565 research outputs found
FORGE enabling FIRE facilities for the eLearning community
International audienceMany engineering students at third-level institutions across the world will not have the advantage of using real-world experimentation equipment, as the infrastructure and resources required for this activity are too expensive. This paper explains how the FORGE (Forging Online Education through FIRE) FP7 project transforms Future Internet Research and Experimentation (FIRE) testbed facilities into educational resources for the eLearning community. This is achieved by providing a framework for remote experimentation that supports easy access and control to testbed infrastructure for students and educators. Moreover, we identify a list of recommendations to support development of eLearning courses that access these facilities and highlight some of the challenges encountered by FORGE
On the canonical map of surfaces with q>=6
We carry out an analysis of the canonical system of a minimal complex surface
of general type with irregularity q>0. Using this analysis we are able to
sharpen in the case q>0 the well known Castelnuovo inequality K^2>=3p_g+q-7.
Then we turn to the study of surfaces with p_g=2q-3 and no fibration onto a
curve of genus >1. We prove that for q>=6 the canonical map is birational.
Combining this result with the analysis of the canonical system, we also prove
the inequality: K^2>=7\chi+2. This improves an earlier result of the first and
second author [M.Mendes Lopes and R.Pardini, On surfaces with p_g=2q-3, Adv. in
Geom. 10 (3) (2010), 549-555].Comment: Dedicated to Fabrizio Catanese on the occasion of his 60th birthday.
To appear in the special issue of Science of China Ser.A: Mathematics
dedicated to him. V2:some typos have been correcte
Stability conditions and positivity of invariants of fibrations
We study three methods that prove the positivity of a natural numerical
invariant associated to parameter families of polarized varieties. All
these methods involve different stability conditions. In dimension 2 we prove
that there is a natural connection between them, related to a yet another
stability condition, the linear stability. Finally we make some speculations
and prove new results in higher dimension.Comment: Final version, to appear in the Springer volume dedicated to Klaus
Hulek on the occasion of his 60-th birthda
Heme modulates smooth muscle cell proliferation and migration via NADPH oxidase: A counter-regulatory role for heme oxygenase system
AbstractAccumulation of vascular smooth muscle cells (VSMC) in response to inflammatory stimuli is a key event in atherogenesis, which commonly occurs in sinuous vessels with turbulent blood flow what leads to hemolysis and consequent free heme accumulation, a known pro-oxidant and pro-inflammatory molecule.In this work, we investigated the effects of free heme on VSMC, and the molecular mechanisms underlying this process.Free heme induces a concentration-dependent migration and proliferation of VSMC which depends on the production of reactive oxygen species (ROS) derived from NADPH oxidase (NADPHox) activity. Additionally, heme activates redox-sensitive proliferation-related signaling routes, such as Mitogen Activated Protein Kinase (MAPK) and NF-κB, and induces Heme Oxygenase-1 (HO-1) expression. NADPHox-dependent proliferative effect of heme seems to be endogenously modulated by HO since the pretreatment of VSMC with HO inhibitors potentiates heme-induced proliferation and, in parallel, increases ROS production. These effects were no longer observed in the presence of heme metabolites, carbon monoxide and biliverdin.The data indicate that VSMC proliferation induced by heme is endogenously modulated by a critical counter-regulatory crosstalk between NADPHox and HO systems
Identifying substitutional oxygen as a prolific point defect in monolayer transition metal dichalcogenides with experiment and theory
Chalcogen vacancies are considered to be the most abundant point defects in
two-dimensional (2D) transition-metal dichalcogenide (TMD) semiconductors, and
predicted to result in deep in-gap states (IGS). As a result, important
features in the optical response of 2D-TMDs have typically been attributed to
chalcogen vacancies, with indirect support from Transmission Electron
Microscopy (TEM) and Scanning Tunneling Microscopy (STM) images. However, TEM
imaging measurements do not provide direct access to the electronic structure
of individual defects; and while Scanning Tunneling Spectroscopy (STS) is a
direct probe of local electronic structure, the interpretation of the chemical
nature of atomically-resolved STM images of point defects in 2D-TMDs can be
ambiguous. As a result, the assignment of point defects as vacancies or
substitutional atoms of different kinds in 2D-TMDs, and their influence on
their electronic properties, has been inconsistent and lacks consensus. Here,
we combine low-temperature non-contact atomic force microscopy (nc-AFM), STS,
and state-of-the-art ab initio density functional theory (DFT) and GW
calculations to determine both the structure and electronic properties of the
most abundant individual chalcogen-site defects common to 2D-TMDs.
Surprisingly, we observe no IGS for any of the chalcogen defects probed. Our
results and analysis strongly suggest that the common chalcogen defects in our
2D-TMDs, prepared and measured in standard environments, are substitutional
oxygen rather than vacancies
Measuring vertebrate telomeres: applications and limitations
Telomeres are short tandem repeated sequences of DNA found at the ends of eukaryotic
chromosomes that function in stabilizing chromosomal end integrity.
In vivo
studies of
somatic tissue of mammals and birds have shown a correlation between telomere length and
organismal age within species, and correlations between telomere shortening rate and
lifespan among species. This result presents the tantalizing possibility that telomere length
could be used to provide much needed information on age, ageing and survival in natural
populations where longitudinal studies are lacking. Here we review methods available for
measuring telomere length and discuss the potential uses and limitations of telomeres as
age and ageing estimators in the fields of vertebrate ecology, evolution and conservation
Fructose consumption reduces hippocampal synaptic plasticity underlying cognitive performance
AbstractMetabolic syndrome (MetS) is a global epidemic, which involves a spectrum of metabolic disorders comprising diabetes and obesity. The impact of MetS on the brain is becoming to be a concern, however, the poor understanding of mechanisms involved has limited the development of therapeutic strategies. We induced a MetS-like condition by exposing mice to fructose feeding for 7weeks. There was a dramatic deterioration in the capacity of the hippocampus to sustain synaptic plasticity in the forms of long-term potentiation (LTP) and long-term depression (LTD). Mice exposed to fructose showed a reduction in the number of contact zones and the size of postsynaptic densities (PSDs) in the hippocampus, as well as a decrease in hippocampal neurogenesis. There was an increase in lipid peroxidation likely associated with a deficiency in plasma membrane excitability. Consistent with an overall hippocampal dysfunction, there was a subsequent decrease in hippocampal dependent learning and memory performance, i.e., spatial learning and episodic memory. Most of the pathological sequel of MetS in the brain was reversed three month after discontinue fructose feeding. These results are novel to show that MetS triggers a cascade of molecular events, which disrupt hippocampal functional plasticity, and specific aspects of learning and memory function. The overall information raises concerns about the risk imposed by excessive fructose consumption on the pathology of neurological disorders
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