17-year Report on the Owensboro-Hartford Co-operative Investigation of Joint Spacing in Concrete Pavements

In 1940, the Kentucky Department of Highways constructed an experimental concrete pavement which was one of a group of six built in co-operation with the Bureau of Public Roads by the States of Minnesota, California, Kentucky, Michigan, Missouri and Oregon. The purpose of these projects was to study and evaluate the performance of such pavements over a period of years with specific regard to types of joints and spacings. The Kentucky project, consisting of 6.27 miles, was constructed in Daviess County, beginning approximately 6 miles south of Owensboro on US Route 231 (formerly Ky. Route 71). This report is a continuation of the 1940 joint-spacing and pavement performance study. A complete discussion of the original scope, purpose, and early performance of this project has been given in previous reports (l, 2, 3, and 4). The present report is essentially a 17-yr. performance report but includes some data obtained through 1958. Subgrade, traffic, riding quality, and over-all condition data are provided

Kiss Me Sweet

Illustration of man and woman embracing with flowers flowing around them; Home and trees in circular frame in backgroundhttps://scholarsjunction.msstate.edu/cht-sheet-music/7734/thumbnail.jp

Results obtained during accelerated transonic tests of the Bell XS-1 airplane in flights to a Mach number of 0.92

Results are presented of tests up to a Mach number of 0.92 at altitudes around 30,000 feet. The data obtained show that the airplane can be flown to this Mach number above 30,000 feet. Longitudinal trim changes have been experienced but the forces involved have been small. The elevator effectiveness decreased about one-half with increase of Mach number from 0.70 to 0.87. Buffeting has been experienced in level flight but it has been mild and the associated tail loads have been small. No aileron buzz or other flutter phenomena have been noted

The current status of clinical trials in emergency gastrointestinal surgery. A systematic analysis of contemporary clinical trials

BACKGROUND: Emergency gastrointestinal surgery (EGS) conditions represent a significant healthcare burden globally requiring emergency operations that are associated with mortality rates as high as 80%. EGS is currently focussed on quality improvement and internal audits, which occurs at a national or local level. An appreciation of what EGS trials are being conducted is important to reduce research wastage and develop coordinated research strategies in surgery. The primary aim of this study was to identify and quantify recent and active trials in emergency gastrointestinal surgery. The secondary aim was to identify conditions of interest, and which aspects of care were being modified. METHODS: A systematic search of WHO, UK, US, Australian and Canadian trials databases was undertaken using broad terms to identify studies addressing emergency abdominal surgery and specific high-risk diagnoses. Studies registered between 2013-2018 were eligible for inclusion. Data on study topic, design, and funding body were collected. Interventions were classified into 'peri-operative', 'procedural', 'post-operative', 'non-surgical' and 'other' categories. RESULTS: Searches identified 5603 registered trials. After removal of duplicates, 4492 studies remained and 42 were eligible for inclusion. Almost 50% of trials were located in Europe and 17% (n=7) in the USA. The most common condition addressed was acute appendicitis (n=11), with the most common intervention being procedure based (n=23). Hospital based funding was the most common funder (n=30). CONCLUSION: There is large disparity in the number of surgical trials in emergency surgery, which are primarily focussed on high-volume conditions. More research is needed into high-mortality conditions. EVIDENCE LEVEL: 1a (oxford)

She Broke My Heart in Three Places

Map of United States inside broken hearthttps://scholarsjunction.msstate.edu/cht-sheet-music/12226/thumbnail.jp

Three North African dust source areas and their geochemical fingerprint

North Africa produces more than half of the world’s atmospheric dust load. Once entrained 24 into the atmosphere, this dust poses a human health hazard locally. It also modifies the 25 radiative budget regionally, and supplies nutrients that fuel primary productivity across the 26 North Atlantic Ocean and as far afield as the Amazonian Basin. Dust accumulation in deep 27 sea and lacustrine sediments also provides a means to study changes in palaeoclimate, 28 particularly those associated with rainfall climate change. Systematic analysis of satellite 29 imagery has greatly improved our understanding of the trajectories of long-range North 30 African dust plumes, but our knowledge of the dust-producing source regions and our ability 31 to fingerprint their contribution to these export routes is surprisingly limited. Here we 32 report new radiogenic isotope (Sr and Nd) data for sediment samples from known dust33 producing substrates (dried river and lakes beds), integrate them with published isotope 34 data and weight them for dust source activation. We define three isotopically distinct 35 preferential dust source areas (PSAs): a Western, a Central and an Eastern North African 36 PSA. More data are needed, particularly from the Western PSA, but our results show a 37 change in PSA dust source composition to more radiogenic Nd- and less radiogenic Sr38 isotope values from west to east, in line with the overall decreasing age of the underlying 39 bedrock. Our data reveal extreme isotopic heterogeneity within the Chadian region of the 40 Central PSA, including an extremely distinctive geochemical fingerprint feeding the Bodélé 41 Depression, the most active dust source on Earth. Our new analysis significantly improves 42 the reliability by which windblown dust deposits can be geochemically fingerprinted to their 43 distant source regions

C 3 grasses have higher nutritional quality than C 4 grasses under ambient and elevated atmospheric CO 2

Grasses with the C 3 photosynthetic pathway are commonly considered to be more nutritious host plants than C 4 grasses, but the nutritional quality of C 3 grasses is also more greatly impacted by elevated atmospheric CO 2 than is that of C 4 grasses; C 3 grasses produce greater amounts of nonstructural carbohydrates and have greater declines in their nitrogen content than do C 4 grasses under elevated CO 2 . Will C 3 grasses remain nutritionally superior to C 4 grasses under elevated CO 2 levels? We addressed this question by determining whether levels of protein in C 3 grasses decline to similar levels as in C 4 grasses, and whether total carbohydrate : protein ratios become similar in C 3 and C 4 grasses under elevated CO 2 . In addition, we tested the hypothesis that, among the nonstructural carbohydrates in C 3 grasses, levels of fructan respond most strongly to elevated CO 2 . Five C 3 and five C 4 grass species were grown from seed in outdoor open-top chambers at ambient (370 ppm) or elevated (740 ppm) CO 2 for 2 months. As expected, a significant increase in sugars, starch and fructan in the C 3 grasses under elevated CO 2 was associated with a significant reduction in their protein levels, while protein levels in most C 4 grasses were little affected by elevated CO 2 . However, this differential response of the two types of grasses was insufficient to reduce protein in C 3 grasses to the levels in C 4 grasses. Although levels of fructan in the C 3 grasses tripled under elevated CO 2 , the amounts produced remained relatively low, both in absolute terms and as a fraction of the total nonstructural carbohydrates in the C 3 grasses. We conclude that C 3 grasses will generally remain more nutritious than C 4 grasses at elevated CO 2 concentrations, having higher levels of protein, nonstructural carbohydrates, and water, but lower levels of fiber and toughness, and lower total carbohydrate : protein ratios than C 4 grasses.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72210/1/j.1365-2486.2004.00833.x.pd

Galileo, Poetry, and Patronage: Giulio Strozzi's Venetia edificata and the Place of Galileo in Seventeenth-Century Italian Poetry

This is the publisher's version, © 2013 by The University of Chicago Press.The Venetian poet and librettist Giulio Strozzi (1583 –1652) spent much of his career glorifying the Serenissima through a series of theatrical pieces. His only epic poem, the Venetia edificata (1621, 1624), while ostensibly a celebration of the republic, shows a level of commitment to Galileo Galilei (1564 –1643) and to Galileo’s science that is unique among poets of the time, Venetian or otherwise. It is the apex of Strozzi’s artistic project to incorporate Galileo’s discoveries and texts into poetic works. The Venetia edificata also represents the culmination of a fifteen-year effort to gain patronage from the Medici Grand Dukes in Florence. While the first, incomplete version is dedicated to the Venetian Doge, the second, finished version is dedicated to Grand Duke Ferdinando II de’ Medici of Florence. More than a decade after Galileo’s departure from the Veneto to Florence, Strozzi cites from Galileo’s early works, creates a character inspired by Galileo, incorporates the principles of Galileo’s science into the organizing structure of the poem, and answers one of Galileo’s loudest complaints about Torquato Tasso’s Jerusalem Delivered (1581). Strozzi’s strategies both in writing the Venetia edificata and in seeking patronage for it underscore the ambivalent response to Galileo in contemporary poetry

Curriculum design for inquiry: Preservice elementary teachers' mobilization and adaptation of science curriculum materials

Curriculum materials are crucial tools with which teachers engage students in science as inquiry. In order to use curriculum materials effectively, however, teachers must develop a robust capacity for pedagogical design, or the ability to mobilize a variety of personal and curricular resources to promote student learning. The purpose of this study was to develop a better understanding of the ways in which preservice elementary teachers mobilize and adapt existing science curriculum materials to plan inquiry-oriented science lessons. Using quantitative methods, we investigated preservice teachers' curriculum design decision-making and how their decisions influenced the inquiry orientations of their planned science lessons. Findings indicate that preservice elementary teachers were able to accurately assess how inquiry-based existing curriculum materials are and to adapt them to make them more inquiry-based. However, the inquiry orientations of their planned lessons were in large part determined by how inquiry-oriented curriculum materials they used to plan their lessons were to begin with. These findings have important implications for the design of teacher education experiences that foster preservice elementary teachers' pedagogical design capacities for inquiry, as well as the development of inquiry-based science curriculum materials that support preservice and beginning elementary teachers to engage in effective science teaching practice. © 2009 Wiley Periodicals, Inc. J Res Sci Teach 47:820–839, 2010Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/84401/1/20379_ftp.pd

DNA Encoding an HIV-1 Gag/Human Lysosome-Associated Membrane Protein-1 Chimera Elicits a Broad Cellular and Humoral Immune Response in Rhesus Macaques

Previous studies of HIV-1 p55Gag immunization of mice have demonstrated the usefulness of targeting antigens to the cellular compartment containing the major histocompatibility complex type II (MHC II) complex molecules by use of a DNA antigen formulation encoding Gag as a chimera with the mouse lysosome-associated membrane protein (mLAMP/gag). In the present study, we have analyzed the magnitude and breadth of Gag-specific T-lymphocyte and antibody responses elicited in Rhesus macaques after immunization with DNA encoding a human LAMP/gag (hLAMP/gag) chimera. ELISPOT analyses indicated that the average Gag-specific IFN-γ response elicited by the hLAMP/gag chimera was detectable after only two or three naked DNA immunizations in all five immunized macaques and reached an average of 1000 spot-forming cells (SFC)/10(6) PBMCs. High IFN-γ ELISPOT responses were detected in CD8(+)-depleted cells, indicating that CD4(+) T-cells play a major role in these responses. The T-cell responses of four of the macaques were also tested by use of ELISPOT to 12 overlapping 15-amino acids (aa) peptide pools containing ten peptides each, encompassing the complete Gag protein sequence. The two Mamu 08 immunized macaques responded to eight and twelve of the pools, the Mamu B01 to six, and the other macaque to five pools indicating that the hLAMP/gag DNA antigen formulation elicits a broad T-cell response against Gag. Additionally, there was a strong HIV-1-specific IgG response. The IgG antibody titers increased after each DNA injection, indicating a strong amnestic B-cell response, and were highly elevated in all the macaques after three immunizations. Moreover, the serum of each macaque recognized 13 of the 49 peptides of a 20-aa peptide library covering the complete Gag amino acid sequence. In addition, HIV-1-specific IgA antibodies were present in the plasma and external secretions, including nasal washes. These data support the findings of increased immunogenicity of genetic vaccines encoded as LAMP chimeras, including the response to DNA vaccines by non-human primates