651 research outputs found
Personalized movies
- Author
- Publication venue
- Massachusetts Institute of Technology
- Publication date
- 01/01/1979
- Field of study
Thesis. 1979. M.S.--Massachusetts Institute of Technology. Dept. of Architecture.MICROFICHE COPY AVAILABLE IN ARCHIVES AND ROTCH.Bibliography: leaves 108-109.by Ralph J. Mayer.M.S
Impact of Sequencing Targeted Therapies With High-dose Interleukin-2 Immunotherapy: An Analysis of Outcome and Survival of Patients With Metastatic Renal Cell Carcinoma From an On-going Observational IL-2 Clinical Trial: PROCLAIM
- Author
- Agarwal Neeraj
- Agarwala Sanjiv S
- Amin Asim
- Aung Sandra
- Clark Joseph I
- Cranmer Lee D
- Curti Brendan
- Daniels Gregory A
- Dutcher Janice P
- Ernstoff Marc S
- Fishman Mayer
- Gonzalez René
- Hallmeyer Sigrun
- Hauke Ralph J
- Hua Hong
- Jeter Joanne M
- Kaufman Howard L
- Lewis Lionel D
- Lutzky Jose
- McDermott David F
- Miletello Gerald
- Milhem Mohammed M
- Morse Michael A
- Patel Sapna P
- Perritt Jessica C
- Rao Tharak B
- Richart John M
- Rudraptna Venkatesh
- Stewart John H
- Taback Bret
- Treisman Jonathan S
- Vaishampayan Ulka
- Van Veldhuizen Peter
- Wong Michael K K
- Publication venue
- Providence St. Joseph Health Digital Commons
- Publication date
- 01/02/2017
- Field of study
BACKGROUND: This analysis describes the outcome for patients who received targeted therapy (TT) prior to or following high-dose interleukin-2 (HD IL-2).
PATIENTS AND METHODS: Patients with renal cell carcinoma (n = 352) receiving HD IL-2 were enrolled in Proleukin
RESULTS: Overall, there were 4% complete response (CR), 13% partial response (PR), 39% stable disease (SD), and 43% progressive disease (PD) with HD IL-2. The median overall survival (mOS) was not reached in patients with CR, PR, or SD, and was 15.5 months in patients with PD (median follow-up, 21 months). Sixty-one patients had prior TT before HD IL-2 with an overall response rate (ORR) to HD IL-2 of 19% (1 CR, 9 PR) and an mOS of 22.1 months. One hundred forty-nine patients received TT only after HD IL-2 with an mOS of 35.5 months. One hundred forty-two patients had no TT before or after HD IL-2, and mOS was not reached. The mOS was 8.5 months in PD patients who received HD IL-2 without follow-on TT and 29.7 months in PD patients who received follow-on TT after HD IL-2.
CONCLUSIONS: HD IL-2 as sole front-line therapy, in the absence of added TT, shows extended clinical benefit (CR, PR, and SD). Patients with PD after HD IL-2 appear to benefit from follow-on TT. Patients who progressed on TT and received follow-on HD IL-2 experienced major clinical benefit. HD IL-2 therapy should be considered in eligible patients
Contemporary experience with high-dose interleukin-2 therapy and impact on survival in patients with metastatic melanoma and metastatic renal cell carcinoma
- Author
- A Hauschild
- Ajjai Alva
- Asim Amin
- B Escudier
- BI Rini
- BI Rini
- Brendan Curti
- C Robert
- C Robert
- C Robert
- C Robert
- David F. McDermott
- DF McDermott
- DY Heng
- EM Allen Van
- FD Birkhauser
- FS Hodi
- G Fyfe
- GA Daniels
- GA McArthur
- Gerald Miletello
- Gregory A. Daniels
- H Shi
- HL Kaufman
- Hong Hua
- Howard L. Kaufman
- J Larkin
- James N. Lowder
- Janice P. Dutcher
- John M. Kirkwood
- Joseph I. Clark
- K Trunzer
- KT Flaherty
- M Hanzly
- MA Morse
- MA Postow
- Mayer Fishman
- MB Atkins
- Michael A. Morse
- Michael K. K. Wong
- Neeraj Agarwal
- O Hamid
- R Payne
- R Siegel
- Ralph J. Hauke
- Rene Gonzalez
- RI Fisher
- RJ Motzer
- RJ Motzer
- Sandra Aung
- Sanjiv S. Agarwala
- SL Topalian
- Theodore F. Logan
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
AI is a viable alternative to high throughput screening: a 318-target study
- Author
- Abaffy Tatjana
- Abraham Elena Theres
- Abrahão Jônatas Santos
- Abramyan Tigran M.
- Agianian Bogos
- Agogo-Mawuli Percy
- Agoulnik Alexander I.
- Agrawal Rajendra K.
- Aguilera Elena
- Ahmed Mostafa
- Akk Gustav
- Akopian Tatos
- Al-Yozbaki Minnatallah
- Aldhamen Yasser Ali
- Alkan Cigdem
- Alramadhani Dina
- Alteen Matthew G.
- Alvarez Guzmán
- Ammendola Serena
- Anastasio Noelle C.
- Anderson Brandon M.
- Anderson Deborah H.
- Andricopulo Adriano D.
- Angell Richard M.
- Anthis Nicholas J.
- Antonelli Lorenzo
- Apfel Athena Marie
- Arias Juan Antonio Sanchez
- Arozarena Imanol
- Arrigoni Cristina
- Artía Zoraima
- Ashkar Shireen R.
- Ashton Mark R.
- Austin Richard C.
- Ayachi Aicha Gharbi
- Azeem Syeda Maryam
- Bailey-Elkin Ben A.
- Balakrishnan Bijina
- Balaña-Fouce Rafael
- Ballatore Carlo
- Banerjee Sourav
- Banerji Versha
- Banjo Toshihiro
- Barghash Marim M.
- Batey Robert A.
- Battistoni Andrea
- Baumann Ulrich
- Bdira Fredj Ben
- Bedi Mel
- Ben-Johny Manu
- Bergman Bastiaan
- Bernard Denzil
- Berti Andrew
- Bharambe Nikhil
- Bishop Ozlem Tastan
- Blanchet Xavier
- Blelloch Robert
- Blumenthal Robert M.
- Bognár Gabriella
- Bogomolovas Julijus
- Bon Carlotta
- Boorman Jacob
- Borowska Anna
- Borriello Francesco
- Bowman Gregory R.
- Bradley Robert K.
- Bradshaw William J.
- Brady-Kalnay Susann M.
- Breton Hairol E.
- Bruning John B.
- Bruning John Burt
- Bryant-Friedrich Amanda
- Buckner Frederick S.
- Buroni Silvia
- Butler Brittany
- Byrne Lee J.
- Byun Soo Young
- Caflisch Amedeo
- Cakir Isin
- Caliandro Ileana
- Caljon Guy
- Cann Andrew B.
- Caporali Andrea
- Capuzzi Stephen J.
- Caroleo Maria Cristina
- Cathcart Ann M.
- Celano Stephanie L.
- Cerna Mark Vincent C. dela
- Chadni Somaia Haque
- Champion Matthew M.
- Chan Nei-Li
- Chapman Carly J.
- Chaton Catherine T.
- Chatterjee Arnab K.
- Chaudhuri Dipayan
- Chauhan Shefali
- Chaytow Helena
- Chen Daniel
- Chen Lifeng
- Chen Yicheng
- Chern Ting-Rong
- Chini Andrea
- Chou Tristan
- Chou Tsui-Fen
- Christensen Emily M.
- Christodoulides Myron
- Chu Shaoyou
- Chua Benjamin Soon Kai
- Chuah Janelle
- Chung Zara
- Chuong Patrick
- Ciccia Alberto
- Cildir Gökhan
- Cione Erika
- Clayton W. Brent
- Coles John G.
- Colomba Audrey
- Colotti Gianni
- Conn Graeme L.
- Conticello Silvestro G.
- Contreras Stephanie
- Cools Julie
- Coombe Deirdre R.
- Corson Timothy W.
- Cortopassi Gino
- Corvo Ileana
- Costoya Jose A.
- Cowen Leah E.
- Cox Bryan D.
- Cuddihy Andrew R.
- Cullinane Ryan T.
- Cunningham Kathryn A.
- D'Antuono Anna
- Dahal Gopal
- Dallman Sydney
- Dame Remus T.
- Davtyan Aram
- De Keulenaer Gilles
- De Luise Monica
- de Oliveira Aldo Sena
- de Oliveira Saulo
- de Sousa Alessandra Mara
- de Souza Guilherme Eduardo
- Debonsi Hosana Maria
- Degterev Alexei
- DeHaan Nicholas
- Del Rio Flores Antonio
- Dempsey Garrett
- Desai Umesh R.
- Diallo Bakary N'tji
- Dickhout Jeffrey
- Dickinson Bryan C.
- Dieck Chelsea L.
- Dirksen Dorian
- do Monte-Neto Rubens Lima
- Dolce Vincenza
- Donaldson William A.
- Douville Renée N.
- Dowling David J.
- Drewry David H.
- Duggan Brendan M.
- Duncan Dustin
- Dymock Brian W.
- Dzhumaev Sergei
- Ebright Richard H.
- Eckert Sam
- Edelman Benjamin L.
- Eitzen Gary
- ElSheikh Assmaa
- Englinger Bernhard
- Escaffre Olivier
- Espinoza Stefano
- Evans Jay D.
- Faller Kiterie M. E.
- Fan Erkang
- Fan Hua-Ying
- Fathallah M. Dahmani
- Feng Hui
- Ferrando Adolfo A.
- Ferraris Davide Maria
- Ferreira Jacob
- Ferreira Rafaela Salgado
- Fiermonte Giuseppe
- Finkelstein Joshua M.
- Fiorillo Annarita
- Fish Paul V.
- Foong Wuen Ee
- Foote Andrea Talbot
- Francisco Karol R.
- Frangos Zachary J.
- Fraser Cameron
- Freiberg Alexander N.
- Freywald Andrew
- Friedland Greg
- Fries Jacob
- Gadar Kavita
- Gandhi Neha S.
- Garaeva Alisa A.
- Garavaglia Silvia
- Garcia George A.
- García-Cuesta Eva M.
- Garmendia Antonio E.
- Gasparre Giuseppe
- Gavathiotis Evripidis
- Gebauer Jan M.
- Geden Sandra E.
- Geisbrecht Brian V.
- Gelardi Edoardo Luigi Maria
- Gerwick William H.
- Ghilarducci Kim
- Ghosh Agnidipta
- Giardini Miriam A.
- Gierse Robin Matthias
- Giesler Kyle
- Giles Ellie
- Gillingwater Thomas H.
- Gingras Alexandre R.
- Giorgis Marta
- Girolimetti Giulia
- Glubb Dylan M.
- Glukhov Evgenia
- Gniewek Pawel
- Goldenberg Joshua M.
- Gong Bin
- Gorgoglione Ruggiero
- Granneman James G.
- Greene Geoffrey L.
- Greig Iain R.
- Gruber Joshua J.
- Guido Rafael V. C.
- Gumede Njabulo Joyfull
- Gunasekharan Vignesh
- Gupta Tushita
- Gupta Yogesh K.
- Gustincich Stefano
- Haas Arthur L.
- Hahn William C.
- Haikarainen Teemu
- Hammock Bruce D.
- Hannink Mark
- Hansen Kasper B.
- Hare Stephanie
- Harijan Rajesh K.
- Haupt Larisa M.
- He Yuan
- Hedstrom Lizbeth
- Hedstrom Lizbeth
- Heifets Abraham
- Henriksen Niel
- Herdendorf Timothy J.
- Hermle Tobias
- Herr Andrew B.
- Hickey Robert J.
- Hildeman David A.
- Hirsch Anna K. H.
- Ho Gregory
- Hopkins Kevin M.
- Hoppe Heinrich
- Horstmann Nicola
- Hosfield David J.
- Hossain Sakib
- Houry Walid A.
- Hsiao Edward C.
- Hu Di
- Hu Yanmei
- Huang Chang
- Huimei Chen
- Hussain Muhammad Saddam
- Iglesias Pablo
- Ikegami Tetsuro
- Ilari Andrea
- Inde Zintis
- Ingoglia Filippo
- Iommarini Luisa
- Ip Philbert
- Jackson Michael R.
- Jafar-Nejad Hamed
- Jayasinghe Thilina D.
- Jo Eunji
- Johannsen Sandra
- John Ashley L. St.
- Jones Peter L.
- Jossart Jennifer N.
- Jung Hoyoung
- Kahler Charlene M.
- Kampourakis Thomas
- Kandror Olga
- Karan Charles
- Katyal Sachin
- Kee Jung-Min
- Kee Jung-Min
- Keedy Daniel A.
- Kejriwal Rishabh
- Keller Charles
- Kelm Robert J.
- Kemet Chinyere Maat
- Kenyon Victor
- Kerr William G.
- Khalaf Noureddine Ben
- Kilkenny Mairi Louise
- Kim Hyeong Jun
- Kim Kyu Kwang
- Kootstra Neeltje A.
- Koppisetti Rama K.
- Korotkov Konstantin V.
- Kotzé Timothy J.
- Kováts Benjámin
- Kratz Jadel Müller
- Krishnamurthy Durga
- Krist David T.
- Kroon Erna Geessien
- Kushnir Alexander
- Kwiatkowski Jacek
- Laggner Christian
- Lai Kent
- Lake Robert J.
- Lam Andrew
- Lama Eleonora
- Lan Tong
- Landfear Scott M.
- Lasarte Juan José
- Lawrence Daniel A.
- Lee Andreia H.
- Lee Donghan
- Lee Gyeongeun
- Lee Jiyoun
- Lee Kyung Hyeon
- Lee Pil H.
- Legare Scott
- Lehtiö Lari
- Lembo Gaia
- Lempicki Camille
- Lenci Elena
- Leng Fenfei
- Lescar Julien
- Leung Elisa
- Leuzzi Giuseppe
- Levin Michael
- Li Hai
- Li Shan
- Li Wei
- Li Yihe
- Li Yong
- Li Yunlong
- Liao Jiayu
- Liao Junzhuo
- Lieberman Howard B.
- Lin Jiabei
- Lin Jiusheng
- Liou Benjamin
- Lisabeth Erika Mathes
- Liu Chen
- Liu Koting
- Liu Pengda
- Liu Pengda
- Liu Zhongle
- Lobb Kevin A.
- Lolicato Marco
- Lolli Marco Lucio
- Longo Nicola
- Lotsaris Irina
- Lowther W. Todd
- Loy Cody A.
- Lu Xin
- Luh Frank
- Lukacs Gergely L.
- Luo Dahai
- Lussier Marc P.
- Lynn Edward G.
- Machaca Khaled
- Maciag Joseph J.
- Macias Maria J.
- MacKeigan Jeffrey P.
- Mahmoodi Niusha
- Maksimainen Mirko M.
- Malkas Linda H.
- Maltarollo Vinícius Gonçalves
- Mameli Eleonora
- Manor Danny
- Mantri Chinmay Kumar
- Maranda Vincent
- Martin Katie R.
- Martin-Malpartida Pau
- Maruta Shinsaku
- Marx Steven O.
- Mason Emily R.
- Matheeussen An
- Matovic Nick
- Mattevi Andrea
- Maurice Martin St.
- Mayer Gaétan
- Maynes Jason T.
- Mazitschek Ralph
- McCarthy Ronan R.
- McDowell Mary Ann
- McManus Kirk James
- Mehedi Masfique
- Mehlman Tamar
- Mellado Mario
- Mellor Paul
- Merrill Nathan M.
- Michlewski Gracjan
- Milosavljevic Julian
- Minakova Anna
- Miner Jaden
- Moharreri Ehsan
- Molyneaux Kathleen A.
- Montanaro Anna
- Moore Hannah P.
- Moore Richard G.
- Moreda Teresa Lozano
- Moreira David
- Moreira Paulo Otávio Lourenço
- Morisseau Christophe
- Morrison Adrian
- Morten Brianna C.
- Mostert Konrad J.
- Mota Bruno Eduardo Fernandes
- Motyl Anna A. L.
- Mousa Jarrod J.
- Mowat Michael
- Muli Christine S.
- Mungrue Imran N.
- Mushtaq Aisha
- Musta Kirsikka
- Müller Anna
- Müller Christa E.
- Myhr Courtney
- Mysinger Michael
- Mysore Venkatesh
- Nagai Maira Harume
- Nagamori Kiyo
- Namasivayam Vigneshwaran
- Nasburg Joshua Alexander
- Ng Ho Leung
- Ng James
- Ngo Lien
- Ngoi Peter
- Nguyen Kong
- Novina Carl D.
- null null
- O'Brien Terrence E.
- O'Connell Patrick
- O'Dea Austin
- O'Donoghue Anthony J.
- O'Mara Megan L.
- O'Mara Tracy A.
- O'Meara Timothy R.
- O'Sullivan Ann Marie
- Ogunwa Tomisin Happy
- Ojha Anil K.
- Ojo Kayode K.
- Olson Steven H.
- Ortiz Diana
- Oyarzabal Julen
- Pai Vaibhav P.
- Paige Mikell
- Palazzo Teresa
- Panganiban Antonito T.
- Paparella Ashleigh S.
- Parang Keykavous
- Parico Gian Carlo G.
- Park Soonju
- Partch Carrie L.
- Pascal John M.
- Pasquali Marzia
- Patel Amit K.
- Paulino Cristina
- Pederick Jordan L.
- Peltier Cheryl
- Pemberton Ryan P.
- Perry Benjamin
- Perry J. Jefferson P.
- Petretto Enrico
- Pérez-Pertejo Yolanda
- Phadke Sameer
- Pham Kien
- Pineda-Lucena Antonio
- Poirier Steve
- Popowicz Grzegorz Maria
- Porcelli Anna Maria
- PrasadPrasad Srimukh Veccham Krishna
- Presser Adam G.
- Pressly Brandon
- Prikler Gergely
- Prince Ashutosh
- Puchades-Carrasco Leonor
- Pusztai Lajos
- Qi Xin
- Qin Xingping
- Qureshi Insaf Ahmed
- Rabal Obdulia
- Radhakrishnan Senthil K.
- Ramachandran Rajesh
- Randall Lía M.
- Rangarajan Amith Vikram
- Rayman Joseph B.
- Reglero Clara
- Reguera Rosa Maria
- Reidenbach Andrew G.
- Reis Joana
- Ribeiro Beatriz Murta Rezende Moraes
- Richardson Timothy I.
- Riches David W. H.
- Rizzi Menico
- Robinson Victoria L.
- Rocha Rafael Eduardo Oliveira
- Rodriguez G. Marcela
- Rodríguez-Frade José Miguel
- Rohde Kyle H.
- Ronchi Virginia Paola
- Ronning Donald R.
- Rosnik Andreana
- Roti Giovanni
- Rouzbeh Nirvan
- Rowswell-Turner Rachael B.
- Rubin Eric J.
- Rucinski Gwennan
- Safo Martin K.
- Sainas Stefano
- Salas Brenda P. Medellin
- Samantha Ariela
- Samudio Ben
- Santiago César
- Sarangapani Krishna
- Sarilla Suryakala
- Sarosiek Kristopher
- Schneider Nicholas O.
- Schroedl Stefan
- Scoffone Viola Camilla
- Segers Vincent F. M.
- Seo Seung-Yong
- Serafim Mateus Sá Magalhães
- Shaqra Ala M.
- Shek Stefani
- Shelburne Samuel A.
- Shim Heesung
- Shorter James
- Shoue Douglas A.
- Shum David
- Shyng Show-Ling
- Siderovski David P.
- Sidorova Yulia A.
- Silva Elany Barbosa
- Silvennoinen Olli
- Singh Nathanael
- Singh Neeraj
- Singh Rakesh K.
- Siqueira-Neto Jair L.
- Sishtla Kamakshi
- Sistla Jyothi C.
- Skorodinsky Maxim
- Slotboom Dirk J.
- Smith David M.
- Smith Kristiana S.
- Smrcka Alan V.
- So Jonathan
- Sobrado Pablo
- Soellner Matthew B.
- Solano Roberto
- Sorenson Jon M.
- Stafford Kate
- Stahl Andreas
- Statsyuk Alexander V.
- Stec Natalia
- Stecula Adrian
- Stetefeld Joerg
- Strauss Erick
- Stuchbury Grant David
- Su Leila
- Su Tong
- Su Zhengchen
- Sugamori Kim S.
- Sun Ying
- Suterwala Shabbir
- Svensson Fredrik
- Sverzhinsky Aleksandr
- Swart Tarryn
- Taglialatela Angelo
- Tam Heng-Keat
- Tandon Vasudha
- Tang Weiping
- Tang Young
- Tanner John J.
- Taylor Richard E.
- Teixeira Thaiz Rodrigues
- Teramoto Tadahisa
- Thai Van Chi
- Thayer Desiree
- Thomas Bill
- Thompson Erik W.
- Tilford Hannah
- Tiwari Rakesh Kumar
- Toh Alan Kie Leong
- Tomilov Alexey
- Toogood Peter
- Torner Carles
- Trabocchi Andrea
- Trader Darci J.
- Trakhtenberg Ephraim F.
- Trinh Nguyen Mai
- Truong Ha
- Tse-Dinh Yuk-Ching
- Tsimbalyuk Sofiya
- Tumes Damon J.
- Tye Mark A.
- Uribe Ruben Vazquez
- Valli Marilia
- van den Akker Focco
- van den Bedem Henry
- Van Doren Steven R.
- Van Grack Tessa
- Van Hung Le Vuong
- Van Pelt Natascha
- Van Remmen Holly
- Van Voorhis Wesley C.
- Vandenberg Robert J.
- Veit Guido
- Verhamme Ingrid M.
- Verma Rajkumar
- Viola Ronald E.
- Virtanen Anniina
- Vizeacoumar Franco J.
- Vizeacoumar Frederick S.
- Vleminckx Margot
- von Hundelshausen Philipp
- Voss Jan Hendrik
- Vrielink Alice
- Waggoner Stephen N.
- Walensky Loren D.
- Wallach Izhar
- Wang Feng
- Wang Jianghai
- Wang Jun
- Wang Xingyou
- Wang Zhenghe
- Warrington Jeffrey M.
- Watkins Joshua
- Wazir Sarah
- Weber Christian
- Welsbie Derek S.
- Wentworth Kelly L.
- Wert-Lamas Leon
- White Andrew
- White Simon J.
- Whitesell Luke
- Williams Tiffany
- Wilson Cornelia M.
- Wilson Mark A.
- Windisch Marc P.
- Wong Keith S.
- Woods Virgil A.
- Worley Brad
- Wu Pengpeng
- Wu Xiaoyang
- Wulff Heike
- Xiang Fei
- Xu Hongyang
- Xu Jiake
- Xu Jingyi
- Xu Sophia Q.
- Xu Xin
- Yan Riqiang
- Yang Chao-Yie
- Yen Yun
- Young Matthew A.
- Yu Fang
- Yu Xinfang
- Yuan Haynes
- Yuan Xinrui
- Zahler Stefan
- Zeina Christina M.
- Zelinskaya Natalia
- Zhang Dingqiang
- Zhang Gang
- Zhang Wenjun
- Zhang Xu
- Zhang Yan Jessie
- Zhang Zhiguo
- Zhao Jinshi
- Zhou Han
- Zhou Hui
- Zhou Jia
- Zhou Pei
- Zhou Shan
- Zhu Jiaqi
- Zhu Siran
- Zhu Yini
- Zhuo Ling
- Zochodne Douglas William
- Publication venue
- Publication date
- 01/01/2024
- Field of study
: High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNet® model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. Our empirical results suggest that computational methods can substantially replace HTS as the first step of small-molecule drug discovery
The Changing Landscape for Stroke\ua0Prevention in AF: Findings From the GLORIA-AF Registry Phase 2
- Author
- Abban Dzifa
- Abdul Nasser
- Abelson Mark
- Ackermann Alan
- Adams Fran
- Adams Luthando
- Adrag\ue3o Pedro
- Ageno Walter
- Aggarwal Rajesh
- Agosti Sergio
- Aguilar Linares Julio Alberto
- Aguilar Francisco
- Aguinaga Luis
- Ahmad Zia
- Ainsworth Paul
- Al Dallow Raed
- Al Ghalayini Kamal
- Al Ismail Saad
- Al Joundi Tammam
- Al Mahameed Soufian
- Al Obaidi Mohamed
- Al Zoebi Ayham
- Alasfar Abdelfatah
- Alawwa Abdul
- Alderson Lisa
- Alexopoulos Dimitrios
- Ali Abdullah
- Ali Malik
- Aliyar Pareed
- Almassi Hossein
- Almuti Khalid
- Alshehri Mohamed
- Altmann Ute
- Alves Alvaro Rabelo
- Amara Walid
- Amelot Mathieu
- Amjadi Nima
- Ammirati Fabrizio
- Andrawis Nabil
- Angela Koh Su Mei
- Angoulvant Denis
- Annoni Giorgio
- Ansalone Gerardo
- Antonescu Sorin Alexandru
- Ariani Mehrdad
- Arias Juan Carlos
- Armero S\ue9bastien
- Arora Chander
- Arora Rohit
- Ashcraft William
- Aslam M. Shakil
- Astesiano Alfredo
- Audouin Philippe
- Augenbraun Charles
- Aydin S.
- Azar Rabih
- Azim Abul
- Aziz Shahid
- B\uf8hmer Ellen
- Backes Luciano Marcelo
- Baig Mirza
- Bains Suchdeep
- Bakbak Asaad
- Baker Seth
- Bakhtiar Karim
- Bala Richard
- Banayan Jonathan
- Bandh Stellan
- Bando Shigenobu
- Banerjee Subhash
- Bank Alan
- Bar\uf3n Gonzalo
- Barbarash Olga
- Barr Craig
- Barrera Carlos
- Bartels Dorothee B.
- Barton John
- Baula Giovanni
- Bayeh Hamid
- Bazargani Nooshin
- Behrens Steffen
- Bell Alan
- Benezet Mazuecos Juan
- Benhalima Bouziane
- Berdagu\ue9 Philippe
- Berg van den B. J.
- Bergen van P. F. M. M.
- Berngard Edvard
- Bernstein Richard
- Berrospi Percy
- Berti Sergio
- Bertomeu Vicente
- Berz Andrea
- Bettencourt Paulo
- Betzu Robert
- Beyer Westendorf Jan
- Bhagwat Ravi
- Black Toby
- Blanco Ibaceta Jorge Hugo
- Bloom Stephen
- Blumberg Edwin
- Bo Mario
- Bockisch Valerie
- Bongiorni Maria Grazia
- Boriani Giuseppe
- Borret Mariano Ruiz
- Bosch Ralph
- Boswijk D. J.
- Bott Jochen
- Bottacchi Edo
- Brandes Axel
- Bratland Bj\uf8rn
- Brautigam Donald
- Breton Nicolas
- Briones Ignacio Rodriguez
- Brkljacic Diana Delic
- Brouwers P. J. A. M.
- Browne Kevin
- Bruguera Jordi
- Brunehaut Myriam
- Brunschwig Claude
- Bryan Yan Ping Yen
- Buathier Herv\ue9
- Buenostro Gabriel Contreras
- Buhl Aur\ue9lie
- Bullinga John
- Butcher Kenneth
- Cabrera Honorio Jose Walter
- Caccavo Alberto
- Cadinot Didier
- Cai Shanglang
- Caiedo Carolina Guevara
- Calin Podoleanu Cristian Gheorghe
- Calvi Valeria
- Camm John
- Candeias Rui
- Cao Phai G\ue9rald Phan
- Capo James
- Capucci Alessandro
- Cardoso Juliano Novaes
- Carlson Brian
- Carvalho Paula
- Cary Susanna
- Casanova Rene
- Casu Gavino
- Cattan Simon
- Cavallini Claudio
- Cayla Guillaume
- Cha Kwang Soo
- Cha Tae Joon
- Chaaban Said
- Chae Jei Keon
- Challappa Krishnan
- Chand Sunil
- Chandrashekar Harinath
- Chang Mark
- Charbel Paul
- Chartier Ludovic
- Chatterjee Kausik
- Cheema Aamir
- Chen Shih Ann
- Chevallereau Pierre
- Chiang Fu Tien
- Chiarella Francesco
- Chih Chan Lin
- Cho Yong Keun
- Choi Dong Ju
- Chouinard Guy
- Chow Hoi Fan
- Chreih Rami Mihail
- Chrysos Dimitrios
- Chumakova Galina
- Cieza Lara Tomas
- Ciobotaru Vlad
- Cislowski David
- Citerne Olivier
- Claus Matthias
- Clay Anthony
- Clifford Piers
- Cocina Emilio Gonzalez
- Cohen Andrew
- Cohen Serge
- Colivicchi Furio
- Collins R\uf3n\ue1n
- Compton Steve
- Connors Sean
- Conti Alberto
- Coodley Gregg
- Cooper Martin
- Corbett Lynn
- Corey Oran
- Coronel Juli\ue1n
- Corrigan John
- Cotrina Pereyra Rosa Ysabel
- Cottin Yves
- Coutu Benoit
- Cracan Aurel
- Crean Peter
- Crenshaw James
- Crijns H. J. G. M.
- Crump Charles
- Cucher Fred
- Cudmore David
- Cui Lianqun
- Culp John
- D'Souza Anthony
- Daniel Oh Chia Theng
- Danny Null
- Darius Harald
- Dary Patrick
- Dascotte Olivier
- Dauber Ira
- Davee Thomas
- Davies Ruth
- Davis Gershan
- Davy Jean Marc
- Dayer Mark
- De La Briolle Axel
- de Los Rios Ibarra Manuel Odin
- de Mora Manuel
- de Souza Olga Ferreira
- De Teresa Eduardo
- De Wolf Luc
- Decoulx Eric
- Deepak Sasalu
- Defaye Pascal
- Del Carpio Munoz Freddy
- Deluche Laurent
- Destrac Sylvain
- Deumite N. Joseph
- Di Legge Silvia
- Dibon Olivier
- Diemberger Igor
- Diener Hans Christoph
- Dillinger Jean
- Dion\uedsio Pedro
- Dotani Imran
- Dotcheva Elena
- Duarte Vera Yan Carlos
- Dubner Sergio J.
- Dubrey Simon
- Ducrocq Xavier
- Dupljakov Dmitry
- Duthinh Vuong
- Dutra Oscar Pereira
- Dutta Dipankar
- Duvilla Nathalie
- Dy Johnny
- Dziewas Rainer
- Eaton Charles
- Eaves William
- Ebinger Matthew
- Eck van J. W. M.
- Edwards Tim
- Egocheaga Isabel
- Ehrlich Clifford
- Eisenberg Steven
- El Hallak Abdel
- El Hamdani Mehiar
- El Jabali Adnan
- El Mahmoud Rami
- El Sayed Hassan
- El Shahawy Mahfouz
- Eldadah Zayd
- Elghelbazouri Fouad
- Elhag Omar
- Elias Darlene
- Ellery Adam
- Elsaesser Amelie
- Elvan A.
- Erickson Bernard
- Espaliat Eric
- Essandoh Louis
- Everington Tamara
- Evonich Rudolph
- Ezhov Andrey
- F\ue1cila Lorenzo
- Farsad Ramin
- Fayard Maxime
- Fedele Francesco
- Ferreira Daniel
- Ferrier Anna
- Finsen Alexandra
- First Brian
- Fisher Raymond
- Floyd John
- Folk Thomas
- Fonseca Catarina
- Fonseca Luisa
- Fonteles Ritt Luiz Eduardo
- Forman Steven
- Forsgren Magnus
- Foster Malcolm
- Foster Nathan
- Frais Michael
- Frandsen Brad
- Frapp\ue9 Thierry
- Freixa Ramon
- French William
- Freydlin Marina
- Frickel Siegfried
- Fruntelata Ana Gabriela
- Fujii Shigeru
- Fujino Yusuke
- Fukunaga Hiroshi
- Furukawa Yutaka
- G\uf6tte Andreas
- Gabelmann Matthias
- Gabris Michael
- Gadsb\uf8ll Niels
- Galin Pavel
- Galinier Michel
- Ganim Ricky
- Garcia Ronnie
- Gartenlaub Olivier
- Genz Conrad
- Georger Fr\ue9d\ue9ric
- Georges Jean Louis
- Georgeson Steven
- Ghanbasha Ali
- Giedrimas Evaldas
- Gierba Mariusz
- Gillespie Eve
- Giniger Alberto
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- Gniot Jacek
- Goethals Peter
- Goldberg Ronald
- Goldmann Britta
- Goldscher David
- Golitsyn Sergey
- Gomes Ferreira Luis Gustavo
- Gomez Lopez Efrain Alonso
- Gomez Mesa Juan Esteban
- Gonzalez Efrain
- Gorbunov Vladimir
- Gordon Brian
- Gorka Herv\ue9
- Gornick Charles
- Gorog Diana
- Goss Franz
- Goube Pascal
- Goudevenos Ioannis
- Goulden Dudley
- Gr\uf6nefeld Gerian
- Graham Brett
- Grande Angel
- Greco Cesare
- Green Martin
- Greer Gerald
- Gremmler Uwe
- Grena Paul
- Grinshstein Yuriy
- Grond Martin
- Gronda Edoardo
- Grondin Francois
- Groot de J. R.
- Guardigli Gabriele
- Guarnieri Thomas
- Guignier Alexandre
- Gulizia Michele
- Gumbley Michael
- Gupta Dhiraj
- Hack Terrence
- Haerer Winfried
- Hakas Joseph
- Hall Christian
- Halperin Jonathan L.
- Hampsey James
- Hananis Georgios
- Hanbali Basel
- Handel Franklin
- Hargrove Joe
- Hargroves David
- Harris Kenneth
- Hartley David
- Haruna Tetsuya
- Hata Yoshiki
- Hayek Emil
- Healey Jeff
- Hearne Steven
- Heggelund Geir
- Hemels M. E. W.
- Hemery Yann
- Henein Sam
- Henz Benhur
- Her Sung Ho
- Hermany Paul
- Hern\ue1ndez Norberto Matadamas
- Hernandes Mauro Esteves
- Higashino Yorihiko
- Hill Michael
- Hisadome Tetsuo
- Hishida Eiji
- Hitchcock James
- Hoffer Etienne
- Hoghton Matthew
- Holmes Clare
- Hong Suk Keun
- Houppe Nousse Marie Paule
- Howard Victor
- Hsu Li Fern
- Huang Chi Hung
- Huckins David
- Huehnergarth Kier
- Huisman Menno V
- Huizenga A.
- Huntley Richard
- Hussein Gamal
- Hwang Gyo Seung
- Igbokidi Oyidie
- Iglesias Ignacio
- Ikpoh Margaret
- Imberti Davide
- Ince H\ufcseyin
- Indolfi Ciro
- Ionova Tatiana
- Ip John
- Irles Didier
- Iseki Harukazu
- Ismail Younus
- Israel Noah
- Isserman Steven
- Iteld Bruce
- Ivanchura Galina
- Iyer Ramakrishnan
- Iyer Venkat
- Iza Villanueva Ruben Omar
- J\ue4ger Frank
- Jackson Voyzey Ewart
- Jaffrani Naseem
- Jain Manish
- James Martin
- Jamon Yann
- Jang Sung Won
- Jarmukli Nabil
- Jeanfreau Robert
- Jenkins Ronald
- Jiang Heng
- Jiang Nan
- Jiang Tiemin
- Jiang Xianyan
- Jimenez Javier
- Jobe Robert
- Joffe Ian
- Johansson Bengt
- Jones Nick
- Jos\ue9 Roberto Chuquiure Valenzuela Eduardo Juli\ue1n
- Jouve Bernard
- Juanatey Carlos Gonzalez
- Jundi Mayar
- Jung Byung Chun
- Jung Kyung Tae
- Jung Werner
- K\uf6hrmann Martin
- K\ufcmler Thomas
- K\ufcppers Achim
- Kabbani Samer
- Kabour Ameer
- Kafkala Chrystalenia
- Kajiwara Koji
- Kalan Marica Bracic
- Kalinina Larisa
- Kampus Priit
- Kanda Junji
- Kapadia Shaival
- Karim Amin
- Karolyi Laszlo
- Kashou Hisham
- Kastrup Andreas
- Katsivas Apostolos
- Kaufman Elizabeth
- Kawai Kazuya
- Kawajiri Kenji
- Kazmierski John
- Keeling Phil
- Kerfes Galal Ali
- Kerr Saraiva Jos\ue9 Francisco
- Kes Vanja Basic
- Ketova Galina
- Khaira Ajit
- Khalid Muhammad
- Khludeeva Elena
- Khripun Aleksey
- Kim Dae Kyeong
- Kim Doo Il
- Kim Jeong Su
- Kim Jin bae
- Kim June Soo
- Kim Ki Seok
- Kim Nam Ho
- Kim Young Hoon
- Kinova Elena
- Klein Alexander
- Kleinschnitz Christoph
- Kmetzo James
- Kneller G. Larsen
- Knezevic Aleksandar
- Koch Stanley
- Koenig Kai
- Koons Jay
- Korabathina Ravikiran
- Korennova Olga
- Koschutnik Martin
- Kosinski Edward
- Kovacic Dragan
- Kowalczyk Jacek
- Koziolova Natalya
- Kragten J. A.
- Krause Lars Udo
- Kreidieh Imad
- Krenning B. J.
- Krishnaswamy Kannappan
- Krysiak Waldemar
- Kuck Karl Heinz
- Kumar Somnath
- Kuniss Malte
- Kuo Jen Yuan
- Kurrelmeyer Karla
- Kwan Tak
- Kyo Eisho
- L\uf3pez Send\uf3n Jos\ue9
- Labovitz Arthur
- Lacroix Alain
- Lam Andy
- Lanas Zanetti Fernando Tomas
- Landau Charles
- Landini Giancarlo
- Lang Wilfried
- Larsen Torben Bjerregaard
- Laske Volker
- Lavandier Karine
- Law Nicki
- Lawrence Wong Ka Sing
- Lee Daniel
- Lee Moon Hyoung
- Leit\ue3o Ana
- Lejay Dominique
- Lelonek Malgorzata
- Lenarczyk Radoslaw
- Leprince Patrick
- Lequeux Benoit
- Leschke Matthias
- Ley Nicolas
- Li Weihua
- Li Xiaodong
- Li Yansheng
- Li Zhanquan
- Li Zicheng
- Liang Jianqiu
- Lieber Ira
- Lillestol Michael
- Limon Rodriguez Ramon Horacio
- Lin Hailong
- Lip Gregory
- Lip Gregory Y. H.
- Litchfield Jennifer
- Liu Feng
- Liu Wenhui
- Liu Xuebo
- Liu Yalin
- Liu Zhitao
- Llamas Esperon Guillermo Antonio
- Llisterri Jose Luis
- Lo Eric
- Lo Ted
- Lobos Jose Maria
- Lodde Bernhard Paul
- Loiselet Philippe
- Lorga Filho Adalberto Menezes
- Lori Ido
- Luo Ming
- Lupovitch Steven
- Lyrer Philippe
- M\ufcgge Andreas
- Ma Chang Sheng
- Ma Changsheng
- Ma Genshan
- Ma Hong
- Madariaga Irene
- Maeno Koji
- Magnin Dominique
- Mahmood Shahid
- Mahood Karen
- Maid Gustavo
- Mainigi Sumeet
- Makaritsis Konstantinos
- Maldonado Villalon Jos\ue9 Arturo
- Malhotra Rohit
- Malik Amir
- Mallecourt Catherine
- Mallik Rajiv
- Manning Rickey
- Manolis Athanasios
- Mantas Ioannis
- Manzur Jattin Fernando Gabriel
- Mar\uedn Francisco
- Marcionni Niccolo'
- Marin Javier Aguila
- Martinez Jorge
- Martinez Luis
- Maskova Petra
- Matskeplishvili Simon
- Matsuda Katsuhiro
- Mavri Alenka
- May Erik
- Mayer Nolan
- Mazon Pilar
- Mcclure John
- Mccormack Terry
- Mcgarity William
- Mcguire Michael
- Mcintyre Hugh
- Mclaughlin Paul
- Mclaurin Brent
- Medina Palomino Feliz Alvaro
- Mehta Paresh
- Mehzad Reza
- Meinel Andreas
- Melandri Francesco
- Mena Amparo
- Meno Hirosi
- Menzies Dhananjai
- Metcalf Kneale
- Meyer Beat
- Miarka Jacek
- Mibach Frank
- Michalski Dominik
- Michel Patrik
- Mikdadi Ghiath
- Mikhail Magdy
- Mikus Milan
- Milicic Davor
- Militaru Constantin
- Miller Gary
- Milonas Christos
- Minescu Bogdan
- Mintale Iveta
- Miralles Aur\ue9lien
- Mirault Tristan
- Mistry Dinesh
- Mitchell George
- Miu Nicoleta Violeta
- Miyamoto Naomasa
- Moccetti Tiziano
- Mohammed Akber
- Molina de Salazar Dora Ines
- Molon Giulio
- Molony David
- Mondillo Sergio
- Mont Lluis
- Moodley Rajendra
- Moore Roger
- Morales Oscar Saenz
- Mori Kiyoo
- Moriarty Andrew
- Morka Jacek
- Moschos Nikitas
- Mota Gomes Marco Ant\uf4nio
- Moura Jorge Jose Carlos
- Mousallem Nicolas
- Moya Angel
- Mulhearn Thomas
- Muller Jean Joseph
- Muresan Carmen Manuela
- Muse Derek
- Musial Wlodzimierz
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- Nadar Venkatesh
- Nageh Thuraia
- Nair Priya
- Nakagawa Hidemitsu
- Nakamura Yuichiro
- Nakayama Toru
- Nam Ki Byeong
- Napalkov Dmitry
- Natarajan Indira
- Nayak Hemal
- Naydenov Stefan
- Nechvatal Libor
- Neiman James
- Nerheim Pamela
- Neuenschwander Fernando Carvalho
- Nica Violeta Cindea
- Nishida Kunihiro
- Nizov Alexey
- Nor Azlisham Mohd
- Novikova Tatiana
- Novo Salvatore
- Nowalany Kozielska Ewa
- Nsah Emmanuel
- Nunez Fragoso Juan Carlos
- Nyvad Ole
- O'Donnell Martin
- O'Donnell Philip
- O'Hara Gilles
- Oh Dong Jin
- Oh Yong Seog
- Oikonomou Kostas
- Olalla Juan Jose
- Olivari Zoran
- Oliver Richard
- Olympios Christoforos
- Osborne John
- Osca Joaquin
- Osman Raed
- Osunkoya Abayomi
- Padanilam Benzy
- Panchenko Elizaveta
- Pandey A. Shekhar
- Paquette Miney
- Paraschos Alexander
- Pardell Herbert
- Park Hyung Wook
- Park Jong Sung
- Parkash Ratika
- Parker Ian
- Parrens Eric
- Parris Robert
- Pascual Carlos Rodr\uedguez
- Passamonti Enrico
- Patel Jaydutt
- Patel Rajesh
- Pentz William H.
- Pereira Jardim Cesar Augusto
- Persic Viktor
- Perticone Francesco
- Peters Patrick
- Petkar Sanjiv
- Pezo Luis Felipe
- Pham David
- Phlaum Stephen
- Pineau Julien
- Pineda Velez Armando
- Pini Riccardo
- Pinter Arnold
- Pinto Fausto
- Pirelli Salvatore
- Pivac Nediljko
- Pizzini Attilia Maria
- Pocanic Darko
- Polanczyk Carisi Anne
- Polasek Petr
- Poljakovic Zdravka
- Pollock Stewart
- Polo Jose
- Poock James
- Poppert Holger
- Porro Yamile
- Pose Antonio
- Poulain Fran\ue7ois
- Poulard Jean Ernst
- Pouzar Joe
- Povolny Petr
- Pozzer Domingo
- Pras Athanasios
- Prasad Neeraj
- Prevot S\ue9bastien
- Protasov Konstantin
- Prunier Laurent
- Puleo John
- Pye Maurice
- Qaddoura Fatma
- Quedillac Jean Michel
- Quintana Antonio Garcia
- Raev Dimitar
- Rahimi Sidiqullah
- Raisaro Arturo
- Rama Bhola
- Ranadive Nandkishore
- Randall Katie
- Ranjith Naresh
- Raposo Nuno
- Rashid Haroon
- Raters Christa
- Rauch Kroehnert Ursula
- Rebane Thomas
- Regner Stefan
- Renzi Michael
- Reyes Rocha Miguel Agustin
- Reyes Humberto Rodriguez
- Reza Shabbir
- Ria Luigi
- Ribeiro Moreira Dalmo Antonio
- Richter Dimitrios
- Rickli Hans
- Rickner Kyle
- Rieker Werner
- Rigo Fausto
- Ripoll Tomas
- Roberts Douglas
- Roelke Marc
- Roman Mark
- Romeo Francesco
- Ronner E.
- Ronziere Thomas
- Rooyer F. A.
- Rosenbaum David
- Roth Sherryn
- Rothman Kenneth J.
- Rozkova Nadezda
- Rubacek Miroslav
- Rubalcava Frank
- Rubanenko Olesya
- Rubin Andrew
- Rybak Karin
- Sabbour Hani
- Sakai Tetsuo
- Salacata Abraham
- Salecker Ilsbe
- Salem Adrien
- Salfity Marwan
- Salguero Rafael
- Salvioni Alessandro
- Samson Mercedes
- Sanchez Gregorio
- Sandesara Chirag
- Santana Antonio Mart\uedn
- Santos Jos\ue9 Ferreira
- Saporito Wladmir Faustino
- Sasaoka Taishi
- Sattar Payman
- Savard Daniel
- Scala Pierre Jean
- Scemama Jacques
- Sch\uf6n Norbert
- Schaupp Thierry
- Schellinger Peter
- Scherr Carlos
- Schmitz Bettina
- Schmitz Karl Heinz
- Schmitz Lisa
- Schnitzler Robert
- Schnupp Steffen
- Schoeniger Peter
- Schuster Stefan
- Schwimmbeck Peter
- Seamark Clare
- Seebass Ruediger
- Seidl Karl Heinz
- Seidman Barry
- Sek Jaroslaw
- Sekaran Lakshmanan
- Seko Yoshinori
- Sepulveda Varela Pablo Andres
- Sevilla Bego\uf1a
- Shah Aman
- Shah Anil
- Shah Neerav
- Shah Vinay
- Shanes Jeffrey
- Sharareh Ali
- Sharma Vijay Kumar
- Shaw Louise
- Shimizu Yutaka
- Shimomura Hideki
- Shin Dong Gu
- Shin Eun Seok
- Shite Junya
- Shoukfeh Mohammad
- Shoultz Charles
- Silver Frank
- Sime Iveta
- Simmers T. A.
- Singal Dinesh
- Singh Narendra
- Siostrzonek Peter
- Sirajuddin Mohiburrahman
- Skeppholm Mika
- Smadja Didier
- Smith David
- Smith Richard
- Soda Hassan
- Sofley C. Wilson
- Sokal Adam
- Sotolongo Rodolfo
- Sparby Jon Arne
- Spinar Jindrich
- Sprigings David
- Spyropoulos Alex
- Stakos Dimitrios
- Steinberg Alon
- Steinwender Clemens
- Stergiou Georgios
- Stites H. William
- Stoikov Anastas
- Strasser Ruth
- Streb Witold
- Styliadis Ioannis
- Su Guohai
- Su Xi
- Suarez Rafael Martin
- Sudnik Wanda
- Sueyoshi Atsushi
- Sukles Kai
- Sun Li
- Suneja Randeep
- Svensson Peter
- Szavits Nossan Janko
- Taggeselle Jens
- Takagi Yuichiro
- Takhar Amrit
- Tallet Julio
- Tamm Angelika
- Tanaka Katsumi
- Tanaka Shozo
- Tang Aylmer
- Tang Sherman
- Tassinari Tiziana
- Tayama Shinji
- Tayebjee Muzahir
- Tebbe Ulrich
- Teixeira Jose
- Tesloianu Dan Nicolae
- Tessier Pascal
- Teutsch Christine
- The S. H. K.
- Thevenin J\ue9rome
- Thomas Harold
- Timsit Serge
- Topkis Robert
- Torosoff Mikhail
- Touze Emmanuel
- Traissac Thalie
- Trendafilova Elina
- Troyan Barry
- Tsai Wenchi Kevin
- Tse Hung Fat
- Tsutsui Hiroshi
- Tsutsui Takashi
- Tuininga Y. S.
- Turakhia Minang
- Turk Samir
- Turner Wayne
- Tveit Arnljot
- Twiddy Shannon
- Tytus Richard
- Ukrainski Gerald
- Valdovinos Chavez Salvador Bruno
- Van De Graaff Eric
- Vanacker Peter
- Vardas Panagiotis
- Vargas Michael
- Vassilikos Vassilios
- Vazquez Juan
- Venkataraman Asok
- Verdecchia Paolo
- Vester Ernst G\ufcnter
- Vial Hubert
- Vicenzo de Paola Angelo Amato
- Vinereanu Dragos
- Vlastaris Anthony
- Vogel Craig
- vom Dahl J\ufcrgen
- von Mering Matthias
- Vora Kishor
- Wakefield Paul
- Walia Jasjit
- Walter Thomas
- Wang Feng
- Wang Kuo Yang
- Wang Mingsheng
- Wang Ningfu
- Wang Xinhua
- Wang Zulu
- Watanabe Kouki
- Wei Jeanne
- Weimar Christian
- Weinrich Renate
- Wen Ming Shien
- Wheelan Kevin
- Wicke Jens
- Wiemer Marcus
- Wild Beate
- Wilke Andreas
- Willems Stephan
- Williams David
- Williams Marcus
- Winkler Andreas
- Wirtz Jost Henner
- Witzenbichler Bernhard
- Wong Brian
- Wong Danny H. K.
- Wozakowska Kaplon Beata
- Wu Shulin
- Wu Zhaohui
- Wyatt Nell
- Xu Xiangdong
- Xu Yong
- Yamada Akira
- Yamamoto Kazuya
- Yamanoue Hiroki
- Yamashita Takeshi
- Yang Tianlun
- Yang Yanmin
- Yao Jing
- Yarlagadda Chakri
- Yeh Kuo Ho
- Yotov Yoto
- Yvorra Serge
- Zahn Ralf
- Zamorano Jos\ue9
- Zanini Roberto
- Zarich Stuart
- Zebrack James
- Zenin Sergei
- Zeuthen Elisabeth Louise
- Zhang Dadong
- Zhang Donghui
- Zhang Huanyi
- Zhang Quansan
- Zhang Xingwei
- Zhao Shuiping
- Zhao Xinwen
- Zheng Qiangsun
- Zheng Yang
- Zhou Jian
- Zhou Jing
- Ziekenhuis Antonius
- Zimmermann Rainer
- Zimmermann Sergio Luiz
- Zint Kristina
- Zuhairy Hamed M.
- Zukerman L. Steven
- Zwaan van der C.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non\u2013vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients\u2019 baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age 6575 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score 652; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701
Use of ovary culture techniques in reproductive toxicology
- Author
- Adams
- Adewale
- Agnes Stefansdottir
- Aldyreva
- Alm
- Anderson
- Anderson
- Ankley
- Anway
- Assies
- Ayotte
- Baillet
- Bal
- Bal
- Balabanič
- Baldridge
- Bar-Joseph
- Barclay
- Basavarajappa
- Basini
- Baukloh
- Bellingham
- Ben-Aharon
- Bernal
- Birklett
- Blandau
- Borgeest
- Bristol-Gould
- Brotons
- Burridge
- Calafat
- Campbell
- Can
- Can
- Canipari
- Chedrese
- Chen
- Chuma
- Cimafranca
- Comish
- Cortvrindt
- Cortvrindt
- Craig
- Craig
- Craig
- Crain
- Crellin
- Crellin
- Damstra
- Daston
- Davila
- Davis
- De Vos
- Delclos
- Desmeules
- Devine
- Devine
- Devine
- Devine
- Diamanti-Kandaris
- Doerge
- EFSA
- Eichenlaub-Ritter
- Eichenlaub-Ritter
- Eichenlaub-Ritter
- Eppig
- Eppig
- Eppig
- Eroschenko
- European Commission
- Fisher
- Flaws
- Fowler
- Fragouli
- Fung
- Gilbert
- Gilchrist
- Goldberg
- Goldberg
- Gotz
- Grande
- Graselli
- Gray
- Gray
- Gregoraszczuk
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- Wordinger
- Xu
- Xu
- Xuying
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- Zhuang
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- 01/11/2014
- Field of study
Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved. Acknowledgements The author's studies in this field are supported by MRC grants G1002118 (NS and RAA) and G110357 (RAA), MR/L010011/1 (PAF), the European Community's Seventh Framework Programme (FP7/2007–2013) under grant agreement no. 212885 (PAF) and the Wellcome Trust (080388 to PAF). AS was funded by a BBSRC CASE Studentship co-funded by AstraZeneca.Peer reviewedPublisher PD
Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications
- Author
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- 01/01/2017
- Field of study
This work was supported by a restricted research grant of Bayer AG
Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial
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- Abab Julie
- Abbas Ali
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- Abd Alazeez Mohamed
- Abdulwahid Danya
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- Abed Jessy
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- Adams Marion
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- Corwin Charlotte
- Cossette Danielle
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- Crellin Perric
- Crook Juanita
- Cross Vanessa
- Cross William R.
- Crossley Lin
- Crowe (nee Hughes) Dawn
- Crowley Claire
- Crundwell M
- Cserbane Anita
- Cuffe Donna
- Cumming Kirsty
- Cunningham Amy
- Curtis Samantha
- Curtis Sandra
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- Dawson-Athey Linda
- Dayes Ian S
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- Dean Lynsey
- Dearnaley David
- Deenihan Emma
- Degendorfer Sarah
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- Downs Nichola
- Doyle Kerrie
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- Gauntlett Monica
- Gauthier Isabelle C
- Gearing Jennifer
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- Gibbins Andrew
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- Glaholm John
- Glaholm John
- Gleave Martin E
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- Golden Sophie
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- Goldstein Cindy
- Goldstein Cindy
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- Griffen Ailsa
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- Griffiths Theresa
- Griffiths Theresa
- Gruschy Lisa
- Guarino Robyn
- Gudelis Susan O
- Guerrero-Urbano Teresa
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- Guerrero-Urbano Teresa
- Gujral Sandeep
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- Hardstaff Lisa
- Hare Jennifer A
- Hargreaves Carolyn
- Hargreaves Jeanette
- Hargreaves Jeanette
- Harinarayanan Sathish
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- Harland Keith
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- Haskell Annelise
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- Haydock Helen
- Hayes Jill A
- Hayward Lesley
- Healey Gail
- Healey-Mariano Jennifer
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- Heasley Karen
- Heath Catherine
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- Henson (nee Savidge) Verity
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- Ibrahim Azman
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- Innes Helen
- Iordanidi Elina
- Iqbal Fawaad
- Irwin P
- Isaew Andrea
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- Jastrzebska Patrycja
- Javle P
- Jayachandran Resmi
- Jayachandran Resmi
- Jeffcutt Nicole
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- Jepson Debbie
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- Jewers Karen
- Jeyasanger Ganesan
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- Jonnada Sai
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- Jose Sanal
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- Joseph Paul K
- Joshi Manisha
- Joshi Manisha
- Joslin Vicky
- Jovic Gordana
- Kaa Bach Birgit
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- Kalejaiye Odunayo
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- Kanaga-Sundaram Subramanian
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- Kapur Guarav
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- Karunakaran Subashini
- Karvat Anand
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- Kavanagh Roisin
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- Kay Anne Marie
- Kazingizi Memory
- Keane Patrick
- Kearney S
- Kedge Liz
- Kehoe Laura
- Keith Sarah
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- Kelkar Anand
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- Kelly Alison
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- Kendal Wayne S
- Keng-Koh Pek
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- Keni Manjusha
- Kennedy Julie
- Kenny Shannon
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- Khoury Ghassan
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- Kilmartin John
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- Kiltie Anne
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- Klapp Kathi
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- Knight (n. Sherburn) Victoria
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- Kockelbergh Roger
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- Kokholm Kathrine Friser
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- Kowalczyk-Williams Wioletta
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- Lalani Nafisha
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- Lang Monika
- Langridge Nicole
- Laniado M
- Lao Bernadeth
- Larkins Rachel
- Larocque Stephanie
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- Larson Beverly
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- Liu Stanley
- Livsey Jacqueline
- Livsey Jacqueline
- Lloyd-Jones Hugh
- Loblaw Douglas Andrew
- Lock Michael I
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- Logue John
- Logue John
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- Logue John
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- MacGregor Barbara
- Macgregor Carol
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- MacMullin Lisa
- MacRae Robert M
- Macrory Joanne
- MacVicar Jennifer
- MacVicar Karen
- Madeleine Jude
- Madhava Kudingila
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- Magwaro Sophia
- Magwaro Sophia
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- Mahmood Rana
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- Malone Shawn
- Malone Shawn C.
- Manetta Caroline
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- Mangar Stephen
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- Masson Susan
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- McKinna Fiona
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- Melcher Lucinda
- Melcher Lucinda
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- Merrick Richard
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- Michael Elena
- Michaelidou Andriana
- Michels Jorg
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- Mikropoulos Christos
- Millage Helen
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- Milosevic Michael
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- Morris Stephen
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- Myatt Alison
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- Nabid Abdenour
- Nabid Abdenour
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- Ong Aldrich D.
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- Oni Titilayo
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- Oommen Nikhil
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- Zafar Waheed
- Zaidi Sadaf
- Zarkar Anjali
- Zarkar Anjali
- Zarkar Anjali M.
- Zaza Khaled O
- Zelley Sarah
- Zeltser Fred
- Zhang Hanbo
- Zhang Tina Wanting
- Zietz Maria
- Zilkha Helene
- Zinck Connie
- Zinyemba Vivian
- Zurakovsky Hilary
- Zwarych Darlene
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/06/2024
- Field of study
Background
Previous evidence indicates that adjuvant, short-course androgen deprivation therapy (ADT) improves metastasis-free survival when given with primary radiotherapy for intermediate-risk and high-risk localised prostate cancer. However, the value of ADT with postoperative radiotherapy after radical prostatectomy is unclear.
Methods
RADICALS-HD was an international randomised controlled trial to test the efficacy of ADT used in combination with postoperative radiotherapy for prostate cancer. Key eligibility criteria were indication for radiotherapy after radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to radiotherapy alone (no ADT) or radiotherapy with 6 months of ADT (short-course ADT), using monthly subcutaneous gonadotropin-releasing hormone analogue injections, daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as distant metastasis arising from prostate cancer or death from any cause. Standard survival analysis methods were used, accounting for randomisation stratification factors. The trial had 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 80% to 86% (hazard ratio [HR] 0·67). Analyses followed the intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and ClinicalTrials.gov, NCT00541047.
Findings
Between Nov 22, 2007, and June 29, 2015, 1480 patients (median age 66 years [IQR 61–69]) were randomly assigned to receive no ADT (n=737) or short-course ADT (n=743) in addition to postoperative radiotherapy at 121 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 9·0 years (IQR 7·1–10·1), metastasis-free survival events were reported for 268 participants (142 in the no ADT group and 126 in the short-course ADT group; HR 0·886 [95% CI 0·688–1·140], p=0·35). 10-year metastasis-free survival was 79·2% (95% CI 75·4–82·5) in the no ADT group and 80·4% (76·6–83·6) in the short-course ADT group. Toxicity of grade 3 or higher was reported for 121 (17%) of 737 participants in the no ADT group and 100 (14%) of 743 in the short-course ADT group (p=0·15), with no treatment-related deaths.
Interpretation
Metastatic disease is uncommon following postoperative bed radiotherapy after radical prostatectomy. Adding 6 months of ADT to this radiotherapy did not improve metastasis-free survival compared with no ADT. These findings do not support the use of short-course ADT with postoperative radiotherapy in this patient population
Duration of androgen deprivation therapy with postoperative radiotherapy for prostate cancer: a comparison of long-course versus short-course androgen deprivation therapy in the RADICALS-HD randomised trial
- Author
- Abab Julie
- Abbas Ali
- Abbassi Sara
- Abd Alazeez Mohamed
- Abdulwahid Danya
- Abdulwahid Danya
- Abed Jessy
- Adab Fawzi
- Adams Marion
- Adamson Vanessa
- Addison Anglise
- Adeyoju Adebanji
- Adinkra Victoria
- Adnaan Jamila
- Afzal Naveed
- Agdiran Didem
- Aggarwal Ajay
- Ahamadali Sheefa
- Ahmad Belal
- Ahmed Ilyas
- Ahmed Imtiaz
- Ahmed Shahida
- Aiku Abimbola
- Ainsworth Sarah
- Ainsworth Sarah
- Aitken Katherine
- Ajzensztejn Daniel
- Akhtar Naeem
- Al-Chamali Hiba
- Al-hasso Abdulla
- Al-hasso Abdulla
- Al-Samarraie Amir
- Albrecht Virginia
- Alcock Christopher
- Alder Leanne
- Alderton Kate
- Aldous Mary
- Ali Jennyfa
- Ali Maryam
- Ali Zulfiqer
- Ali Zulfiqer
- Allan Elaine
- Allan Elaine
- Allen Julie
- Allen Kirsten
- Allen Rachael
- Allen Susan
- Allison Joanna
- Allison Michele
- Alonzi Roberto
- AlRashdan Abdulla
- Alzouebi Mymoona
- Amanie John Oliver
- Ammeter Barb
- Amoaten Thomas
- Amos Claire
- Anderson Beverley
- Anderson Chris
- Anderson Jim
- Anderson John
- Anderson John
- Anderson Juliette
- Anderson Leanne
- Anderson Naomi
- Anderson Susan
- Anderson Susan
- Andrade Gerard
- Andrews (nee Moore) Eleanor
- Andrews Kelly
- Andrews Stephen
- Ang Daniel
- Ann Taehee
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- Ansari Jawaher
- Ansari Jawaher
- Anscombe Eleanor
- Anyamene Nicola
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- Appleby Rowan
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- Archer Denise
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- Archer Simon
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- Ashworth Sue
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- Bolton Olivia
- Bolton Olivia
- Bond Brittany
- Bone Linzi
- Bonner Scott
- Bonner-Shand Shelagh
- Bonsu Nicole
- Boon Ian
- Borgaonkar Sudhir
- Borre Michael
- Borynec Carol
- Bott Trevor
- Bottomley David
- Bottomley David
- Bottomley David M
- Bottomley Ian
- Bouchard Myriam
- Bourke Amie
- Bourque JeanMarc
- Boutflower Jane
- Bowen Jo
- Bowen Jo
- Bowen Katie
- Bower Lorna
- Bower Lorna C
- Bowers Dawn
- Bowers Richard
- Bowes-Cavanagh Jeanette
- Bowling Lorna
- Bowman Sue
- Bowmer Amanda
- Bownie-Mukumbu Godfrey
- Brady Joanne
- Brady Joanne
- Brain Carol
- Branagan Jenny
- Brander Mike
- Branson (née Dineen) Amy
- Brasso Klaus
- Brasso Klaus
- Braun Michael W
- Brawley Chris
- Brawley Chris
- Breakspear Sally
- Breckin Edmund
- Breen Vivienne
- Brennan Maria
- Brewster Simon
- Briand Wayne
- Briggs Maxine
- Bristow Robert
- Brittain Paul
- Broadley Eve
- Brock Sue
- Brock Sue
- Brogan (nee Roddie) Stephanie
- Brookes Claire
- Brookman Catherine
- Broom Jane
- Broomfield Barbara
- Brough Richard
- Brough Richard
- Brough WA
- Brown Emmanuel
- Brown Grace
- Brown Joanne
- Brown Maggie
- Brown Rebecca
- Brown Richard B
- Brown Richard B
- Brown Sandra
- Brown Simon
- Brown Stephen CW
- Brown Teddy
- Brownless Caroline
- BrucePayne Kim
- Brulinski Patryk
- Brulinski Patryk
- Brundage Michael
- Bryan Rachel
- Bryant Hanna
- Brydon-Hill Ruth
- Bucci Catherine
- Buchan Jonathan
- Buckley Jon
- Buckley Julie
- Bujold Rachel
- Bunn Sarah
- Burbridge Susan
- Burgoyne Jamie-Rae
- Burlace Barbara
- Burlace Barbara
- Burns Rebecca
- Burrage Su
- Bursey Kara
- Butler-Barnes Jenny
- Butt Zainab
- Butterfield Anne
- Butterworth Caryl
- Buus Simon
- Byrne Mary Marg
- Caballes Mark
- Cadiz Lovely
- Callam Sara
- Calvert Clare
- Camara Mary Jane
- Camburn Sister Tracey
- Camilleri Philip
- Camilleri Philip
- Camilleri Philip
- Camilleri Philip
- Campbell Allister
- Campbell Audrey
- Campbell Hilary
- Campbell Yvonne
- Campos Monica
- Canavan Joycelin
- Cannon Philip
- Capaldi Lisa
- Capaldi Lisa
- Capaldi Lisa
- Carbonaro Adriana
- Carefoot Layton
- Carini Serrafina
- Carkner Amy
- Carlino Giulia
- Carlson Cindy
- Carmel Michel
- Carpenter Janice
- Carpenter Janice
- Carpio Viviana
- Carr Philippa
- Carroll Weronika
- Carruthers Ross
- Carter Adam
- Carter Vanda
- Cartwright Debbie
- Carvery Lane
- Casanova Nathalie
- Casanova Nathalie
- Casey Linda
- Casey Sue
- Catt Natalie
- Catton Charles
- Catton Charles N
- Caumont Tom
- Cavanagh Kerrie
- Chadwick David
- Chadwick Eliot
- Chahal Rohit
- Chahine Jacqueline
- Chakraborti Prabir
- Challipalli Amarnath
- Challipalli Amarnath
- Chamberlain Shelley
- Chambers Carla
- Chan Andrew
- Chan Andrew
- Chan Heidi
- Chan Hin Fan
- Chan Olivia
- Chandrashekara Madhura
- Charnley Natalie
- Chatelain AnneMarie
- Chatfield Jenny
- Chauhan Zainab
- Chedham Alison
- Chennattukungu Indukala
- Cherepak Kathy
- Chetiyawardana Samantha
- Chetiyawardana Samantha
- Chettle Judith
- Cheung Arthur
- Cheung Patrick CF
- Chikkamuniyappa Bindu
- Chikkamuniyappa Bindu
- Chikopela Loveness
- Chilcott Helen
- Chipman Penny
- Chivers Rachael
- Chornopyski Tracy
- Choudhury Ananya
- Choudhury Ananya
- Chowdhury Amitava D
- Christensen Anne Juel
- Christensen Tine
- Christmas Sallyanne
- Chrystal Melanie
- Chu William
- Chui Amadeus
- Chung Christina
- Chung Hans T
- Chung Hans T
- Chung Peter
- Chung Peter W M
- Churn Mark
- Churn Mark
- Clancy Joanna
- Clapp Felicity
- Clark Alison
- Clark Diane
- Clark Helen
- Clark Katy
- Clark Su
- Clarke Elizabeth
- Clarke Jude
- Clarke Maria
- Clarke Noel
- Clarke Noel W
- Clarke Peter
- Clarke Rachael
- Clarke Samantha
- Cleary Kristy
- Clements Colette
- Clements Mia AnnaMaria
- Clitheroe Pat
- Cobos-Arrivabene Marta
- Cocks Tracie
- Coe Marc
- Coffin Teresa
- Cogley Lyn
- Cole Aiden
- Cole David J
- Cole David J
- Collard Susan
- Colligan Steve
- Collins Gerald
- Collins Gerald
- Collins Lucy
- Commisso Angela
- Conibear John
- Connolly nee McKenna Sarah
- Connor Marie
- Conroy Ruth
- Conroy Ruth
- Conroy Ruth
- Conway Lisa-Jane
- Conway Rachel
- Cook Adrian
- Cook Adrian D
- Cook Audrey
- Cook Audrey
- Cook Wendy
- Cooke Jill
- Cooke Juniebel
- Cooke Peter
- Coomber Kristy
- Coombs Sarah
- Cooper Adele
- Cooper Sophie
- Coppins Helen
- Corbett Thomas B
- Corcoran Sam
- Corderoy Helen
- Cordwell Amanda
- Corkery Danylle
- Corless Rebecca
- Cormack Margaret
- Cornaby Andrew
- Corner Victoria
- Cornthwaite Stephanie
- Corwin Charlotte
- Cossette Danielle
- Cote Genevieve
- Cotterill Lauren
- Cotts Shannon
- Coubrough Claudia
- Couch Ellie
- Coughlan Tricia
- Cousins Jane
- Cousins Rebecca
- Coutts Tim
- Coventry Thomas
- Cowan Chloe
- Cowan Chloe
- Cowan Richard
- Cowan Richard
- Cowley Sue
- Cox Adam
- Cox Christine
- Coyle Catherine
- Coyle Catherine
- Crawford Melanie
- Crawford Sister Denise
- Creelman Brianna
- Crellin Perric
- Crellin Perric
- Crook Juanita
- Cross Vanessa
- Cross William R
- Crossley Lin
- Crowe (nee Hughes) Dawn
- Crowley Claire
- Crundwell M
- Cserbane Anita
- Cuffe Donna
- Cumming Kirsty
- Cunningham Amy
- Curtis Samantha
- Curtis Sandra
- Cusan Leonello
- Custins Laura
- Cyriac Abby
- Dabbs Marianne
- Dahar Nazeer
- Dahmane Rafika
- Dallas Nicola
- Dalton-Short Ross
- Dalton-Short Ross
- Daly Deirdre
- Danaswamy Patricia
- Danaswamy Patricia
- Daniel Amelia
- Danielson Brita
- Danjoux Cyril
- Darby Helen
- Darch Flora
- Daruwala Pallon
- Das Prantik
- Davda Reena
- Davey Alison
- Davey Elizabeth
- Davidson Cathy
- Davies Emily
- Davies Flor
- Davies Heather
- Davies Joe
- Davies Joseph
- Davies Julie-Ann
- Davies Kirstin
- Davies Llinos
- Davies Stacey
- Davies Sue
- Davies Tracey
- Davison Alison
- Davison Sue
- Dawe David
- Dawson Elizabeth
- Dawson Louise
- Dawson-Athey Linda
- Dayes Ian S
- De Silva-Minor Shiroma
- Dean Lynsey
- Dearnaley David
- Deenihan Emma
- Degendorfer Sarah
- Dekaj Fatjon
- Dell Gillian
- Dellar Conor
- Delouya Guila
- Dent Kathleen
- Desai Parth
- Desai Parth
- Desrosiers Isabelle
- Dewar Lorna
- Dharmaprasad Soney
- Dhinakaran Kathirvelu
- Di Maria Fabio
- Dias Heather
- Dickinson Peter
- Dickson Jeanette
- Dill Kendra
- DiLullo Elenor
- DiMarco Christine
- Din Omar
- Ding Ian
- Dion Helene
- Ditchfield Julie
- Dixit Sanjay
- Dixit Sanjay
- Dlodlo Jessica
- Dobson Tracey
- Dodds David
- Dodge Sister Jan
- Doherty A
- Donaghey Sally
- Donaldson David
- Donnison Michelle
- Douch Emma
- Doughty Victoria
- Dover Serena
- Downs Nichola
- Doyle Kerrie
- Drachenberg Darrel E
- Drakeley Susan
- Drew Ellen
- Drew Mary (Ellen)
- Driscoll Celine
- DSouza David
- Dubey Arbind
- Dubey Arbind
- Duckett Tracey
- Duclos Marie
- Duffy Annie
- Dufour Nathalie
- Dugas Stevie
- Duley Emma
- DuMontier Joelle
- Duncan (nee Keatley) Claire
- Duncan Graeme
- Duncan Ian
- Dunn Sharon
- Dunne Emma
- Durkan Garret
- Durrant Lisa
- Dymond Harvey
- E Choan
- Eady Robin
- Eapen Libni
- Ebacher Annie
- Eccleson Helen
- Edwards Abigail
- Edwards Albert
- Edwards Jackie
- Edwards Steve
- Edwards Steve
- Egan Lisa
- Eichenberger Lois
- El-Modir Ahmed
- El-Saghir Mohammed
- Eleftheriadis Symeon
- ElKerdawy Hala
- Ellard Rose
- Elliott Mark
- Elliott Tony
- Elliott Tony
- ElSokhn Nidale
- Elwell Christine
- Elwell Christine
- Elwell Sue
- Embleton Andrew
- Ennis Dawn
- Erskine Susan
- Escueta Vivette
- Eska Tiffani
- Etheridge Charlotte
- Evans Angela
- Evans Clary
- Evans Elizabeth
- Evans Marion
- Evans Melanie
- Evans Richard
- Eze Nancy
- Fair Kim
- Fairfax Claire
- Falconer Alison
- Falconer Alison
- Fallah Fereshteh
- Fallaize Adrian
- Faria Sergio Luiz
- Farnworth Christine
- Farrar Michelle
- Farrell Helen
- Fawcitt Sara
- Fazekasne Fulep Adrienn
- Fearnley Mark
- Featherstone Wendy
- Fellows Kathryn
- Fennelly Ruth
- Ferguson Catherine
- Ferguson Catherine
- Fernandez Claire
- Ferreira Miguel
- Fiddes Kathleen
- Fielding Bethany
- Fielding Bethany
- Fildes Diane
- Finnegan Niall
- Firth Alexandra
- Firth Alexandra
- Firth Alexandra
- Firth Elizabeth
- Fish Matt
- Fish Nathan
- Flaherty Jan
- Flaherty Jan
- Flanagan Laura
- Flavin Aileen
- Fletcher Joanne
- Fletcher Julie
- Fletcher Mandy
- Flynn-Batham Marian
- Fode Kirsten
- Folkes Linda
- Follows Josh
- Foo Maxine
- Foot Jayne
- Forcat Silvia
- Ford Amanda
- Ford Amy
- Ford Chris
- Ford Daniel
- Ford Daniel
- Ford Nicky
- Ford Vicky
- Ford Victoria
- Ford Victoria
- Forkes Janet
- Forkes Janet
- Forkes Janet
- Forman Susan
- Forrest Diane
- Forrest Diane
- Fortin Jacqueline
- Fosker Chris
- Fossey Gavin
- Foster Emma
- Foster William
- Fourt Monica
- Fox Shirley
- Foxwell Sue
- Francis Olesya
- Francis Peggy
- Francisco Cristina
- Frankland Helen
- Frankland Helen
- Franklin Alex
- Frattaroli Paul
- Frazzi Alexandra
- Frew John
- Frim Olivera
- Froese Jane
- Froude Nancy
- Funnell Sarah
- Gagne Vanessa
- Galante Joao
- Gallimore Elizabeth
- Galloway Lucy
- Galway Denise
- Gamble Tina
- Gamble Tina
- Gamez Raquel
- Ganabady Malavika
- Gao Annie
- Garcia Leni Santiago
- Gardiner Fiona
- Garner Victoria
- Garrett Gina
- Garrido-Perez Sandra
- Gauntlett Monica
- Gauthier Isabelle C
- Gearing Jennifer
- George Siny
- GeorgeChayka Danielle
- Geraghty Kerry
- Ghoul Mokhtar
- Gibbins Andrew
- Gibbins Jackie
- Gibbins Kate
- Gibbs Stephanie
- Gibson Sian
- Giddings Emma
- Gilbert Duncan
- Gilbert Duncan
- Gilbert Jeanette
- Gilby Lisa
- Gilchrist Gail
- Gill Lisa
- Gill Shafiq
- Gillatt David
- Gillatt David
- Gillesen Annelies
- Gillespie Sally
- Gillian Andrew
- Gilmartin Claire
- Gilmour Christina
- Ginnelly Helen
- Ginnelly Helen
- Giovannini Julia
- Gipson Anna
- Girolametto Carla
- Gladwell Louise
- Gladwish Adam
- Glaholm John
- Glaholm John
- Gleave Martin E
- Glen Hilary
- Glen Tracy
- Glick Daniel
- Goel Roshni
- Goh Chee
- Goh Chee L
- Golden Sophie
- Goldenberg S Larry
- Goldstein Cindy
- Goldsworthy Simon
- Gollapothu Srilakshmi
- Gomez JoseLuis
- Gomez-Marcos Raquel
- Gonzalez Celia
- Gooch Carol
- Goodhind Frances
- Goodsell Josie
- Goodsell Josie
- Goodwin Emma
- Gopaul Darindra
- Gordon Hussain
- Gore Alexandra
- Gospodarowicz Mary
- Goss Vanessa
- Gough Jessica
- Gould Aaron
- Goulden Kay
- Goulding James
- Goyena Ruby
- Grabey Jenna
- Graham Janet
- Graham Jeffrey
- Graham John
- Graham Susan
- Gramlich Colin
- Grant Anna
- Grant Cordelia
- Grant Judith
- Grant Susan
- Grant Warren
- Gratton Albert
- Grau Isabel
- Gray Emma
- Gray Emma
- Grayland Sarah
- Greedus Helen
- Green James
- Green Sara
- Green Sarah
- Green Sue
- Green Trish
- Greenland Jonathan
- Gregg Jane
- Gregorcic Emily
- Gregory Debbie
- Grieve Sylvia
- Griffen Ailsa
- Griffin Hannah
- Griffiths Dorothy
- Griffiths Leyshon
- Griffiths Theresa
- Griffiths Theresa
- Gruschy Lisa
- Guarino Robyn
- Gudelis Susan O
- Guerrero-Urbano Teresa
- Guerrero-Urbano Teresa
- Guerrero-Urbano Teresa
- Gujral Sandeep
- Gumapac Nicole
- Gunn Melanie
- Gupta Kamalnayan
- Gupta Nishi
- Gurzanski Christina
- Guy Peter
- Gwilt Julie
- Gwilt Julie
- Gwilt Julie
- Haddad Alain
- Hagan Chris
- Hague Dominic
- Haidar Imran
- Haidar Imran
- Haigh Steve
- Haldeos Anne
- Hale Jennifer
- Hall Jane
- Hall Julia
- Hall Julia
- Halperin Ross
- Hamid Abdel
- Hamill Maureen
- Hamilton Beatrice
- Hamilton Joanna
- Hamilton Ronald
- Hammonds John Christopher
- Hanna Emma
- Hannaford Zeta
- Happle Liz
- Hardie Maryon
- Harding Claudia
- Harding Joshua
- Hardman John
- Hardstaff Lisa
- Hare Jennifer A
- Hargreaves Carolyn
- Hargreaves Jeanette
- Hargreaves Jeanette
- Harinarayanan Sathish
- Harinarayanan Sathish
- Harland Keith
- Harney Jackie
- Harnwell Juliette
- Harpell Rhonda
- Harris (n. Marchant) Emily
- Harris Catherine
- Harris Sarah
- Harris-Burland Angie
- Harrison Alison
- Harrow Sister Kath
- Hart Amber
- Hart Andrew
- Harter Leah
- Hartley Jasmine
- Hartman Carrie
- Hartt Nancy
- Hartwell Lyn
- Harvey Julie
- Harvey Sally
- Harving Niels
- Haskell Annelise
- Hassall Alison
- Hassan Nebah
- Hassan Nebah
- Hathout Lara
- Hatimy Umi
- Haydock Helen
- Haydock Helen
- Hayes Jill A
- Hayward Lesley
- Healey Gail
- Healey-Mariano Jennifer
- Healey-Mariano Jennifer
- Heasley Karen
- Heath Catherine
- Heath Catherine M
- Heckford Louise
- Hedges Andy
- Heeley Janine
- Hefferon Billy
- Hegarty Gemma
- Hejlesen Finn
- Helou Joelle
- Hendel Debra
- Henry Ann
- Henry Ann
- Henry Ann
- Henry Ann
- Henry Joanne
- Henry Joanne
- Henson (nee Savidge) Verity
- Henson Helen
- Herasimtschuk Anna
- Herbert Chris
- Herbert Gaynor
- Heron Jane
- Hetherington Stacey
- Hicks Kimberly
- Higgins Linda
- Hijab Adham
- Hill Elaine
- Hill Judy
- Hill Pipa
- Hill Pippa
- Hillman Paul
- Hillman Paul
- Hilman Serena
- Hilman Serena
- Hindle Margaret
- Hines John
- Hoare Kathryn
- Hocking Christopher
- Hodder June
- Hodge Simon
- Hodges Samantha
- Hodgkinson Sheila
- Hodson Hayley
- Hodson Hayley
- Hogan Holly
- Hogan Vesna
- Hogbin Emma
- Hogbin Emma
- Holbrook Andy
- Holbrook Becky
- Holden Simon
- Holdsworth Amanda
- Hollenhorst Helmut
- Holliday Samantha
- Hollingdale Abigail
- Hollis Keri
- Hollister Robert
- Holloway Caroline
- Holmes Evelyn
- Holwerda Eleanor
- Homer David
- Hood Marion
- Hooper Simon
- Hooton Georgia
- Hore Brendan
- Horne Rhian
- Hornzee Gillian
- Hornzee Gillian
- Horton Sarah
- Horwich Alan
- Hoskin Peter
- Hoskins Ashley
- Hoskins Chloe
- Hotine Jodie
- Hough Adele
- Hough Chris
- Houghton Fionnuala
- Houle Stefanie
- House Gail
- Howard Joanna
- Howard Lucy
- Howard Lucy
- Howitt Pamela
- Hsien John
- Hubley Lynn
- Huddart Robert
- Huddart Robert
- Hudson Zoe
- Hughes Claire
- Hughes Faye
- Hughes Hayley
- Hughes Joanne
- Hughes Kathryn
- Hughes Owen
- Hughes Robert
- Hughes Simon
- Hughes-Davies Luke
- Hugill Angela
- Hugill Angela
- Humber Caroline
- Humpreys Louise
- Hunt Allison
- Hunter Catherine
- Hunter William
- Hunting Liz
- Hutchinson Camille
- Hyde Katherine
- Hyde Katherine
- Hyde Katherine
- Hynds Sharon
- Ibrahim Azman
- Ingham Jo
- Ingle Charlotte
- Inman Hayley
- Innes Helen
- Iordanidi Elina
- Iqbal Fawaad
- Irwin P
- Isaew Andrea
- Iskender Amanda
- Islam Zaheer
- Issa Rami
- Ivie Stephanie
- Jackman Dee
- Jackson Cathy
- Jackson Kim
- Jackson Sister Ann
- Jain Suneil
- Jakeman Christine
- James Naomi
- James Nicholas
- James Nicholas D
- Jamieson Ceri
- Jampana Raj
- Janke Susan
- Jannapureddy Revanth
- Jarvis Claire
- Jastrzebska Patrycja
- Javle P
- Jayachandran Resmi
- Jayachandran Resmi
- Jeffcutt Nicole
- Jeffrey David
- Jelski Joseph
- Jenkins Peter
- Jenkins Suzanne
- Jenner Abigail
- Jennings Marian
- Jepson Debbie
- Jevons Cody
- Jewers Karen
- Jewers Karen
- Jeyasanger Ganesan
- Joe Howard
- John Babbin
- Johns Louise
- Johnson Arlissa
- Johnson Craig
- Johnson Joanne
- Johnson Lyndsey
- Johnson Nigel
- Johnson-Rollings Ashley
- Johnston Laurel
- Johnston Ruth
- Johnstone Dawn
- Johnstone Maria
- Joncas MarieClaude
- Jones (Birch) Janine
- Jones Andrea
- Jones Ania
- Jones Carys
- Jones Cathryn
- Jones Clare
- Jones Dawn
- Jones Gareth
- Jones Ifan
- Jones Jules
- Jones Julia
- Jones Kathryn
- Jones Katie
- Jones Lesley
- Jones Lewis
- Jones Richard
- Jones Rob
- Jones Stephanie
- Jones Stephanie
- Jones-Skipper Kay
- Jonnada Sai
- Jope Carmel
- Jose Sanal
- Joseph Joji
- Joseph Paul K
- Joshi Manisha
- Joshi Manisha
- Joslin Vicky
- Jovic Gordana
- Kaa Bach Birgit
- Kader Nicole
- Kalejaiye Odunayo
- Kaliski Alexandre
- Kalyvas Maria
- Kamran Asim
- Kanaga-Sundaram Subramanian
- Kancherla Kiran
- Kanji Femina
- Kanyi Karen
- Kapur Guarav
- Karim Omer
- Karp Stephen
- Karsera Louise
- Karunakaran Subashini
- Karvat Anand
- Kaushal Malan
- Kavanagh Roisin
- Kavanagh Roisin
- Kay Anne Marie
- Kazingizi Memory
- Keane Patrick
- Kearney S
- Kedge Liz
- Kehoe Laura
- Keith Sarah
- Keith Sarah
- Kelkar Anand
- Kellaway Joanne
- Kelly Alison
- Kelly Kay
- Kemp Gail
- Kempel Mette Moe
- Kendal Wayne S
- Keng-Koh Pek
- Keng-Koh Pek
- Keni Manjusha
- Kennedy Julie
- Kenny Shannon
- Kent Christopher
- Kent Emma
- Kenyon Lucille
- Kershaw Elizabeth
- Key Claire
- Keyes Mira
- Khaksar Sara
- Khan Omar
- Khan Yakhub
- Khaouam Nader
- Khong Rachel
- Khoo Vincent
- Khoo Vincent
- Khoury Ghassan
- Kiff Janet
- Kift Shannon
- Kilmartin John
- Kilroy Stephen
- Kilroy Stephen
- Kiltie Anne
- Kiltie Anne
- Kim David
- Kim TuongVan
- Kim-Sing Charmaine
- KimSing Charmaine
- King Amy
- King Jennifer
- King Jennifer
- King Lisa
- Kinrade Yvonne
- KirbyBello Denise
- Kirk Christine
- Kirk Sister Sarah
- Kirkbride Peter
- Kirkbride Peter
- Kirkby Amy
- Kirkby Sarah
- Kirkpatrick Suriya
- Kisanga Mary
- Kitkowski Caitlin
- Klapp Kathi
- Klotz Laurence
- Klovgaard Karina
- Knackstedt Jochen
- Knapp Jeanette
- Knight (n. Sherburn) Victoria
- Knott Helen
- Knox WF
- Kockelbergh Roger
- Kodavatiganti Ravi
- Koehler Ingrid
- Kokholm Kathrine Friser
- Koll Wayne
- Kong Vickie
- Kotze Michelle
- Koul Rashmi
- Koulouris Zoe
- Koupparis Anthony
- Kowalczyk-Williams Wioletta
- Kowalewska Paulina
- Kronstal Flo
- Krysta Beata
- Kuenzig Greg
- Kujawa Magda
- Kuk Joda
- Kullane Sagal
- Kumar Daniel
- Kumar Muthar
- Kumar Shiyam
- Kumar Vikaash
- Kurian-Downer Sunita
- Kurup Rahul
- Kuzyk Valerie
- Kwan Winkle
- Kyffin Phillippa
- Kynaston Howard
- Kynaston Howard
- Lacey Cathy
- Lachance Nicole
- Lactao Ranee
- Ladouceur Cynthia
- Laing Robert
- Lajoie MarieAndree
- Lake Sister Judith
- Lalani Nafisha
- Laliberte Benoit
- Lam Jacqueline
- Lambert Carole
- Lambert Katy
- Lamoureux Alexandra
- Lang Monika
- Langridge Nicole
- Laniado M
- Lao Bernadeth
- Larkins Rachel
- Larocque Stephanie
- Larouche Julie
- Larson Beverly
- Lassen Yasmin
- Last Debbie
- Lau Maurice
- Laubscher Angelique
- Laughlin Anne
- Laursen Vibeke
- Lavender Helene
- Laverick Rosaleen
- Lavertu Sophie
- Lawless Claire
- Lawless Theresa
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- Lawrence Steph
- Lawrey Sarah
- Lawson Daeria
- Lazarte Jannika
- Leach Deborah
- Lebrun Benoit
- Ledger Kate
- Lee Bernard
- Lee Brenda
- Lee Vivienne
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- Leitao Madalena
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- Lemng Kruse Helle
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- Leone Priscilla
- Leong Nelson
- Leung Michael
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- Lewington Val
- Lewis Amanda
- Lewis Christina
- Lewis Joanne
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- Ley Samantha
- Li Audrey
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- Liau Joy
- Light Teresa
- Lim Jan
- Lim Jun
- Lindberg Henriette
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- Lipsham Margaret
- Liptrott Sarah
- Lister Debbie
- Litchfield Jayne
- Little Erin
- Little Jessica
- Littler John
- Littler Stephen
- Liu Stanley
- Livsey Jacqueline
- Livsey Jacqueline
- Lloyd-Jones Hugh
- Loblaw Douglas Andrew
- Lock Michael I
- Locke Angela
- Lockwood Carol
- Logue John
- Logue John
- Logue John
- Logue John
- Lokes Rachel
- Lokes Rachel
- Lomas Alia
- Lomas Claire
- Lomax Laurie
- London Clare
- Long Carol
- Long Heather
- Loughlin Kate
- Loughrey Carmel
- Love Clare
- Love Sally
- Lowe Amelia
- Lowi Suzy
- Lucakova Slavka
- Lukka Himu
- Lunau Anne Sofie
- Lydon Anna
- Lydon Anne Marie
- Lynch Rory
- Lyons Ciara
- Mabelin Louies
- Macavoy Tina
- Macdonald Alison
- MacDonald Angela
- MacDonald Graham
- Macefield Rhiannon
- MacGregor Barbara
- Macgregor Carol
- MacIsaac Kathy
- MacIsaac Patricia
- Mackay Rachel
- Macleod Nicholas
- MacMillan Antonia
- MacMullin Lisa
- MacRae Robert M
- Macrory Joanne
- MacVicar Jennifer
- MacVicar Karen
- Madeleine Jude
- Madhava Kudingila
- Madine John
- Magwaro Sophia
- Magwaro Sophia
- Magwaro Sophia
- Mahmood Rana
- Mahmood Rana
- Mahmood Sana
- Mahmud Aamer
- Mahoney Catriona
- Mahoney Sue
- Maitland Katrina
- Maize Christine
- Majumdar Arpita
- Makepeace Barbara
- Malde Rohit
- Malek Leila
- Malik Zafar
- Mallett Debbie
- Malone Shawn
- Malone Shawn C
- Manetta Caroline
- Manganaro Aileen
- Mangar Stephen
- Maniatis Christos
- Manley Rachel
- Mannan Aliyah
- Manning Courtney
- Manning Kimberley
- Mansell Gemma
- Mansfield Carolyn
- Mantle Mark
- Manyangadze Sarah
- Marange Josephine
- Mardell Stephen
- Marek Kathleen
- Mariappan Param
- Marineau Line
- Mark Ian
- Markus Sarah
- Marley Hazel
- Marquis Tania
- Marriott Sue
- Marshall John
- Marshall Lynn
- MarshGray Kimberley
- Marston Kerrie
- Martin AndreGuy
- Martin Jackie
- Martin Joseph
- Martin Karen
- Martindale John
- Martindale John
- Martindale John
- Martinez Maria
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- Mashegede Beverley
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- McAleese Jonathan
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- McCabe Alastair
- McCadden Angela
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- Mikropoulos Christos
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- Smedley (nee McCabe) Janine
- Smedley (nee McCabe) Janine
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- Smith Lucy
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- Tighe Helen
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- Todd Joanna
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- Toussi H
- Townley Barbara
- Townley Luke
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- Turley Claudia
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- Tweedle James
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- Vandborg Maria
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- Varley Gail
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- Varughese Mohini
- Vasanthan Subramanian
- Vaughn Jamie
- Vavassis Peter
- Velec Erin
- Vengalil Salil
- Venkatesan Varagur M
- Venkitaraman Ramachandran
- Venkitaraman Ramachandran
- Vermette Tracy
- Vesprini Danny
- Vickery Kathryn
- Vigneault Eric
- Vijayakumar Vijitha
- Vilarino-Varela Maria
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- Waldron Eleanor
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- Wall Elaine
- Wallace Jan
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- Wallbutton Rebecca
- Walmsley Catherine
- Walsh Donna
- Walton Jenny
- Walton Sharon
- Ward Angela
- Ward Colin
- Warde Padraig
- Waring Lynsey
- Waring Lynsey
- Wassall Rebecca
- Watkinson Catrin
- Watson Melanie R
- Watson Michaella
- Watson-Jones Phillip
- Watts Angela
- Watts Erica
- Weaver Andrew
- Weaver Emma
- Webb Andrew
- Webb Claire
- Webb Kerrie
- Webb Paula
- Websdale Cheryl
- Webster Christine
- Wei Joyce
- Weir JoAnn
- Wellman Sandie
- Wells Paula
- Wells Paula
- Wells Paula
- Wells Tom
- Welsh Liam
- Welsh Linda
- Westley Rosalyne
- Weston Alison
- Weston Philip
- Westrop Anna
- Westrop Anna
- Westrop Anna
- Wheatley Duncan
- Wheeler Lucie
- Wheelwright Roger
- Whelan Kate
- Whillis David
- Whinn Samantha
- Whitcher Alison
- White Ann
- White Holly
- White Joanna
- Whitehouse James
- Whitehouse James
- Whiteway Chrystal
- Whittle Stacy
- Whotton Nikita
- Wiggins Sarah
- Wightman John
- Wignall Suzy
- Wild Karen
- Wilke Derek
- Wilkie Karen
- Wilkins Marie
- Wilkinson Nicola
- Williams (Née Allen) Sister Tania
- Williams Amanda
- Williams Bethan
- Williams Candra
- Williams Jo
- Williams Joanne
- Williams Rachel
- Williams Rachel
- Williams-Yesson Barbara
- Williamson Elizabeth
- Williamson Nicola
- Willing Stephanie
- Wilson David
- Wilson Jim
- Wilson Jo
- Wilson Mark
- Wilson Paula
- Wilson Paula
- Wilson Russ
- Winn Carol
- Winter Sister Helen
- Wise Marcus
- Wise Marcus
- Wise Marcus
- Wiss Elliott
- Wollaston Julie
- Woloshyn Rose
- Wong Jason W T
- Wood Allison
- Wood Catherine
- Wood Cathryn
- Wood Marian
- Wood Pauline
- Wood Pauline
- Wood Sister Kim
- Wood Sister Kim
- Wood Sister Kim
- Woodhouse Iain
- Woods Catherine
- Woods Jane
- Woods Martin
- Woodward Cathryn
- Woodward Elizabeth
- Woolf David
- Woolf David
- Workman Bridget
- Worlding Jane
- Worlding Jane
- Worsley Lucy
- Worthington Hannah
- Wright Ann
- Wright Natalie
- Wright Seonaid
- Wrigley Martha
- Wronski Sue
- Wu Helen
- Wu Min
- Wyatt Clare
- Wylie James
- Wylie James
- Wylie James
- Wynn Hazel
- Wynn Hazel
- Yanchuk Janet
- Yarrow Sue
- Yassa Michael
- yates Victoria
- Yee Don
- Yeo Tanya
- Yoon Frederick
- Youd Sister Jill
- Young Anita
- Young Bobbie
- Young Douglas
- Young Sally
- Youngs Nora
- Yu Jason
- Yunace Lorrie
- Yusof Hilawati
- Zafar Waheed
- Zaidi Sadaf
- Zarkar Anjali
- Zarkar Anjali
- Zaza Khaled O
- Zelley Sarah
- Zeltser Fred
- Zhang Hanbo
- Zhang Tina Wanting
- Zietz Maria
- Zilkha Helene
- Zinck Connie
- Zinyemba Vivian
- Zurakovsky Hilary
- Zwarych Darlene
- Publication venue
- Elsevier
- Publication date
- 07/06/2024
- Field of study
Background
Previous evidence supports androgen deprivation therapy (ADT) with primary radiotherapy as initial treatment for intermediate-risk and high-risk localised prostate cancer. However, the use and optimal duration of ADT with postoperative radiotherapy after radical prostatectomy remains uncertain.
Methods
RADICALS-HD was a randomised controlled trial of ADT duration within the RADICALS protocol. Here, we report on the comparison of short-course versus long-course ADT. Key eligibility criteria were indication for radiotherapy after previous radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to add 6 months of ADT (short-course ADT) or 24 months of ADT (long-course ADT) to radiotherapy, using subcutaneous gonadotrophin-releasing hormone analogue (monthly in the short-course ADT group and 3-monthly in the long-course ADT group), daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as metastasis arising from prostate cancer or death from any cause. The comparison had more than 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 75% to 81% (hazard ratio [HR] 0·72). Standard time-to-event analyses were used. Analyses followed intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and
ClinicalTrials.gov
,
NCT00541047
.
Findings
Between Jan 30, 2008, and July 7, 2015, 1523 patients (median age 65 years, IQR 60–69) were randomly assigned to receive short-course ADT (n=761) or long-course ADT (n=762) in addition to postoperative radiotherapy at 138 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 8·9 years (7·0–10·0), 313 metastasis-free survival events were reported overall (174 in the short-course ADT group and 139 in the long-course ADT group; HR 0·773 [95% CI 0·612–0·975]; p=0·029). 10-year metastasis-free survival was 71·9% (95% CI 67·6–75·7) in the short-course ADT group and 78·1% (74·2–81·5) in the long-course ADT group. Toxicity of grade 3 or higher was reported for 105 (14%) of 753 participants in the short-course ADT group and 142 (19%) of 757 participants in the long-course ADT group (p=0·025), with no treatment-related deaths.
Interpretation
Compared with adding 6 months of ADT, adding 24 months of ADT improved metastasis-free survival in people receiving postoperative radiotherapy. For individuals who can accept the additional duration of adverse effects, long-course ADT should be offered with postoperative radiotherapy.
Funding
Cancer Research UK, UK Research and Innovation (formerly Medical Research Council), and Canadian Cancer Society
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