299 research outputs found
Modeling Kinetic Glomerular Filtration Rate in Adults with Stable and Unstable Kidney Function: Vancomycin as the Motivating Example
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/162720/2/phar2442_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/162720/1/phar2442.pd
The anisotropy of magnetic susceptibility (AMS) in low-grade, cleaved pelitic rocks: influence of cleavage/bedding angle and type and relative orientation of magnetic carriers
Poor glycaemic control in secondary care insulin treated patients correlates with bad process indicators
peer reviewe
Comparison of Body Size, Morphomics, and Kidney Function as Covariates of High‐Dose Methotrexate Clearance in Obese Adults with Primary Central Nervous System Lymphoma
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154919/1/phar2379.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154919/2/phar2379_am.pd
Mycobacterium ulcerans in Mosquitoes Captured during Outbreak of Buruli Ulcer, Southeastern Australia
Mosquitoes positive for M. ulcerans were linked to
outbreaks of Buruli ulcer in humans
Antimicrobial use in European acute care hospitals: results from the second point prevalence survey (PPS) of healthcare-associated infections and antimicrobial use, 2016 to 2017
Antimicrobial agents used to treat infections are life-saving. Overuse may result in more frequent adverse effects and emergence of multidrug-resistant microorganisms. In 2016-17, we performed the second point-prevalence survey (PPS) of healthcare-associated infections (HAIs) and antimicrobial use in European acute care hospitals. We included 1,209 hospitals and 310,755 patients in 28 of 31 European Union/European Economic Area (EU/EEA) countries. The weighted prevalence of antimicrobial use in the EU/EEA was 30.5% (95% CI: 29.2-31.9%). The most common indication for prescribing antimicrobials was treatment of a community-acquired infection, followed by treatment of HAI and surgical prophylaxis. Over half (54.2%) of antimicrobials for surgical prophylaxis were prescribed for more than 1 day. The most common infections treated by antimicrobials were respiratory tract infections and the most commonly prescribed antimicrobial agents were penicillins with beta-lactamase inhibitors. There was wide variation of patients on antimicrobials, in the selection of antimicrobial agents and in antimicrobial stewardship resources and activities across the participating countries. The results of the PPS provide detailed information on antimicrobial use in European acute care hospitals, enable comparisons between countries and hospitals, and highlight key areas for national and European action that will support efforts towards prudent use of antimicrobials
Rapid and sensitive detection of mycobacterium ulcerans by use of a loop-mediated isothermal amplification test
This work reports the design and evaluation of a rapid loop-mediated isothermal amplification test for detecting Mycobacterium ulcerans DNA based on the multicopy insertion sequence IS2404. The test is robust and specific with a detection limit equivalent to 20 copies of the target sequence (0.01 to 0.1 genome). The test has potential for the diagnosis of Buruli ulcer under field conditions
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