Desarrollop galénico de nuevas formulaciones de anfotericina B

En los últimos años, las infecciones fúngicas invasivas (IFIs), en concreto las candidiasis, causan una elevada morbilidad y mortalidad tras la realización de trasplantes pulmonares. Por otro lado, diferentes especies de Aspergillus han emergido como una de las causas más importantes de mortalidad y morbilidad en pacientes inmunocomprometidos. El principal foco de infección de este tipo de infecciones fúngicas en humanos es el pulmón, con diseminación en otros órganos, a medida que la enfermedad progresa. Para un tratamiento eficaz de la aspergilosis pulmonar es necesario alcanzar elevadas concentraciones pulmonares de anfotericina B. Las bajas concentraciones pulmonares en las primeras 48 horas de la formulación liposomal de anfotericina B unido a sus altos costes, limitan su uso. Por otro lado, la formulación comercial dimérica deanfotericina B con desoxicolato sódico presenta menor eficacia y causa una elevada nefrotoxicidad. Debido a todo esto, es necesario encontrar nuevas formulaciones de anfotericina B, como son sistemas poliagregados deanfotericina B con desoxicolato sódico que garanticen mayor eficacia frente a agentes patógenos pulmonares..

Comparación de usabilidad entre captcha basado en texto y captcha basado en imágenes

En la actualidad los captchas basados en texto son pruebas utilizadas para diferenciar un humano de una computadora, sin embargo existen programas llamados OCR que engañan al captcha basado en texto, el avance de la tecnología de los OCR ha ido evolucionando y con esto ha superado en varias ocasiones a estos captchas, provocando que se utilicen diferentes métodos para disminuir su vulnerabilidad y sean más difíciles de engañar; lo anterior ocasiona que los usuarios tiendan a equivocarse e impedirles el acceso a la información. En este estudio se comparó el uso del captcha basado en texto con un captcha más reciente que es el captcha basado en imágenes para evaluar cuál de ellos se soluciona más rápido y la cantidad de aciertos en la solución que son aspectos relacionados con su usabilidad

Maslinic Acid Enhances Signals for the Recruitment of Macrophages and Their Differentiation to M1 State

The inflammatory process is involved in the genesis and evolution of different diseases like obesity, cardiovascular disease, and cancer. Macrophages play a central role in inflammation. In addition, they can regulate some stages of cancer development. Macrophages can polarize into M1 or M2 functional phenotype depending on the cytokines present in the tissue microenvironment. On the other hand, triterpenes found in virgin olive oil are described to present different properties, such as antitumoral and anti-inflammatory activity. The present study was designed to elucidate if the four major triterpenes found in virgin olive oil (oleanolic acid, maslinic acid, uvaol, and erythrodiol) are able to enhance M1 macrophage response which represents an important defense mechanism against cancer. Our results indicated that maslinic acid modulated the inflammatory response by enhancing the production of IL-8, IL-1α, and IL-1β; it promoted M1 response through the synthesis of IFN-γ; and finally it did not modify significantly the levels of NFκβ or NO. Overall, our results showed that maslinic acid could prevent chronic inflammation, which represents a crucial step in the development of some cancers

Validating the TDRT-Q to assess the quality of the teacher-dancer relationship

La capacidad de los entrenadores para potenciar o desincentivar el compromiso de sus deportistas y para desarrollar su potencial a través de la cualidad de las relaciones que entre ellos se establecen ha recibido una considerable atención desde la investigación; sin embargo, la diada equivalente en el contexto de la danza, la relación entre el maestro y el bailarín, ha sido un área relativamente poco explorada. El propósito de este artículo es extrapolar el modelo de las 3C's de las Relaciones Entrenador-Deportista de Jowett al contexto de la danza y adaptar y validar al español el CART-Q, un instrumento ampliamente utilizado para la evaluación de las relaciones deportista-entrenador. Para ello, 175 bailarines y bailarinas españoles de entre 18 y 40 años (M = 22.47; DT = 4.85) de diferentes niveles y disciplinas de baile completaron el denominado Cuestionario sobre las Relaciones entre Maestro y Bailarín (TDRT-Q), la traducción española del CART-Q adaptado al contexto de la danza. El análisis factorial confirmatorio puso de manifiesto la estructura jerárquica de las relaciones como habían sido originalmente postuladas, incluyendo las dimensiones de Cercanía, Compromiso y Complementariedad. En términos generales, el TDRT-Q demostró unas adecuadas propiedades psicométricas. En línea con los resultados obtenidos, el modelo de las 3C's puede ser transferido para el análisis de las relaciones maestro-bailarín. Más aún, el TDRT-Q puede utilizarse para la evaluación de la cualidad de las relaciones maestro bailarín y para avanzar en el conocimiento y comprensión de este contexto artístico orientado al rendimiento.The capacity of coaches to enable or disable athletes' engagement and ability to reach their potential through the quality of the relationship they develop with them has received substantial research attention, yet the equivalent dyad in dance contexts-the teacher-dancer relationship-has remained relatively unexplored. Thus, the purpose of this paper is to extrapolate Jowett's 3C's Coach-Athlete Relationship Model to the dance context and adapt and validate a Spanish translation of the CART-Q, a psychometric tool that has been extensively used to assess the coach-athlete relationship, to examine the teacher-dancer relationship. 175 Spanish dancers aged 18 to 40 (M = 22.47, SD = 4.85) of diverse performance levels and various dance disciplines completed the renamed Teacher-Dancer Relationship Questionnaire (TDRT-Q), the Spanish translation of the CART-Q adapted to dance contexts. A confirmatory factor analysis highlighted the hierarchical nature of the relationship as has been originally postulated containing Closeness, Commitment, and Complementarity. Overall the TDRT-Q demonstrated adequate psychometric properties. In line with these results, the 3C's model can be transferred to analyse the teacher dancer relationship. Moreover, the TDRT-Q can be used to assess the quality of the teacher-dancer relationship and further advance knowledge and understanding in this achievement-orientated performing arts context.A capacidade dos técnicos para potencializar ou desencorajar o compromisso de seus atletas e para desenvolver o potencial dos mesmos através da qualidade das relações que se estabelecem entre ambos tem recebido considerável atenção da investigação; no entanto, a díade equivalente no contexto da dança, a relação entre o professor e o dançarino, tem sido uma área relativamente pouco explorada. O propósito deste artigo é extrapolar o modelo dos 3C's das Relações Treinador-Atleta de Jowett ao contexto da dança e adaptar e validar ao espanhol o CART-Q, um instrumento amplamente utilizado para a avaliação das relações atleta-treinador. Para tanto, 175 dançarinos e dançarinas espanhóis entre 18 e 40 anos (M = 22.47; DT = 4.85) de diferentes níveis e disciplinas de dança responderam o denominado Questionário sobre as Relações entre Professor e Dançarino (TDRT-Q), a tradução espanhola do CART-Q adaptado ao contexto da dança. A análise fatorial confirmatória revelou a estrutura hierárquica das relações como haviam sido originalmente postuladas, incluindo as dimensões de Proximidade, Compromisso e Complementaridade. Em termos gerais, o TDRT-Q demonstrou propriedades psicométricas adequadas. Em linha com os resultados obtidos, o modelo dos 3C's pode ser transferido para a análise das relações professor-dançarino. Além disso, o TDRT-Q pode ser utilizado para a avaliação da qualidade das relações professor-dançarino e para avançar no conhecimento e na compreensão deste contexto artístico orientado ao rendimento

Dynamics of iterative families with memory based on weight functions procedure

[EN] In this paper, we analyze the stability of a parametric family of iterative methods with memory for solving nonlinear equations. This family is obtained from an optimal class of fourth -order schemes without memory designed by means of weight functions procedure. By studying the real fixed and critical points of the rational function resulting from the application of the family with memory on quadratic polynomials, the best elements of the family, in terms of absence of chaotic behavior, are selected. Finally, a numerical study is performed verifying the dynamical theoretical results. (C) 2018 Elsevier B.V. All rights reserved.The authors would like to thank the anonymous reviewers for their useful comments and suggestions. This research was partially supported by both Ministerio de Economia y Competitividad and Generalitat Valenciana, Spain, under grants MTM2014-52016-C2-2-P and PROMETE0/2016/089, respectively.Chicharro López, FI.; Cordero Barbero, A.; Torregrosa Sánchez, JR. (2019). Dynamics of iterative families with memory based on weight functions procedure. Journal of Computational and Applied Mathematics. 354:286-298. https://doi.org/10.1016/j.cam.2018.01.019S28629835

Characteristic planes of microstrip and unilateral finline tee-junctions

A unique set of reference planes which enters into the description of a three port E or H-plane tee-junction are its characteristics planes. These planes correspond to the positions of a short circuit at one typical port that will decouple a second port from one input port. The purpose of this paper is to establish these planes in the cases of microstrip and unilateral finline circuits. This is done in each case for a number of different geometries. The spacing between the first two characteristic planes across the junction is 360 deg. In the case of the H-plane tee junction, it is 180 deg in the case of the E-plane geometry.The authors would like to thank the Spanish Ministry of Science and Innovation (MICINN) by the financial support provided through project TEC2011-29126-C03-01 and CONSOLIDER-INGENIO 2010 CSD2008-00068

A dual linear polarization feed antenna system for satellite communications

A dual lineal polarization feed antenna system for satellite communication will be described. It consists of a turnstile-based orthomode transducer (OMT) and two identical duplexers formed by a plane T-junction and of two iris filters. This 4-ports subsystem transmits and receives radio frequency signals in double track in which the transmission Tx is made through two ports having as access the standard rectangular waveguide WR229 while the reception Rx is made through two ports having as access the standard rectangular waveguide WR159. The proposed subsystem overcomes the current practical bandwidth limitations by using a very compact octave bandwidth OMT along with two robust duplexers. The subsystem is working in the extended C-band, the 5.8-7.1 GHz range is used for the uplink, whereas the 3.6-4.8 GHz range is set to the downlink. The presented architecture exhibits a return loss better than 20 dB in all ports, an isolation between the different rectangular ports better than 70 dB and a transmission loss less than 0.15 dB in both frequency bands (3.6-4.8 GHz and 5.8-7.1 GHz) which represents state-of-the-art achievement in terms of bandwidth.This work was supported by the Ministerio de Educacion y Ciencia (Spain), Plan Nacional de I+D+I, Astronomy and Astrophysics program AYA2007-68058-C03-03, and the FPI grant BES-2005-6730. The authors like to thank Spanish MICINN and AECID through their codes TEC-2008-06684-C03-01, CSD2008-68, and D/018607/08 for their human capital support. The authors wish also to thank the staff of the Spanish Agency for International Development Cooperation (AECID)

Juicio en línea justo

Juicio en línea justo, se adscribe a la propuesta de unametodología por Indicadores sobre derechos humanos para medirel cumplimiento de éstos en todo procedimiento judicial e inclusoadministrativo; adaptándola al contexto nacional y regional denuestro país, priorizando en todo tiempo el mayor beneficio al serhumano y procurando no incurrir en prácticas discriminatorias y deensanchamiento de la brecha digital en México

Validación de un instrumento para detectar síntomas indicativos de cáncer de ovario en Querétaro, México

El objetivo de este trabajo fue validar un instrumento para detectar a mujeres con riesgo de padecer Cáncer de Ovario (CaOva). Material y Métodos: se realizó una búsqueda exhaustiva de datos que revelen síntomas indicativos del CaOva, dicha búsqueda se refiere a los principales síntomas sugestivos y con ello se realizó una entrevista estructurada, en la colecta de datos se analizaron palabras claves y con ello se formularon preguntas concernientes a los antecedentes, síntomas y duración; también dolor y/o inflamación abdominal/pélvico, frecuencia urinaria y saciedad temprana, así como antecedentes familiares y propios; se realizó una prueba piloto a 100 mujeres en UNEME-DEDICAM. Resultados preliminares: La evaluación de la consistencia interna fue de KR-20 = 0,19. Se obtuvo que el 2 % presentó saciedad temprana, 1% dolor abdominal, 17% tuvo antecedente de Cáncer familiar, 7% antecedente propio. Conclusiones: El instrumento empleado funciona como método de tamizaje y puede complementarse con pruebas de laboratorio y gabinete. Los resultados obtenidos concuerdan con los síntomas referidos por el colegio Mexicano de especialistas en ginecológica y obstetricia (COMEGO).The objective of this research was an instrument to detect women with risk of obtaining ovarian cancer (CaOva). Materials and Methods: an exhaustive search was conducted to collect data in order to show symptoms from CaOva, that research it means to principal suggestive symptoms and with that it realized an unstructured interview, in data collect were analyzed key words and with that questions were asked about the background, symptoms and length; also pain and abdominal pain, pelvic pain, urinary regularity, early satiety and medical background family and individual. A pilot test was conducted to 100 women on UNEME-DEDICAM. Preliminary Results: The evaluation of the consistent intern were as follow: KR-20=0,19. 2% presented with early relief, 1% abdominal pain, 17% had a history of family cancer, 7% were own history. Conclusion: The instrument used works as screening method with laboratory test and cabinet. The results agree with the symptom reported by Mexican school of specialist in gynecology and obstetrics (COMEGO).Este trabajo recibió el apoyo financiero del Consejo Nacional de Ciencia y Tecnología (CONACYT) a través del Programa Nacional de Posgrados de Calidad (PNPC)

Strategies for Solving Addition Problems Using Modified Schema-Based Instruction in Students with Intellectual Disabilities

A study is presented on the strategies employed to solve additive change problems by three students with intellectual disabilities (two of them with autism spectrum disorder). The students followed a program involving modified schema-based instruction. The results show an improvement in the problem-solving skills of the three students, who achieved successful formal strategies associated with identifying the operation. We analyze the importance of adapting and/or emphasizing certain steps in the instruction process in order to tailor them to the difficulties of each student