Fall Concert - KSU Chorale, Men\u27s Ensemble, & Chamber Singers

The KSU Men\u27s Ensemble and Chorale, led by Reid Masters, and the KSU Chamber Singers, led by Leslie Blackwell, present their fall concert.https://digitalcommons.kennesaw.edu/musicprograms/2235/thumbnail.jp

KSU Choral Ensembles Fall Concert

The combined choral ensemble area presents their 2019 fall concert.https://digitalcommons.kennesaw.edu/musicprograms/2255/thumbnail.jp

School of Music Holiday Concert

The Kennesaw State University School of Music presents its 2019 Holiday Concert.https://digitalcommons.kennesaw.edu/musicprograms/2277/thumbnail.jp

HIghMass - High HI Mass, HI-Rich Galaxies at z∼0z\sim0: Combined HI and H2_2 Observations

We present resolved HI and CO observations of three galaxies from the HIghMass sample, a sample of HI-massive ($M_{HI} > 10^{10} M_\odot$), gas-rich ($M_{HI}$ in top $5\%$ for their $M_*$) galaxies identified in the ALFALFA survey. Despite their high gas fractions, these are not low surface brightness galaxies, and have typical specific star formation rates (SFR$/M_*$) for their stellar masses. The three galaxies have normal star formation rates for their HI masses, but unusually short star formation efficiency scale lengths, indicating that the star formation bottleneck in these galaxies is in the conversion of HI to H$_2$, not in converting H$_2$ to stars. In addition, their dark matter spin parameters ($\lambda$) are above average, but not exceptionally high, suggesting that their star formation has been suppressed over cosmic time but are now becoming active, in agreement with prior H$\alpha$ observations.Comment: 20 pages, 13 figure

Kennesaw State University Choral Ensembles Spring Concert

Please join us for an evening of choral masterworks presented by KSU choral ensembles. The evening will feature performances by the KSU Chamber Choir, led by Interim Director of the School of Music and Director of Choral Activities Dr. Leslie J. Blackwell, as well as the University Chorale and Men\u27s Ensemble, both led by Dr. Reid Masters. The Chamber Singers will be giving a preview of their performance at the 2020 ACDA Southern Division Conference.https://digitalcommons.kennesaw.edu/musicprograms/2304/thumbnail.jp

Optimal division of data for neural network models in water resources applications

The way that available data are divided into training, testing, and validation subsets can have a significant influence on the performance of an artificial neural network (ANN). Despite numerous studies, no systematic approach has been developed for the optimal division of data for ANN models. This paper presents two methodologies for dividing data into representative subsets, namely, a genetic algorithm (GA) and a self-organizing map (SOM). These two methods are compared with the conventional approach commonly used in the literature, which involves an arbitrary division of the data. A case study is presented in which ANN models developed using each data division technique are used to forecast salinity in the River Murray at Murray Bridge (South Australia) 14 days in advance. When tested on a validation data set from July 1992 to March 1998, the models developed using the GA and SOM data division techniques resulted in a reduction in RMS error of 24.2% and 9.9%, respectively, over the conventional data division method. It was found that a SOM could be used to diagnose why an ANN model has performed poorly, given that the poor performance is primarily related to the data themselves and not the choice of the ANN's parameters or architecture.Gavin J. Bowden, Holger R. Maier and Graeme C. Dand

Hypothalamic Reactive Oxygen Species Are Required for Insulin-Induced Food Intake Inhibition: An NADPH Oxidase–Dependent Mechanism

1939-327X (Electronic) Journal Article Research Support, Non-U.S. Gov'tOBJECTIVE: Insulin plays an important role in the hypothalamic control of energy balance, especially by reducing food intake. Emerging data point to a pivotal role of reactive oxygen species (ROS) in energy homeostasis regulation, but their involvement in the anorexigenic effect of insulin is unknown. Furthermore, ROS signal derived from NADPH oxidase activation is required for physiological insulin effects in peripheral cells. In this study, we investigated the involvement of hypothalamic ROS and NADPH oxidase in the feeding behavior regulation by insulin. RESEARCH DESIGN AND METHODS: We first measured hypothalamic ROS levels and food intake after acute intracerebroventricular injection of insulin. Second, effect of pretreatment with a ROS scavenger or an NADPH oxidase inhibitor was evaluated. Third, we examined the consequences of two nutritional conditions of central insulin unresponsiveness (fasting or short-term high-fat diet) on the ability of insulin to modify ROS level and food intake. RESULTS: In normal chow-fed mice, insulin inhibited food intake. At the same dose, insulin rapidly and transiently increased hypothalamic ROS levels by 36%. The pharmacological suppression of this insulin-stimulated ROS elevation, either by antioxidant or by an NADPH oxidase inhibitor, abolished the anorexigenic effect of insulin. Finally, in fasted and short-term high-fat diet-fed mice, insulin did not promote elevation of ROS level and food intake inhibition, likely because of an increase in hypothalamic diet-induced antioxidant defense systems. CONCLUSIONS: A hypothalamic ROS increase through NADPH oxidase is required for the anorexigenic effect of insulin

HIghMass—High H I Mass, H I-rich Galaxies at z ~ 0: Combined H I and H_2 Observations

We present resolved and CO observations of three galaxies from the HIghMass sample, a sample of -massive (M_(H I) > 10^(10) M⊙), gas-rich (M_(H I) in the top 5% for their M *) galaxies identified in the ALFALFA survey. Despite their high gas fractions, these are not low-surface-brightness galaxies and have typical specific star formation rates (SFR/M*) for their stellar masses. The three galaxies have normal SFRs for their masses, but unusually short star formation efficiency scale lengths, indicating that the star formation bottleneck in these galaxies is in the conversion of H I to H_2, not in converting H_2 to stars. In addition, their dark matter spin parameters (λ) are above average, but not exceptionally high, suggesting that their star formation has been suppressed over cosmic time but is now becoming active, in agreement with prior Hα observations

EVALUATION OF DENTAL HEALTH EDUCATION IN A SCHOOL DENTAL CARE PROGRAM

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65546/1/j.1752-7325.1978.tb03715.x.pd

Prophylactic evaluation of verubecestat on disease- and symptom-modifying effects in 5XFAD mice.

Introduction: Alzheimer\u27s disease (AD) is the most common form of dementia. Beta-secretase (BACE) inhibitors have been proposed as potential therapeutic interventions; however, initiating treatment once disease has significantly progressed has failed to effectively stop or treat disease. Whether BACE inhibition may have efficacy when administered prophylactically in the early stages of AD has been under-investigated. The present studies aimed to evaluate prophylactic treatment of the BACE inhibitor verubecestat in an AD mouse model using the National Institute on Aging (NIA) resources of the Model Organism Development for Late-Onset Alzheimer\u27s Disease (MODEL-AD) Preclinical Testing Core (PTC) Drug Screening Pipeline. Methods: 5XFAD mice were administered verubecestat ad libitum in chow from 3 to 6 months of age, prior to the onset of significant disease pathology. Following treatment (6 months of age), in vivo imaging was conducted with 18F-florbetapir (AV-45/Amyvid) (18F-AV45) and 18-FDG (fluorodeoxyglucose)-PET (positron emission tomography)/MRI (magnetic resonance imaging), brain and plasma amyloid beta (Aβ) were measured, and the clinical and behavioral characteristics of the mice were assessed and correlated with the pharmacokinetic data. Results: Prophylactic verubecestat treatment resulted in dose- and region-dependent attenuations of 18F-AV45 uptake in male and female 5XFAD mice. Plasma Aβ40 and Aβ42 were also dose-dependently attenuated with treatment. Across the dose range evaluated, side effects including coat color changes and motor alterations were reported, in the absence of cognitive improvement or changes in 18F-FDG uptake. Discussion: Prophylactic treatment with verubecestat resulted in attenuated amyloid plaque deposition when treatment was initiated prior to significant pathology in 5XFAD mice. At the same dose range effective at attenuating Aβ levels, verubecestat produced side effects in the absence of improvements in cognitive function. Taken together these data demonstrate the rigorous translational approaches of the MODEL-AD PTC for interrogating potential therapeutics and provide insight into the limitations of verubecestat as a prophylactic intervention for early-stage AD