98 research outputs found
Universal jurisdiction and the International Court of Justice: a comment on the Congo cases
Universal jurisdiction relates to unprecedented developments which occurred in international law over the last decades, especially since the creation of the United Nations. Universal jurisdiction is linked with the emergence of international human rights law and criminal law and unfortunately conflicts with traditional international law principles such as equality among states and state sovereignty. International lawyers gave it renewed attention in the aftermath of the Pinochet case. However, the International Court of Justice was still to pronounce on its legality. The DRC case provided the first test but as some uncertainty remained, Africa in the Congo case returned to the World Court to help it dispose of the matter, making yet another contribution to the development of international law. The Congo case is still pending. This article discusses universal jurisdiction and sovereign immunity briefly. Against the backdrop of the DRC and the Congo cases, the author reflects on the prospects for universal jurisdiction. He contends that the ICJ will remain primarily a court for states and finally urges that the combat that culminated in the establishment of the International Criminal Court should continue to mark a new era for human and peoples’ rights in international law in this new century
Hookworm Infection and Environmental Factors in Mbeya Region, Tanzania: A Cross-sectional, Population-based study.
Hookworm disease is one of the most common infections and cause of a high disease burden in the tropics and subtropics. Remotely sensed ecological data and model-based geostatistics have been used recently to identify areas in need for hookworm control. Cross-sectional interview data and stool samples from 6,375 participants from nine different sites in Mbeya region, south-western Tanzania, were collected as part of a cohort study. Hookworm infection was assessed by microscopy of duplicate Kato-Katz thick smears from one stool sample from each participant. A geographic information system was used to obtain remotely sensed environmental data such as land surface temperature (LST), vegetation cover, rainfall, and elevation, and combine them with hookworm infection data and with socio-demographic and behavioral data. Uni- and multivariable logistic regression was performed on sites separately and on the pooled dataset. Univariable analyses yielded significant associations for all ecological variables. Five ecological variables stayed significant in the final multivariable model: population density (odds ratio (OR) = 0.68; 95% confidence interval (CI) = 0.63-0.73), mean annual vegetation density (OR = 0.11; 95% CI = 0.06-0.18), mean annual LST during the day (OR = 0.81; 95% CI = 0.75-0.88), mean annual LST during the night (OR = 1.54; 95% CI = 1.44-1.64), and latrine coverage in household surroundings (OR = 1.02; 95% CI = 1.01-1.04). Interaction terms revealed substantial differences in associations of hookworm infection with population density, mean annual enhanced vegetation index, and latrine coverage between the two sites with the highest prevalence of infection. This study supports previous findings that remotely sensed data such as vegetation indices, LST, and elevation are strongly associated with hookworm prevalence. However, the results indicate that the influence of environmental conditions can differ substantially within a relatively small geographic area. The use of large-scale associations as a predictive tool on smaller scales is therefore problematic and should be handled with care
Multilingual representations for low resource speech recognition and keyword search
© 2015 IEEE. This paper examines the impact of multilingual (ML) acoustic representations on Automatic Speech Recognition (ASR) and keyword search (KWS) for low resource languages in the context of the OpenKWS15 evaluation of the IARPA Babel program. The task is to develop Swahili ASR and KWS systems within two weeks using as little as 3 hours of transcribed data. Multilingual acoustic representations proved to be crucial for building these systems under strict time constraints. The paper discusses several key insights on how these representations are derived and used. First, we present a data sampling strategy that can speed up the training of multilingual representations without appreciable loss in ASR performance. Second, we show that fusion of diverse multilingual representations developed at different LORELEI sites yields substantial ASR and KWS gains. Speaker adaptation and data augmentation of these representations improves both ASR and KWS performance (up to 8.7% relative). Third, incorporating un-transcribed data through semi-supervised learning, improves WER and KWS performance. Finally, we show that these multilingual representations significantly improve ASR and KWS performance (relative 9% for WER and 5% for MTWV) even when forty hours of transcribed audio in the target language is available. Multilingual representations significantly contributed to the LORELEI KWS systems winning the OpenKWS15 evaluation
The Simons Observatory: Cryogenic Half Wave Plate Rotation Mechanism for the Small Aperture Telescopes
We present the requirements, design and evaluation of the cryogenic
continuously rotating half-wave plate (CHWP) for the Simons Observatory (SO).
SO is a cosmic microwave background (CMB) polarization experiment at Parque
Astron\'{o}mico Atacama in northern Chile that covers a wide range of angular
scales using both small (0.42 m) and large (6 m) aperture telescopes. In
particular, the small aperture telescopes (SATs) focus on large angular scales
for primordial B-mode polarization. To this end, the SATs employ a CHWP to
modulate the polarization of the incident light at 8~Hz, suppressing
atmospheric noise and mitigating systematic uncertainties that would
otherwise arise due to the differential response of detectors sensitive to
orthogonal polarizations. The CHWP consists of a 505 mm diameter achromatic
sapphire HWP and a cryogenic rotation mechanism, both of which are cooled down
to 50 K to reduce detector thermal loading. Under normal operation the
HWP is suspended by a superconducting magnetic bearing and rotates with a
constant 2 Hz frequency, controlled by an electromagnetic synchronous motor.
The rotation angle is detected through an angular encoder with a noise level of
0.07. During a cooldown, the rotor is held in
place by a grip-and-release mechanism that serves as both an alignment device
and a thermal path. In this paper we provide an overview of the SO SAT CHWP:
its requirements, hardware design, and laboratory performance.Comment: 19 pages, 21 figures, submitted to RS
Investigational new drug enabling angiotensin oral-delivery studies to attenuate pulmonary hypertension
Pulmonary arterial hypertension (PAH) is a deadly and uncurable disease characterized by remodeling of the pulmonary vasculature and increased pulmonary artery pressure. Angiotensin Converting Enzyme 2 (ACE2) and its product, angiotensin-(1-7) [ANG-(1-7)] were expressed in lettuce chloroplasts to facilitate affordable oral drug delivery. Lyophilized lettuce cells were stable up to 28 months at ambient temperature with proper folding, assembly of CTB-ACE2/ANG-(1-7) and functionality. When the antibiotic resistance gene was removed, Ang1-7 expression was stable in subsequent generations in marker-free transplastomic lines. Oral gavage of monocrotaline-induced PAH rats resulted in dose-dependent delivery of ANG-(1-7) and ACE2 in plasma/tissues and PAH development was attenuated with decreases in right ventricular (RV) hypertrophy, RV systolic pressure, total pulmonary resistance and pulmonary artery remodeling. Such attenuation correlated well with alterations in the transcription of Ang-(1-7) receptor MAS and angiotensin II receptor AGTRI as well as IL-1β and TGF-β1. Toxicology studies showed that both male and female rats tolerated ~10-fold ACE2/ANG-(1-7) higher than efficacy dose. Plant cell wall degrading enzymes enhanced plasma levels of orally delivered protein drug bioencapsulated within plant cells. Efficient attenuation of PAH with no toxicity augurs well for clinical advancement of the first oral protein therapy to prevent/treat underlying pathology for this disease
ePOCT+ and the medAL-suite: Development of an electronic clinical decision support algorithm and digital platform for pediatric outpatients in low- and middle-income countries
Spoken term detection ALBAYZIN 2014 evaluation: overview, systems, results, and discussion
The electronic version of this article is the complete one and can be found online at: http://dx.doi.org/10.1186/s13636-015-0063-8Spoken term detection (STD) aims at retrieving data from a speech repository given a textual representation of the search term. Nowadays, it is receiving much interest due to the large volume of multimedia information. STD differs from automatic speech recognition (ASR) in that ASR is interested in all the terms/words that appear in the speech data, whereas STD focuses on a selected list of search terms that must be detected within the speech data. This paper presents the systems submitted to the STD ALBAYZIN 2014 evaluation, held as a part of the ALBAYZIN 2014 evaluation campaign within the context of the IberSPEECH 2014 conference. This is the first STD evaluation that deals with Spanish language. The evaluation consists of retrieving the speech files that contain the search terms, indicating their start and end times within the appropriate speech file, along with a score value that reflects the confidence given to the detection of the search term. The evaluation is conducted on a Spanish spontaneous speech database, which comprises a set of talks from workshops and amounts to about 7 h of speech. We present the database, the evaluation metrics, the systems submitted to the evaluation, the results, and a detailed discussion. Four different research groups took part in the evaluation. Evaluation results show reasonable performance for moderate out-of-vocabulary term rate. This paper compares the systems submitted to the evaluation and makes a deep analysis based on some search term properties (term length, in-vocabulary/out-of-vocabulary terms, single-word/multi-word terms, and in-language/foreign terms).This work has been partly supported by project CMC-V2
(TEC2012-37585-C02-01) from the Spanish Ministry of Economy and
Competitiveness. This research was also funded by the European Regional
Development Fund, the Galician Regional Government (GRC2014/024,
“Consolidation of Research Units: AtlantTIC Project” CN2012/160)
Results of gravitational lensing and primordial gravitational waves from the POLARBEAR experiment
POLARBEAR is a Cosmic Microwave Background radiation (CMB) polarization experiment that is located in the Atacama Desert in Chile. The scientific goals of the experiment are to characterize the B-mode signal from gravitational lensing, as well as to search for B-mode signals created by primordial gravitational waves (PGWs). Polarbear started observations in 2012 and has published a series of results. These include the first measurement of a nonzero B-mode angular auto-power spectrum at sub-degree scales where the dominant signal is gravitational lensing of the CMB. In addition, we have achieved the first measurement of crosscorrelation between the lensing potential, which was reconstructed from the CMB polarization data alone by Polarbear, and the cosmic shear field from galaxy shapes by the Subaru Hyper Suprime-Cam (HSC) survey. In 2014, we installed a continuously rotating half-wave plate (CRHWP) at the focus of the primary mirror to search for PGWs and demonstrated the control of low-frequency noise. We have found that the low-frequency B-mode power in the combined dataset with the Planck high-frequency maps is consistent with Galactic dust foreground, thus placing an upper limit on the tensor-to-scalar ratio of r < 0.90 at the 95% confidence level after marginalizing over the foregrounds
Psychological distress and its relationship with non-adherence to TB treatment: a multicentre study
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