4,723 research outputs found
Deviational simulation of phonon transport in graphene ribbons with ab initio scattering
We present a deviational Monte Carlo method for solving the Boltzmann-Peierls equation with ab initio 3-phonon scattering, for temporally and spatially dependent thermal transport problems in arbitrary geometries. Phonon dispersion relations and transition rates for graphene are obtained from density functional theory calculations. The ab initio scattering operator is simulated by an energy-conserving stochastic algorithm embedded within a deviational, low-variance Monte Carlo formulation. The deviational formulation ensures that simulations are computationally feasible for arbitrarily small temperature differences, while the stochastic treatment of the scattering operator is both efficient and exhibits no timestep error. The proposed method, in which geometry and phonon-boundary scattering are explicitly treated, is extensively validated by comparison to analytical results, previous numerical solutions and experiments. It is subsequently used to generate solutions for heat transport in graphene ribbons of various geometries and evaluate the validity of some common approximations found in the literature. Our results show that modeling transport in long ribbons of finite width using the homogeneous Boltzmann equation and approximating phonon-boundary scattering using an additional homogeneous scattering rate introduces an error on the order of 10% at room temperature, with the maximum deviation reaching 30% in the middle of the transition regime.Singapore-MIT Alliance for Research and TechnologyAmerican Society for Engineering Education. National Defense Science and Engineering Graduate FellowshipNational Science Foundation (U.S.). Graduate Research Fellowshi
Mixed-mode oscillations and interspike interval statistics in the stochastic FitzHugh-Nagumo model
We study the stochastic FitzHugh-Nagumo equations, modelling the dynamics of
neuronal action potentials, in parameter regimes characterised by mixed-mode
oscillations. The interspike time interval is related to the random number of
small-amplitude oscillations separating consecutive spikes. We prove that this
number has an asymptotically geometric distribution, whose parameter is related
to the principal eigenvalue of a substochastic Markov chain. We provide
rigorous bounds on this eigenvalue in the small-noise regime, and derive an
approximation of its dependence on the system's parameters for a large range of
noise intensities. This yields a precise description of the probability
distribution of observed mixed-mode patterns and interspike intervals.Comment: 36 page
Rosa hybrid gene GAPC is mutated in the presence of the Rose Rosette Virus
Rose Rosette Disease (RRD) harms the global rose supply by modification of the growth and development in rose cultivar. RRD spreads via a negative-sense RNA plant virus transmitted by eriophyid mites. Importantly, there is no pre-existing knowledge about the biochemistry by which this virus debilitates roses. Here we implicate glyceraldehyde-3-phosphate dehydrogenase (GAPDH), one of the major metabolic enzymes in plants, as a possible target of the virus. Genomic DNA of the cytosolic form of the protein encoded by GAPC was extracted from both virally-infected and non-infected samples of the Rosa hybrid cultivar Rosa Tropicana. The sequence results provided several distinct differences in the GAPC gene of the non-infected rose compared to the virally-infected rose. Importantly, these modified nucleotide bases resulted in a putative protein sequence containing four unique non-conserved amino acid substitutions in the GAPDH enzyme. This study provides the first evidence of a gene impacted in virally-infected rose plants
Who is to blame? The relationship between ingroup identification and relative deprivation is moderated by ingroup attributions
Contradictory evidence can be found in the literature about whether ingroup identification and perceived relative deprivation are positively or negatively related. Indeed, theoretical arguments can be made for both effects. It was proposed that the contradictory findings can be explained by considering a hitherto unstudied moderator: The extent to which deprivation is attributed to the ingroup. It was hypothesised that identification would only have a negative impact on deprivation, and that deprivation would only have a negative impact on identification, if ingroup attributions are high. To test this, attributions to the ingroup were experimentally manipulated among British student participants (N = 189) who were asked about their perceived deprivation vis-à-vis German students, yield ing support for the hypotheses
Hematological Changes in Women and Infants Exposed to an AZT-Containing Regimen for Prevention of Mother-to-child-transmission of HIV in Tanzania.
Tanzanian guidelines for prevention of mother-to-child-transmission of HIV (PMTCT) recommend an antiretroviral combination regimen involving zidovudine (AZT) during pregnancy, single-dosed nevirapine at labor onset, AZT plus Lamivudine (3TC) during delivery, and AZT/3TC for 1-4 weeks postpartum. As drug toxicities are a relevant concern, we assessed hematological alterations in AZT-exposed women and their infants. A cohort of HIV-positive women, either with AZT intake (n = 82, group 1) or without AZT intake (n = 62, group 2) for PMTCT during pregnancy, was established at Kyela District Hospital, Tanzania. The cohort also included the infants of group 1 with an in-utero AZT exposure ≥4 weeks, receiving AZT for 1 week postpartum (n = 41), and infants of group 2 without in-utero AZT exposure, receiving a prolonged 4-week AZT tail (n = 58). Complete blood counts were evaluated during pregnancy, birth, weeks 4-6 and 12. For women of group 1 with antenatal AZT intake, we found a statistically significant decrease in hemoglobin level, red blood cells, white blood cells, granulocytes, as well as an increase in red cell distribution width and platelet count. At delivery, the median red blood cell count was significantly lower and the median platelet count was significantly higher in women of group 1 compared to group 2. At birth, infants from group 1 showed a lower median hemoglobin level and granulocyte count and a higher frequency of anemia and granulocytopenia. At 4-6 weeks postpartum, the mean neutrophil granulocyte count was significantly lower and neutropenia was significantly more frequent in infants of group 2. AZT exposure during pregnancy as well as after birth resulted in significant hematological alterations for women and their newborns, although these changes were mostly mild and transient in nature. Research involving larger cohorts is needed to further analyze the impact of AZT-containing regimens on maternal and infant health
Kitaev's quantum double model from a local quantum physics point of view
A prominent example of a topologically ordered system is Kitaev's quantum
double model for finite groups (which in particular
includes , the toric code). We will look at these models from
the point of view of local quantum physics. In particular, we will review how
in the abelian case, one can do a Doplicher-Haag-Roberts analysis to study the
different superselection sectors of the model. In this way one finds that the
charges are in one-to-one correspondence with the representations of
, and that they are in fact anyons. Interchanging two of such
anyons gives a non-trivial phase, not just a possible sign change. The case of
non-abelian groups is more complicated. We outline how one could use
amplimorphisms, that is, morphisms to study the superselection
structure in that case. Finally, we give a brief overview of applications of
topologically ordered systems to the field of quantum computation.Comment: Chapter contributed to R. Brunetti, C. Dappiaggi, K. Fredenhagen, J.
Yngvason (eds), Advances in Algebraic Quantum Field Theory (Springer 2015).
Mainly revie
Rank-based model selection for multiple ions quantum tomography
The statistical analysis of measurement data has become a key component of
many quantum engineering experiments. As standard full state tomography becomes
unfeasible for large dimensional quantum systems, one needs to exploit prior
information and the "sparsity" properties of the experimental state in order to
reduce the dimensionality of the estimation problem. In this paper we propose
model selection as a general principle for finding the simplest, or most
parsimonious explanation of the data, by fitting different models and choosing
the estimator with the best trade-off between likelihood fit and model
complexity. We apply two well established model selection methods -- the Akaike
information criterion (AIC) and the Bayesian information criterion (BIC) -- to
models consising of states of fixed rank and datasets such as are currently
produced in multiple ions experiments. We test the performance of AIC and BIC
on randomly chosen low rank states of 4 ions, and study the dependence of the
selected rank with the number of measurement repetitions for one ion states. We
then apply the methods to real data from a 4 ions experiment aimed at creating
a Smolin state of rank 4. The two methods indicate that the optimal model for
describing the data lies between ranks 6 and 9, and the Pearson test
is applied to validate this conclusion. Additionally we find that the mean
square error of the maximum likelihood estimator for pure states is close to
that of the optimal over all possible measurements.Comment: 24 pages, 6 figures, 3 table
Differential (2+1) Jet Event Rates and Determination of alpha_s in Deep Inelastic Scattering at HERA
Events with a (2+1) jet topology in deep-inelastic scattering at HERA are
studied in the kinematic range 200 < Q^2< 10,000 GeV^2. The rate of (2+1) jet
events has been determined with the modified JADE jet algorithm as a function
of the jet resolution parameter and is compared with the predictions of Monte
Carlo models. In addition, the event rate is corrected for both hadronization
and detector effects and is compared with next-to-leading order QCD
calculations. A value of the strong coupling constant of alpha_s(M_Z^2)=
0.118+- 0.002 (stat.)^(+0.007)_(-0.008) (syst.)^(+0.007)_(-0.006) (theory) is
extracted. The systematic error includes uncertainties in the calorimeter
energy calibration, in the description of the data by current Monte Carlo
models, and in the knowledge of the parton densities. The theoretical error is
dominated by the renormalization scale ambiguity.Comment: 25 pages, 6 figures, 3 tables, submitted to Eur. Phys.
Novel Naphthalene-Based Inhibitors of Trypanosoma brucei RNA Editing Ligase 1
African sleeping sickness is a devastating disease that plagues sub-Saharan Africa. Neglected tropical diseases like African sleeping sickness cause significant death and suffering in the world's poorest countries. Current treatments for African sleeping sickness either have high costs, terrible side effects, or limited effectiveness. Consequently, new medicines are urgently needed. RNA editing ligase 1 is an important protein critical for the survival of Trypanosoma brucei, the unicellular parasite that causes African sleeping sickness. In this paper, we describe our recent efforts to use advanced computer techniques to identify chemicals predicted to prevent RNA editing ligase 1 from functioning properly. We subsequently tested our predicted chemicals and confirmed that a number of them inhibited the protein's function. Additionally, one of the chemicals was effective at stopping the growth of the parasite in culture. Although substantial work remains to be done in order to optimize these chemicals so they are effective and safe to use in human patients, the identification of these parasite-killing compounds is nevertheless a valuable step towards finding a better cure for this devastating disease
Multiplicity Structure of the Hadronic Final State in Diffractive Deep-Inelastic Scattering at HERA
The multiplicity structure of the hadronic system X produced in
deep-inelastic processes at HERA of the type ep -> eXY, where Y is a hadronic
system with mass M_Y< 1.6 GeV and where the squared momentum transfer at the pY
vertex, t, is limited to |t|<1 GeV^2, is studied as a function of the invariant
mass M_X of the system X. Results are presented on multiplicity distributions
and multiplicity moments, rapidity spectra and forward-backward correlations in
the centre-of-mass system of X. The data are compared to results in e+e-
annihilation, fixed-target lepton-nucleon collisions, hadro-produced
diffractive final states and to non-diffractive hadron-hadron collisions. The
comparison suggests a production mechanism of virtual photon dissociation which
involves a mixture of partonic states and a significant gluon content. The data
are well described by a model, based on a QCD-Regge analysis of the diffractive
structure function, which assumes a large hard gluonic component of the
colourless exchange at low Q^2. A model with soft colour interactions is also
successful.Comment: 22 pages, 4 figures, submitted to Eur. Phys. J., error in first
submission - omitted bibliograph
- …