10 research outputs found
Induction of a transmissible tau pathology by traumatic brain injury.
Traumatic brain injury is a risk factor for subsequent neurodegenerative disease, including chronic traumatic encephalopathy, a tauopathy mostly associated with repetitive concussion and blast, but not well recognized as a consequence of severe traumatic brain injury. Here we show that a single severe brain trauma is associated with the emergence of widespread hyperphosphorylated tau pathology in a proportion of humans surviving late after injury. In parallel experimental studies, in a model of severe traumatic brain injury in wild-type mice, we found progressive and widespread tau pathology, replicating the findings in humans. Brain homogenates from these mice, when inoculated into the hippocampus and overlying cerebral cortex of naĂŻve mice, induced widespread tau pathology, synaptic loss, and persistent memory deficits. These data provide evidence that experimental brain trauma induces a self-propagating tau pathology, which can be transmitted between mice, and call for future studies aimed at investigating the potential transmissibility of trauma associated tau pathology in humans
Recommended from our members
Monitoring bee health in European agroecosystems using wing morphology and fat bodies
Current global change substantially threatens pollinators, which directly impacts the
pollination services underpinning the stability, structure and functioning of ecosystems.
Amongst these threats, many synergistic drivers, such as habitat destruction and
fragmentation, increasing use of agrochemicals, decreasing resource diversity, as well as
climate change, are known to affect wild and managed bees. Therefore, reliable indicators
for pollinator sensitivity to such threats are needed. Biological traits, such as phenotype
(e.g. shape, size and asymmetry) and storage reserves (e.g. fat body size), are important
pollinator traits linked to reproductive success, immunity, resilience and foraging efficiency
and, therefore, could serve as valuable markers of bee health and pollination service
potential.
This data paper contains an extensive dataset of wing morphology and fat body content for
the European honeybee (Apis mellifera) and the buff-tailed bumblebee (Bombus terrestris)
sampled at 128 sites across eight European countries in landscape gradients dominated
by two major bee-pollinated crops (apple and oilseed rape), before and after focal crop
bloom and potential pesticide exposure. The dataset also includes environmental metrics
of each sampling site, namely landscape structure and pesticide use. The data offer the
opportunity to test whether variation in the phenotype and fat bodies of bees is structured
by environmental factors and drivers of global change. Overall, the dataset provides
valuable information to identify which environmental threats predominantly contribute to the
modification of these traits
Recommended from our members
Induction of a transmissible tau pathology by traumatic brain injury.
Traumatic brain injury is a risk factor for subsequent neurodegenerative disease, including chronic traumatic encephalopathy, a tauopathy mostly associated with repetitive concussion and blast, but not well recognized as a consequence of severe traumatic brain injury. Here we show that a single severe brain trauma is associated with the emergence of widespread hyperphosphorylated tau pathology in a proportion of humans surviving late after injury. In parallel experimental studies, in a model of severe traumatic brain injury in wild-type mice, we found progressive and widespread tau pathology, replicating the findings in humans. Brain homogenates from these mice, when inoculated into the hippocampus and overlying cerebral cortex of naĂŻve mice, induced widespread tau pathology, synaptic loss, and persistent memory deficits. These data provide evidence that experimental brain trauma induces a self-propagating tau pathology, which can be transmitted between mice, and call for future studies aimed at investigating the potential transmissibility of trauma associated tau pathology in humans
Pollination and the city: a collaborative study to measure pollination function in a range of European cities
International audienc
Pollination and the city: a collaborative study to measure pollination function in a range of European cities
International audienc
A large-scale dataset reveals taxonomic and functional specificities of wild bee communities in urban habitats of Western Europe
International audienceWild bees are declining, mainly due to the expansion of urban habitats that have led to land-use changes. Effects of urbanization on wild bee communities are still unclear, as shown by contrasting reports on their species and functional diversities in urban habitats. To address this current controversy, we built a large dataset, merging 16 surveys carried out in 3 countries of Western Europe during the past decades, and tested whether urbanization influences local wild bee taxonomic and functional community composition. These surveys encompassed a range of urbanization levels, that were quantified using two complementary metrics: the proportion of impervious surfaces and the human population density. Urban expansion, when measured as a proportion of impervious surfaces, but not as human population density, was significantly and negatively correlated with wild bee community species richness. Taxonomic dissimilarity of the bee community was independent of both urbanization metrics. However, occurrence rates of functional traits revealed significant differences between lightly and highly urbanized communities, for both urbanization metrics. With higher human population density, probabilities of occurrence of above-ground nesters, generalist and small species increased. With higher soil sealing, probabilities of occurrence of above-ground nesters, generalists and social bees increased as well. Overall, these results, based on a large European dataset, suggest that urbanization can have negative impacts on wild bee diversity. They further identify some traits favored in urban environments, showing that several wild bee species can thrive in cities
Pollination and the city: a collaborative study to measure pollination function in a range of European cities
International audienc
Pollination and the city: a collaborative study to measure pollination function in a range of European cities
International audienc
A large-scale dataset reveals taxonomic and functional specificities of wild bee communities in urban habitats of Western Europe
Wild bees are declining, mainly due to the expansion of urban habitats that have led to land-use changes. Effects of urbanization on wild bee communities are still unclear, as shown by contrasting reports on their species and functional diversities in urban habitats. To address this current controversy, we built a large dataset, merging 16 surveys carried out in 3 countries of Western Europe during the past decades, and tested whether urbanization influences local wild bee taxonomic and functional community composition. These surveys encompassed a range of urbanization levels, that were quantified using two complementary metrics: the proportion of impervious surfaces and the human population density. Urban expansion, when measured as a proportion of impervious surfaces, but not as human population density, was significantly and negatively correlated with wild bee community species richness. Taxonomic dissimilarity of the bee community was independent of both urbanization metrics. However, occurrence rates of functional traits revealed significant differences between lightly and highly urbanized communities, for both urbanization metrics. With higher human population density, probabilities of occurrence of above-ground nesters, generalist and small species increased. With higher soil sealing, probabilities of occurrence of above-ground nesters, generalists and social bees increased as well. Overall, these results, based on a large European dataset, suggest that urbanization can have negative impacts on wild bee diversity. They further identify some traits favored in urban environments, showing that several wild bee species can thrive in cities