Study of the doubly charmed tetraquark T+cc

Quantum chromodynamics, the theory of the strong force, describes interactions of coloured quarks and gluons and the formation of hadronic matter. Conventional hadronic matter consists of baryons and mesons made of three quarks and quark-antiquark pairs, respectively. Particles with an alternative quark content are known as exotic states. Here a study is reported of an exotic narrow state in the D0D0π+ mass spectrum just below the D*+D0 mass threshold produced in proton-proton collisions collected with the LHCb detector at the Large Hadron Collider. The state is consistent with the ground isoscalar T+cc tetraquark with a quark content of ccu⎯⎯⎯d⎯⎯⎯ and spin-parity quantum numbers JP = 1+. Study of the DD mass spectra disfavours interpretation of the resonance as the isovector state. The decay structure via intermediate off-shell D*+ mesons is consistent with the observed D0π+ mass distribution. To analyse the mass of the resonance and its coupling to the D*D system, a dedicated model is developed under the assumption of an isoscalar axial-vector T+cc state decaying to the D*D channel. Using this model, resonance parameters including the pole position, scattering length, effective range and compositeness are determined to reveal important information about the nature of the T+cc state. In addition, an unexpected dependence of the production rate on track multiplicity is observed

A comparison of discrete event simulation and system dynamics for modelling health care systems

In this paper we discuss two different approaches to simulation, discrete event simulation and system dynamics. Both have been used widely in the health care domain, although there are fewer applications of system dynamics. The aim of this paper is not to give a comprehensive survey of the literature, but rather to discuss whether the choice of methodology is purely the personal preference of the modeller, or whether there are identifiable features of certain systems that make one methodology superior to the other. We illustrate the use of these techniques by considering two case studies, a simple discrete event simulation model of HIV/AIDS and a system dynamics model of the UK cardiac surgery system. We attempt to draw up some guidelines to assist the modeller in making the choice of technique

Exploration into the behaviour of cardiac waiting lists

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Urinary tract effects of HPSE2 mutations

PubMedID: 25145936Urofacial syndrome (UFS) is an autosomal recessive congenital disease featuring grimacing and incomplete bladder emptying. Mutations of HPSE2, encoding heparanase 2, a heparanase 1 inhibitor, occur in UFS, but knowledge about the HPSE2 mutation spectrum is limited. Here, seven UFS kindreds with HPSE2 mutations are presented, including one with deleted asparagine 254, suggesting a role for this amino acid, which is conserved in vertebrate orthologs. HPSE2 mutations were absent in 23 non-neurogenic neurogenic bladder probands and, of 439 families with nonsyndromic vesicoureteric reflux, only one carried a putative pathogenic HPSE2 variant. Homozygous Hpse2 mutant mouse bladders contained urine more often than did wild-type organs, phenocopying human UFS. Pelvic ganglia neural cell bodies contained heparanase 1, heparanase 2, and leucine-rich repeats and immunoglobulin-like domains-2 (LRIG2), which is mutated in certain UFS families. In conclusion, heparanase 2 is an autonomic neural protein implicated in bladder emptying, but HPSE2 variants are uncommon in urinary diseases resembling UFS. Copyright © 2015 by the American Society of Nephrology.Kidney Research UK Wellcome Trust: 066647 Medical Research Council: G0600040 Medical Research Council: MR/L002744/

Archaeological cereals as an isotope record of long-term soil health and anthropogenic amendment in southern Scandinavia

Maintaining soil health is integral to agricultural production, and the archaeological record contains multiple lines of palaeoclimatic and palaeoenvironmental proxy evidence that can contribute to the understanding and analysis of long-term trajectories of change that are key for contextualizing 21st century global environmental challenges. Soil is a capital resource and its nutrient balance is modified by agricultural activities, making it necessary to ensure soil productivity is maintained and managed through human choices and actions. Since prehistory this has always been the case; soil is a non-renewable resource within a human lifetime. Here, we present and interpret carbon and nitrogen isotope analysis of charred cereals from southern Scandinavia. Anthropogenic effects on soils are evident from the initiation of farming 6000 years ago, as is amendment to counteract its effects. The earliest cereals were planted on pristine soils, and by the late Neolithic, agriculture extensified. By the Iron Age it was necessary to significantly amend depleted soils to maintain crop yields. We propose that these data provide a record of soil water retention, net precipitation and amendment. From the start of the Neolithic there is a concurrent decrease in both Δ13C and δ15N, mitigated only by the replacement of soil organic content in the form of manure in the Iron Age. The cereal isotopes provide a record of trajectories of agricultural sustainability and anthropogenic adaptation for nearly the entire history of farming in the region

Development of an End-to-End Demonstration Readout Chain for Athena/X-IFU

International audienceThe X-ray Integral Field Unit (X-IFU) of the Athena observatory, scheduled for launch in the mid 2030's, will provide X-ray spectroscopy data with unprecedented spectral and spatial resolution. This will be achieved with a 2 kilo-pixel array of transition-edge sensor (TES) microcalorimeters. The complete detection chain is under development by a large international collaboration. In order to perform an end-to-end demonstration of the X-IFU readout chain, a 50 mK test bench is being developed at IRAP in collaboration with CNES. The test bench uses a two-stage ADR cryostat from Entropy GmbH, a 1024-pixel array, and will initially be operated using a warm electronics chain from NIST and NASA Goddard Space Flight Center. We describe the complete system being installed in the cryostat and the current results obtained with these electronics. We also review the status of the integration of the digital readout electronics (DRE) prototype into the demonstration chain and the plan for integrating and testing the complete X-IFU readout chain