Design of the strategic direction for the company Eventos 1A Recreación y Turismo SAS of the city of Duitama Boyacá

La empresa Eventos 1A Recreación y Turismo S.A.S es una empresa Boyacense que presta los servicios en actividades de bienestar empresarial, mercadeo BTL, producción y organización de eventos y turismo, la cual requiere establecer una planificación estratégica de acuerdo a los continuos cambios del mercado y las exigencias de la competitividad. Un diseño del direccionamiento estratégico permitirá encaminar a la organización hacia la prestación de un mejor servicio, posicionarse en el sector y conocer mejor la organización para que el proceso de toma de decisiones sea efectivo integrando las áreas de la empresa. El objetivo general es elaborar la propuesta de intervención enfocada en el diseño del direccionamiento estratégico para la empresa Eventos 1A Recreación y turismo S.A.S. de la ciudad de Duitama Boyacá, para lograr este objetivo se plantea realizar el diagnóstico de la situación actual de la empresa en lo referente a la gestión estratégica mediante un análisis del microentorno, macroentorno e interno; construir un marco de referencia alrededor de los modelos de gestión estratégica como PEST, Matriz EFAS, MMGO (Modelo de modernización para la gestión de organizaciones), 5 fuerzas de Porter, Matriz IFAS, Prospectiva Estratégica (escenarios), Matriz Dofa y Cuadro de Mando Integral; diseñar estrategias del direccionamiento estratégico y elaborar un plan de acción para las estrategias diseñadas. El tipo de investigación fue descriptivo, con enfoque cualitativo. Se hizo uso de entrevista a directivos, empleados, clientes, proveedores y empresas competidoras cuya información se plasma en las herramientas de administración estratégica.The company Eventos 1A Recreación y Turismo S.A.S is a Boyacense company that provides services in business wellness activities, BTL marketing, production and organization of events and tourism, which requires establishing strategic planning according to continuous market changes and the demands of the competitiveness. A design of the strategic direction will allow the organization to be directed towards providing a better service, positioning itself in the sector and getting to know the organization better so that the decision-making process is effective integrating the areas of the company. The general objective is to prepare the intervention proposal focused on the design of the strategic direction for the company Eventos 1 A Recreación y turismo S.A.S. from the city of Duitama Boyacá, in order to achieve this objective, a diagnosis of the current situation of the company in relation to strategic management is proposed, through an analysis of the macro, micro and internal environments; build a frame of reference around strategic management models such as PEST, EFAS Matrix, MMGO (Modernization Model for Organizational Management), Porter's 5 Forces, IFAS Matrix, Strategic Prospective (scenarios); Dofa Matrix and Balanced Scorecard; design strategies of the strategic direction and elaborate an action plan for the designed strategies. The type of research was descriptive, with a qualitative approach. An interview was used with managers, employees, clients, suppliers and competing companies whose information is reflected in the strategic management toolsMagíster en Administración de Empresas - MB

From Microscopic to Macroscopic Description of Composite Thin Panels: A Roadmap for their Simulation in Time Domain

In this paper, we show a simulation strategy for composite dispersive thin-panels, starting from their microscopic characteristics and ending into a time-domain macroscopic model. In a first part, we revisit different semianalytic methods that may be used to obtain the S-parameter matrices. The validity of them is assessed with numerical simulations and experimental data. We also include some formulas that may be used to tailor the shielding effectiveness of panels in a design phase. In a second part, we present an extension to dispersive media of a subgridding hybrid implicit–explicit algorithm finite difference time domain (FDTD) devised by the authors to deal with that kind of materials. The method, here presented and applied to the FDTD method, is a robustly stable alternative to classical impedance boundary condition techniques. For this, a previous analytical procedure allowing to extract an equivalent effective media from S-parameters is presented, thus making this road map able to simulate any kind of dispersive thin layer. A numerical validation of the algorithm is finally shown by comparing with experimental data

La producción caprina en el Chaco Árido Riojano – Catamarqueño

“Red de Innovación para el Desarrollo Rural del Gran Chaco Americano en el Contexto del Cambio Climático”. - ATN/RF-16112-RGLas provincias de La Rioja y Catamarca integran la gran región del Chaco Americano, con una superficie estimada de 9,6 Km2, ocupan la porción Sudoeste del mismo; La Rioja comprendida en el Chaco Árido y Catamarca en el Chaco Semiárido y Árido, siendo este último la expresión más seca y menos productiva del Chaco Americano. Es una región con características ambientales limitadas, fundamentalmente relacionada con la disponibilidad de agua de lluvia, siendo este recurso crítico y decisivo para su crecimiento integral. En estas áreas, los caprinos cumplen un rol importante en la economía local y regional que cuentan con recursos y condiciones poco propicias para desarrollar actividades alternativas. Este trabajo tiene como objetivo presentar algunos aspectos destacados de la actividad caprina en la región del Chaco Árido de las provincias de La Rioja y Catamarca, atendiendo especialmente a sus características socio-productivas y de comercialización en el marco del proyecto Red de Innovación para el Desarrollo Rural del Gran Chaco Americano en el Contexto del Cambio Climático, ref. ATN/RF- 16112-RG. Entre los temas de análisis se consideró el stock caprino y sus variaciones en el tiempo, utilizando censos nacionales agropecuarios que han sido, punto de referencia en diferentes ámbitos gubernamentales para la toma de decisiones; también se aborda aspectos relevantes del sistema de producción, como prácticas de manejo, aspectos de la reproducción, infraestructura, comercialización, entre otros. Para la elaboración de este documento se han utilizado datos provenientes de diversas fuentes y autores descritos en el apéndice bibliográfico, complementada con observaciones y relevamientos propios en campo de productores insertos en el área de estudio. La información obtenida y analizada, destaca la relevancia de la actividad ganadera, en el ambiente de estudio; siendo la ganadería caprina una de las actividades socio económicas más desarrollada en la región.EEA CatamarcaFil: Gonzalez, Maria Florencia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Catamarca; ArgentinaFil: Ricarte, Ramon Armando. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria La Rioja; ArgentinaFil: Guzman, Luis Miguel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria La Rioja; ArgentinaFil: Castro, Ornella Eugenia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Catamarca; ArgentinaFil: Diaz, Raul Fernando. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria La Rioja; ArgentinaFil: Castignani, Horacio. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentin

T-cell epitopes of the major peach allergen, Pru p 3: Identification and differential T-cell response of peach-allergic and non-allergic subjects

Lipid transfer proteins (LTPs), particularly peach Pru p 3, are the most relevant plant food allergens in the South of Europe, and, therefore, their allergic properties have been extensively studied. However, neither T-cell epitopes nor their effect on the patients’ T-cell response has been investigated in any member of the LTP panallergen family. The objective of the present study was to map the major T-cell epitopes of Pru p 3, as well as to evaluate their induced T-cell response in peach-allergic versus control subjects. Thus, peripheral blood mononuclear cells (PBMCs) from 18 peach-allergic patients and Pru p 3-specific T-cell lines (TCLs) from 9 of them were cultured with Pru p 3 and with a panel of 17 derived peptides (10-mer overlapping in 5 amino acids representing the full sequence of Pru p 3). Proliferation in 5-day assays was carried out via tritiated-thymidine incorporation, while IL4 and IFNγ production was assessed via sandwich enzyme-linked immunosorbent tests (ELISA) of TCL culture supernatants. The results were compared to those obtained from 10 non-peach allergic control volunteers. Two consecutive peptides showed the highest activation capacity. About 74% of PBMCs and TCLs recognized them, forming a single T-epitope: Pru p 365–80. Additionally, other specific T-cell epitopes were observed. Pru p 325–35 was detected by more than 60% of TCLs from peach-allergic patients, and Pru p 345–55 only activated PBMCs from control subjects. Interestingly, TCLs from patients were associated with a Th2-type, whereas control TCLs presented a Th1-type cytokine response. The major immunogenic T-cell epitope identified in Pru p 3, Pru p 365–80, is a good candidate to develop new vaccines for hypersensitivity reactions associated with LTP allergens from Rosaceae fruits

Validation of Electroencephalographic Recordings Obtained with a Consumer-Grade, Single Dry Electrode, Low-Cost Device: A Comparative Study

The functional validity of the signal obtained with low-cost electroencephalography (EEG) devices is still under debate. Here, we have conducted an in-depth comparison of the EEG-recordings obtained with a medical-grade golden-cup electrodes ambulatory device, the SOMNOwatch + EEG-6, vs those obtained with a consumer-grade, single dry electrode low-cost device, the NeuroSky MindWave, one of the most a ordable devices currently available. We recorded EEG signals at Fp1 using the two di erent devices simultaneously on 21 participants who underwent two experimental phases: a 12-minute resting state task (alternating two cycles of closed/open eyes periods), followed by 60-minute virtual-driving task. We evaluated the EEG recording quality by comparing the similarity between the temporal data series, their spectra, their signal-to-noise ratio, the reliability of EEG measurements (comparing the closed eyes periods), as well as their blink detection rate. We found substantial agreement between signals: whereas, qualitatively, the NeuroSky MindWave presented higher levels of noise and a biphasic shape of blinks, the similarity metric indicated that signals from both recording devices were significantly correlated. While the NeuroSky MindWave was less reliable, both devices had a similar blink detection rate. Overall, the NeuroSky MindWave is noise-limited, but provides stable recordings even through long periods of time. Furthermore, its data would be of adequate quality compared to that of conventional wet electrode EEG devices, except for a potential calibration error and spectral differences at low frequencies.Spanish Department of Transportation, Madrid, Spain (Grant No. SPIP2014-1426 to L.L.D.S.)A.C. is funded by a Spanish Ministry of Economy and Competitiveness grant (PSI2016-80558-R to A.C.)S.R. is funded by an Andalusian Government Excellence Research grant (P11-TIC-7983)L.J.F. is funded by a Spanish Ministry of Economy and Competitiveness grant (PSI2014-53427-P) and a Fundación Séneca grant (19267/PI/14)L.L.D.S. is currently supported by the Ramón y Cajal fellowship program (RYC-2015-17483)C.D.-P. is currently supported by the CEIMAR program (CEIMAR2018-2)C.D.-P. and L.L.D.S. are supported by a Santander Bank—CEMIX UGR-MADOC grant (Project PINS 2018-15

Influence of Salix babylonica extract in combination or not with increasing levels of minerals mixture on in vitro rumen gas production kinetics of a total mixed ration

Plant extracts, with high concentrations of secondary metabolites, are good candidates for enhancing nutrient utilization (Patra et al., 2006; Cedillo et al., 2014). Administration of Salix babylonica (SB) extract to ruminants as feed additives modified in vitro ruminal fermentation in lambs (Jiménez-Peralta et al., 2011; Salem et al., 2014b), improved in vivo digestibility as well as average daily gain of lambs (Salem et al., 2011a, 2014b) and milk production (Salem et al., 2014a). Some plant extracts also improved animal growth and nutrient digestion (Mapiye et al., 2010; Salem et al., 2011a) due to positive impacts of their secondary metabolites on activity of ruminal microorganisms (Jiménez-Peralta et al., 2011) and/or increased amino acid flow to the duodenum (Mueller-Harvey, 2006). This can result in more muscle deposition and, consequently, heavier carcasses (Gleghorn et al., 2004) and improved meat quality (Mapiye et al., 2010).The aim of this study was to determine the effects of increasing levels of two feed additives composed of Salix babylonica (SB) extract and minerals mixture (MM) or their combination on in vitro gas production (GP) and dry matter (DM) degradability of total mixed ration (TMR; 50 concentrate: 50 corn silage, on DM basis). Combinations of four levels of SB extract (0, 0.6, 1.2 and 1.8 mL/g DM) with four levels of MM (0, 0.5, 1.5 and 2.5 g/100 g DM) were evaluated in a completely random design. Samples of TMR (1 g) were weighed in 120 mL serum bottles with addition of SB extract and/or MM. Then, 10 mL of particle free ruminal fluid were added followed by 40 mL of the buffer solution. The GP was recorded at 2, 4, 6, 8, 10, 12, 24, 48 and 72 h of incubation. Addition of SB extract, without MM, increased (P<0.05) asymptotic GP (mL/g DM), the rate of GP (/h), GP and DM degradability (DMD)

En la costa aún sin mar

Los trabajos que conforman este volumen son una muestra de la presencia y actualidad de la obra de César Vallejo. Su poesía aún da lugar a nuevas y diversas interpretaciones; también a ciertas reconsideraciones. Asimismo, la narrativa del escritor peruano, poco atendida, está presente y exige estudio además de revalorización. La persona y obra de César Vallejo, en fin, son actuales incluso como un fenómeno metapoético.César Vallejo es un escritor esencial en el ámbito de la literatura contemporánea. Su obra literaria, escrita a principios del siglo pasado, sigue vigente. En su poesía, en particular, captó la sensibilidad de toda una época. Asimismo, supo traducir lo que él llamaba “el ritmo interior y el espíritu que se desprende de la realidad actual”. En cuanto a su obra en prosa, los estudios recientes dan muestra de su importancia, valor social y artístico. A casi cien años de la publicación de libros como Trilce y Los heraldos negros, la obra de César Vallejo sigue siendo fuente de goce estético y, por su complejidad, de búsqueda de conocimiento profundo de la realidad social y humana

American heart association's life simple 7 and the risk of atrial fibrillation in the PREDIMED study cohort

Background and aims The American Heart Association proposed 7 ideal cardiovascular health metrics (Life's Simple 7 [LS7]) namely, not smoking, body mass index <25 kg/m2, healthy diet, moderate physical activity ≥150 min/week, total blood cholesterol <200 mg/dL, blood pressure <120/80 mmHg and fasting blood glucose <100 mg/dL. Our objective was to assess the association between these LS7 metrics and the incidence of atrial fibrillation (AF). Methods and results A total of 6,479 participants of the PREDIMED study were included. We calculated the participants’ baseline LS7 index ranging 0–7 points to categorize them according to their adherence to these LS7 health metrics. Multivariable Cox regression models were used to estimate Hazard Ratios (HR) and their 95% Confidence Intervals (95% CI). After a median follow-up of 4.8 years, we identified 250 incident cases of AF. After adjusting for potential confounders, adherence to LS7 index was not associated with the incidence of AF (adjusted HR 0.90 [95% CI: 0.56–1.45] for highest vs. lowest LS7 categories). Body mass index <25 kg/m2 was the only health metric individually associated with a lower risk of AF (HR 0.36 [95% CI: 0.16–0.78]). Conclusions In a high cardiovascular risk Spanish population, adherence to American Heart Association's LS7 metrics was not associated with the risk of incident AF

Enfrentando los riesgos socionaturales

El objetivo del libro es comprender la magnitud de los Riesgos Socionaturales en México y Latinoamérica, para comprender el peligro que existe por algún tipo de desastre, ya sea inundaciones, sismos, remoción en masa, entre otros, además conocer qué medidas preventivas, correctivas y de contingencias existen para estar atentos ante alguna señal que la naturaleza esté enviando y así evitar alguna catástrofe. El libro se enfoca en los aspectos básicos de análisis de los peligros, escenarios de riesgo, vulnerabilidad y resiliencia, importantes para la gestión prospectiva o preventiva

Non-productive angiogenesis disassembles Aß plaque-associated blood vessels

The human Alzheimer’s disease (AD) brain accumulates angiogenic markers but paradoxically, the cerebral microvasculature is reduced around Aß plaques. Here we demonstrate that angiogenesis is started near Aß plaques in both AD mouse models and human AD samples. However, endothelial cells express the molecular signature of non-productive angiogenesis (NPA) and accumulate, around Aß plaques, a tip cell marker and IB4 reactive vascular anomalies with reduced NOTCH activity. Notably, NPA induction by endothelial loss of presenilin, whose mutations cause familial AD and which activity has been shown to decrease with age, produced a similar vascular phenotype in the absence of Aß pathology. We also show that Aß plaque-associated NPA locally disassembles blood vessels, leaving behind vascular scars, and that microglial phagocytosis contributes to the local loss of endothelial cells. These results define the role of NPA and microglia in local blood vessel disassembly and highlight the vascular component of presenilin loss of function in AD