Proyecto de reformas a la Ley 3.909 de Procedimiento Administrativo de Mendoza con el fin de incorporar las formas instrumentales públicas digitales

La ley mendocina 7234 del año 2004, no fue diferente en rasgos generales a la normativa adoptada por la mayoría de las provincias argentinas, con un breve y escueto articulado que tan sólo refería a la adhesión al régimen de la ley 25506 de firma digital de la república argentina. Esta invitación y adhesión, resultan insuficientes a la hora de verificar con cierto grado de constitucionalidad la posibilidad de encontrar sustento legal para articular los dispositivos de la ley 25.506 con la ley 3909. Es menester una reforma de esta última y éste es el contenido de la investigación: formular un proyecto legislativo en tal sentido.

Development of mucoadhesive sprayable gellan gum fluid gels

The nasal mucosa provides a potentially good route for local and systemic drug delivery. However, the protective feature of the nasal cavity make intranasal delivery challenging. The application of mucoadhesive polymers in nasal drug delivery systems enhances the retention of the dosage form in the nasal cavity. Several groups have investigated using low acyl gellan as a drug delivery vehicle but only limited research however, has been performed on high acyl gellan for this purpose, despite its properties being more conducive to mucoadhesion. High acyl gellan produces highly elastic gels below 60 °C which make it difficult to spray using a mechanical spray device. Therefore, in this study we have tried to address this problem by making fluid gels by introducing a shear force during gelation of the gellan polymer. These fluid gel systems contain gelled micro-particles suspended in a solution of un-gelled polymer. These systems can therefore behave as pourable viscoelastic fluids. In this study we have investigated the rheological behavior and mucoadhesion of fluid gels of two different types of gellan (high and low acyl) and fluid gels prepared from blends of high and low acyl gellan at a 50:50 ratio. The results demonstrated that by preparing fluid gels of high acyl gellan, the rheological properties were sufficient to spray through a standard nasal spray device. Moreover fluid gels also significantly enhance both high acyl and low acyl gellan mucoadhesion properties

Extended ML: Past, present and future

An overview of past, present and future work on the Extended ML formal program development framework is given, with emphasis on two topics of current active research: the semantics of the Extended ML specification language, and tools to support formal program development

Natural and sail-displaced doubly-symmetric Lagrange point orbits for polar coverage

This paper proposes the use of doubly-symmetric, eight-shaped orbits in the circular restricted three-body problem for continuous coverage of the high-latitude regions of the Earth. These orbits, for a range of amplitudes, spend a large fraction of their period above either pole of the Earth. It is shown that they complement Sun-synchronous polar and highly eccentric Molniya orbits, and present a possible alternative to low thrust pole-sitter orbits. Both natural and solar-sail displaced orbits are considered. Continuation methods are described and used to generate families of these orbits. Starting from ballistic orbits, other families are created either by increasing the sail lightness number, varying the period or changing the sail attitude. Some representative orbits are then chosen to demonstrate the visibility of high-latitude regions throughout the year. A stability analysis is also performed, revealing that the orbits are unstable: it is found that for particular orbits, a solar sail can reduce their instability. A preliminary design of a linear quadratic regulator is presented as a solution to stabilize the system by using the solar sail only. Finally, invariant manifolds are exploited to identify orbits that present the opportunity of a ballistic transfer directly from low Earth orbit

Gellan Gum Fluid Gels for Topical Administration of Diclofenac

Diclofenac topical formulations are often preferred for drug administration to patients who experience serious GIT problems. Absorption of the drug through the skin, however, can be challenging due to the natural protective feature of the stratum corneum (SC). In this article, fluid gels prepared from gellan gum were explored as a topical drug delivery vehicle. Rheological analysis of the formulations showed that it was possible to produce a topical gel with a viscosity and the mechanical strength similar to that of the commercially available Voltaren® gel using 1 % w/w of a 50:50 low acyl/high acyl (LA/HA) gellan blend. Soft-tribology was used to assess the lubrication properties of gellan fluid gels. The lubrication of the gellan gum fluid gel formulations at high rubbing speeds was similar to the lubrication of the Voltaren® gel. The use of gellan gum dramatically increased skin permeation of diclofenac when compared with the commercially available formulation and could be controlled by changing the gellan gum concentration and/or sodium ion concentration in the formulation. This study highlights the potential use of fluid gels that can be easily tuned to have physical properties suitable for topical formulations with the added advantage of increasing drug permeation

Validity and reliability of the satel 40 HZ stabilometric force platform for measuring quiet stance and dynamic standing balance in healthy subjects

Background: A force platform must have validity and reliability for optimal use. The objective of this study was to analyze the validity and the reliability of the Satel 40 Hz stabilometric force platform. Methods: A study of instrumental validity and reliability, involving a cross-sectional correlational and comparative analysis was performed. To determine the validity, four certified weights located on three axes were used and the ability of the stabilometric force platform to detect changes in the position of the different axes was observed. A test–retest was performed to analyze the reliability. Forty-two symptom-free volunteers participated in the study. Assessments were taken in a standing static position and in a dynamic position, with the eyes open and closed. Three measurements were taken and the intra-class correlation coefficient (ICC) was calculated. Results: The validity increased as the weight increased for all the variables measured in the stabilometric parameters (p < 0.05). The reliability was shown to be good to excellent for the two visual conditions. The positional variables obtained a higher ICC. The variable with the best ICC was the Y mean in OE (ICC 0.874 and a p < 0.001). All the values showed an increase in a dynamic situation. Conclusion: The findings support the reliability and validity of the Satel 40 Hz stabilometric force platform. The platform could be recommended to evaluate static and dynamic standing balance in healthy adult individuals. Guidelines for treatment and the level of quality of stabilometry could be obtained from its use

Evaluation of gellan gum fluid gels as modified release oral liquids

Oral liquids are often preferred for drug administration to patients for whom swallowing is difficult, however formulating modified release versions can be challenging. A potential route to achieve modified release in oral liquids is by using fluid (sheared) gels formed by introducing a shear field during gelation in gel-forming biopolymers. These fluid gels can act as pourable viscoelastic fluids but retain true gel micro/nano structure. Here, we have demonstrated that fluid gels have potential as paediatric oral liquids preventing release of ibuprofen in simulated gastric fluid. Subsequent release at pH 7.4 was affected by the duration of exposure and magnitude of acid pH with a linear relationship between onset of release and the preceding acidic exposure duration. Delayed release was a result of increasing gel stiffness, a consequence of the acidity of the initial release media and exposure time. A much faster release rate was measured when exposure time in acid was 10 min compared with 60 min. This study highlights the potential to design fluid gels that are tuned to have a specified stiffness at a particular pH and exposure time. This could enable the preparation oral liquids with modified release behaviour

Influencia de las propiedades reológicas en las características sensoriales de cremas solares A/O y O/A

Resumen Se describen los métodos de caracterización de cuatro cremas solares, dos de las cuales (una de tipo A/O y otra O/A) derivan de las otras dos mediante cambios en su composición, con el fin de predecir las posibles variaciones en las propiedades sensoriales táctiles de las mismas a partir de los cambios observados en determinadas propiedades, en particular reológicas. Los resultados muestran que los cambios en las formulaciones originan cremas más viscosas y estables y sin modificación significativa de las propiedades táctiles. Los resultados de la evaluación sensorial se ajustan a las predicciones efectuadas a partir de los del análisis reológico. Palabras clave: Emulsiones, reología, evaluación sensorial, estabilidad, filtros solare

CT-guided intratumoural administration of cisplatin/epinephrine gel for treatment of malignant liver tumours

To analyze prospectively the interventional and clinical aspects of computed tomography-guided direct intratumoural injection of a novel chemotherapeutic administration and the parenchymal changes of tumour and necrosis in malignant liver tumours. Eight patients with 17 colorectal liver metastases were treated with a mean of 5.1 injections and nine patients with 13 hepatocellular carcinoma nodules with a mean of 3.1 treatments with computed tomography guided local applications of a novel cisplatin/epinephrine gel. This application provides a higher local and lower systemic drug concentration. Volumes of tumour and necrosis prior and after treatment were measured by computer generated volumetric analysis. Contrast enhanced studies verified pretherapeutic viable tumour volumes with a value of 77.4 ml in the metastases and 29.2 ml in the hepatocellular carcinoma nodules. Intratumoural drug application resulted in a significant increase of necrosis and a decrease in viable tumour volume to be 68.3 ml in metastases and 14.5 ml in hepatocellular carcinoma. Local therapy control rate for the follow up to 6 months was 38 and 71% for the group of metastases and hepatocellular carcinoma, respectively. Direct intratumoural injection of cisplatin/epinepthrine injectable gel is a feasible and good tolerated method and results in the development of a statistically significant increase in necrosis in malignant liver tumours. For hepatocellular carcinoma a higher local therapy control rate compared to colorectal metastases can be reported

Adaptación al castellano de la escala de valoración de competencias en simulación de Creighton (C-SEI)

Podeu consultar la Vuitena trobada de professorat de Ciències de la Salut completa a: http://hdl.handle.net/2445/66524Introducción: Una herramienta útil para la evaluación de competencias enfermeras en la docencia es utilizar rúbricas durante la simulación, de manera que es necesario disponer de instrumentos que evalúen factores cognitivos, afectivos y psicomotores. Objetivos: Adaptar al castellano el instrumento de evaluación de competencias “Creighton Simulation Evaluation InstrumentTM (C-SEI)” en estudiantes de Grado en Enfermería. Metodología: El estudio se realizó en dos fases, siendo la primera la adaptación al castellano del instrumento. La validez de contenido se realizó mediante el consenso de expertos. La segunda fase, consiste en el análisis métrico del instrumento, evaluando la fiabilidad analizando la consistencia interna mediante el coeficiente alfa de Cronbach, y la estabilidad temporal testretest. Para estudiar la validez convergente y discriminante se correlacionó las dimensiones del instrumento con el instrumento total..