Retaining Heifers: Is It Worth It?

Replacing females in the beef cow herd plays a pivotal role in a sustainable and profitable cow-calf operation. Analyzing the cost of raising replacements versus purchasing them can help make informed decisions. If retaining replacements, cattle producers must consider both the costs and potential returns associated with raising and integrating these heifers into the breeding herd. This article offers some key financial considerations

Comparison of Two Alternate Prostaglandin Products in Yearling Beef Heifers

Yearling heifers were administered 1 of 2 alternate prostaglandin products (Lutalyse vs. Lutalyse HighCon), which differ in concentration of active ingredient and administration route. Timing of estrus, pregnancy rate to AI, and final pregnancy rate did not differ between treatments. Body weight and ADG were also not affected by prostaglandin treatment. These results indicate producers can utilize Lutalyse HighCon, administered subcutaneously (s.c.), to avoid injection site blemishes and reduce carcass discounts with no impact on estrus synchronization or pregnancy rates

Timed Insemination vs. Modified Estrus Detection in Beef Heifers

Th e objective of this study was to compare a modified estrus detection and fixed time AI vs. no estrus detection and fixed time AI on subsequent pregnancy rates. Yearling heifers were estrus synchronized and AI at 72 ± 2 h after prostaglandin injection. In one group estrus was not detected and all heifers received gonadotropin releasing hormone at the fixed- time AI; in the other group estrus was detected at 58 ± 2 and 70 ± 2 h after prostaglandin and inseminated in the following order at 72 ± 2 h: heifers in estrus at 58 h, heifers in estrus at 70 h, and heifers not appearing in estrus at either observation. Similar AI conception and final pregnancy rates were achieved without the added labor of estrus detection

Post Weaning Management of Heifer Calves Impacts ADG and Feed Efficiency as Pregnant Heifers

Replacement heifers were developed on cornstalks (Exp. 1, 2, and 3), dry lot (Exp. 1 and 2), or winter range (Exp. 3). In Exp. 1, pregnant heifers were individually fed during mid to late gestation. Heifers developed on cornstalks were more feed efficient than heifers developed in a dry lot. In Exp. 2 and 3, pregnant heifers grazed cornstalks during mid to late gestation. Heifers developed on cornstalks gained more and were more efficient, especially compared to heifers developed in a dry lot. These data provide evidence of an adaptive response to grazing low quality forages and may be beneficial in the critical period leading up to the first calving season

Growth and Performance of Terminal Sired Calves Grazing Range or Meadow Pasture

Multiparous dams were assigned to be bred by artificial insemination or natural service to bulls with terminal traits. Additionally, the cow- calf pairs grazed upland range or sub- irrigated meadow from June 1 to weaning in November. Two weeks aft er weaning, calves entered the feedlot as calffeds. Natural service range calves had the lightest weaning weights, final live weights, and hot carcass weights. Additional days on feed may be required for natural service range calves to reach similar body weights and carcass characteristics as other treatments. Average daily gain and feed conversion was improved in calves that grazed range pastures prior to feedlot entry. Estrus synchronization and artificial insemination may be an effective way to increase body weights and carcass characteristics of calves that graze range pastures prior to feedlot entry

Effect of Heifer Development System on Reproduction and Subsequent Gain as a Pregnant Heifer

Weaned heifers grazed corn residue, upland range, or were fed 1 of 2 drylot diets differing in energy. Heifer development diets did not impact their resulting AI or final pregnancy rates. Cost per pregnant heifer was similar among treatments. A subset of AI- pregnant heifers was placed in a Calan Broadbent individual feeding system during late gestation. As a pregnant heifer, feed efficiency was not impacted by development system. These results indicate producers may utilize their most readily available and/or cost- effective feed resources with no detriment to pregnancy rates or feed efficiency as first- calf heifers

Discussing Depression with Vietnamese American Patients

Background Asian patients preferentially seek mental health care from their primary care providers but are unlikely to receive it. Primary care providers need culturally-informed strategies for addressing stigmatizing illnesses. Methods 11 Vietnamese American community members participated in semi-structured interviews. Interviews were audio-taped and transcribed. The grounded theory approach was used for qualitative coding and thematic analysis. Results Vietnamese community members describe experiences with depression under four themes: (1) Stigma and face; (2) Social functioning and the role of the family; (3) Traditional healing and beliefs about medications; and (4) Language and culture. Based on this data, we offer suggestions for improving culturally-informed care for Vietnamese Americans. Disucssion Our study adds to the research aimed at improving communication and health care relationships between physicians and Vietnamese American patients. Physicians should learn to tailor their interviewing style to the increasingly diverse patient population

Genetic architecture of subcortical brain structures in 38,851 individuals

Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease

Genetic architecture of subcortical brain structures in 38,851 individuals

Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder