Caracterização físico-química, microbiológica e de compostos bioativos de suco tropical e néctar de juçara, acerola e misto de juçara com acerola / Physical-chemical, microbiological and bioactive compounds characterization of tropical juice and juçara, acerola and mixed juçara with acerola néctar

O desenvolvimento de bebidas mistas de juçara com acerola apresenta potencial de valorização da biodiversidade e fornecimento de um produto com elevado valor nutricional. O objetivo deste trabalho foi caracterizar suco tropical e néctar nos sabores acerola, juçara e misto de acerola com juçara quanto a suas características físico-químicas, microbiológicas e bioativas ao longo de 120 dias de armazenamento. As bebidas de juçara apresentaram maiores médias (1088,41mg AGE. mL-1) para compostos fenólicos totais, enquanto as bebidas mistas apresentaram médias de 734,9 mg AGE.mL-1 e as de acerola 184,48 mg AGE.mL-1. As bebidas de acerola apresentaram maiores médias de capacidade antioxidante (11.276,39 ?M Trolox.mL-1). No suco tropical misto houve redução da capacidade antioxidante ao longo dos 120 dias (p<0,05). As antocianinas totais se mantiveram estáveis até os 90 dias (p>0,05) e aos 120 dias de armazenamento foi observado um decréscimo 17,8% (p<0,05). Os carotenoides para suco tropical das bebidas puras foram as mais altas (p<0,05). As bebidas de acerola apresentaram as maiores médias para ácido ascórbico, enquanto as mistas e puras de juçara apresentaram médias semelhantes (p>0,05). As bebidas de acerola apresentaram degradação de 23% de ácido ascórbico a partir do tempo 60 dias. As bebidas mistas apresentaram maiores médias para o parâmetro de cor a* e médias superiores que as bebidas de juçara para o parâmetro b* (p<0,05) indicando que o suco tendeu à cor vermelho amarelada. Apesar dos compostos fenólicos, antocianinas e capacidade antioxidante terem reduzido ao longo do tempo, o desenvolvimento de bebidas mistas de acerola e juçara apresentou uma estratégia interessante de desenvolvimento de produtos com alegação funcional, combinando as melhores características das duas frutas

A completeness indicator of gestational and congenital syphilis information in Brazil

OBJECTIVE: To evaluate the quality of information on gestational syphilis (GS) and congenital syphilis (CS) on the Sistema de Informação de Agravos de Notificação (SINAN-Syphilis Brazil – Notifiable Diseases Information System) by compiling and validating completeness indicators between 2007 and 2018. METHODS: Overall, care, and socioeconomic completeness scores were compiled based on selected variables, by using ad hoc weights assigned by experts. The completeness scores were analysed, considering the region and area of residence, the pregnant woman’s race/colour, and the year of case notification. Pearson’s correlation coefficients were used to validate the scores obtained by the weighted average method, compared with the values obtained by principal component analysis (PCA). RESULTS: Most selected variables presented a good or excellent degree of completeness for GS and CS, except for clinical classification, pregnant woman’s level of education, partner’s treatment, and child’s race/colour, which were classified as poor or very poor. The overall (89.93% versus 89.69%) and socioeconomic (88.71% versus 88.24%) completeness scores for GS and CS, respectively, were classified as regular, whereas the care score (GS-90.88%, and CS-90.72%) was good, despite improvements over time. Differences in the overall, care and socioeconomic completeness scores according to region, area of residence, and ethnic-racial groups were reported for syphilis notifications. The completeness scores estimated by the weighted average method and PCA showed a strong linear correlation (> 0.90). CONCLUSION: The completeness of GS and CS notifications has been improving in recent years, highlighting the variables that form the care score, compared with the socioeconomic scores, despite differences between regions, area of residence, and ethnic-racial groups. The weighted average was a viable methodological alternative easily operationalised to estimate data completeness scores, allowing routine monitoring of the completeness of gestational and congenital syphilis records

Prevalence of oral mucosal lesions in a brazilian military police population

Background: Data obtained from oral health surveys are very important for identifying disease-susceptible groups and for developing dental care and prevention programs. So, the purpose of the current article was to investigate the prevalence of oral mucosa lesions (OMLs) in a population of Brazilian police. Material and Methods: Interviews and oral cavity examinations were performed on a sample of 395 police officers who were randomly selected by the calibrated researcher. The number of individuals was obtained by a sample calculation using the finite population correction. The diagnostic criteria were based on the WHO (1997) criteria and adapted to Brazilian surveys. Results: In total, 8.61% of the population presented some OML. Traumatic injuries and benign migratory glossitis (BMG) were the most prevalent lesions. Conclusions: The prevalence of potentially malignant disorders was lower than among the Brazilian population. The most prevalent lesion among the police officers was related to trauma. Patients dissatisfied with oral health had a higher risk of presenting OMLs

Juliano Moreira : o brasileiro negro que influenciou profundamente a escola de Neurologia no Brasil

Juliano Moreira was a black Brazilian physician, well recognized for his role in the foundation of scientific psychiatry in Brazil; however, little is known about his influences on modern Neurology. Our aim is to highlight Moreira’s importance in the field of Neurology and his role in the development of scientific and medical societies in Brazil. We describe his contributions from his doctoral thesis in 1891 to his 27- year tenure as the director of the National Hospice for the Insane. We also review Moreira’s role in the foundation of societies including the Brazilian Academy of Sciences and the first Brazilian journal dedicated to Neuropsychiatry, concluding that Moreira was one of the most important influential figures for the development of Neurology in Brazil. In addition to his influences on various medical fields, Moreira distinguished himself as an impactful citizen who fought against racist and xenophobic medical theories of his time.Juliano Moreira foi um médico negro brasileiro reconhecido por seu papel na fundação da psiquiatria científica no Brasil; no entanto, pouco sabemos sobre sua influência na Neurologia moderna no país. Nosso objetivo é destacar a importância de Moreira no campo da Neurologia e seu papel no desenvolvimento de sociedades científicas e médicas no Brasil. Descrevemos suas contribuições desde sua tese de doutorado, em 1891, até a sua atuação durante 27 anos como diretor do Hospital Nacional de Alienados. Revisamos também o papel de Moreira na fundação de sociedades como a Academia Brasileira de Ciências, e da primeira revista brasileira dedicada à Neuropsiquiatria, concluindo que Moreira foi um dos mais importantes influenciadores para o desenvolvimento da Neurologia no Brasil. Além de sua ampla influência no campo da medicina, destacou-se como cidadão brasileiro, lutando contra teorias médicas racistas e xenófobas de seu tempo

Bisphenol A increases hydrogen peroxide generation by thyrocytes both in vivo and in vitro

Bisphenol A (BPA) is the most common monomer in polycarbonate plastics and an endocrine disruptor. Though some effects of BPA on thyroid hormone (TH) synthesis and action have been described, the impact of this compound on thyroid H2O2 generation remains elusive. H2O2 is a reactive oxygen species (ROS), which could have deleterious effect on thyrocytes if in excess. Therefore, herein we aimed at evaluating the effect of BPA exposition both in vivo and in vitro on H2O2 generation in thyrocytes, besides other essential steps for TH synthesis. Female Wistar rats were treated with vehicle (control) or BPA 40 mg/kg BW for 15 days, by gavage. We then evaluated thyroid iodide uptake, mediated by sodium-iodide symporter (NIS), thyroperoxidase (TPO) and dual oxidase (DOUX) activities (H2O2 generation). Hydrogen peroxide generation was increased, while iodide uptake and TPO activity were reduced by BPA exposition. We have also incubated the rat thyroid cell line PCCL3 with 10−9 M BPA and evaluated Nis and Duox mRNA levels, besides H2O2 generation. Similar to that found in vivo, BPA treatment also led to increased H2O2 generation in PCCL3. Nis mRNA levels were reduced and Duox2 mRNA levels were increased in BPA-exposed cells. To evaluate the importance of oxidative stress on BPA-induced Nis reduction, PCCL3 was treated with BPA in association to N-acetylcysteine, an antioxidant, which reversed the effect of BPA on Nis. Our data suggest that BPA increases ROS production in thyrocytes, what could lead to oxidative damage thus possibly predisposing to thyroid disease

PREDIÇÃO DE HABILIDADES COGNITIVAS POR MEIO DAS CAPACIDADES FÍSICAS DE ACORDO COM SEXO

Este estudo teve como objetivo analisar se as capacidades físicas e nível de escolaridade de idosos são capazes de predizer suas habilidades cognitivas, considerando ainda se há influência do sexo na execução de tarefas simultâneas. Para tanto, foram avaliados 100 idosos com 60 anos ou mais de idade, de ambos os sexos, a partir da utilização dos instrumentos Montreal Cognitive Assesment (MoCA), a fim de verificar comprometimentos cognitivos, mensuração da força de preensão palmar por meio da medida no dinamômetro Jamar®, e mensuração da mobilidade funcional pelo teste Timed Get Up and Go (TUG), com e sem tarefa cognitiva. Os resultados obtidos neste estudo demonstraram que a idade, o nível de escolaridade e as capacidades físicas, a especificar a força de preensão palmar e mobilidade funcional, são capazes de predizer o desempenho no teste cognitivo MoCA, além de que os valores preditores encontrados são diferentes conforme o sexo em idosos. Concluiu-se que há relações entre capacidades físicas e o desempenho cognitivo em idosos, sendo esta última variável influenciada pelo grau de escolaridade apresentada pelo indivíduo. Ainda, cita-se a importância de adotar dinâmicas intervencionistas eficazes e mais adaptadas conforme o sexo, a fim de proporcionar uma melhora cognitiva na população idosa

A completeness indicator of gestational and congenital syphilis information in Brazil.

OBJECTIVE: To evaluate the quality of information on gestational syphilis (GS) and congenital syphilis (CS) on the Sistema de Informação de Agravos de Notificação (SINAN-Syphilis Brazil - Notifiable Diseases Information System) by compiling and validating completeness indicators between 2007 and 2018. METHODS: Overall, care, and socioeconomic completeness scores were compiled based on selected variables, by using ad hoc weights assigned by experts. The completeness scores were analysed, considering the region and area of residence, the pregnant woman's race/colour, and the year of case notification. Pearson's correlation coefficients were used to validate the scores obtained by the weighted average method, compared with the values obtained by principal component analysis (PCA). RESULTS: Most selected variables presented a good or excellent degree of completeness for GS and CS, except for clinical classification, pregnant woman's level of education, partner's treatment, and child's race/colour, which were classified as poor or very poor. The overall (89.93% versus 89.69%) and socioeconomic (88.71% versus 88.24%) completeness scores for GS and CS, respectively, were classified as regular, whereas the care score (GS-90.88%, and CS-90.72%) was good, despite improvements over time. Differences in the overall, care and socioeconomic completeness scores according to region, area of residence, and ethnic-racial groups were reported for syphilis notifications. The completeness scores estimated by the weighted average method and PCA showed a strong linear correlation (> 0.90). CONCLUSION: The completeness of GS and CS notifications has been improving in recent years, highlighting the variables that form the care score, compared with the socioeconomic scores, despite differences between regions, area of residence, and ethnic-racial groups. The weighted average was a viable methodological alternative easily operationalised to estimate data completeness scores, allowing routine monitoring of the completeness of gestational and congenital syphilis records

Erratum to: The study of cardiovascular risk in adolescents – ERICA: rationale, design and sample characteristics of a national survey examining cardiovascular risk factor profile in Brazilian adolescents

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SARS-CoV-2 introductions and early dynamics of the epidemic in Portugal

Genomic surveillance of SARS-CoV-2 in Portugal was rapidly implemented by the National Institute of Health in the early stages of the COVID-19 epidemic, in collaboration with more than 50 laboratories distributed nationwide. Methods By applying recent phylodynamic models that allow integration of individual-based travel history, we reconstructed and characterized the spatio-temporal dynamics of SARSCoV-2 introductions and early dissemination in Portugal. Results We detected at least 277 independent SARS-CoV-2 introductions, mostly from European countries (namely the United Kingdom, Spain, France, Italy, and Switzerland), which were consistent with the countries with the highest connectivity with Portugal. Although most introductions were estimated to have occurred during early March 2020, it is likely that SARS-CoV-2 was silently circulating in Portugal throughout February, before the first cases were confirmed. Conclusions Here we conclude that the earlier implementation of measures could have minimized the number of introductions and subsequent virus expansion in Portugal. This study lays the foundation for genomic epidemiology of SARS-CoV-2 in Portugal, and highlights the need for systematic and geographically-representative genomic surveillance.We gratefully acknowledge to Sara Hill and Nuno Faria (University of Oxford) and Joshua Quick and Nick Loman (University of Birmingham) for kindly providing us with the initial sets of Artic Network primers for NGS; Rafael Mamede (MRamirez team, IMM, Lisbon) for developing and sharing a bioinformatics script for sequence curation (https://github.com/rfm-targa/BioinfUtils); Philippe Lemey (KU Leuven) for providing guidance on the implementation of the phylodynamic models; Joshua L. Cherry (National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health) for providing guidance with the subsampling strategies; and all authors, originating and submitting laboratories who have contributed genome data on GISAID (https://www.gisaid.org/) on which part of this research is based. The opinions expressed in this article are those of the authors and do not reflect the view of the National Institutes of Health, the Department of Health and Human Services, or the United States government. This study is co-funded by Fundação para a Ciência e Tecnologia and Agência de Investigação Clínica e Inovação Biomédica (234_596874175) on behalf of the Research 4 COVID-19 call. Some infrastructural resources used in this study come from the GenomePT project (POCI-01-0145-FEDER-022184), supported by COMPETE 2020 - Operational Programme for Competitiveness and Internationalisation (POCI), Lisboa Portugal Regional Operational Programme (Lisboa2020), Algarve Portugal Regional Operational Programme (CRESC Algarve2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF), and by Fundação para a Ciência e a Tecnologia (FCT).info:eu-repo/semantics/publishedVersio