ÎČ1 and PDGF AA override Collagen type I inhibition of proliferation in human liver connective tissue cells
BACKGROUND: A marked expansion of the connective tissue population and an abnormal deposition of extracellular matrix proteins are hallmarks of chronic and acute injuries to liver tissue. Liver connective tissue cells, also called stellate cells, derived from fibrotic liver have been thoroughly characterized and correspond phenotypically to myofibroblasts. They are thought to derive from fat-storing Ito cells in the perisinusoidal space and acquire a contractile phenotype when activated by tissue injury. In the last few years it has become evident that several peptide growth factors such as PDGF AA and TGF-ÎČ are involved in the development of fibrosis by modulating myofibroblast proliferation and collagen secretion. The fact that during the development of chronic fibrosis there is concomitant deposition of collagen, a known inhibitory factor, and sustained cell proliferation, raises the possibility that stellate cells from chronic liver fibrosis patients fail to respond to normal physiologic controls. METHODS: In this study we address whether cells from fibrotic liver patients respond to normal controls of proliferation. We compared cell proliferation of primary human liver connective tissue cells (LCTC) from patients with liver fibrosis and skin fibroblasts (SF) in the presence of collagens type I and IV; TGF-ÎČ, PDGF AA and combinations of collagen type I and TGF-ÎČ or PDGF AA. RESULTS: Our results indicate that despite displaying normal contact and collagen-induced inhibition of proliferation LCTC respond more vigorously to lower concentrations of PDGF AA. In addition, we show that collagen type I synergizes with growth factors to promote mitogenesis of LCTC but not SF. CONCLUSIONS: The synergistic interaction of growth factors and extracellular matrix proteins may underlie the development of chronic liver fibrosis
Global trends in ultraprocessed food and drink product sales and their association with adult body mass index trajectories
This study evaluated global trends in ultraprocessed food and drink (UPFD) volume sales/capita and associations with adult body mass index (BMI) trajectories. Total food/drink volume sales/capita from Euromonitor for 80 countries (2002â2016) were matched to mean adult BMI from the NCD Risk Factor Collaboration (2002â2014). Products were classified as UPFD/nonâUPFD according to the NOVA classification system. Mixed models for repeated measures were used to analyse associations between UPFD volume sales/capita and adult BMI trajectories, controlling for confounding factors. The increase in UPF volume sales was highest for South and Southeast Asia (67.3%) and North Africa and the Middle East (57.6%), while for UPD, the increase was highest for South and Southeast Asia (120.0%) and Africa (70.7%). In 2016, baked goods were the biggest contributor to UPF volume sales (13.1%â44.5%), while carbonated drinks were the biggest contributor to UPD volume sales (40.2%â86.0%). For every standard deviation increase (51 kg/capita, 2002) in UPD volume sales, mean BMI increased by 0.195 kg/m2 for men (P < .001) and 0.072 kg/m2 for women (P = .003). For every standard deviation (40 kg/capita, 2002) increase in UPF volume sales, mean BMI increased by 0.316 kg/m2 for men (P < .001), while the association was not significant for women. Increases in UPFD volume sales/capita were positively associated with populationâlevel BMI trajectories
Predicting the detectability of oscillations in solar-type stars observed by Kepler
Asteroseismology of solar-type stars has an important part to play in the
exoplanet program of the NASA Kepler Mission. Precise and accurate inferences
on the stellar properties that are made possible by the seismic data allow very
tight constraints to be placed on the exoplanetary systems. Here, we outline
how to make an estimate of the detectability of solar-like oscillations in any
given Kepler target, using rough estimates of the temperature and radius, and
the Kepler apparent magnitude.Comment: 21 pages, 6 figures, accepted for publication Astrophysical Journa
Seasonal Depletion of the Dissolved Iron Reservoirs in the Sub-Antarctic zone of the Southern Atlantic Ocean
Seasonal progression of dissolved iron (DFe) concentrations in the upper water column were examined during four occupations in the Atlantic sector of the Southern Ocean. DFe inventories from euphotic and aphotic reservoirs decreased progressively from July to February, while dissolved inorganic nitrogen (DIN) decreased from July to January with no significant change between January and February. Results suggest that between July and January, DFe loss from both euphotic and aphotic reservoirs were predominantly in support of phytoplankton growth (Iron to carbon (Fe:C) uptake ratio of 16±3 ÎŒmol molâ1) highlighting the importance of the âwinter DFeâreservoirâ for biological uptake. During January to February, excess loss of DFe relative to DIN (Fe:C uptake ratio of 44±8 ÎŒmol molâ1 and aphotic DFe loss rate of 0.34±0.06 ÎŒmol mâ2 dâ1) suggests that scavenging is the dominant removal mechanism of DFe from the aphotic, while continued production is likely supported by recycled nutrients.
Plain Language Summary
Trace metal iron is one of the limiting nutrients for primary productivity in the Southern Ocean; however the relative importance of seasonal iron supply and sinks remains poorly understood, due to sparse data coverage across the seasonal cycle and lack of highâresolution dissolved iron (DFe) measurements. Here, we present four âsnapâshotsâ of DFe measurements at a single station in the southâeast Southern Atlantic Ocean (one in winter and three in late springâsummer), to address the seasonal evolution of DFe and dissolved inorganic nitrogen (DIN) concentrations within the biologically active sunlit and subsurface reservoirs. We observed a seasonal depletion of DFe inventories from JulyâFebruary, while DIN inventories decreases from JulyâJanuary with no concomitant changes between JanuaryâFebruary. This suggests that, in addition to biological uptake in the sunlit layer, the observed decrease in DFe inventories below this (relative to DIN) is driven by aggregation and incorporation of iron particles into larger "marine snow" sinking particles, while nutrient recycling is driving the observed continuation of primary productivity during late summer. Our results provide insight into seasonal change of DFe availability in different reservoirs where interplay between removal and supply processes are controlling its distributions and bioavailability to support upper surface primary production
Asteroseismology and Interferometry
Asteroseismology provides us with a unique opportunity to improve our
understanding of stellar structure and evolution. Recent developments,
including the first systematic studies of solar-like pulsators, have boosted
the impact of this field of research within Astrophysics and have led to a
significant increase in the size of the research community. In the present
paper we start by reviewing the basic observational and theoretical properties
of classical and solar-like pulsators and present results from some of the most
recent and outstanding studies of these stars. We centre our review on those
classes of pulsators for which interferometric studies are expected to provide
a significant input. We discuss current limitations to asteroseismic studies,
including difficulties in mode identification and in the accurate determination
of global parameters of pulsating stars, and, after a brief review of those
aspects of interferometry that are most relevant in this context, anticipate
how interferometric observations may contribute to overcome these limitations.
Moreover, we present results of recent pilot studies of pulsating stars
involving both asteroseismic and interferometric constraints and look into the
future, summarizing ongoing efforts concerning the development of future
instruments and satellite missions which are expected to have an impact in this
field of research.Comment: Version as published in The Astronomy and Astrophysics Review, Volume
14, Issue 3-4, pp. 217-36
EMSY links breast cancer gene 2 to the 'Royal Family'
Although the role of the breast cancer gene 2 (BRCA2) tumor suppressor gene is well established in inherited breast and ovarian carcinomas, its involvement in sporadic disease is still uncertain. The recent identification of a novel BRCA2 binding protein, EMSY, as a putative oncogene implicates the BRCA2 pathway in sporadic tumors. Furthermore, EMSY's binding to members of the 'Royal Family' of chromatin remodeling proteins may lead to a better understanding of the physiological function of BRCA2 and its role in chromatin remodeling
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