Procedimiento de instalación, en un suelo o depósito de residuos, con elementos o compuestos contaminantes, de una barrera física multicapa para interrumpir flujos hídricos verticales

Número de publicación: 2 552 672 Número de solicitud: 201531013Procedimiento de instalación, en un suelo (1) o depósito de residuos, con elementos o compuestos contaminantes, de una barrera física multicapa para interrumpir flujos hídricos verticales, que supone una optimización de eficiencia y coste. Comprende disponer primera (4), segunda (6), tercera (8), cuarta (10) y quinta (12) capas de áridos (4, 6, 8, 10, 12) consecutivas, de granulometrías alternadas respectivamente, de abajo a arriba, de tipo grava, arenas, grava, arenas y grava, así como intercalar una capa de un material separador (3, 5, 7, 9, 11), inmediatamente antes de cada capa de áridos (4, 6, 8, 10, 12), para evitar mezcla de materiales entre suelo (1) y la primera capa de áridos (4) y entre cada dos capas de áridos (4, 6, 8, 10, 12) consecutivas. Las capas de áridos segunda (6) y cuarta (10) son compactadas para evitar filtración, preferentemente de acuerdo con su valor máximo de compactación Proctor.Universidad Politécnica de Cartagen

Magnetómetro para medida de campos electromagnéticos débiles en la banda ELF

Número de publicación: ES2557702 A1 (27.01.2016) Número de Solicitud: Consulta de Expedientes OEPM (C.E.O.) P201400462 (28.05.2014)La invención comprende un sistema para la medición de campos electromagnéticos débiles, en la banda de frecuencias comprendida entre 1 a 100 Hz, donde se localizan señales derivadas de la resonancia natural que ocurre entre la tierra y la ionosfera, las resonancias de Schumann. El sistema está compuesto por un núcleo de material ferromagnético (1) y un conjunto de bobinas separadas entre sí (2), conectadas mediante cables unifilares (8). Un cable de par trenzado (3) conecta el sensor a un sistema electrónico de medida (4) compuesto por un amplificador diferencial (5) al que se acoplan cada par trenzado, en una bifurcación coaxial con las mallas comunes (20), (21) mediante conectores coaxiales (22), (23) y con salida a un convertidor analógico digital (6). La geometría, estructura y materiales del sistema, le confieren sus propiedades de sensibilidad y ancho de banda.Universidad de Almerí

Role of the transient receptor potential vanilloid 1 in inflammation and sepsis

The transient receptor potential vanilloid 1 (TRPV1) is a thermoreceptor that responds to noxious temperatures, as well as to chemical agonists, such as vanilloids and protons. In addition, its channel activity is notably potentiated by proinflammatory mediators released upon tissue damage. The TRPV1 contribution to sensory neuron sensitization by proalgesic agents has signaled this receptor as a prime target for analgesic and anti-inflammatory drug intervention. However, TRPV1 antagonists have notably failed in clinical and preclinical studies because of their unwanted side effects. Recent reports have unveiled previously unrecognized anti-inflammatory and protective functions of TRPV1 in several diseases. For instance, this channel has been suggested to play an anti-inflammatory role in sepsis. Therefore, the use of potent TRPV1 antagonists as a general strategy to treat inflammation must be cautiously considered, given the deleterious effects that may arise from inhibiting the population of channels that have a protective function. The use of TRPV1 antagonists may be limited to treating those pathologies where enhanced receptor activity contributes to the inflamed state. Alternatively, therapeutic paradigms, such as reduction of inflammatory-mediated increase of receptor expression in the cell surface, may be a better strategy to prevent abrogation of the TRPV1 subpopulation involved in anti-inflammatory and protective processes

Improving the effect of incubation and oxidative stress on thawed spermatozoa from red deer by using different antioxidant treatments

P. 856-870Antioxidants could improve sperm media, extending the viability of spermatozoa and protecting their DNA. The protective ability of lipoic acid, melatonin, Trolox and crocin was tested on red deer spermatozoa incubated at 37°C. Cryopreserved spermatozoa were thawed and incubated with 1 mM or 0.1 mM of each antioxidant, with or without oxidative stress (100 μM Fe2+). Motility (CASA), viability, mitochondrial membrane potential and acrosomal status were assessed. Lipoperoxidation (malondialdehyde production), intracellular reactive oxygen species (ROS) and DNA status (TUNEL) were checked at 4 h. Incubation alone increased ROS and decreased motility. Oxidative stress intensified these effects, increasing lipoperoxidation and DNA damage. Lipoic acid had little protective effect, whereas 1 mM melatonin showed limited protection. Trolox lowered ROS and lipoperoxidation both in oxidised and non-oxidised samples. In oxidised samples, Trolox prevented DNA and acrosomal damage, and ameliorated motility. Crocin at 1 mM showed similar results to Trolox, but noticeably stimulated motility and had no effect on lipoperoxidation. In a second experiment, a broader range of crocin and melatonin concentrations were tested, confirming the effects of crocin (positive effects noticeable at 0.5–0.75 mM), but showing an increase in lipoperoxidation at 2 mM. Melatonin was increasingly effective at 2.5 and 5 mM (ROS, lipoperoxidation and DNA status). Crocin seems a promising new antioxidant, but its particular effects on sperm physiology must be further studied, especially the consequences of motility stimulation and confirming its effect on lipoperoxidation. Melatonin might be useful at relatively high concentrations, compared to Trolox.S

Inclusión en las aulas de Educación Física. Estudio de casos

In a short time, we have gone from the paradigm of the integration where students with and without disabilities are educated with a differentiated curriculum, the paradigm of inclusion where students share the same curriculum. The objective of this study is to examine as is carried out the inclusion in the area of physical education in the educative center through the methodology of case study, centering on 2 students from the center Juan Comenius with Cerebral Palsy (CP). Have been interviewed (semistructured interview) 7 people who are part of the inclusive process (2 physical education teachers, the director, the head of primary education, parents of students with disabilities and the 2 students with CP). The results show that the address and the teachers are betting on the inclusion of pupils with Special Educational Needs due to disability in the classroom using curricular adaptations, psychopedagogical reports and an awareness of the students. However, there is not an offer of training for teachers to expand their knowledge about the PSEN, Parents do not maintain direct contact with the physical education teachers and unaware of what made their children in these classes. En poco tiempo hemos pasado del paradigma de la integración donde el alumnado con y sin discapacidad estudian con un currículum diferenciado, al paradigma de la inclusión donde los alumnos comparten el mismo currículum. El objetivo del presente estudio es examinar como se lleva a cabo la inclusión en el área de Educación Física en el centro educativoa través de la metodología de estudio de casos centrado en 2 alumnos del centro Juan Comenius con Parálisis Cerebral (PC). El instrumento de investigación ha sido la entrevista semiestructurada. Han sido entrevistadas 7 personas que forman parte del proceso inclusivo; 2 profesores de educación física, la directora, el jefe de estudios de primaria, los padres de los alumnos con discapacidad y los 2 alumnos con PC. Los resultados muestran que la dirección y los docentes apuestan por la inclusión de losAlumnos con Necesidades Educativas Especiales(ACNEE) derivadas de discapacidad en las aulas utilizando adaptaciones curriculares, informes psicopedagógicos y una sensibilización del alumnado. Sin embargo, no existe una oferta de formación para que los docentes amplíen su conocimiento sobre los ACNEE, los padres no mantienen contacto directo con los profesores de Educación Física y desconocen lo que realizan sus hijos/as en estas clases. &nbsp

Regulation of insulin-stimulated glucose uptake in rat white adipose tissue upon chronic central leptin infusion: effects on adiposity

Copyright (2011) The Endocrine Society .The paper can be found at the following URL on the website http://endo.endojournals.org

Aging impairs the hepatic subcellular distribution of ChREBP in response to fasting/feeding in rats: Implications on hepatic steatosis

© 2015 Elsevier Inc. All rights reserved. Aging is associated with alterations of lipid metabolism and increased prevalence of non alcoholic hepatic steatosis.Nevertheless, themechanisms bywhich fat is accumulated in the liver during aging remain incompletely understood. In the present study, we investigated potential alterations that might contribute to the development of hepatic steatosis with aging. To this end, we analyzed the expression and the subcellular localization of key transcriptional factors involved in lipid metabolism such as ChREBP, Foxo1, Foxa2 and SREBP-1c in the liver of 3- and 24-month oldWistar rats. In addition, we studied the intracellular redistribution of ChREBP in response to fasting/refeeding transition. Old rats were characterized by hepatic steatosis, low serum ketone body levels and postprandial hyperinsulinemia. These observations were paralleled by the cytoplasmic localization and decreased expression of Foxa2, while ChREBP expression was markedly up-regulated and mainly localized in the nucleus. Consequently, the expression of lipogenic and β-oxidation genes was up-regulated or downregulated, respectively. Besides, the intracellular redistribution of ChREBP in response to fasting/refeeding transition was also impaired in old animals. Additionally, a negative correlation between serum ketone body levels and the nuclear localization of ChREBP was observed only in adult but not in old rats. Taken together, these data suggest that an age-related dysfunctional adaptation of ChREBP, in response to changes in the nutritional state, might contribute to the development of liver steatosis with aging.Junta de Comunidades de Castilla-La Mancha (JCCM), BFU2012- 39705-C03-01 from Ministerio de Ciencia e Innovación, and S2010/BMC2423 from Comunidad de Madrid, Spain. A.S. was supported by FPU predoctoral fellowship from Ministerio de Educación y Ciencia (MEC), Spain, and B.B. was supported by CONACyT predoctoral fellowship from México. The Centre of Molecular Biology “Severo Ochoa” is the recipient of institutional aid from the Ramón Areces FoundationPeer Reviewe

Cooperative learning of requirements engineering through an international educational scenario enabled by the MOY programme

The International Excellence Campus for Higher Education and Research of the Region of Murcia, and the Mediterranean Office for Youth (MOY) programme are new initiatives that offer opportunities for designing educational activities in which can take part international students enrolled in academic degrees at different universities. Besides, a significant rise in distributed and collaborative software development has been observed in recent years (Global Software Development, GSD), which involves space, time and socio-cultural distances and requires new techniques, tools and practices to meet new challenges and opportunities. In addition, poor requirements are one of the most common causes of project failure in any domain. Projects which devote more resources to Requirements Engineering (RE) result in lower costs and lower deviations of their planning. Therefore, the relevance of education and training the future systems and software professionals in RE activities and techniques, in particular in GSD environments, must be stressed. We have conducted an educational innovation activity based on teaching RE in co-located and GSD contexts. This activity has been carried out in the form of an experiment with students. This paper presents the scenario in which this educational activity is framed as well as some preliminary results of this experiment

Way Combination for an Adaptive and Scalable Coherence Directory

© 2019 IEEE. Personal use of this material is permitted. Permissíon from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertisíng or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.[EN] This manuscript opens the way to a new class of coherence directory structures that are based on the brand-new concept of way combining. A Way-Combining Directory (WC-dir) builds on a typical sparse directory but allows to take advantage of several ways in the same set to codify the sharing information of each memory block. The result is a sparse directory with variable effective associativity per set and variable length entries, thus being able to dynamically adapt the directory structure to the particular requirements of each application. In particular, our proposal uses just enough bits per entry to store a single pointer, which is optimal for the common case of having just one sharer. For those addresses that have more than one sharer, we have observed that in the majority of cases extra bits could be taken from other empty ways in the same set. All in all, our proposal minimizes the storage overheads without losing the flexibility to adapt to several sharing degrees and without the complexities of other previously proposed techniques. Detailed simulations of a 128-core multicore architecture running benchmarks from PARSEC-3.0 and SPLASH-3 demonstrate that WC-dir can closely approach the performance of a non-scalable bit vector sparse directory, beating the state-of-the-art Scalable Coherence Directory (SCD) and Pool directory proposals.This work has been supported by the Spanish MCIU and AEI, as well as European Commission FEDER funds, under grant "RTI2018-098156-B-C53".Titos-Gil, R.; Flores, A.; Fernández-Pascual, R.; Ros, A.; Petit Martí, SV.; Sahuquillo Borrás, J.; Acacio, ME. (2019). Way Combination for an Adaptive and Scalable Coherence Directory. IEEE Transactions on Parallel and Distributed Systems. 30(11):2608-2623. https://doi.org/10.1109/TPDS.2019.2917185S26082623301

Documento de consenso SEA/SEMERGEN 2019. Recomendaciones dietéticas en la prevención cardiovascular

El actual paradigma en las ciencias de la nutrición establece que la unidad nutricional básica no son los nutrientes, sino los alimentos que los contienen (aceites, frutos secos, productos lácteos, huevos, carnes rojas o procesadas, etc.), que actúan como matriz alimentaria en la que los diferentes nutrientes modulan sinérgica o antagónicamente sus efectos sobre diversas vías metabólicas determinantes para la salud y la enfermedad. La alimentación no se basa en nutrientes ni en alimentos aislados sino en complejas mezclas de unos y otros que forman parte de un patrón alimentario concreto, concepto que se ha señalado como el más pertinente para evaluar las asociaciones entre nutrición y salud o enfermedad. Este documento resume las evidencias disponibles sobre la relación existente entre los diferentes alimentos y la salud cardiovascular, y ofrece recomendaciones sencillas para ser implementadas en el consejo dietético que se ofrezca por parte del profesional sanitario