30 research outputs found
Luminescence Sensors Applied to Water Analysis of Organic PollutantsâAn Update
The development of chemical sensors for environmental analysis based on fluorescence, phosphorescence and chemiluminescence signals continues to be a dynamic topic within the sensor field. This review covers the fundamentals of this type of sensors, and an update on recent works devoted to quantifying organic pollutants in environmental waters, focusing on advances since about 2005. Among the wide variety of these contaminants, special attention has been paid polycyclic aromatic hydrocarbons, pesticides, explosives and emerging organic pollutants. The potential of coupling optical sensors with multivariate calibration methods in order to improve the selectivity is also discussed
La renovaciĂłn de la palabra en el bicentenario de la Argentina : los colores de la mirada lingĂŒĂstica
El libro reĂșne trabajos en los que se exponen resultados de investigaciones presentadas por investigadores de Argentina, Chile, Brasil, España, Italia y Alemania en el XII Congreso de la Sociedad Argentina de LingĂŒĂstica (SAL), Bicentenario: la renovaciĂłn de la palabra, realizado en Mendoza, Argentina, entre el 6 y el 9 de abril de 2010. Las temĂĄticas abordadas en los 167 capĂtulos muestran las grandes lĂneas de investigaciĂłn que se desarrollan fundamentalmente en nuestro paĂs, pero tambiĂ©n en los otros paĂses mencionados arriba, y señalan ademĂĄs las ĂĄreas que reciĂ©n se inician, con poca tradiciĂłn en nuestro paĂs y que deberĂan fomentarse. Los trabajos aquĂ publicados se enmarcan dentro de las siguientes disciplinas y/o campos de investigaciĂłn: FonologĂa, Sintaxis, SemĂĄntica y PragmĂĄtica, LingĂŒĂstica Cognitiva, AnĂĄlisis del Discurso, PsicolingĂŒĂstica, AdquisiciĂłn de la Lengua, SociolingĂŒĂstica y DialectologĂa, DidĂĄctica de la lengua, LingĂŒĂstica Aplicada, LingĂŒĂstica Computacional, Historia de la Lengua y la LingĂŒĂstica, Lenguas AborĂgenes, FilosofĂa del Lenguaje, LexicologĂa y TerminologĂa
Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTICâHF: baseline characteristics and comparison with contemporary clinical trials
Aims:
The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTICâHF) trial. Here we describe the baseline characteristics of participants in GALACTICâHF and how these compare with other contemporary trials.
Methods and Results:
Adults with established HFrEF, New York Heart Association functional class (NYHA)ââ„âII, EF â€35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokineticâguided dosing: 25, 37.5 or 50âmg bid). 8256 patients [male (79%), nonâwhite (22%), mean age 65âyears] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NTâproBNP 1971âpg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTICâHF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressureâ<â100âmmHg (n = 1127), estimated glomerular filtration rate <â30âmL/min/1.73 m2 (n = 528), and treated with sacubitrilâvalsartan at baseline (n = 1594).
Conclusions:
GALACTICâHF enrolled a wellâtreated, highârisk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation
Luminescence Sensors Applied to Water Analysis of Organic PollutantsâAn Update
The development of chemical sensors for environmental analysis based on fluorescence, phosphorescence and chemiluminescence signals continues to be a dynamic topic within the sensor field. This review covers the fundamentals of this type of sensors, and an update on recent works devoted to quantifying organic pollutants in environmental waters, focusing on advances since about 2005. Among the wide variety of these contaminants, special attention has been paid polycyclic aromatic hydrocarbons, pesticides, explosives and emerging organic pollutants. The potential of coupling optical sensors with multivariate calibration methods in order to improve the selectivity is also discussed
Online third-order liquid chromatographic data with native and photoinduced fluorescence detection for the quantitation of organic pollutants in environmental water
Third-order liquid chromatographic data were generated online for the simultaneous quantitation of six organic environmental pollutants. The employed strategy consists in reducing the linear flow rate at the column outlet. A postcolumn UV reactor and a fluorimetric detector allowed to properly record both photoinduced and native excitationâemission fluorescence matrices (EEPIFMs and EEFMs, respectively). The obtained third-order liquid chromatography data were chemometrically processed with the multivariate curve resolutionâalternating least-squares model. The sensitivity of the overall analytical method was enhanced by a very simple solid-phase extraction with C18 membranes, to be able to successfully apply it to natural water samples tested as real matrices. Favorable detection limits for the investigated pollutants, ranging from 0.02 to 0.27 ng mLâ1, were attained, with relative prediction errors between 2 and 7%. Since the studied samples contain uncalibrated interferents, the applied strategy achieves the second-order advantage. Implications regarding the potential achievement of the third-order advantage are discussed.Fil: Pellegrino Vidal, RocĂo BelĂ©n. Universidad Nacional de Rosario. Facultad de Ciencias BioquĂmicas y FarmacĂ©uticas. Instituto de QuĂmica Rosario (IQUIR-CONICET); Argentina.Fil: Olivieri, Alejandro CĂ©sar. Universidad Nacional de Rosario. Facultad de Ciencias BioquĂmicas y FarmacĂ©uticas. Instituto de QuĂmica Rosario (IQUIR-CONICET); Argentina.Fil: Ibañez, Gabriela A. Universidad Nacional de Rosario. Facultad de Ciencias BioquĂmicas y FarmacĂ©uticas. Instituto de QuĂmica Rosario (IQUIR-CONICET); Argentina.Fil: Escandar, Graciela MĂłnica. Universidad Nacional de Rosario. Facultad de Ciencias BioquĂmicas y FarmacĂ©uticas. Instituto de QuĂmica Rosario (IQUIR-CONICET); Argentina
Data from: Zoogeographic patterns of pelagic oceanic cephalopods along the eastern Pacific Ocean
Aim: To analyse the diversity and distribution of oceanic pelagic cephalopods along the Eastern Pacific Ocean, assessing the existence of biogeographic structuring, and the role of physical variables in generating geographical patterns. We hypothesized that the control by environmental factors, and the effect of geometric constraints, determine the range size and limits of distribution of oceanic cephalopods along the eastern Pacific Ocean, generating a latitudinal gradient in species richness. Location: Eastern Pacific Ocean (60°N â 60°S), from the Gulf of Alaska to the Southern Ocean. Methods: Based on a literature review and >5,000 records obtained from collections, we constructed a presence-absence matrix including 61 latitudinal bands (2° each) along the Eastern Pacific, and estimated species richness and range endpoints at each band. Biogeographic units were determined by means of multivariate analyses. Species richness was compared with null model predictions in order to test for the existence of geometric constraints using the Mid-Domain Null model. The effects on species richness of environmental variables (temperature, salinity and oxygen) were evaluated separately for surface and depth (0-1,000 m) data, by means of ordinary least squares regression and simultaneous autoregressive models. Rapoportâs pattern was assessed by applying the Stevensâ method and the range midpoint method. Results: Species richness was high across the tropics and decreased towards the both poles. We identified five biogeographic units, highlighting two major distribution breaks at 40°N and 42°S. Species richness was strongly related with environmental variables, although the combined variables accounted for a large fraction of the variance between 0-1,000 m (R2 = 0.99), while temperature was the best single predictor at the surface (R2 = 0.98). Species richness curves showed a mid-domain effect (MDE), and the mean latitudinal range was higher in the tropics and at warm latitudes, generating an inverse Rapoportâs pattern.
Main conclusions: Along the Eastern Pacific Ocean, oceanic cephalopods exhibit both a clear biogeographic patterning and an interhemispheric (poleward decreasing) diversity gradient, which appear strongly related with physical factors and external forcing, as well as with a MDE as a seemingly consequence of the naturally bounded domain of the Eastern Pacific
Data from: Zoogeographic patterns of pelagic oceanic cephalopods along the eastern Pacific Ocean
Aim: To analyse the diversity and distribution of oceanic pelagic cephalopods along the Eastern Pacific Ocean, assessing the existence of biogeographic structuring, and the role of physical variables in generating geographical patterns. We hypothesized that the control by environmental factors, and the effect of geometric constraints, determine the range size and limits of distribution of oceanic cephalopods along the eastern Pacific Ocean, generating a latitudinal gradient in species richness. Location: Eastern Pacific Ocean (60°N â 60°S), from the Gulf of Alaska to the Southern Ocean. Methods: Based on a literature review and >5,000 records obtained from collections, we constructed a presence-absence matrix including 61 latitudinal bands (2° each) along the Eastern Pacific, and estimated species richness and range endpoints at each band. Biogeographic units were determined by means of multivariate analyses. Species richness was compared with null model predictions in order to test for the existence of geometric constraints using the Mid-Domain Null model. The effects on species richness of environmental variables (temperature, salinity and oxygen) were evaluated separately for surface and depth (0-1,000 m) data, by means of ordinary least squares regression and simultaneous autoregressive models. Rapoportâs pattern was assessed by applying the Stevensâ method and the range midpoint method. Results: Species richness was high across the tropics and decreased towards the both poles. We identified five biogeographic units, highlighting two major distribution breaks at 40°N and 42°S. Species richness was strongly related with environmental variables, although the combined variables accounted for a large fraction of the variance between 0-1,000 m (R2 = 0.99), while temperature was the best single predictor at the surface (R2 = 0.98). Species richness curves showed a mid-domain effect (MDE), and the mean latitudinal range was higher in the tropics and at warm latitudes, generating an inverse Rapoportâs pattern.
Main conclusions: Along the Eastern Pacific Ocean, oceanic cephalopods exhibit both a clear biogeographic patterning and an interhemispheric (poleward decreasing) diversity gradient, which appear strongly related with physical factors and external forcing, as well as with a MDE as a seemingly consequence of the naturally bounded domain of the Eastern Pacific
Cuerpo(s), Subjetividad(es) y Conflicto(s) : hacia una sociologĂa de los cuerpos y las emociones desde LatinoamĂ©rica
El libro reĂșne una serie de trabajos que contribuyen significativamente al debate interdisciplinario desde mĂșltiples estrategias para indagar los vĂnculos entre cuerpo(s), subjetividad(es) y conflicto(s), presentando las voces de algunos sujetos actuantes, analizando las acciones que producen resistiendo (o no), sus experiencias.
A partir de la convicción de que todo lo que sabemos del mundo lo interpretamos por y a través de nuestros cuerpos, la obra compila diferentes reflexiones al respecto desde América Latina:
* AnĂĄlisis de modos de sensibilidades, prĂĄcticas y representaciones que ponen en palabras la dominaciĂłn.
* La programaciĂłn televisiva aparentemente banal en formatos como CuestiĂłn de peso y PolicĂas en acciĂłn donde se imponen paradigmas que discuten desde la estĂ©tica hasta el horror y la crueldad.
* Los carreros y cirujas de CĂłrdoba y las polĂticas estatales destinadas a focalizar y atender sus necesidades inmediatas, como mecanismos para contener posibles alteraciones del sistema.
* El discurso mediĂĄtico referido al cuerpo enfermo (sida/cĂĄncer).
* Las emociones de lo abyecto: repugnancia e indignaciĂłn.
Estos son algunos de los estudios aquĂ presentados con la intenciĂłn de conformar una sociologĂa que construya el disfrute, la felicidad y la esperanza como temas teĂłricos y como acto descolonizador.Estudio preliminar: De los estudios de acciĂłn colectiva a la sociologĂa del
cuerpo. Un itinerario a través de las transformaciones de la estructuración
social en el capitalismo de Latinoamérica
Por MarĂa Eugenia Boito y Marcelo DAmico 9
Cuerpo y subjetividades en las sociedades de la incertidumbre
Por Flavio Borghi 23
Conflicto y emociones. Un retrato de la vergĂŒenza en Simmel, ElĂas y Giddens
como excusa para interpretar prĂĄcticas en contextos de expulsiĂłn
Por Gabriela Vergara 35
ImĂĄgenes crudas y mirada cruel sobre el otro de clase en PolicĂas en
AcciĂłn. Construcciones ideolĂłgicas sobre la alteridad de clase en la escena
mediĂĄtica contemporĂĄnea
Por MarĂa Eugenia Boito 53
Trama(s) hecha(s) cuerpo(s): una estrategia de lectura de las vivencias de
niños/as y jóvenes que habitan Ciudad de Mis Sueños
Por MarĂa BelĂ©n Espoz Dalmasso e Ileana DesirĂ©e Ibañez 69
Los surcos de las experiencias placenteras en la vida escolarizada y no
escolarizada
Por Graciela Magallanes 83
Cuerpos Recuperados / Cuerpos en Custodia. Una lectura sintomal de la
acciĂłn colectiva de la Cooperativa JunĂn de Salud Limitada
Por Pedro Lisdero 101
Enfermedad, cuerpo, discursos: tres relatos sobre la experiencia
Por Alicia Vaggione 119
Las emociones de lo abyecto: repugnancia e indignaciĂłn
Por Carlos Euardo Figari 131
A modo de EpĂlogo
¿Por qué una mirada sociológica de los cuerpos y las emociones?
Por AdriĂĄn Scribano 141
Los Autores 15
Unlipidated Outer Membrane Protein Omp16 (U-Omp16) from Brucella spp. as Nasal Adjuvant Induces a Th1 Immune Response and Modulates the Th2 Allergic Response to Cowâs Milk Proteins
The discovery of novel mucosal adjuvants will help to develop new formulations to control infectious and allergic diseases. In this work we demonstrate that U-Omp16 from Brucella spp. delivered by the nasal route (i.n.) induced an inflammatory immune response in bronchoalveolar lavage (BAL) and lung tissues. Nasal co-administration of U-Omp16 with the model antigen (Ag) ovalbumin (OVA) increased the amount of Ag in lung tissues and induced OVA-specific systemic IgG and T helper (Th) 1 immune responses. The usefulness of U-Omp16 was also assessed in a mouse model of food allergy. U-Omp16 i.n. administration during sensitization ameliorated the hypersensitivity responses of sensitized mice upon oral exposure to Cowâs Milk Protein (CMP), decreased clinical signs, reduced anti-CMP IgE serum antibodies and modulated the Th2 response in favor of Th1 immunity. Thus, U-Omp16 could b