1,953 research outputs found
Lithium, sodium and potassium enolate aggregates and monomers: syntheses and structures
\ua9 2024 The Royal Society of Chemistry. In this Article, we report the syntheses and comparative structural studies of lithium, sodium, and potassium anthracen-9-yl enolates, as their aggregates (Li, Na: hexamer; K: tetramer) and ligand-stabilized monomers (for Li and Na). The monomers add new members to the rare collection of group-1 metal monomeric enolates. Moreover, the series covers different group-1 metal cations (Li+, Na+ and K+) and aggregate sizes, allowing comparative structural studies to elucidate how the metal identity and aggregate size influence the enolate structure
A semi-Markov model for stroke with piecewise-constant hazards in the presence of left, right and interval censoring.
This paper presents a parametric method of fitting semi-Markov models with piecewise-constant hazards in the presence of left, right and interval censoring. We investigate transition intensities in a three-state illness-death model with no recovery. We relax the Markov assumption by adjusting the intensity for the transition from state 2 (illness) to state 3 (death) for the time spent in state 2 through a time-varying covariate. This involves the exact time of the transition from state 1 (healthy) to state 2. When the data are subject to left or interval censoring, this time is unknown. In the estimation of the likelihood, we take into account interval censoring by integrating out all possible times for the transition from state 1 to state 2. For left censoring, we use an Expectation-Maximisation inspired algorithm. A simulation study reflects the performance of the method. The proposed combination of statistical procedures provides great flexibility. We illustrate the method in an application by using data on stroke onset for the older population from the UK Medical Research Council Cognitive Function and Ageing Study
Designing a physical activity parenting course : parental views on recruitment, content and delivery
Background
Many children do not engage in sufficient levels of physical activity (PA) and spend too much time screen-viewing (SV). High levels of SV (e.g. watching TV, playing video games and surfing the internet) and low levels of PA have been associated with adverse health outcomes. Parenting courses may hold promise as an intervention medium to change childrenâs PA and SV. The current study was formative work conducted to design a new parenting programme to increase childrenâs PA and reduce their SV. Specifically, we focussed on interest in a course, desired content and delivery style, barriers and facilitators to participation and opinions on control group provision.
Methods
In-depth telephone interviews were conducted with thirty two parents (29 female) of 6â8âyear olds. Data were analysed thematically. An anonymous online survey was also completed by 750 parents of 6â8âyear old children and descriptive statistics calculated.
Results
Interview participants were interested in a parenting course because they wanted general parenting advice and ideas to help their children be physically active. Parents indicated that they would benefit from knowing how to quantify their childâs PA and SV levels. Parents wanted practical ideas of alternatives to SV. Most parents would be unable to attend unless childcare was provided. Schools were perceived to be a trusted source of information about parenting courses and the optimal recruitment location. In terms of delivery style, the majority of parents stated they would prefer a group-based approach that provided opportunities for peer learning and support with professional input. Survey participants reported the timing of classes and the provision of childcare were essential factors that would affect participation. In terms of designing an intervention, the most preferred control group option was the opportunity to attend the same course at a later date.
Conclusions
Parents are interested in PA/SV parenting courses but the provision of child care is essential for attendance. Recruitment is likely to be facilitated via trusted sources. Parents want practical advice on how to overcome barriers and suggest advice is provided in a mutually supportive group experience with expert input
Collective Excitations of Holographic Quantum Liquids in a Magnetic Field
We use holography to study N=4 supersymmetric SU(Nc) Yang-Mills theory in the
large-Nc and large-coupling limits coupled to a number Nf << Nc of
(n+1)-dimensional massless supersymmetric hypermultiplets in the Nc
representation of SU(Nc), with n=2,3. We introduce a temperature T, a baryon
number chemical potential mu, and a baryon number magnetic field B, and work in
a regime with mu >> T,\sqrt{B}. We study the collective excitations of these
holographic quantum liquids by computing the poles in the retarded Green's
function of the baryon number charge density operator and the associated peaks
in the spectral function. We focus on the evolution of the collective
excitations as we increase the frequency relative to T, i.e. the
hydrodynamic/collisionless crossover. We find that for all B, at low
frequencies the tallest peak in the spectral function is associated with
hydrodynamic charge diffusion. At high frequencies the tallest peak is
associated with a sound mode similar to the zero sound mode in the
collisionless regime of a Landau Fermi liquid. The sound mode has a gap
proportional to B, and as a result for intermediate frequencies and for B
sufficiently large compared to T the spectral function is strongly suppressed.
We find that the hydrodynamic/collisionless crossover occurs at a frequency
that is approximately B-independent.Comment: 45 pages, 8 png and 47 pdf images in 22 figure
Physical Response Functions of Strongly Coupled Massive Quantum Liquids
We study physical properties of strongly coupled massive quantum liquids from
their spectral functions using the AdS/CFT correspondence. The generic model
that we consider is dense, heavy fundamental matter coupled to SU(N_c) super
Yang-Mills theory at finite temperature above the deconfinement phase
transition but below the scale set by the baryon number density. In this setup,
we study the current-current correlators of the baryon number density using new
techniques that employ a scaling behavior in the dual geometry. Our results,
the AC conductivity, the quasi-particle spectrum and the Drude-limit parameters
like the relaxation time are simple temperature-independent expressions that
depend only on the mass-squared to density ratio and display a crossover
between a baryon- and meson-dominated regime. We concentrated on the
(2+1)-dimensional defect case, but in principle our results can also be
generalized straightforwardly to other cases.Comment: 21 pages, 10 figures, extra paragraph and figure are added in
response to referee's comment
Large scale patterns in vertical distribution and behavior of mesopelagic scattering layers
Recent studies suggest that previous estimates of mesopelagic biomasses are severely biased, with
the new, higher estimates underlining the need to unveil behaviourally mediated coupling between shallow and deep ocean habitats. We analysed vertical distribution and diel vertical migration (DVM)
of mesopelagic acoustic scattering layers (SLs) recorded at 38 kHz across oceanographic regimes encountered during the circumglobal Malaspina expedition. Mesopelagic SLs were observed in all areas covered, but vertical distributions and DVM patterns varied markedly. The distribution of mesopelagic backscatter was deepest in the southern Indian Ocean (weighted mean daytime depth: WMD 590 m) and shallowest at the oxygen minimum zone in the eastern Pacific (WMD 350 m). DVM was evident in all areas covered, on average ~50% of mesopelagic backscatter made daily excursions from mesopelagic depths to shallow waters. There were marked differences in migrating proportions between the regions, ranging from ~20% in the Indian Ocean to ~90% in the Eastern Pacific. Overall the data suggest strong spatial gradients in mesopelagic DVM patterns, with implied ecological and biogeochemical consequences. Our results suggest that parts of this spatial variability can be explained by horizontal patterns in physical-chemical properties of water masses, such as oxygen, temperature and turbidity.En prensa2,927
Who should be prioritized for renal transplantation?: Analysis of key stakeholder preferences using discrete choice experiments
Background
Policies for allocating deceased donor kidneys have recently shifted from allocation based on Human Leucocyte Antigen (HLA) tissue matching in the UK and USA. Newer allocation algorithms incorporate waiting time as a primary factor, and in the UK, young adults are also favoured. However, there is little contemporary UK research on the views of stakeholders in the transplant process to inform future allocation policy. This research project aimed to address this issue.
Methods
Discrete Choice Experiment (DCE) questionnaires were used to establish priorities for kidney transplantation among different stakeholder groups in the UK. Questionnaires were targeted at patients, carers, donors / relatives of deceased donors, and healthcare professionals. Attributes considered included: waiting time; donor-recipient HLA match; whether a recipient had dependents; diseases affecting life expectancy; and diseases affecting quality of life.
Results
Responses were obtained from 908 patients (including 98 ethnic minorities); 41 carers; 48 donors / relatives of deceased donors; and 113 healthcare professionals. The patient group demonstrated statistically different preferences for every attribute (i.e. significantly different from zero) so implying that changes in given attributes affected preferences, except when prioritizing those with no rather than moderate diseases affecting quality of life. The attributes valued highly related to waiting time, tissue match, prioritizing those with dependents, and prioritizing those with moderate rather than severe diseases affecting life expectancy. Some preferences differed between healthcare professionals and patients, and ethnic minority and non-ethnic minority patients. Only non-ethnic minority patients and healthcare professionals clearly prioritized those with better tissue matches.
Conclusions
Our econometric results are broadly supportive of the 2006 shift in UK transplant policy which emphasized prioritizing the young and long waiters. However, our findings suggest the need for a further review in the light of observed differences in preferences amongst ethnic minorities, and also because those with dependents may be a further priority.</p
Holographic zero sound at finite temperature in the Sakai-Sugimoto model
In this paper, we study the fate of the holographic zero sound mode at finite
temperature and non-zero baryon density in the deconfined phase of the
Sakai-Sugimoto model of holographic QCD. We establish the existence of such a
mode for a wide range of temperatures and investigate the dispersion relation,
quasi-normal modes, and spectral functions of the collective excitations in
four different regimes, namely, the collisionless quantum, collisionless
thermal, and two distinct hydrodynamic regimes. For sufficiently high
temperatures, the zero sound completely disappears, and the low energy physics
is dominated by an emergent diffusive mode. We compare our findings to
Landau-Fermi liquid theory and to other holographic models.Comment: 1+24 pages, 19 figures, PDFTeX, v2: some comments and references
added, v3: some clarifications relating to the different regimes added,
matches version accepted for publication in JHEP, v4: corrected typo in eq.
(3.18
Group interventions to improve health outcomes : a framework for their design and delivery
Peer reviewedPublisher PD
Presynaptic partner selection during retinal circuit reassembly varies with timing of neuronal regeneration in vivo
Whether neurons can restore their original connectivity patterns during circuit repair is unclear. Taking advantage of the regenerative capacity of zebrafish retina, we show here the remarkable specificity by which surviving neurons reassemble their connectivity upon regeneration of their major input. H3 horizontal cells (HCs) normally avoid red and green cones, and prefer ultraviolet over blue cones. Upon ablation of the major (ultraviolet) input, H3 HCs do not immediately increase connectivity with other cone types. Instead, H3 dendrites retract and re-extend to contact new ultraviolet cones. But, if regeneration is delayed or absent, blue-cone synaptogenesis increases and ectopic synapses are made with red and green cones. Thus, cues directing synapse specificity can be maintained following input loss, but only within a limited time period. Further, we postulate that signals from the major input that shape the H3 HC's wiring pattern during development persist to restrict miswiring after damage
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