9 research outputs found
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
- Author
- A Abbate
- A Abhyankar
- A Adams
- A Agafina
- A Akyea-Djamson
- A Alan
- A Alfieri
- A Alfrey
- A Alvarisqueta
- A Amos
- A Anadiotis
- A Anneveldt
- A Antolick
- A Arthur
- A Aslam
- Abaci F
- Abdullakutty J
- Abhaichand R
- Abib E Jr
- Aboufakher R
- Abrantes J
- Abreu M
- Abulencia K
- Acampora D
- Acampora M
- Accini Mendoza Jl
- Aceto L
- Acevedo B
- Acevedo L
- Acheatel R
- Actis Mv
- Adams M
- Adjic Nc
- Affaki Gs
- Agarwal Dk
- Aggarwal Rk
- Agosta Gf
- Aguilar M
- Aguilar M
- Ahire N
- Ahmad I
- Ahmed Sh
- Ahn Y
- Aish B
- Aiub F
- Aiub J
- Ajax K
- Ajioka M
- Akai Y
- Akatova E
- Akrap B
- Al Joundi T
- Al-Khalili F
- Albisu J
- Alcalde Jm
- Alcide P
- Alfonso T
- Allen J
- Alllison Dc
- Almaliky T
- Amerena J
- Andersen K
- Andor M
- Angelova I
- Angiolillo D
- Anita S
- Anker Sd
- Antalik L
- Antonicelli R
- Aparicio Cv
- Apel T
- Apostolovic S
- Ara M
- Aragorn L
- Arango Jl
- Araujo Fonseca M
- Ardissino D
- Arenas Leon Jl
- Arevalo S
- Argiolas G
- Arif I
- Armas E
- Aron G
- Arora S
- Asafu-Adjaye N
- Ashcom T
- Ashford M
- Ashino K
- Asim Oktay Ao
- Assarsson E
- Ata B
- Ather N
- Atieh M
- Aull L
- Avalos V
- Avdonina N
- Awasthi Ak
- Axthelm C
- Ayala M
- Ayasse D
- Ayasse M
- Azizad M
- Azize Gm
- B Becker
- Baar M
- Babu R
- Backer T
- Badea C
- Baden M
- Baehl S
- Baek C
- Baeumer A
- Bagi Es
- Bai A
- Bailey K
- Bailey S
- Bair S
- Baker A
- Baker C
- Bakhai A
- Bakker H
- Baksi A
- Baldin Mg
- Bali Hk
- Ballantyne C
- Ballmajo M
- Balode A
- Balukova E
- Bang Sa
- Banker D
- Banker K
- Baquero A
- Barbarash Ol
- Barbato E
- Barbosa E
- Barnett S
- Baron S
- Barreto M
- Barroso A
- Barroso W
- Bartkowiak A
- Bartosh L
- Bartuseviciene S
- Bashir K
- Baszak J
- Bata Ir
- Bayram E
- Beall K
- Beaudry M
- Beauregard La
- Beckett L
- Belejchak P
- Belle Isle J
- Belohlavek J
- Bendelow T
- Bender D
- Benedetti G
- Benjamin S
- Benton J
- Berdoff R
- Berger V
- Bergeron P
- Bergholtz T
- Bergler-Klein J
- Berk M
- Berli Ma
- Bernstein M
- Berra Fc
- Berti S
- Berulfsen A
- Bevilacqua Mt
- Bhadade S
- Bilazarian S
- Bilodeau N
- Binder A
- Binns Y
- Birdane A
- Bisne V
- Bitzer V
- Blagdon M
- Blahey M
- Blankenberg S
- Blazsek Z
- Bloch S
- Blom Kb
- Bluemel J
- Blumberg C
- Blumenthal R
- Bocanera M
- Bodanese L
- Boffetti P
- Bohra P
- Bohula E
- Boivin Mc
- Bolduc H
- Boley K
- Bolognesi Mg
- Bolsmann C
- Boman K
- Bonner J
- Borrayo Na
- Boström På
- Botelho R
- Botta C
- Boudreaux R
- Boulanger K
- Bourgeois S
- Bouvy C
- Bowen L
- Boyarkin M
- Bradley A
- Brady L
- Bramlet D
- Brath H
- Braun P
- Bredlau C
- Brickman T
- Briggs S
- Briké C
- Brodmann M
- Brons S
- Brousalis L
- Brouwer M
- Brown C
- Brown N
- Brown S
- Buchannan C
- Budaj A
- Budassi N
- Budkova J
- Bugan V
- Buhlman S
- Bulashova O
- Bunschoten P
- Burke W
- Burley T
- Burova N
- Burris H
- Burton C
- Burton J
- Burton M
- Burtt D
- Busak L
- Busic N
- Byars W
- Bøen Rh
- C Clavier-Firmin
- C Conradie
- C Contzen
- C Cotes
- C Covert
- C Cuneo
- Caballero-Valiente B
- Cabau Jr
- Calabrese A
- Campanale Eg
- Candusso R
- Cantor W
- CANTOS Trial Group. Krum H
- Capova L
- Carabajal T
- Carr K
- Carrillo J
- Caruso G
- Casala J
- Caso P
- Casoinic F
- Castillo J
- Castillo T
- Cech V
- Cei L
- Cendali G
- Cepinskiene L
- Cerda L
- Cermak O
- Chachalis G
- Chaggar S
- Chambers J
- Chamblee T
- Chang K
- Chang Kc
- Chang Wh
- Charlier F
- Charmarthi B
- Chattin W
- Chauhan D
- Chauhan H
- Chaussé I
- Chavada J
- Chaverra I
- Chaware G
- Chee L
- Chella S
- Chen Cp
- Chen J
- Chen Mh
- Chen Y
- Chen Yc
- Chen Zc
- Cheng Jj
- Cheng S
- Cheng Sm
- Cherlin R
- Cheung D
- Chhabra A
- Chintala P
- Chiodi L
- Choi Aj
- Chou S
- Chouinard G
- Christensen L
- Christenson S
- Chung A
- Churina S
- Cifkova R
- Ciglenecki N
- Cioffi A
- Cislowski D
- Cleveland T
- Clocotan M
- Cmrecnjak J
- Colfer H
- Colhoun H
- Collier D
- Collins R
- Coloma G
- Colquhoun D
- Colvin T
- Coman S
- Commerford P
- Commerford P
- Conrado Y
- Cools F
- Cornel Jh
- Corona V
- Coronel J
- Cosgrove N
- Cosgrove S
- Cosmi F
- Costa Amorim R
- Coufalova Z
- Covell W
- Cox B
- Cox R
- Craig W
- Crandall L
- Crawford G
- Crea F
- Crepps K
- Crocamo A
- Cromer M
- Cruz H
- Cruz H
- Cruz M
- Csala L
- Cucher F
- Cuentas I
- Cuervo A
- Curiac D
- Cymerman K
- Cyprian R
- Czerski T
- D'Amours Dg
- D Dash
- D Dattani
- D Denham
- D Desai
- D Desalle
- D Digangi
- D Dunn
- Da Costa F
- Da Silva A
- Da Silva D Jr
- Da Silva O Jr
- Dahlen G
- Dalseg Am
- Damron M
- Danik J
- Davalos C
- Dave B
- Dave K
- Davidsson K
- Davies M
- Davies N
- Davis B
- Davis M
- Dawkins-Hughes S
- Dawood Sy
- Dayer M
- De Boer P
- De Caterina R
- De Jong C
- De Knijf K
- De Krumbach L
- De Los Milagros Had M
- De Los Rios M
- De Rosa S
- De Vos A
- De Wolf L
- Dean J
- Debnam S
- Decsi K
- Decsi Kl
- Dedek V
- Dedkova S
- Defosse C
- Degennaro N
- Dehning M
- Dela Llana A
- Delfonso F
- Delforge M
- Delgadillo T
- Dellasa M
- Dellborg M
- Dellorso M
- Demidova M
- Den Hartog F
- Denecke C
- Dengler T
- Dermitzakis A
- Deslongchamps F
- Dessalvi Cc
- Destro M
- Dettmer M
- Devasia T
- Deweerdt N
- Dhanak R
- Dhawan M
- Di Biase M
- Diago M
- Diaz M
- Dicken T
- Dickstein K
- Diederich C
- Diederich M
- Diehl R
- Diller P
- Dimattia M
- Dimitrov G
- Diodati J
- Dobariya H
- Dobilas V
- Dodds G
- Doesborg L
- Doggett J
- Dognini Gp
- Doi M
- Dokupilova A
- Dommerholt R
- Donahue K
- Donath M
- Donaubauer T
- Dong X
- Dormidontova G
- Dorogova I
- Dos Santos A
- Dos Santos F
- Dos Santos P
- Doughty A
- Doughty L
- Dovgalevskiy Y
- Dovgolis S
- Dragutksy B
- Dreese M
- Drost I
- Drouin K
- Duchesne L
- Duckert A
- Duda N
- Dudarev M
- Dudhatra N
- Duff J
- Duhan S
- Dunhurst F
- Dussan Ma
- Dutka C
- Dwenger E
- Dzupina A
- Dékány Jn
- E Eleuteri
- E Englmann
- Earl J
- East C
- Eaton C
- Eaves W
- Ebeling K
- Ebrahim I
- Eccleston D
- Echeverria L
- Eder F
- Edgerton L
- Edillo C
- Edwards J
- Edwards T
- Eichinger G
- Einhorn D
- Eki Y
- El Hachem M
- El Hafi S
- Ellenbroek D
- Ellis M
- Emil B
- Endo T
- Engelen W
- Erhard M
- Erickson B
- Ervin W
- Eskridge L
- Espinosa V
- Everett Bm
- F Fedele
- F Fonseca
- F Fucci
- Facello A
- Facello M
- Faghih M
- Fail P
- Falcon D
- Fang C
- Fang Cy
- Farias E
- Fattal P
- Fawson A
- Feitosa G
- Felario Junior Ga
- Felix L
- Feng Y
- Feng Z
- Ferdinand K
- Ferkl R
- Fernandez Aa
- Ferrari V
- Ferrario M
- Ferraz R
- Ferreira Dos Santos T
- Ferreira-Jardim A
- Fien E
- Filardi Pp
- Filho P
- Fintel D
- Firek C
- Fischer Sm
- Fisher J
- Fitilev S
- Fitz-Patrick D
- Fitzpatrick L
- Flaksa I
- Flather M
- Flezar M
- Fliesser-Goerzer E
- Flores E
- Flores E
- Flores Gs
- Flores H
- Floro T
- Foerster A
- Folkeringa Rj
- Fonseca A
- Fontaine S
- Forgon T
- Forgosh L
- Forker A
- Forster T
- Foster M
- Foucauld J
- Fowler V
- Fox B
- Franco M
- Francoeur L
- Frandsen B
- Frandsen B
- Frankenstein L
- Fratczak M
- Freitas E
- French J
- Frivold G
- Fruchter G
- Fu G
- Fucak E
- Fuchs R
- Fucili A
- Fukuike C
- Fullerton D
- Fulop P
- Fulop T
- Fulwani M
- Furch G
- Furuseth B
- G Gacioch
- G Gosselin
- Gabito A
- Gabor M
- Gabriel J
- Gabrielli D
- Gaeb-Strasas B
- Gamba C
- Ganau A
- Gapon L
- Garas S
- Garcia Duran R
- Garcia Pinna J
- Garcia Rinaldi R
- Garcia F
- Garcia N
- Garcia-Fragoso V
- Garcia-Portela M
- Garner K
- Gazizianova V
- Gelb R
- Genest J
- Genova D
- George F
- Germann H
- Gersh B
- Gervais B
- Ghali J
- Ghondale N
- Ghosh N
- Ghosh S
- Giese C
- Gilbert J
- Gilley J
- Gits F
- Glancy R
- Glenny J
- Glover J
- Glynn Rj
- Godoy Sanchez M
- Goette A
- Goff R
- Goffinet C
- Gohel P
- Goldberg N
- Gomez Sanchez J
- Gonsorcik J
- Gonzales D
- Gonzales V
- Gonzalez E
- Gordeev I
- Gorges R
- Gospodinov K
- Gotcheva N
- Goudev A
- Gould R
- Govindaraj D
- Goyal B
- Goyal S
- Grabeau R
- Grable M
- Graham J
- Graham Ja
- Graif J
- Gralow J
- Gravellone M
- Gravenhorst-Muenter U
- Green E
- Greener R
- Greenway F
- Grieshaber V
- Griffin S
- Grigaraviciene I
- Grigorova V
- Gros C
- Grosse A
- Grover A
- Grundtvig M
- Gudipati Rvc
- Guerrero A
- Guillinta P
- Gundala Ak
- Gupta A
- Gupta A
- Gupta M
- Gupta V
- Gutmann J
- Guzman I
- Guzman P
- Gwyn M
- Gyorgyova E
- H Haldane
- H Hansen
- H Haught
- H Hill
- Haase F
- Haege R
- Haenel T
- Hage F
- Hageman T
- Hagemann D
- Hagenow A
- Hagiwara Y
- Haidar A
- Haider K
- Hakas J
- Haldis T
- Hall C
- Hall L
- Hall S
- Halliwell Tc
- Halpern S
- Hamer Bjb
- Hamud-Socoro A
- Han B
- Han S
- Hanak P
- Hanefeld M
- Hangyal T
- Hansson A
- Hanustiakova A
- Hao Y
- Hardas S
- Hardee L
- Harrell W
- Harrington A
- Harris B
- Hartleib M
- Hartwell J
- Hasan F
- Hasbani E
- Hasegawa K
- Hattler B
- Haughton G
- Haynes E
- Haywood A
- He Y
- He Z
- Heaney L
- Hecht J
- Heeren G
- Hegedus V
- Heider J
- Heisters J
- Henley L
- Hennig D
- Henriksson A
- Hermans K
- Hernandez E
- Hernandez I
- Hernandez M
- Hernández N
- Herrman Jp
- Herzog W
- Hess E
- Hettwer Magedanz E
- Hickey L
- Hiden C
- Hielscher S
- Higuchi T
- Higuchi Y
- Hilkert R
- Hilton T
- Himpel-Boenninghoff A
- Hinderaker P
- Hioki M
- Hirayama A
- Hiroma J
- Ho Cj
- Hodnett P
- Hoffman M
- Hofsoey K
- Hogan C
- Hollanders G
- Holmes Z
- Holoubek D
- Holscher A
- Hominal M
- Homza M
- Hong T
- Hong T
- Hoogslag Pam
- Horackova K
- Horak A
- Hornig M
- Horvat P
- Hosokawa S
- Hotchkiss D
- Houra M
- Hristova K
- Hsieh Ic
- Huang A
- Huang P
- Huang Ph
- Humbert J
- Hurtig U
- Hutchens E
- Huynh T
- Hwang Jj
- Hwang Jj
- Hyun K
- Härstedt N
- Høivik Ho
- I Ilic
- I Ivanov
- Iachini K
- Iannopollo G
- Ibarra J
- Ibarra M
- Ibañez J
- Iby M
- Ichisawa M
- Igbokidi O
- Iijima T
- Ilahi T
- Ilic S
- Ilsley M
- Imbrognio M
- Imre Bs
- Inada T
- Inagaki M
- Indolfi C
- Infusino F
- Invitti C
- Ipp E
- Isaza D
- Istratoaie O
- Istvan Kp
- Iteld B
- Ito K
- Ivan P
- Iveta H
- Izmozherova N
- J Jiang
- J Johnson
- J Johnston
- J Jose
- Jacques G
- Jafri A
- Jafry B
- Jagtap P
- Jaguszewska G
- Jain A
- Jansen M
- Jardula M
- Jayasinghe R
- Jefferson D
- Jenkins R
- Jensen Ed
- Jeric M
- Jerzewski A
- Jeserich M
- Jia Z
- Jiang T
- Jiang X
- Jimenez D
- Jirvankar P
- Johansen Bb
- Johansen E
- Johansson K
- Johnson E
- Jones S
- Jonsson Je
- Joosten C
- Joshi U
- Julien Ve
- Julião K
- Jure D
- Jure H
- Jutrisa N
- K Kaigawa
- K Katahira
- K Kiroglu
- K Kordic
- K Kostov
- Kabakchieva Vm
- Kaczmarek N
- Kafarakis P
- Kaiserova L
- Kajihara S
- Kala P
- Kaldara E
- Kalina A
- Kalkman C
- Kam J
- Kamensky G
- Kamiya H
- Kamiya J
- Kan G
- Kaneno Y
- Kanitz S
- Kapp I
- Kara Yd
- Karakai H
- Karel I
- Karpuram M
- Karsai Xz
- Kastelein Jjp
- Kataoka M
- Katona A
- Katova T
- Kaur H
- Kawahara M
- Kawai M
- Kawasaki T
- Kawka-Urbanek T
- Kazanskay E
- Ke Y
- Keba E
- Keenan S
- Kelehan S
- Kellnerova I
- Kelly R
- Kelt T
- Kendall T
- Kereiakes D
- Khan A
- Khan M
- Khan R
- Khan S
- Khariouzov A
- Khirmanov V
- Khromtsova O
- Kick J
- Kiefer R
- Kietselaer B
- Kim B
- Kim Ks
- Kim M
- Kimmel M
- King A
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- Kirkland S
- Kiss Rg
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- Kitchens D
- Klamm M
- Klein C
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- Klemsdal To
- Kleve R
- Klugherz B
- Knight J
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- Kobalava Z
- Kodem Dr
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- Kojima E
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- Koleckar P
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- Kolleroy C
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- Komati S
- Komura Y
- Kondagunta V
- Konradi A
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- Kopczyńska M
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- Kovacic D
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- Kreutter F
- Krupciakova B
- Krupicka J
- Kuenzler J
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- Kulkarni L
- Kullal P
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- Kumbla M
- Kuntzsch A
- Kuo Jy
- Kuramochi T
- Kuruma T
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- Kyo E
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- Labovitz R
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- Ledger G
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- Ligueros M
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- Lorenzatti A
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- Luecke-Uzar M
- Luedemann J
- Lukac J
- Lundqvist M
- Lupkovics G
- Luquez H
- Luz Serrano H
- Lv Y
- Lynd S
- Lysek R
- Lönnberg I
- M Malek
- M Mallagray
- M Mandati
- M Mandviwala
- M Marsters
- M Mays
- M Mcdonald
- M Medvegy
- M Meinrich
- M Mikus
- M Milanova
- M Moustafa
- Ma C
- Ma G
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- Macdonald J
- Macfadyen Jg
- Machova V
- Madder R
- Maehara G
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- Magness K
- Maheshwari A
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- Maia L
- Majercak I
- Majul C
- Makedonska Jj
- Makhe B
- Makotoko E
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- Malhotra S
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- Malik J
- Mancikova I
- Mandic L
- Manenti E
- Manfreda S
- Manga P
- Mani Ck
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- Manning B
- Mannucci E
- Manolis A
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- Manov E
- Mantas I
- Manuel J
- Manukov D
- Manukov I
- Manyari D
- Manzur F
- Marcela Wenetz Lm
- Marchelletta N
- Marchi Al
- Marcinkeviciene J
- Marcun R
- Marengo Garcia De Carvalho L
- Marinaro S
- Marino P
- Mariottoni B
- Maron B
- Marschke T
- Marshall L
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- Martinez J
- Maruzzo S
- Marziali A
- Masarikova L
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- Mathew A
- Matyasek I
- Mauersberger K
- Maus O
- Mavromatis K
- Maximov D
- Mayer T
- Maynard R
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- Mazutavicius R
- Mbulaiteye A
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- Mccrary D Jr
- Mccullough-O'Brien H
- Mcgill J
- Mcgrew F
- Mcintosh C
- Mckenzie A
- Mckenzie C
- Mckibbin A
- Mclaurin B
- Mclellan Ba
- Mcmahon G
- Mcneil D
- Mcneill R
- Mcpherson C
- Medina F
- Megalou A
- Mehrle A
- Mehta A
- Mehta S
- Meijlis P
- Meissner A
- Mejia I
- Melbie K
- Mellberg L
- Melliza T
- Mendoza N
- Mendoza Y
- Mercuro G
- Merkely B
- Messina T
- Mestdagh I
- Meyer R
- Michalaros Y
- Michalska A
- Michaud N
- Michel K
- Mickel C
- Micko K
- Mihaly N
- Mikdadi G
- Mikusova T
- Milicic D
- Militaru C
- Miliuniene R
- Milkas A
- Miller A
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- Miller G
- Miller R
- Miller W
- Minescu B
- Minocha G
- Mitchell J
- Mittal A
- Miyamoto T
- Moats Djr
- Modi R
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- Z Zhai
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- Zadionchenko V
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- Zieve F
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- Zirlik A
- Zucchetti C
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.
Wissen, Arbeit, Freundschaft: Ökonomien und soziale Beziehungen an den Akademien in London, Paris und Berlin um 1700. By Sebastian Kühn. Göttingen: V&R Unipress. 2011. Pp. 361. ISBN 978-3-8997-1836-2.
- Author
- Publication venue
- 'Cambridge University Press (CUP)'
- Publication date
- Field of study
Exorcism and Enlightenment: Johann Joseph Gassner and the Demons of Eighteenth-Century Germany. By H. C. Erik Midelfort. New Haven and London: Yale University Press. 2005. Pp. xiii+219. Cloth $35.00. ISBN 0-300-10669-6.
- Author
- Publication venue
- 'Cambridge University Press (CUP)'
- Publication date
- Field of study
Pietismus und Ökonomie bei deutschen reformierten Kaufleuten südniederländischer Herkunft am Ende des 17. Jahrhunderts
- Publication venue
- 'Vandenhoeck & Ruprecht GmbH & Co, KG'
- Publication date
- 01/01/2021
- Field of study
Funders as principals
- Author
- Anheier
- Anheier
- Baker
- Barman
- Benjamin
- Benjamin
- Bogart
- Brilliant
- Caers
- Cairns
- Campbell
- Christensen
- Cobb
- Cutt
- Davis
- Denzin
- Donahue
- Drucker
- Ebrahim
- Ebrahim
- Edwards
- Eikenberry
- Eisenhardt
- Firstenberg
- Fischer
- Frumkin
- Frumkin
- Frumkin
- Grace
- Grønbjerg
- Jenkins
- Jensen
- Letts
- Letts
- Light
- MacDonald
- Marschke
- Morely
- Murray
- Ospina
- Ostrander
- Ostrander
- Ostrower
- Patton
- Patton
- Poister
- Porter
- Preston
- Ross
- Ryan
- Sawhill
- Speckbacher
- Wagner
- Waterman
- Yin
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Bearing More Risk for Results
- Author
- Beck U.
- Behn R.D.
- Belenky M.F.
- Bernstein P.L.
- Chaskin R.J.
- Chiles T.H.
- Denzin N.
- Donahue J.D.
- Dorfman M.S.
- Edwards B.
- Edwards M.
- Eisenhardt K.M.
- Evans S.M.
- Field J.
- Fisher R.
- Frumkin P.
- Gecan M.
- Giddens A.
- Gittell R.
- Goldsmith S.
- Hatry H.
- Hendry J.
- Herman M.
- Herman M.L.
- Lehn M. Benjamin
- MacMurray J.
- March J.G.
- Marschke G.
- McIntosh E.
- O'Neill O.
- Patton M.Q.
- Poister T.H.
- Power M.
- Pratt J.W.
- Ryan G.W.
- Sheppard B.H.
- Sitkin S.B.
- Skocpol T.
- Smock K.
- Stoker R.P.
- Wiseman R.M.
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
Wein und falsche Freunde
- Author
- Add BL
- Anhalt-Dessau
- Bahlcke
- Benjamin Marschke Zum Hintergrund
- Bericht des Gesandten Havard Dies
- Berlin So
- Borgmann Karl
- Braubach
- Braubach
- Braubach
- Braubach
- BrCz
- Béla Köpeczi
- den älteren Zu
- Dies
- Diplomatiegeschichte der Frühen Zu »akteursbezogener«
- Fiedler
- Friedberg
- Friedrich Wilhelm
- Harnack Adolf
- Jablonski Die Briefe
- Jablonski Rákóczi
- Jarnut-Derbolav Elke
- Joachim Bahlcke Beispiele
- Klement Jablonski
- Kontext Zum
- Library London Lambeth Palace
- Marlborough Memoire Klements
- Oppeln-Bronikowski
- Oppeln-Bronikowski
- Oppeln-Bronikowski
- Oppeln-Bronikowski S.
- Révész Imre
- Schäufele Wolf-Friedrich
- Ulrich Naujokat Zu Rabys
- Vaters Edward Chamberlayne Dabei
- Von Anspielungen
- von Friedberg Heinrich
- Zu Hales
- Zu Jablonskis
- Zur Kultur
- ßischer Zu Amt
- ühneuzeitlichen Zum
- ührlichen Memoriale Siehe
- Publication venue
- 'Boehlau Verlag Ges.m.b.H. & Co. KG'
- Publication date
- Field of study
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- Brigitte Döring
- Brück Helga
- Brück Helga
- Brückner Heidemarie Gruppe
- Brückner Wolfgang
- Brückner Wolfgang
- Bugge-Amundsen Arne
- Burke Peter
- Bußmann Heinz Schilling
- Bähr Andreas
- Bähr Andreas
- Bärwinkel Richard
- Bäseler Gregoria M
- Calvi Dario Biocca
- Choné Paulette
- Cohen A. H.
- Collinson Patrick
- Conermann Klaus
- Constable Giles
- Copenhaver Brian P
- Creveld
- Damgaard Peter
- Davis
- Dedekind Henning
- Demos John
- Denzler Georg
- Diehl Wilhelm
- Dieterich H. A.
- Dorothy Walter L
- Dowding W.
- Drews
- Duhr
- Durston Christopher
- Dülmen
- Elsner Bartholomäus
- Elsner Bartholomäus
- Evenius
- Falckenstein
- Faller Stefan
- Flacius Matthias
- Flemming
- Forssberg
- Freund Wolfgang
- Freytag Georgina Malcolm
- Freytag Georgina Malcolm
- Freytag Georgina Malcolm
- Friedeburg Michael Seidler
- Friedrichs Christopher
- Friedrichs Christopher
- Frijhoff Willem
- Fritz Friedrich
- Fulda Daniel
- Gaenschalz Erich
- Gangl Peter
- Gantet Claire
- Gantet Claire
- Gelderen
- Genuth
- Gestrich Andreas
- Gordon Bruce
- Graf Klaus
- Graff Paul
- Göransson Sven
- Haag Norbert
- Hadin Bert
- Hagendorn Wilhelm
- Hallier Christian
- Hallier Christian
- Harms Wolfgang
- Harms Wolfgang
- Haude Sigrun
- Heal Bridget
- Heiligensetzer Lorenz
- Helbing Harald Rockstuhl
- Held Wieland
- Henke
- Henning Hans
- Herrmann Rudolf
- Hesse
- Hesse
- Hesse
- Heubel Michael
- Hildebrand Wolfgang
- Hill Christopher
- Hoffmann Philip R
- Hogg James
- Hohmeyer Susanne
- Holl Karl
- Holländer Eugen
- Holzem Andreas
- Holzem Andreas
- Holzem Andreas
- Holzem Andreas
- Huntebrinker Jan
- Hupe
- Huschke Wolfgang
- Huth Robert
- Huth Robert
- Huth Robert
- Häussermann
- Ingen
- Ingen
- Jacob Hugo
- Jacob Hugo
- Jakubowski-Tiessen Hartmut
- Jakubowski-Tiessen Hartmut
- Jean Delumeau
- Jean Delumeau
- Johanek Peter
- Johannesson Kurt
- Johannsson Kenneth
- Kaiser Michael
- Kaufmann Thomas
- Kaufmann Thomas
- Kaufmann Thomas
- Kirchhoff Alfred
- Klee Ernst
- Kleineidam Erich
- Klingebiel Thomas
- Klinger Andreas
- Klueting Harm
- Koch Ernst
- Konkordienformel
- Kordes Uwe
- Krebs Julius
- Kreter Karljosef
- Krusenstjern
- Krusenstjern
- Krusenstjern
- Krusenstjern
- Krusenstjern
- Kruspe Heinrich
- Kröhn Vorstellungswelt
- Königshof Kaspar
- Könnecke Georg
- Kühlmann Wilhelm
- Lawee Eric
- Le Cam Jean-Luc
- Lehmann Hartmut
- Lehmann Hartmut
- Lehmann Hartmut
- Lehmann Hartmut
- Leibniz
- Levi Giovanni
- Lind Gunner
- Lind Gunner
- Lindqvist
- Linné
- Lockhart
- Lorenz Maren
- Loth
- Loth Richard
- Lotz-Heumann Ute
- Ludscheidt Michael
- Luther Martin
- Luther Martin
- Luther Martin
- Luther Martin
- Luther Martin
- MacDonald Michael
- Macfarlane Alan
- Macfarlane Alan
- Madison Gaillard
- Mager Inge
- Mahlmann Theodor
- Mahlmann Theodor
- Marschke Benjamin
- Marshall Peter
- Martens Carl
- Martens Karl
- Martens Karl
- Martens Karl
- Marti Hanspeter
- Marx Jr.
- Matthias Markus
- Matthäus Klaus
- Mauer Benedikt
- Medick Hans
- Medick Hans
- Medick Hans
- Medick Hans
- Meissner Temperantia
- Melanchthon Philipp
- Melanchthon Philipp
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- Monro Robert
- Mori Ryoko
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- Pargament Kenneth I
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- Philosophie
- Pleiss Detlev
- Pleiss Detlev
- Pohl Susanne
- Pontoppidan Erik
- Popkin Beate
- Prass Reiner
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- Racaut Luc
- Rach Alfred
- Rathey Markus
- Rathey Markus
- Rathjen Jörg
- Rau Susanne
- Rehefeld Johann
- Rehefeld Johann
- Reiffenberg Hermann
- Roberts Michael
- Roeck Bernd
- Rohden
- Rohmer Ernst
- Rohr Christian
- Roper Trevor
- Roseberry William
- Rublack Hans-Christoph
- Rydberg Olof
- Rydberg Olof
- Röhrich Lutz
- Sabean David
- Scharold
- Schauerte Franz
- Schenda Rudolf
- Schenda Rudolf
- Schenda Rudolf
- Schilling Heinz
- Schindler Norbert
- Schlögl Rudolf
- Schmidt
- Schmidt
- Schmidt Jörg
- Schnabel
- Schnabel-Schüle Helga
- Schorn-Schütte Luise
- Schrader
- Schrader
- Schreiner Klaus
- Schröder
- Schröter Axel
- Schultz Georg
- Schum Wilhelm
- Schwegler Michaela
- Schönstädt Hans-Jürgen
- Scott Dixon Charles
- Scribner W.
- Scribner W.
- Scribner W.
- Scribner W.
- Seaver Paul S
- Secher
- Sehling Emil
- Singer Samuel
- Sixty-Fifth Birthday
- Soergel Philip M
- Spener Philipp Jakob
- Spener Philipp Jakob
- Stearns Carol Z
- Steiger
- Steiger
- Steiger
- Stenermark Yngve
- Stieler F.
- Stievermann Dieter
- Stievermann Dieter
- Strom Jonathan
- Sträter Udo
- Studt Birgit
- Stögmann Arthur
- Subrahmanyam Sanjay
- Szamatólski Siegfried
- Taylor Archer
- Taylor Archer
- Telle Joachim
- Tettau Wilhelm J
- Theibault John
- Theibault John
- Theibault John
- Theibault John
- Tholuck August
- Tlusty
- Tolley Bruce
- Trepp
- Trevor-Roper Hugh
- Tubach Jürgen
- Tümmler Hans
- Uhland Ludwig
- Ulbrich Claudia
- Ulbricht Otto
- Utermöhlen Gerda
- Vanja Christina
- Veit Patrice
- Veit Patrice
- Veit Patrice
- Veit Patrice
- Venables
- Venables
- Ventzke Marcus
- Ventzke Marcus
- Vollbracht Johann
- Waas
- Wagner Ernst
- Wagner Ernst
- Wagner Ernst
- Wagner Ernst
- Wahl Johannes
- Wallmann Johannes
- Wallmann Johannes
- Wallmann Johannes
- Wallmann Johannes
- Walsham Alexandra
- Walter Catastrophes
- Walz Rainer
- Watt Tessa
- Weaver
- Weber
- Weber Johannes
- Wegele
- Weissenborn
- Weiß Ulman
- Weiß Ulman
- Weiß Ulman
- Weiß Ulman
- Weiß Ulman
- Weiß Ulman
- Weiß Ulman
- Weller Emil
- Wiegand Fritz
- Williamson Philipp
- Winnige Norbert
- Winnige Norbert
- Wintruff Wilhelm
- Wolf Stephanie
- Wolfrum Heinrich
- Wölfel Dieter
- Zapf Nicolaus
- Zeller Rosmarie
- Zeng Michael
- Zigra Johann
- Zschiesche Paul
- Publication venue
- 'Vandenhoeck & Ruprecht GmbH & Co, KG'
- Publication date
- Field of study
Antiinflammatory therapy with canakinumab for atherosclerotic disease
- Author
- Abaci F.
- Abbate A.
- Abdullakutty J.
- Abhaichand R.
- Abhyankar A.
- Abib E.Jr.
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- Acheatel R.
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- Field of study
BACKGROUND: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. METHODS: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P=0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P=0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P=0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P=0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P=0.31). CONCLUSIONS: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. Copyright © 2017 Massachusetts Medical Society