iAnn: an event sharing platform for the life sciences

Summary: We present iAnn, an open source community-driven platform for dissemination of life science events, such as courses, conferences and workshops. iAnn allows automatic visualisation and integration of customised event reports. A central repository lies at the core of the platform: curators add submitted events, and these are subsequently accessed via web services. Thus, once an iAnn widget is incorporated into a website, it permanently shows timely relevant information as if it were native to the remote site. At the same time, announcements submitted to the repository are automatically disseminated to all portals that query the system. To facilitate the visualization of announcements, iAnn provides powerful filtering options and views, integrated in Google Maps and Google Calendar. All iAnn widgets are freely available. Availability: http://iann.pro/iannviewer Contact: [email protected]

Climate change, malaria and neglected tropical diseases: a scoping review

To explore the effects of climate change on malaria and 20 neglected tropical diseases (NTDs), and potential effect amelioration through mitigation and adaptation, we searched for papers published from January 2010 to October 2023. We descriptively synthesised extracted data. We analysed numbers of papers meeting our inclusion criteria by country and national disease burden, healthcare access and quality index (HAQI), as well as by climate vulnerability score. From 42 693 retrieved records, 1543 full-text papers were assessed. Of 511 papers meeting the inclusion criteria, 185 studied malaria, 181 dengue and chikungunya and 53 leishmaniasis; other NTDs were relatively understudied. Mitigation was considered in 174 papers (34%) and adaption strategies in 24 (5%). Amplitude and direction of effects of climate change on malaria and NTDs are likely to vary by disease and location, be non-linear and evolve over time. Available analyses do not allow confident prediction of the overall global impact of climate change on these diseases. For dengue and chikungunya and the group of non-vector-borne NTDs, the literature privileged consideration of current low-burden countries with a high HAQI. No leishmaniasis papers considered outcomes in East Africa. Comprehensive, collaborative and standardised modelling efforts are needed to better understand how climate change will directly and indirectly affect malaria and NTDs

ELM: the status of the 2010 eukaryotic linear motif resource

Linear motifs are short segments of multidomain proteins that provide regulatory functions independently of protein tertiary structure. Much of intracellular signalling passes through protein modifications at linear motifs. Many thousands of linear motif instances, most notably phosphorylation sites, have now been reported. Although clearly very abundant, linear motifs are difficult to predict de novo in protein sequences due to the difficulty of obtaining robust statistical assessments. The ELM resource at http://elm.eu.org/ provides an expanding knowledge base, currently covering 146 known motifs, with annotation that includes >1300 experimentally reported instances. ELM is also an exploratory tool for suggesting new candidates of known linear motifs in proteins of interest. Information about protein domains, protein structure and native disorder, cellular and taxonomic contexts is used to reduce or deprecate false positive matches. Results are graphically displayed in a ‘Bar Code’ format, which also displays known instances from homologous proteins through a novel ‘Instance Mapper’ protocol based on PHI-BLAST. ELM server output provides links to the ELM annotation as well as to a number of remote resources. Using the links, researchers can explore the motifs, proteins, complex structures and associated literature to evaluate whether candidate motifs might be worth experimental investigation

Developing a Net-Zero Framework for the WPI Campus

Climate change is causing many people globally to consider their energy consumption and how it could be decreased. To achieve this goal, many buildings are being designed as net-zero energy by implementing various energy saving strategies. This project investigates this goal on the Worcester Polytechnic Institute (WPI) campus. Campus-[AD1] wide energy consumption was analyzed for developing baseline energy models. These models were created based on existing building plans, and energy analysis was conducted by implementing strategies and determining the energy savings across the WPI Quadrangle (Quad). From this analysis, recommendations were given for which strategies to implement at WPI, and a modular solar canopy was designed to be implemented across campus

Storying Climate Change: London

In studying climate change, the focus is often placed solely on scientific data, yet this is not necessarily correlated to how the public perceives the topic. People understand the world through the lens of their own experiences and, therefore, experiences provide a strong insight into the perceptions of an individual or community. This project details the perspective of London residents climate change related experiences through personal interviews. Storytelling has long been an effective method of communicating personal experiences and through combining this with real experiences, this project communicates London’s climate change story to the world

Exploiting Transitivity for Entity Matching

The goal of entity matching in knowledge graphs is to identify sets of entities that refer to the same real-world object. Methods for entity matching in knowledge graphs, however, produce a collection of pairs of entities claimed to be duplicates. This collection that represents the sameAs relation may fail to satisfy some of its structural properties such as transitivity. We show that an ad-hoc enforcement of transitivity on the set of identified entity pairs may decrease precision. We therefore propose a methodology that starts with a given similarity measure, generates a set of entity pairs, and applies cluster editing to enforce transitivity, leading to overall improved performance

Exploiting Transitivity for Entity Matching

The goal of entity matching in knowledge graphs is to identify sets of entities that refer to the same real-world object. Methods for entity matching in knowledge graphs, however, produce a collection of pairs of entities claimed to be duplicates. This collection that represents the sameAs relation may fail to satisfy some of its structural properties such as transitivity. We show that an ad-hoc enforcement of transitivity on the set of identified entity pairs may decrease precision. We therefore propose a methodology that starts with a given similarity measure, generates a set of entity pairs, and applies cluster editing to enforce transitivity, leading to overall improved performance

<i>Biomphalaria glabrata</i> gene-specific primers used to amplify specific gene fragments included on the microarray.

<p>F-forward facing primer. R- Reverse facing primer.</p

Gene set enrichment analysis (GSEA).

<p>The collated fold changes for each comparison (RE/SE, RC/SC, RE/RC, SE/SC) is shown for the genes in six selected GO categories. The order of the genes along the x-axis is arbitrary.</p