9 research outputs found
Genomic insights into rapid speciation within the world’s largest tree genus Syzygium
- Author
- Ahmad Joffre Ali
- Albert Victor A.
- Ardi Wisnu H.
- Armstrong Kate
- Athen Parusuraman
- Berhaman Ahmad
- Bone Ruth E.
- Burslem David F.R.P.
- Cheek Martin
- Cho Nicholas R.W.
- Choo Le Min
- Cowie Ian D.
- Crayn Darren
- Fleck Steven J.
- Ford Andrew J.
- Forster Paul I.
- Girmansyah Deden
- Goyder David J.
- Gray Bruce
- Heatubun Charlie D.
- Ibrahim Ali
- Ibrahim Bazilah
- Jayasinghe Himesh D.
- Kalat Muhammad Ariffin
- Kathriarachchi Hashendra S.
- Khew Gillian S.W.
- Kintamani Endang
- Koh Sin Lan
- Lai Joseph T.K
- Lee Serena M.L.
- Leong Paul K.F.
- Lim Wei Hao
- Lindqvist Charlotte
- Low Yee Wen
- Lucas Eve J.
- Lum Shawn K.Y.
- Mahyuni Ridha
- McDonald William J.F.
- Metali Faizah
- Michael Todd P.
- Middleton David J.
- Mustaqim Wendy A.
- Naiki Akiyo
- Ngo Kang Min
- Niissalo Matti
- Rajaraman Sitaram
- Ranasinghe Subhani
- Repin Rimi
- Rustiami Himmah
- Salojärvi Jarkko
- Simbiak Victor I.
- Sukri Rahayu S.
- Sunarti Siti
- Tomlin Crystal M.
- Trethowan Liam A.
- Trias-Blasi Anna
- Vasconcelos Thais N.C.
- Wanma Jimmy F.
- Widodo Pudji
- Wijesundara Douglas Siril A.
- Worboys Stuart
- Yap Jing Wei
- Yong Kien Thai
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Species radiations, despite immense phenotypic variation, can be difficult to resolve phylogenetically when genetic change poorly matches the rapidity of diversification. Genomic potential furnished by palaeopolyploidy, and relative roles for adaptation, random drift and hybridisation in the apportionment of genetic variation, remain poorly understood factors. Here, we study these aspects in a model radiation, Syzygium, the most species-rich tree genus worldwide. Genomes of 182 distinct species and 58 unidentified taxa are compared against a chromosome-level reference genome of the sea apple, Syzygium grande. We show that while Syzygium shares an ancient genome doubling event with other Myrtales, little evidence exists for recent polyploidy events. Phylogenomics confirms that Syzygium originated in Australia-New Guinea and diversified in multiple migrations, eastward to the Pacific and westward to India and Africa, in bursts of speciation visible as poorly resolved branches on phylogenies. Furthermore, some sublineages demonstrate genomic clines that recapitulate cladogenetic events, suggesting that stepwise geographic speciation, a neutral process, has been important in Syzygium diversification
Genetic Sharing with Cardiovascular Disease Risk Factors and Diabetes Reveals Novel Bone Mineral Density Loci.
- Author
- Aalto V. (Ville)
- Albagha O.M.E. (Omar M.)
- Alen M. (Markku)
- Alonso N. (Nerea)
- Amin N. (Najaf)
- Andreassen O.A. (Ole)
- Aragaki A.K. (Aaron)
- Aspelund T. (Thor)
- Aulchenko Y.S. (Yurii)
- Balcells S. (Susana)
- Bettella F. (Francesco)
- Brandi M.L.
- Brown M.A. (Matthew)
- Buckley B.M. (Brendan M.)
- Castaño Betancourt M.C. (Martha)
- Cauley J.A. (Jane)
- Center J.R. (Jacqueline)
- Chasman D.I. (Daniel)
- Cheng S. (Sulin)
- Christiansen C.
- Clark G.R. (Graeme)
- Cooper C. (Charles)
- Cummings S.R. (Steven R.)
- Cupples L.A. (Adrienne)
- Dailiana Z. (Zoe)
- Dale A.M. (Anders)
- Danoy P. (Patrick)
- Dedoussis G.V. (George)
- Dennison E.M. (Elaine)
- Desikan R.S. (Rahul S.)
- Djurovic S. (Srdjan)
- Duggan C.
- Duijn C.M. (Cornelia) van
- Duncan E.L. (Emma)
- Eastell R. (Richard)
- Econs M.J. (Michael)
- Eisman J.A. (John)
- Eriksson J. (Joel)
- Estrada Gil K. (Karol)
- Evangelou E. (Evangelos)
- Evans D.M. (David)
- Ford I. (Ian)
- Frost M. (Morten)
- Garcia M. (Melissa)
- Garcia-Giralt N. (Natàlia)
- Gautvik K.M. (Kaare)
- Giroux S. (Sylvie)
- Goltzman D. (David)
- González-Macías J. (Jesús)
- Grundberg E. (Elin)
- Gudnason V. (Vilmundur)
- Hallmans G. (Göran)
- Harris T.B. (Tamara B.)
- Herrera L. (Lizbeth)
- Hocking L.J. (Lynne)
- Hofman A. (Albert)
- Hsu Y.-H. (Yi-Hsiang)
- Husted L.B. (Lise Bjerre)
- Ingvarsson T. (Torvaldur)
- Ioannidis J.P.A. (John P.A.)
- Jackson R.D. (Rebecca)
- Jameson K. (Karen)
- Johannsdottir H. (Hrefna)
- Jones G. (Graeme)
- Jukema J.W. (Jan Wouter)
- Kammerer C.M. (Candace)
- Kaptoge S. (Stephen)
- Karasik D. (David)
- Karlsson M. (Magnus)
- Kemp J.P. (John)
- Khaw K.T.
- Khusainova R. (Rita)
- Khusnutdinova E.K. (Elza)
- Kiel D.P. (Douglas P.)
- Kim G.S. (Ghi Su)
- Koh J.-M. (Jung-Min)
- Koller D.L. (Daniel)
- Kollia P. (Panagoula)
- Kooperberg C. (Charles)
- Koromila T. (Theodora)
- Kruk M. (Marcin)
- Kung A.W.C. (Annie Wai Chee)
- Kwan T. (Tony)
- Kähönen M. (Mika)
- Laaksonen M. (Marika)
- Lacroix A.Z. (Andrea Z.)
- Langdahl B.L. (Bente)
- Leblanc M. (Marissa)
- Lee S.H. (Seung Hun)
- Lehtimäki T. (Terho)
- Leo P.J. (Paul)
- Leslie W.D. (William D.)
- Leung P.C. (Ping C.)
- Lewis J.R. (Joshua)
- Li G. (Guo)
- Li R. (Rui)
- Lips P. (Paul)
- Liu C.-T. (Ching-Ti)
- Liu Y. (YongMei)
- Ljunggren O. (Östen)
- Lorenc R. (Roman)
- Lorentzon M. (Mattias)
- Luben R.N. (Robert)
- Marc J. (Janja)
- Masi L. (Laura)
- McCloskey E.V. (Eugene)
- McEvoy L.K. (Linda K.)
- Medina-Gomez M.C. (Carolina)
- Mellström D. (Dan)
- Mencej-Bedrac S. (Simona)
- Meurs J.B.J. (Joyce) van
- Mills I.G. (Ian G.)
- Minster R.L. (Ryan)
- Mitchell B.D. (Braxton)
- Moayyeri A. (Alireza)
- Nandakumar K. (Kannabiran)
- Nguyen T.V. (Tuan)
- Nicholson G.C. (Geoffrey)
- Nogues X. (Xavier)
- Ntzani E.E. (Evangelia)
- Obermayer-Pietsch B. (Barbara)
- Oei L. (Ling)
- Ohlsson C. (Claes)
- Olmos D. (David)
- Oostra B.A. (Ben)
- Palsson S.T. (Stefan Th)
- Pastinen T. (Tomi)
- Patel M.S. (Millan)
- Peacock M. (Munro)
- Pettersson-Kymmer U. (Ulrika)
- Pols H.A.P. (Huib)
- Prezelj J. (Janez)
- Prince R.L. (Richard)
- Psaty B.M. (Bruce)
- Raitakari O. (Olli)
- Ralston S.H. (Stuart)
- Raychaudhuri S. (Soumya)
- Reeve J. (Jonathan)
- Reid D.M. (David)
- Reid I.R. (Ian)
- Reppe S. (Sjur)
- Riancho J.A. (José)
- Richards J.B. (Brent)
- Ridker P.M. (Paul)
- Rivadeneira Ramirez F. (Fernando)
- Robbins J. (John)
- Rose L.M. (Lynda)
- Rotter J.I. (Jerome I.)
- Rousseau M.F. (Francois)
- Sambrook P.N. (Philip)
- Schoor N.M. (Natasja) van
- Schork N.J. (Nicholas)
- Scollen S. (Serena)
- Sham P.C. (Pak Chung)
- Shuldiner A.R. (Alan)
- Siggeirsdottir K. (Kristin)
- Sigurdsson G. (Gunnar)
- Slagboom P.E. (Eline)
- Smith A.V. (Davey)
- Spector T.D. (Timothy)
- Streeten E.A. (Elizabeth)
- Styrkarsdottir U. (Unnur)
- Svensson O. (Olle)
- Tang N.L.S. (Nelson L.S.)
- Thompson W.K. (Wesley K.)
- Thorleifsson G. (Gudmar)
- Thorsteinsdottir U. (Unnur)
- Trompet S. (Stella)
- Trummer O. (Olivia)
- Tylavsky F.A. (Frances)
- Uitterlinden A.G. (André)
- Urreizti R. (Roser)
- Van Hul W. (Wim)
- Vandenput L. (Liesbeth)
- Verlaan D.J. (Dominique)
- Viikari J. (Jorma)
- Wang Y. (Yunpeng)
- Wareham N.J. (Nicholas J.)
- Williams F.M. (Frances)
- Willner D. (Dana)
- Wilson J.F. (James F)
- Wilson S.G. (Scott)
- Woo J. (Jean)
- Wood A.R. (Andrew)
- Xiao S.-M. (Su-Mei)
- Yerges-Armstrong L.M. (Laura)
- Zarrabeitia M.T. (María)
- Zheng H.-F. (Hou-Feng)
- Zhou Y. (Yanhua)
- Zhu K. (Kun)
- Zillikens M.C. (Carola)
- Zuber V. (Verena)
- Zwart J-A. (John-Anker)
- Publication venue
- PLoS One
- Publication date
- 01/01/2015
- Field of study
Bone Mineral Density (BMD) is a highly heritable trait, but genome-wide association studies have identified few genetic risk factors. Epidemiological studies suggest associations between BMD and several traits and diseases, but the nature of the suggestive comorbidity is still unknown. We used a novel genetic pleiotropy-informed conditional False Discovery Rate (FDR) method to identify single nucleotide polymorphisms (SNPs) associated with BMD by leveraging cardiovascular disease (CVD) associated disorders and metabolic traits. By conditioning on SNPs associated with the CVD-related phenotypes, type 1 diabetes, type 2 diabetes, systolic blood pressure, diastolic blood pressure, high density lipoprotein, low density lipoprotein, triglycerides and waist hip ratio, we identified 65 novel independent BMD loci (26 with femoral neck BMD and 47 with lumbar spine BMD) at conditional FDR < 0.01. Many of the loci were confirmed in genetic expression studies. Genes validated at the mRNA levels were characteristic for the osteoblast/osteocyte lineage, Wnt signaling pathway and bone metabolism. The results provide new insight into genetic mechanisms of variability in BMD, and a better understanding of the genetic underpinnings of clinical comorbidity
Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry
- Author
- Abdelsayed A.A. (Abeer Abeer)
- Acosta A. (Adriana)
- Adams H. (Heath)
- Agostinho J. (João)
- Agostoni P. (Piergiuseppe)
- Airò E. (Edoardo)
- Al Dalaan A. (Abdullah)
- Alexandre M. (Myriam)
- Alexeeva D.E. (Dalyana Eduardovna)
- Alfetlawi M. (Monthir)
- Almagro R.M. (Raúl Menor)
- Alonso L.P. (Lecue Pilar)
- Altraja A. (Alan)
- Andreassen A.K. (Arne K.)
- Anton L. (Ly)
- Argiento P. (Paola)
- Arjona J.J. (Josefa Jiménez)
- Asencio I. (Isabel)
- Atas H. (Halil)
- Avdeev S.N. (Sergey Nikolaevich)
- Avilés F.F. (Francisco Fernandez)
- Badagliacca R. (Roberto)
- Baptista R. (Rui)
- Barberá J.A. (Joan A.)
- Barry L. (Lisa)
- Bartfay S.-E. (Sven-Erik)
- Batalina M.V. (Marina Vadimovna)
- Bauleo C. (Carolina)
- Blanco I. (Isabel)
- Bohacekova M. (Marcela)
- Boogaard H. (H.)
- Boomars K.A.T. (Karin)
- Boonstra A. (Anco)
- Bosio M. (Martin)
- Bruno N. (Noemi)
- Bukatova I.F. (Irina Fedorovna)
- Camacho R.C. (Rafael Conde)
- Campo F. (Felipe)
- Caneva J. (Jorge)
- Capinha M. (Marta)
- Cardoso T. (Tania)
- Castro G. (Graça)
- Cheng C.-C. (Chin-Chang)
- Chu C.Y. (Chun Yuan)
- Church C. (Colin)
- Cifrián Martínez J.M. (José Manuel)
- Conte L. (Luca)
- Correra A. (Anna)
- Corris P. (Paul)
- Costa S. (Serena)
- Cottin V. (Vincent)
- Coutinho D. (Daniel)
- Cresci C. (Chiara)
- Cuesta V.M. (Victor Mora)
- Cárdenas S.L. (Salvador López)
- D'Alto M. (Michele)
- D'Armini A.M. (Andrea Maria)
- De La Pava S. (Sebastian)
- De Luca A. (Anna)
- De Pauw M. (Michel)
- Delcroix M. (Marion)
- Deleo S. (Sabino)
- Di Marco G.M. (Giovanni Maria)
- Diez M. (Mirta)
- Dwyer N. (Nathan)
- Egenlauf B. (Benjamin)
- Elias T. (Teresa)
- Escribano Subías P. (Pilar)
- Espinha M. (Mafalda)
- Evrard P. (Patrick)
- Ewert R. (Ralf)
- Fanaridis M. (Michail)
- Farina S. (Stefania)
- Farkasova I. (Iveta)
- Farruggio S. (Silvia)
- Feenstra J. (John)
- Feistmantl L.-T. (Lisa-Theresa)
- Fernandez D.I. (David Iturbe)
- Filippov E.V. (Evgeny Vladimirovich)
- Fong M.-C. (Man-Cai)
- Gaine S. (Sean)
- Galgano G. (Giuseppe)
- Gall H. (Henning)
- Galyavich A.S. (Albert Sarvatovich)
- Garcea A. (Alessio)
- Garcia A. (Alberto)
- Garcia P. (Paula)
- García S.A. (Salvador Alcaraz)
- Gasche-Soccal P. (Paola)
- Georgopoulos D. (Dimitrios)
- Gerhardt F. (Felix)
- Ghofrani H.A.
- Giannakoulas G. (George)
- Gomez Sanchez M.-A. (Miguel-Angel)
- Gomez J.E. (Juan Esteban)
- Grazioli V. (Valentina)
- Grimminger J. (Jan)
- Gruenberger M. (Margarethe)
- Grünig E. (Ekkehard)
- Guiot J. (Julien)
- Halank M. (Michael)
- Hanta I. (Ismail)
- Harbaum L. (Lars)
- Hegya D.V. (Daria Viktorovna)
- Helmersen D.S. (Douglas S.)
- Ho W.-J. (Wan-Jing)
- Hoeper M.M. (Marius M.)
- Hsu C.-H. (Chih-Hsin)
- Hsu P.-C. (Po-Chao)
- Hsu T.-S. (Tsu-Shiu)
- Huang C.-L. (Chien-Lung)
- Huang W.-C. (Wei-Chun)
- Huang W.-P. (Wen-Pin)
- Huber C. (Charlotte)
- Humbert M.
- Hung C.-S. (Chi-Sheng)
- Ivanov K.I. (Kyundyul Ivanovich)
- Jansa P. (Pavel)
- Jara L. (Luis)
- Karvounis H.I.
- Keogh A. (Anne)
- Klose H. (Hans)
- Klotsche J. (Jens)
- Knoop-Busch S. (Susanne)
- Kolomeytseva T.M. (Tatyana Mikhaylovna)
- Konstantinides S. (Stavros)
- Kotlyar E. (Eugene)
- Kotsia A. (Anna)
- Kramer T. (Tilmann)
- Kulka C. (Christine)
- Kuo P.-H. (Ping-Hung)
- Kuo S.-H. (Shu-Hung)
- Lador F. (Frédéric)
- Lai W.-T. (Wen-Ter)
- Lang I. (Irene)
- Lange T.J. (Tobias J.)
- Langleben D. (David)
- Lavender M. (Melanie)
- Lema C. (Camila)
- Lin J.-L. (Jiunn-Lee)
- Lin T.-H. (Tsung-Hsien)
- Lin Y.-H. (Yen-Hung)
- Lombardi F. (Francesco)
- Londoño A. (Alejandro)
- Lopez M. (Manuel)
- Lopez R. (Raquel)
- Louis R. (Renaud)
- Loureiro M.J. (Maria José)
- Lunardi C. (Claudio)
- Löffler-Ragg J. (Judith)
- Mackenzie M. (Michele)
- Mager J. (J.)
- Maldonado L. (Lorena)
- Manzi G. (Giovanna)
- Marinho A. (António)
- Marrero F.L. (Fernando León)
- Martinez W. (William)
- Martinez-Meñaca A. (Amaya)
- Martins Jesus S.M. (Susana Maria)
- Martynyuk T.V. (Tamila Vitalievna)
- Massola G. (Giulia)
- Mehta S. (Sanjay)
- Meier C. (Christian)
- Melatini L. (Luciano)
- Mellemkjaer S. (Soren)
- Michalis L.K. (Lampros)
- Mielniczuk L.M. (Lisa M.)
- Minson R. (Robert)
- Mitrouska I. (Ioanna)
- Mouratoglou S. (Sofia)
- Mulè M. (Massimiliano)
- Mutlu B. (Bülent)
- Naldi M. (Marco)
- Ndreu R. (Rudina)
- Newnham M. (Michael)
- Ng B. (Benjamin)
- Nielsen-Kudsk J.E. (Jens Erik)
- Nikolaevich B.A. (Bykov Aleksander)
- Nolde A. (Anna)
- Noël-Savina E. (Elise)
- Okumus G. (Gulfer)
- Oliveira A. (Ana)
- Olzik I. (Ilona)
- Ongen G. (Gul)
- Oqueka T. (Tim)
- Orozco-Levi M. (Mauricio)
- Otero R. (Remedios)
- Paciocco G. (Giuseppe)
- Pane F. (Federico)
- Pappas A. (Athanasios)
- Pappas K. (Konstantinos)
- Pavlickova I. (Ivana)
- Pavlova O.B. (Olga Borisovna)
- Peacock A. (Andrew)
- Pepke-Zaba J. (Joanna)
- Pesci A. (Alberto)
- Petruzzi M. (Mario)
- Peñate G.P. (Gregorio Pérez)
- Picariello C. (Claudio)
- Piccari L. (Lucilla)
- Pin M. (Maurizio)
- Pitsiou G. (Georgia)
- Pittrow D. (David)
- Platonov D.Y. (Dmitry Yurievich)
- Poscia R. (Roberto)
- Prediletto R. (Renato)
- Proudman S. (Susanna)
- Quezada C.A. (Carlos Andres)
- Reesink H.J. (Herre)
- Reeves G. (Glenn)
- Regotta S. (Sabine)
- Repolho D. (Débora)
- Rocha A. (Andreia)
- Rochat T. (Thierry)
- Rodríguez P.V. (Patricia Villanueva)
- Roman A. (Antonio)
- Roncon L. (Loris)
- Rosenkranz S. (Stephan)
- Rozas S.F. (Sonia Fernandez)
- Rundqvist B. (Bengt)
- Sadushi-Kolici R. (Roela)
- Sakkijha H. (Hussam)
- Saleemi S. (Sarferaz)
- Sardella L. (Luca)
- Schulz C. (Christian)
- Schwarz E.I. (Esther Irene)
- Sciortino A. (Antonio)
- Sebastian L. (Laura)
- Shearman N. (Nicole)
- Shiang T. (Teresa)
- Simon M. (Marcel)
- Simonneau G. (Gérald)
- Sitbon O. (Olivier)
- Skripkina E.S. (Elena Sergeevna)
- Snijder R.
- Sourla E. (Evdokia)
- Sousa J. (Joana)
- Speich R. (Rudolf)
- Stanopoulos I. (Ioannis)
- Steele P. (Peter)
- Steringer-Mascherbauer R. (Regina)
- Stevens W. (Wendy)
- Su H.-M. (Ho-Ming)
- Sung S.-H. (Shih-Hsien)
- Söderberg S. (Stefan)
- Talavera M.L. (Maria Lujan)
- Tania G. (Gonçalves)
- Tayler S. (Susanne)
- Tilea I. (Ioana)
- Toorn L.M. (Leon) van den
- Torricelli E. (Elena)
- Toshner M. (Mark)
- Tovar P.P. (Patricia Parada)
- Tregubova A.V. (Anna Viktorovna)
- Tsangaris I. (Iraklis)
- Tsareva N.A. (Natalia Anatolievna)
- Tuhay G. (Graciela)
- Têtu L. (Laurent)
- Ulrich S. (Silvia)
- Un Z. (Zeynep)
- Vachiéry J.-L. (Jean-Luc)
- Valkovicova T. (Tatiana)
- Vannucchi V. (Vieri)
- Vasankari T. (Tuija)
- Vihinen T. (Tapani)
- Vizza C.D. (Carmine Dario)
- Vonk Noordegraaf A. (Anton)
- Voon W.-C. (Wen-Chol)
- Vulcano N. (Norberto)
- Wang W.-H. (Wen-Hwa)
- Weheba I. (Ihab)
- Williams E. (Evgenia)
- Wirtz G. (Gil)
- Wirtz H. (Hubert)
- Wodlin P. (Peter)
- Wu C.-K. (Cho-Kai)
- Wu S.-H. (Shu-Hao)
- Yakovleva O.E. (Olga Eduardovna)
- Yen H.-W. (Hsueh-Wei)
- Yih-Jer Wu J. (Jacob)
- Yotti R. (Raquel)
- Zvereva T.N. (Tatyana Nikolaevna)
- Šimková I. (Iveta)
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/03/2021
- Field of study
Objective: The soluble guanylate cyclase stimulator riociguat is approved for the treatment of adult patients with pulmonary arterial hypertension (PAH) and inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH) following Phase
Ionosporus rpb2 fasta alignment
- Author
- Publication venue
- Publication date
- 05/03/2019
- Field of study
A FASTA file of 35 exemplars with aligned rpb2 sequences. 7 of those exemplars were newly seqeunced
The colonial legacy of herbaria
- Author
- Akiyama Shinobu
- Ardiyani Marlina
- Avendaño Neida
- Barina Zoltan
- Belgrano Manuel
- Betancur Julio
- Bijmoer Roxali
- Bjorå Charlotte S.
- Bogaerts Ann
- Bärtschi Blandine
- Cano Asunción
- Danihelka Jiri
- Davis Charles C.
- Feng Xiao
- Garg Arti
- Giblin David E.
- Gogoi Rajib
- Guggisberg Alessia
- Hyvärinen Marko
- James Shelley A.
- Jimena Ponce Maria
- Katagiri Tomoyuki
- Kennedy Jonathan A.
- Komil Tojibaev Sh.
- Lee Byoungyoon
- Lee Serena M.L.
- Magri Donatella
- Marcucci Rossella
- Melnikov Denis
- Mráz Patrik
- Mulenko Wieslaw
- Musili Paul
- Mwachala Geoffrey
- Nelson Burrell E.
- Niezgoda Christine
- Novoa Sepúlveda Carla
- Orli Sylvia
- Park Daniel S.
- Paton Alan
- Payette S.
- Perkins Kent D.
- Rainer Heimo
- Rasingam L.
- Rustiami Himmah
- Sebola Ramagwai J.
- Shiyan Natalia M.
- Solomon James
- Stauffer Fred W.
- Sumadijaya Alex
- Thiers Barbara M.
- Thiébaut Mélanie
- Tsubota Hiromi
- Vaughan Alison
- Virtanen Risto
- Whitfeld Timothy J.S.
- Zhang Dianxiang
- Zuloaga Fernando O.
- Publication venue
- 'Cold Spring Harbor Laboratory'
- Publication date
- 02/11/2021
- Field of study
Herbarium collections shape our understanding of the world’s flora and are crucial for addressing global change and biodiversity conservation. The formation of such natural history collections, however, are not free from sociopolitical issues of immediate relevance. Despite increasing efforts addressing issues of representation and colonialism in natural history collections, herbaria have received comparatively less attention. While it has been noted that the majority of plant specimens are housed in the global North, the extent of this disparity has not been rigorously quantified to date. Here, by analyzing over 85 million specimen records and surveying herbaria across the globe, we assess the colonial legacy of botanical collections and how we may move towards a more inclusive future. We demonstrate that colonial exploitation has contributed to an inverse relationship between where plant biodiversity exists in nature and where it is housed in herbaria. Such disparities persist in herbaria across physical and digital realms despite overt colonialism having ended over half a century ago, suggesting ongoing digitization and decolonization efforts have yet to alleviate colonial-era discrepancies. We emphasize the need for acknowledging the inconvenient history of herbarium collections and the implementation of a more equitable, global paradigm for their collection, curation, and use
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes
- Author
- Abecasis G. (Goncalo)
- Abecasis G.R. (Gonçalo)
- Abecasis G.R. (Gonçalo)
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- Absher D. (Devin)
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- Vatin V. (Vincent)
- Vedantam S. (Sailaja)
- Visscher P.M. (Peter M.)
- Visscher P.M. (Peter)
- Vitart V. (Veronique)
- Vliet-Ostaptchouk J.V. (Jana) van
- Voight B.F. (Benjamin)
- Wabitsch M. (Martin)
- Waeber G. (Gérard)
- Waite L. (Lindsay)
- Walker M. (Mark)
- Wallaschofski H. (Henri)
- Walters G.B. (Bragi)
- Wareham N.J. (Nicholas J.)
- Wareham N.J. (Nick)
- Watanabe R.M. (Richard)
- Watkins H. (Hugh)
- Weedon M.N. (Michael)
- Weedon M.N. (Michael)
- Welch R. (Ryan)
- Welch R.P. (Ryan)
- Wells G.A. (George)
- Weyant R.J. (Robert)
- Wheeler E. (Eleanor)
- White C.C. (Charles)
- Wichmann H.-E. (H-Erich)
- Wichmann H.E. (Heinz Erich)
- Widen E. (Elisabeth)
- Wiegand S. (Susanna)
- Wijmenga C. (Cisca)
- Wiklund F. (Fredrik)
- Wild P.S. (Philipp)
- Wild S.H. (Sarah)
- Wilk A. (Alicja)
- Willemsen G.A.H.M. (Gonneke)
- Willenborg C. (Christina)
- Willer C.J. (Cristen)
- Wilson J.F. (James F.)
- Wingerden S. (Sophie) van
- Winkler T.W. (Thomas W.)
- Witte D.R. (Daniel R.)
- Witte D.R. (Deniel)
- Witteman J. (Jacqueline)
- Witteman J.C.M. (Jacqueline)
- Witteman J.C.M. (Jaqueline C.M.)
- Wood A.R. (Andrew)
- Workalemahu T. (Tsegaselassie)
- Wright A.F. (Alan)
- Wright B.J. (Benjamin)
- Wu G. (Guanming)
- Xie W. (Weijia)
- Xu J. (Jianfeng)
- Yang J. (Jian)
- Yang J. (Joanna)
- Yang T.-P. (Tsun-Po)
- Ye S. (Shu)
- Zabena C. (Carina)
- Zaidi M.A. (Aghar)
- Zaman K.S. (Khan Shah)
- Zeggini E. (Eleftheria)
- Zeller T. (Tanja)
- Zethelius B. (Björn)
- Zgaga L. (Lina)
- Zhang Q. (Qunyuan)
- Zhang W. (Weihua)
- Zhao J.H. (Jing Hua)
- Ziegler A. (Andreas)
- Ziegler A. (Andreas)
- Zillikens M.C. (Carola)
- Zitting P. (Paavo)
- Zondervan K.T. (Krina T.)
- Zondervan K.T. (Krina)
- Zwart J-A. (John-Anker)
- Öhrvik J. (John)
- Östenson C.-G. (Claes-Göran)
- Publication venue
- Publication date
- 01/10/2011
- Field of study
OBJECTIVE - Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired b-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS - We have conducted a meta-analysis of genome-wide association tests of ;2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS - Nine SNPs at eight loci were associated with proinsulin levels (P < 5 × 10-8). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/ C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7 3 10-4), improved b-cell function (P = 1.1 × 10-5), and lower risk of T2D (odds ratio 0.88; P = 7.8 × 10-6). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. CONCLUSIONS - We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: A multi-ethnic meta-analysis of 45,891 individuals
- Author
- Abecasis G.R. (Goncalo R.)
- Abecasis G.R. (Goncalo R.)
- Abecasis G.R. (Gonçalo R.)
- Abecasis G.R. (Gonçalo)
- Adair L.S. (Linda)
- Allison M.A. (Matthew)
- Altshuler D. (David)
- Altshuler D. (David)
- Amin N. (Najaf)
- An P. (Ping)
- Ardlie K.G. (Kristin)
- Ardlie K.G. (Kristin)
- Ariyurek Y. (Yavuz)
- Aulchenko Y.S. (Yurii S.)
- Aulchenko Y.S. (Yurii S.)
- Aulchenko Y.S. (Yurii)
- Bacquer O.L. (Olivier)
- Balkau B. (Beverley)
- Balkau B. (Beverley)
- Ballantyne C. (Christie)
- Ballantyne C.M. (Christie M.)
- Ballantyne C.M. (Christie M.)
- Bandinelli S. (Stefania)
- Bandinelli S. (Stefania)
- Barbalic M. (maja)
- Barroso I.
- Barroso I.E. (Inês)
- Barroso I.E. (Inês)
- Barter P. (Phil)
- Beekman M. (Marian)
- Beilby J.P. (John)
- Ben-Shlomo Y.
- Benediktsson R. (Rafn)
- Benediktsson R. (Rafn)
- Bennett A.J. (Amanda)
- Bennett A.J. (Amanda)
- Bergman R.N. (Richard N.)
- Bergman R.N. (Richard N.)
- Bergman R.N. (Richard N.)
- Bergmann S.M. (Sven)
- Bidulescu A. (Aurelian)
- Bis J.C. (Joshua)
- Blagieva R. (Roza)
- Bochud M. (Murielle)
- Boehm B.O. (Bernhard)
- Boehnke M. (Michael)
- Boehnke M. (Michael)
- Boehnke M. (Michael)
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- Boerwinkle E. (Eric)
- Boerwinkle E. (Eric)
- Boerwinkle E.A. (Eric)
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- Bonnycastle L.L. (Lori L.)
- Bonnycastle L.L. (Lori L.)
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- Publication venue
- Publication date
- 01/01/2012
- Field of study
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P = 4.5×10−8- 1.2 ×10−43). Using a novel method to combine data across ethnicities (N = 4,232 African Americans, N = 1,776 Asians, and N = 29,347 Europeans), we identified two additional novel loci. Expression analyses of 436 human adipocyte samples revealed that mRNA levels of 18 genes at candidate regions were associated with adiponectin concentrations after accounting for multiple testing (p<3×10−4). We next developed a multi-SNP genotypic risk score to test the association of adiponectin decreasing risk alleles on metabolic traits and diseases using consortia-level meta-analytic data. This risk score was associated with increased risk of T2D (p = 4.3×10−3, n = 22,044), increased triglycerides (p = 2.6×10−14, n = 93,440), increased waist-to-hip ratio (p = 1.8×10−5, n = 77,167), increased glucose two hours post oral glucose tolerance testing (p = 4.4×10−3, n = 15,234), increased fasting insulin (p = 0.015, n = 48,238), but with lower in HDL- cholesterol concentrations (p = 4.5×10−13, n = 96,748) and decreased BMI (p = 1.4×10−4, n = 121,335). These findings identify novel genetic determinants of adiponectin levels, which, taken together, influence risk of T2D and markers of insulin resistance
Assessing the Reliability of Commercially Available Point of Care in Various Clinical Fields
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