Aliraza Javaid, Masculinities, Sexualities and Love. Abingdon & New York: Routledge, 2019. Pp. 189.

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The chaperone TRAP1 as a modulator of the mitochondrial adaptations in cancer cells

Mitochondria can receive, integrate, and transmit a variety of signals to shape many biochemical activities of the cell. In the process of tumor onset and growth, mitochondria contribute to the capability of cells of escaping death insults, handling changes in ROS levels, rewiring metabolism, and reprograming gene expression. Therefore, mitochondria can tune the bioenergetic and anabolic needs of neoplastic cells in a rapid and flexible way, and these adaptations are required for cell survival and proliferation in the fluctuating environment of a rapidly growing tumor mass. The molecular bases of pro-neoplastic mitochondrial adaptations are complex and only partially understood. Recently, the mitochondrial molecular chaperone TRAP1 (tumor necrosis factor receptor associated protein 1) was identified as a key regulator of mitochondrial bioenergetics in tumor cells, with a profound impact on neoplastic growth. In this review, we analyze these findings and discuss the possibility that targeting TRAP1 constitutes a new antitumor approach

On the lower semicontinuous envelope of functionals defined on polyhedral chains

In this note we prove an explicit formula for the lower semicontinuous envelope of some functionals defined on real polyhedral chains. More precisely, denoting by $H \colon \mathbb{R} \to \left[ 0,\infty \right)$ an even, subadditive, and lower semicontinuous function with $H(0)=0$, and by $\Phi_H$ the functional induced by $H$ on polyhedral $m$-chains, namely \Phi_{H}(P) := \sum_{i=1}^{N} H(\theta_{i}) \mathcal{H}^{m}(\sigma_{i}), \quad\mbox{for every }P=\sum_{i=1}^{N} \theta_{i} [[ \sigma_{i} ]] \in\mathbf{P}_m(\mathbb{R}^n), we prove that the lower semicontinuous envelope of $\Phi_H$ coincides on rectifiable $m$-currents with the $H$-mass \mathbb{M}_{H}(R) := \int_E H(\theta(x)) \, d\mathcal{H}^m(x) \quad \mbox{ for every } R= [[ E,\tau,\theta ]] \in \mathbf{R}_{m}(\mathbb{R}^{n}). Comment: 14 page

Sonic Hyperbolic Phase Transitions and Chapman-Jouguet Detonations

AbstractWe prove that the Cauchy problem for an n×n system of strictly hyperbolic conservation laws in one space dimension admits a weak global solution also in presence of sonic phase boundaries. Applications to Chapman–Jouguet detonations, liquid–vapor transitions and elastodynamics are considered

Endogenous Transportation Technology in a Cournot Differential Game with Intraindustry Trade

We investigate a dynamic Cournot duopoly with intraindustry trade, where firms invest in R&D to reduce the level of iceberg transportation costs. We adopt both open-loop and closed-loop equilibrium concepts, showing that a unique (saddle point) steady state exists in both cases. In the open-loop model, optimal investments and the resulting efficiency of transportation technology are independent of the relative size of the two countries. On the contrary, in the closed-loop case, a home market effect operates so that thefirm located in the larger country invests more than the rival located in the smaller one. Policy implications are also evaluated

A Differential Game with Investment in Transport and Communication R&D.

In this paper we propose a simple, intuitive approach to asset valuation in terms of marginal contributions to the characteristics (moments) of the market portfolio. Considering only the first two moments, mean and variance, the valuation equation is shown to correspond to Sharpe’s CAPM. A risk-neutral pricing formula is easily derived, showing the equivalence between CAPM and the Black and Scholes’ model. Extensions to higher moments like skewness and kurtosis are straightforward, providing a generalized valuation equation. Finally, the generalized equation is derived in a different, more rigorous way, as a result of a classical intertemporal general equilibrium model