357 research outputs found
Status of ERDA-DOD applications plans
A demonstration program is reported that defines solar terrestrial photovoltaic systems as power sources for DOD applications by developing requirements and implementation plans for each demonstration project. Evaluation criteria emphasize military market potential and military advantages
Quantum Theory and Time Asymmetry
The relation between quantum measurement and thermodynamically irreversible
processes is investigated. The reduction of the state vector is fundamentally
asymmetric in time and shows an observer-relatedness which may explain the
double interpretation of the state vector as a representation of physical
states as well as of information about them. The concept of relevance being
used in all statistical theories of irreversible thermodynamics is shown to be
based on the same observer-relatedness. Quantum theories of irreversible
processes implicitly use an objectivized process of state vector reduction. The
conditions for the reduction are discussed, and I speculate that the final
(subjective) observer system might even be carried by a spacetime point.Comment: Latex version of a paper published in 1979 (with minor revisions), 18
page
A boron-coated CCD camera for direct detection of Ultracold Neutrons (UCN)
A new boron-coated CCD camera is described for direct detection of ultracold
neutrons (UCN) through the capture reactions B
(n,0)Li (6%) and B(n,1)Li (94%).
The experiments, which extend earlier works using a boron-coated ZnS:Ag
scintillator, are based on direct detections of the neutron-capture byproducts
in silicon. The high position resolution, energy resolution and particle ID
performance of a scientific CCD allows for observation and identification of
all the byproducts , Li and (electron recoils). A
signal-to-noise improvement on the order of 10 over the indirect method has
been achieved. Sub-pixel position resolution of a few microns is demonstrated.
The technology can also be used to build UCN detectors with an area on the
order of 1 m. The combination of micrometer scale spatial resolution, few
electrons ionization thresholds and large area paves the way to new research
avenues including quantum physics of UCN and high-resolution neutron imaging
and spectroscopy.Comment: 10 pages, 8 figure
Prediction of Anisotropic Single-Dirac-Cones in BiSb Thin Films
The electronic band structures of BiSb thin films can be
varied as a function of temperature, pressure, stoichiometry, film thickness
and growth orientation. We here show how different anisotropic
single-Dirac-cones can be constructed in a BiSb thin film for
different applications or research purposes. For predicting anisotropic
single-Dirac-cones, we have developed an iterative-two-dimensional-two-band
model to get a consistent inverse-effective-mass-tensor and band-gap, which can
be used in a general two-dimensional system that has a non-parabolic dispersion
relation as in a BiSb thin film system
The Reality of Pervasive Transcription
Despite recent controversies, the evidence that the majority of the human genome is transcribed into RNA remains strong
Quantifying decoherence in continuous variable systems
We present a detailed report on the decoherence of quantum states of
continuous variable systems under the action of a quantum optical master
equation resulting from the interaction with general Gaussian uncorrelated
environments. The rate of decoherence is quantified by relating it to the decay
rates of various, complementary measures of the quantum nature of a state, such
as the purity, some nonclassicality indicators in phase space and, for two-mode
states, entanglement measures and total correlations between the modes.
Different sets of physically relevant initial configurations are considered,
including one- and two-mode Gaussian states, number states, and coherent
superpositions. Our analysis shows that, generally, the use of initially
squeezed configurations does not help to preserve the coherence of Gaussian
states, whereas it can be effective in protecting coherent superpositions of
both number states and Gaussian wave packets.Comment: Review article; 36 pages, 19 figures; typos corrected, references
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A Pathway to Precision Medicine for Aboriginal Australians: A Study Protocol
Published: 21 June 2021(1) Background: Genomic precision medicine (PM) utilises people’s genomic data to inform the delivery of preventive and therapeutic health care. PM has not been well-established for use with people of Aboriginal and Torres Strait Islander ancestry due to the paucity of genomic data from these communities. We report the development of a new protocol using co-design methods to enhance the potential use of PM for Aboriginal Australians. (2) Methods: This iterative qualitative study consists of five main phases. Phase-I will ensure appropriate governance of the project and establishment of a Project Advisory Committee. Following an initial consultation with the Aboriginal community, Phase-II will invite community members to participate in co-design workshops. In Phase-III, the Chief Investigators will participate in co-design workshops and document generated ideas. The notes shall be analysed thematically in Phase-IV with Aboriginal community representatives, and the summary will be disseminated to the communities. In Phase-V, we will evaluate the co-design process and adapt our protocol for the use in partnership with other communities. (3) Discussion: This study protocol represents a crucial first step to ensure that PM research is relevant and acceptable to Aboriginal Australians. Without fair access to PM, the gap in health outcome between Aboriginal and non-Aboriginal Australians will continue to widen.Yeu-Yao Cheng, Jack Nunn, John Skinner, Boe Rambaldini, Tiffany Boughtwood, Tom Calma, Alex Brown, Cliff Meldrum, Marcel E. Dinger, Jennifer A. Byrne, Debbie McCowen, Jayden Potter, Kerry Faires, Sandra Cooper and Kylie Gwynn
The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35
The majority of patients with neuroblastoma due to MYCN oncogene amplification and consequent N-Myc oncoprotein over-expression die of the disease. Here our analyses of RNA sequencing data identify the long noncoding RNA lncNB1 as one of the transcripts most over-expressed in MYCN-amplified, compared with MYCN-non-amplified, human neuroblastoma cells and also the most over-expressed in neuroblastoma compared with all other cancers. lncNB1 binds to the ribosomal protein RPL35 to enhance E2F1 protein synthesis, leading to DEPDC1B gene transcription. The GTPase-activating protein DEPDC1B induces ERK protein phosphorylation and N-Myc protein stabilization. Importantly, lncNB1 knockdown abolishes neuroblastoma cell clonogenic capacity in vitro and leads to neuroblastoma tumor regression in mice, while high levels of lncNB1 and RPL35 in human neuroblastoma tissues predict poor patient prognosis. This study therefore identifies lncNB1 and its binding protein RPL35 as key factors for promoting E2F1 protein synthesis, N-Myc protein stability and N-Myc-driven oncogenesis, and as therapeutic targets
A comparative genome-wide study of ncRNAs in trypanosomatids
<p>Abstract</p> <p>Background</p> <p>Recent studies have provided extensive evidence for multitudes of non-coding RNA (ncRNA) transcripts in a wide range of eukaryotic genomes. ncRNAs are emerging as key players in multiple layers of cellular regulation. With the availability of many whole genome sequences, comparative analysis has become a powerful tool to identify ncRNA molecules. In this study, we performed a systematic genome-wide in silico screen to search for novel small ncRNAs in the genome of <it>Trypanosoma brucei </it>using techniques of comparative genomics.</p> <p>Results</p> <p>In this study, we identified by comparative genomics, and validated by experimental analysis several novel ncRNAs that are conserved across multiple trypanosomatid genomes. When tested on known ncRNAs, our procedure was capable of finding almost half of the known repertoire through homology over six genomes, and about two-thirds of the known sequences were found in at least four genomes. After filtering, 72 conserved unannotated sequences in at least four genomes were found, 29 of which, ranging in size from 30 to 392 nts, were conserved in all six genomes. Fifty of the 72 candidates in the final set were chosen for experimental validation. Eighteen of the 50 (36%) were shown to be expressed, and for 11 of them a distinct expression product was detected, suggesting that they are short ncRNAs. Using functional experimental assays, five of the candidates were shown to be novel H/ACA and C/D snoRNAs; these included three sequences that appear as singletons in the genome, unlike previously identified snoRNA molecules that are found in clusters. The other candidates appear to be novel ncRNA molecules, and their function is, as yet, unknown.</p> <p>Conclusions</p> <p>Using comparative genomic techniques, we predicted 72 sequences as ncRNA candidates in <it>T. brucei</it>. The expression of 50 candidates was tested in laboratory experiments. This resulted in the discovery of 11 novel short ncRNAs in procyclic stage <it>T. brucei</it>, which have homologues in the other trypansomatids. A few of these molecules are snoRNAs, but most of them are novel ncRNA molecules. Based on this study, our analysis suggests that the total number of ncRNAs in trypanosomatids is in the range of several hundred.</p
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