High-Flow Vascular Malformations in Children.

Children can have a variety of intracranial vascular anomalies ranging from small and incidental with no clinical consequences to complex lesions that can cause substantial neurologic deficits, heart failure, or profoundly affect development. In contrast to high-flow lesions with direct arterial-to-venous shunts, low-flow lesions such as cavernous malformations are associated with a lower likelihood of substantial hemorrhage, and a more benign course. Management of vascular anomalies in children has to incorporate an understanding of how treatment strategies may affect the normal development of the central nervous system. In this review, we discuss the etiologies, epidemiology, natural history, and genetic risk factors of three high-flow vascular malformations seen in children: brain arteriovenous malformations, intracranial dural arteriovenous fistulas, and vein of Galen malformations

Reorientation in Antiferromagnetic Multilayers: Spin-Flop Transition and Surface Effects

Nanoscale superlattices with uniaxial ferromagnetic layers antiferromagnetically coupled through non-magnetic spacers are recently used as components of magnetoresistive and recording devices. In the last years intensive experimental investigations of these artificial antiferromagnets have revealed a large variety of surface induced reorientational effects and other remarkable phenomena unknown in other magnetic materials. In this paper we review and generalize theoretical results, which enable a consistent description of the complex magnetization processes in antiferromagnetic multilayers, and we explain the responsible physical mechanism. The general structure of phase diagrams for magnetic states in these systems is discussed. In particular, our results resolve the long standing problem of a ``surface spin-flop'' in antiferromagnetic layers. This explains the different appearance of field-driven reorientation transitions in systems like Fe/Cr (001) and (211) superlattices, and in [CoPt]/Ru multilayers with strong perpendicular anisotropy.Comment: Companion paper for talk at Second Seeheim Conference on Magnetism, June 27- July 1, 2004; 8 pages included 7 figure

Bringing high-grade arteriovenous malformations under control: clinical outcomes following multimodality treatment in children.

OBJECTIVE:Brain arteriovenous malformations (AVMs) consist of dysplastic blood vessels with direct arteriovenous shunts that can hemorrhage spontaneously. In children, a higher lifetime hemorrhage risk must be balanced with treatment-related morbidity. The authors describe a collaborative, multimodal strategy resulting in effective and safe treatment of pediatric AVMs. METHODS:A retrospective analysis of a prospectively maintained database was performed in children with treated and nontreated pediatric AVMs at the University of California, San Francisco, from 1998 to 2017. Inclusion criteria were age ≤ 18 years at time of diagnosis and an AVM confirmed by a catheter angiogram. RESULTS:The authors evaluated 189 pediatric patients with AVMs over the study period, including 119 ruptured (63%) and 70 unruptured (37%) AVMs. The mean age at diagnosis was 11.6 ± 4.3 years. With respect to Spetzler-Martin (SM) grade, there were 38 (20.1%) grade I, 40 (21.2%) grade II, 62 (32.8%) grade III, 40 (21.2%) grade IV, and 9 (4.8%) grade V lesions. Six patients were managed conservatively, and 183 patients underwent treatment, including 120 resections, 82 stereotactic radiosurgery (SRS), and 37 endovascular embolizations. Forty-four of 49 (89.8%) high-grade AVMs (SM grade IV or V) were treated. Multiple treatment modalities were used in 29.5% of low-grade and 27.3% of high-grade AVMs. Complete angiographic obliteration was obtained in 73.4% of low-grade lesions (SM grade I-III) and in 45.2% of high-grade lesions. A periprocedural stroke occurred in a single patient (0.5%), and there was 1 treatment-related death. The mean clinical follow-up for the cohort was 4.1 ± 4.6 years, and 96.6% and 84.3% of patients neurologically improved or remained unchanged in the ruptured and unruptured AVM groups following treatment, respectively. There were 16 bleeding events following initiation of AVM treatment (annual rate: 0.02 events per person-year). CONCLUSIONS:Coordinated multidisciplinary evaluation and individualized planning can result in safe and effective treatment of children with AVMs. In particular, it is possible to treat the majority of high-grade AVMs with an acceptable safety profile. Judicious use of multimodality therapy should be limited to appropriately selected patients after thorough team-based discussions to avoid additive morbidity. Future multicenter studies are required to better design predictive models to aid with patient selection for multimodal pediatric care, especially with high-grade AVMs

Linear-Time Algorithms for Computing Maximum-Density Sequence Segments with Bioinformatics Applications

We study an abstract optimization problem arising from biomolecular sequence analysis. For a sequence A of pairs (a_i,w_i) for i = 1,..,n and w_i>0, a segment A(i,j) is a consecutive subsequence of A starting with index i and ending with index j. The width of A(i,j) is w(i,j) = sum_{i <= k <= j} w_k, and the density is (sum_{i<= k <= j} a_k)/ w(i,j). The maximum-density segment problem takes A and two values L and U as input and asks for a segment of A with the largest possible density among those of width at least L and at most U. When U is unbounded, we provide a relatively simple, O(n)-time algorithm, improving upon the O(n \log L)-time algorithm by Lin, Jiang and Chao. When both L and U are specified, there are no previous nontrivial results. We solve the problem in O(n) time if w_i=1 for all i, and more generally in O(n+n\log(U-L+1)) time when w_i>=1 for all i.Comment: 23 pages, 13 figures. A significant portion of these results appeared under the title, "Fast Algorithms for Finding Maximum-Density Segments of a Sequence with Applications to Bioinformatics," in Proceedings of the Second Workshop on Algorithms in Bioinformatics (WABI), volume 2452 of Lecture Notes in Computer Science (Springer-Verlag, Berlin), R. Guigo and D. Gusfield editors, 2002, pp. 157--17

A photoionization model of the compact HII region G29.96-0.02

We present a detailed photoionization model of G29.96-0.02 (hereafter G29.96), one of the brightest Galactic Ultra Compact HII (UCHII) regions in the Galaxy. This source has been observed extensively at radio and infrared wavelengths. The most recent data include a complete ISO (SWS and LWS) spectrum, which displays a remarkable richness in atomic fine-structure lines. The number of observables is twice as much as the number available in previous studies. In addition, most atomic species are now observed in two ionization stages. The radio and infrared data on G29.96 are best reproduced using a nebular model with two density components: a diffuse (n_e~680cm-3) extended (~1 pc) component surrounding a compact (~0.1 pc) dense (n_e~57000cm-3) core. The properties of the ionizing star were derived using state-of-the-art stellar atmosphere models. CoStar models yield an effective temperature of \~30^{+2}_{-1} kK whereas more recent non-LTE line blanketed atmospheres with stellar winds indicate somewhat higher values, Teff~32--38 kK. This range in Teff is compatible with all observational constraints, including near-infrared photometry and bolometric luminosity. The range 33-36 kK is also compatible with the spectral type O5-O8 determined by Watson and Hanson (97) when recent downward revisions of the effective temperature scale of O stars are taken into account. The age of the ionizing star of G29.96 is found to be a few 10^6 yr, much older than the expected lifetime of UCHII regions. Accurate gas phase abundances are derived with the most robust results being Ne/S=7.5 and N/O=0.43 (1.3 and 3.5 times the solar values, respectively).Comment: Accepted in Astronomy and Astrophysic

The effects of loyalty programs on customer satisfaction, trust, and loyalty toward high- and low-end fashion retailers

This study examines the differential effects of the benefits customers receive from a loyalty program (LP) on satisfaction with the LP, trust in the LP, and store loyalty for high- and low-end fashion retailers. With survey data from U.S. LP subscribers, the study tests the relationships using multiple regressions and analysis of covariance. The results show that symbolic benefits are more important for high-end fashion store consumers' satisfaction with the LP; conversely, utilitarian benefits increase consumers' satisfaction with the LP more in low-end fashion retailing, whereas hedonic benefits increase consumers' satisfaction with the LP in both types of retailers. All benefits in both types of retailers affect trust in the LP. Finally, satisfaction with and trust in the LP are important drivers of loyalty to the retailer. The findings have important implications on how managers of high- and low-end fashion retailing can effectively design their LP rewards to maximize loyalty