Creación empresa periodística digital especializada: Salud Directo.

Este Trabajo de Fin de Grado, que se presenta para la obtención del título en Periodismo por la Universidad de Málaga, enmarcado en la línea ‘Nuevos modelos de negocio y financiación en empresas periodísticas’, propone un proyecto empresarial de una revista digital especializada en el sector sanitario. Para ello, se utilizan técnicas de investigación cualitativa y cuantitativa. Se aplica la entrevista en profundidad a distintos periodistas especializados en sanidad y portavoces de organizaciones públicas. Igualmente se presentan las respuestas de una encuesta online de 18 preguntas para médicos y el análisis de la competencia. Tras el análisis se puede observar que la creación de una revista digital especializada en salud es viable

Diseño curricular para la enseñanza del español como L2 en contextos escolares

En la cub.:

Uso de levaduras seleccionadas osmotolerantes, libres y coinmovilizadas, para la producción de vinos dulces

Algunos vinos dulces se obtienen por fermentación parcial de mostos con elevada concentración de azúcar. Esta elevada concentración de azúcar es causa de numerosos problemas como a) difícil arranque de la fermentación, b) paradas prematuras antes del momento deseado y c) elevado riesgo de contaminación microbiana. En Andalucía, la mayoría de los vinos dulces se elaboran añadiendo alcohol vínico al mosto evitándose, de este modo, la fermentación alcohólica. Estos vinos poseen aromas asociados al proceso de pasificación pero carecen de aromas propios de la fermentación alcohólica. El presente estudio nace de la necesidad de solventar estos problemas. Como solución se plantea la utilización de levaduras osmotolerantes que minimicen los problemas de fermentación y la aplicación de un nuevo sistema de inmovilización celular efectivo con las citadas levaduras. Esta técnica de inmovilización consiste en inducir una co-inmovilización espontánea entre un hongo filamentoso GRAS, Penicillium chrysogenum H3 y una cepa de levadura Saccharomyces cerevisiae, en ausencia de compuestos químicos de unión y de soportes externos. Bajo condiciones especiales, se favorece una simbiosis dando lugar a unas esferas huecas y lisas que hemos denominado “biocápsulas de levaduras”. Se han aislado y seleccionado cepas de Saccharomyces cerevisiae osmoetanol tolerantes y se han realizado estudios microcópicos, proteómicos y metabolómicos con levaduras libres y coinmovilizadas. Los resultados obtenidos en este trabajo de investigación revelan que los vinos dulces parcialmente fermentados mediante la aplicación de biocápsulas de levadura presentan, en general, una mayor cantidad tanto cualitativa como cuantitativa de compuestos volátiles en relación con los vinos elaborados de forma tradicional, lo que influye positivamente en las características organolépticas. Este sistema podría suponer una mejora tecnológica innovadora en procesos fermentativos frente a la utilización de levaduras en forma libre.Some sweet wines are obtained by partial fermentation from high sugar concentration must. And this can involve many problems in the fermentation as a) difficult beginning of fermentation, b) premature stops before the wished moment and c) high risk of microbial pollution. In Andalusia, the majority of sweet wines are elaborated adding wine alcohol to the must, thus the alcoholic fermentation is avoided. These wines possess aromas associated with off-vine grape drying process but they lack aromas of the alcoholic fermentation. This study has tried to solve these problems. The proposed solution is the utilization of osmotolerant yeasts that minimize the problems of fermentation and the application of a new effective cellular immobilization system with these cited yeasts. This technique of immobilization consists of inducing a spontaneous co-immobilization between a filamentous fungus GRAS, Penicillium chrysogenum H3 and a yeast strain Saccharomyces cerevisiae, in the absence of physico-chemical external supports. Under special conditions, a symbiosis is favored obtaining hollow and smooth spheres that we named “yeast biocapsules”. Osmoethanol tolerant Saccharomyces cerevisiae strains have been isolated and selected. Microscopic, proteomic and metabolomic studies with free and coimmobilized yeasts have been realized. The results obtained in this work of investigation reveal that the sweet wines partially fermented by means of the application of yeast biocapsules present generally a major quantity of volatile compounds in relation to the elaborated wines of traditional form, which influences positively on the organoleptic characteristics. This system might suppose a technological innovative improvement in fermentative processes opposite to the utilization of free yeasts

Experimental study of MIMO-OFDM transmissions at 94 GHz in indoor environments

Millimeter wave (mm-wave) frequencies have been proposed to achieve high capacity in 5G communications. Although meaningful research on the channel characteristics has been performed in the 28, 38and 60 GHz bands ─in both indoor and short-range scenarios─,only a small number of trials (experiments) have been carried out in other mm-wave bands. The objective of this work is to study the viability and evaluate the performance of the 94 GHz frequency band for MIMO-OFDM transmission in an indoor environment. Starting from a measurement campaign, the performance of MIMO algorithms is studied in terms of throughput for four different antenna configurations.This work was supported in part by the Ministerio de Economía y Competitividad MINECO, Spain under Grant TEC2016-78028-C3-2-P, and in part by the European FEDER funds

Optimización del tratamiento de daptomicina mediante índices farmacocinéticos y farmacodinámicos

La antibioterapia óptima implica la utilización del régimen de dosificación del antimicrobiano adecuado para conseguir los mejores resultados clínicos con los mínimos efectos adversos para el paciente y el mínimo impacto en el desarrollo de resistencias. Con el fin de conseguir estos resultados en los tratamientos con daptomicina en la práctica clínica, se ha desarrollado un modelo farmacocinético/farmacodinámico de daptomicina, cuyo objetivo es seleccionar las pautas de administración más adecuadas para cada paciente de acuerdo con la sensibilidad del microorganismo causal de la infección garantizando la consecución de los parámetros farmacocinético/farmacodinámico objetivo (área bajo la curva/concentración mínima inhibitoria, AUC/CMI). El modelo farmacocinético/farmacodinámico desarrollado, incluyendo 46 pacientes, es un modelo de dos compartimentos con una distribución periférica de primer orden y una cinética de eliminación que asume una cinética de unión a proteínas no lineal. Se realizaron simulaciones con una combinación fija de aclaramiento de creatinina (30-90 ml/min/1,73 m2) y peso corporal (50-100 kg) para conocer la consecución del objetivo del parámetro farmacocinético/farmacodinámico relacionado con la efectividad bactericida del antibiótico, dado por AUC en 24 horas y CMI: AUC libre/CMI>107,5. Se tuvo en cuenta la seguridad del tratamiento, asegurando que las concentraciones séricas mínimas fueran inferiores a 24,3 mg/L para reducir probabilidad de elevación de niveles de creatinfosfo quinasas (CPK). Los resultados indican que el efecto bactericida para cepas Gram positivas con CMI ≤ 0,5 mg/L podía conseguirse con 5-12 mg/kg diarios de daptomicina en función del peso corporal y la función renal. La administración de 10-17 mg/kg cada 48 horas de daptomicina permitía alcanzar el efecto bactericida para cepas Gram positivo con CMI ≤ 1 mg/L. Esta propuesta de dosificación podría asegurar la eficacia y seguridad del tratamiento con daptomicina de acuerdo a las características individuales de los pacientes.Optimal antibiotherapy involves the use of the appropriate antimicrobial dosing regimen to achieve the best clinical outcomes with minimal adverse effects for the patient and minimal impact on the development of resistance. In order to achieve these results in daptomycin treatment in clinical practice, a pharmacokinetic/pharmacodynamic model of daptomycin has been developed to select the most appropriate dosing regimen for each patient according to the sensitivity of the microorganism causing the infection and to ensure that the target pharmacokinetic/pharmacodynamic parameters (area under the curve/minimum inhibitory concentration, AUC/MIC) are achieved. The pharmacokinetic/pharmacodynamic model developed, including 46 patients, is a two-compartment model with a first-order peripheral distribution and elimination kinetics assuming nonlinear protein binding kinetics. Simulations were performed with a fixed combination of creatinine clearance (30-90 ml/min/1.73 m2) and body weight (50-100 kg) to ascertain the achievement of the target pharmacokinetic/pharmacodynamic parameter related to the bactericidal effectiveness of the antibiotic, given by 24-hour AUC and MIC: free AUC/MIC>107.5. The safety of the treatment was taken into account, ensuring that the minimum serum concentrations were lower than 24.3 mg/L to reduce the probability of elevation of creatine phosphokinase kinase (CPK) levels. The results indicate that the bactericidal effect for Gram-positive strains with MIC ≤ 0.5 mg/L could be achieved with 5-12 mg/kg daily of daptomycin depending on body weight and renal function. Administration of 10-17 mg/kg every 48 hours of daptomycin allowed achieving the bactericidal effect for Gram-positive strains with MIC ≤ 1 mg/L. This dosing approach could ensure the efficacy and safety of daptomycin treatment according to individual patient characteristics

Functional analysis of stress protein data in a flor yeast subjected to a biofilm forming condition

AbstractIn this data article, an OFFGEL fractionator coupled to LTQ Orbitrap XL MS equipment and a SGD filtering were used to detect in a biofilm-forming flor yeast strain, the maximum possible number of stress proteins under the first stage of a biofilm formation conditions (BFC) and under an initial stage of fermentation used as reference, so-called non-biofilm formation condition (NBFC). Protein functional analysis – based on cellular components and biological process GO terms – was performed for these proteins through the SGD Gene Ontology Slim Mapper tool. A detailed analysis and interpretation of the data can be found in “Stress responsive proteins of a flor yeast strain during the early stages of biofilm formation” [1]

Feasibility of Social-Network-Based eHealth Intervention on the Improvement of Healthy Habits among Children

12 p.This study shows the feasibility of an eHealth solution for tackling eating habits and physical activity in the adolescent population. The participants were children from 11 to 15 years old. An intervention was carried out on 139 students in the intervention group and 91 students in the control group, in two schools during 14 weeks. The intervention group had access to the web through a user account and a password. They were able to create friendship relationships, post comments, give likes and interact with other users, as well as receive notifications and information about nutrition and physical activity on a daily basis and get (virtual) rewards for improving their habits. The control group did not have access to any of these features. The homogeneity of the samples in terms of gender, age, body mass index and initial health-related habits was demonstrated. Pre- and post-measurements were collected through self-reports on the application website. After applying multivariate analysis of variance, a significant alteration in the age-adjusted body mass index percentile was observed in the intervention group versus the control group, as well as in the PAQ-A score and the KIDMED score. It can be concluded that eHealth interventions can help to obtain healthy habits. More research is needed to examine the effectiveness in achieving adherence to these new habits.S

Virtual restitution of the parietal decoration in the Sala del Mosaico de los Amores, Cástulo Archaelogical site (Linares, Spain)

The use of photogrammetry in the field of archaeology is increasingly widespread. In the case of restoration, the use of 3D contributes to facilitating the complex process of an intervention and bringing the artwork closer to the general public. This paper describes the application of 3D modelling techniques in the specific case of the Roman wall paintings from the Sala del Mosaico de los Amores, in Castulo Archaeological Site (Linares, province of Jaén). These paintings were found in 2011, collapsed over the mosaic pavement, and they were moved to the University of Granada for their restoration. After the intervention, the photogrammetric surveys of the different fragments and of the room to which they belong were developed, and the virtual restitution was generated, therefore making it possible for the general public to reliably appreciate how the room would look like with the parietal decoration located in-situ.Ministry of Economy and CompetitivenessEuropean Regional Development Fund (MINECO/FEDER, UE) HAR2015-66139-PResearch project "Chromatic treatments in architecture of Islamic tradition. Techniques and Conservation" by the Andalusian Regional Government, Department of Economy, Innovation, Science and Employment P12 HUM 1941German Research Foundation (DFG

Study of biomolecules adsorption on carbon nanotubes for their application as biosensors

Carbon Nanotubes (CNTs) are a new material with electric, mechanical and electrochemical properties that make them interesting for different applications. Due to their high superficial area, the CNTs are very sensitive to molecules adsorbing on them. This property makes them a very good candidate for integrating into biosensors. In this context, the control of the non specific adsorption of molecules different from the one wanting to detect, is a parameter to be known and controlled. Along this Master Final Project, the adsorption of streptavidin, a biomolecule widely used in biomedical research, on the surface of Single Walled NanoTubes (SWNTs) have been studied. The highly specific biotin-streptavidin system have been used for specifically binding the streptavidin to the surface of the nanotube and to control the degree of specific / non specific adsorption. SWNTs with different functional groups at the surface have been considered. The horseradish peroxidase (HRP)-catalyzed oxidation of 3,3’-5,5’-tetramethylbenzidine (TMB) have been used as colorimetric test to determine the presence of streptavidin onto the SWNTs. The non specific adsorption of the protein has been intended to be prevented. Among the great variety of surfactants and molecules used to prevent the adsorption, polyethylene glycol (PEG), Tween20® and Pluronic® F-127 have been used. No complete blockage have been achieved. Once the adsorption of that protein over the surface of SWNTs has been known, it has been used to detect DNA hybridization, binding on strand to the nanotube in a specific way. The detection of the hybridization have been carried out optically by a fluorescent probe on the complementary strand