1,224 research outputs found

    The galaxy power spectrum: precision cosmology from large-scale structure?

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    Published galaxy power spectra from the two-degree field galaxy redshift survey (2dFGRS) and Sloan Digital Sky Survey (SDSS) are not in good agreement. We revisit this issue by analysing both the 2dFGRS and SDSS Data Release 5 (DR5) catalogues using essentially identical techniques. We confirm that the 2dFGRS exhibits relatively more large-scale power than the SDSS, or, equivalently, SDSS has more small-scale power. We demonstrate that this difference is due to the r-band selected SDSS catalogue being dominated by more strongly clustered red galaxies, which have a stronger scale-dependent bias. The power spectra of galaxies of the same rest-frame colours from the two surveys match well. If not accounted for, the difference between the SDSS and 2dFGRS power spectra causes a bias in the obtained constraints on cosmological parameters which is larger than the uncertainty with which they are determined. We also found that the correction developed by Cole et al. to model the distortion in the shape of the power spectrum due to non-linear evolution and scale-dependent bias is not able to reconcile the constraints obtained from the 2dFGRS and SDSS power spectra. Intriguingly, the model is able to describe the differences between the 2dFGRS and the much more strongly clustered Luminous Red Galaxy (LRG) sample, which exhibits greater non-linearities. This shows that more work is needed to understand the relation between the galaxy power spectrum and the linear perturbation theory prediction for the power spectrum of matter fluctuations. It is therefore important to accurately model these effects to get precise estimates of cosmological parameters from these power spectra and from future galaxy surveys like Pan-STARRS, or the Dark Energy Survey, which will use selection criteria similar to the one of SDSS

    Narrowband UVB phototherapy for clinically isolated syndrome: A trial to deliver the benefits of Vitamin D and other UVB-Induced molecules

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    Low vitamin D and insufficient sun exposure are additive independent risk factors for the development of multiple sclerosis (MS). The usual measure of vitamin D status, serum 25-hydroxy vitamin D [25(OH)D], is also a marker of recent exposure to the UVB rays of sunshine. The main evidence for a protective effect for MS development of higher 25(OH)D comes from observational studies, but this study design cannot separate out whether 25(OH)D is acting as a marker of vitamin D status, sun exposure, or both. In light of a lack of definitive outcomes in MS patients after trials of vitamin D supplementation and the ability of narrowband UVB to induce vitamin D, as well as other immune-regulatory molecules in skin, the Phototherapy for Clinically Isolated Syndrome (PhoCIS) trial was established to investigate the benefits of narrowband UVB, in addition to supplemented vitamin D, on MS development in individuals with Clinically Isolated Syndrome. We propose that the PhoCIS trial provides a fresh approach to re-defining the reported associations of 25(OH)D levels with MS development and progression

    Does Proprioception Influence Human Spatial Cognition? A Study on Individuals With Massive Deafferentation.

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    When navigating in a spatial environment or when hearing its description, we can develop a mental model which may be represented in the central nervous system in different coordinate systems such as an egocentric or allocentric reference frame. The way in which sensory experience influences the preferred reference frame has been studied with a particular interest for the role of vision. The present study investigated the influence of proprioception on human spatial cognition. To do so, we compared the abilities to form spatial models of two rare participants chronically deprived of proprioception (GL and IW) and healthy control participants. Participants listened to verbal descriptions of a spatial environment, and their ability to form and use a mental model was assessed with a distance-comparison task and a free-recall task. Given that the loss of proprioception has been suggested to specifically impair the egocentric reference frame, the deafferented individuals were expected to perform worse than controls when the spatial environment was described in an egocentric reference frame. Results revealed that in both tasks, one deafferented individual (GL) made more errors than controls while the other (IW) made less errors. On average, both GL and IW were slower to respond than controls, and reaction time was more variable for IW. Additionally, we found that GL but not IW was impaired compared to controls in visuo-spatial imagery, which was assessed with the Minnesota Paper Form Board Test. Overall, the main finding of this study is that proprioception can influence the time necessary to use spatial representations while other factors such as visuo-spatial abilities can influence the capacity to form accurate spatial representations

    The kk-essence scalar field in the context of Supernova Ia Observations

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    A kk-essence scalar field model having (non canonical) Lagrangian of the form L=V(ϕ)F(X)L=-V(\phi)F(X) where X=1/2gμνμϕνϕX=1/2g^{\mu\nu}\nabla_{\mu}\phi\nabla_{\nu}\phi with constant V(ϕ)V(\phi) is shown to be consistent with luminosity distance-redshift data observed for type Ia Supernova. For constant V(ϕ)V(\phi), F(X)F(X) satisfies a scaling relation which is used to set up a differential equation involving the Hubble parameter HH, the scale factor aa and the kk-essence field ϕ\phi. HH and aa are extracted from SNe Ia data and using the differential equation the time dependence of the field ϕ\phi is found to be: ϕ(t)λ0+λ1t+λ2t2\phi(t) \sim \lambda_0 + \lambda_1 t + \lambda_2 t^2. The constants λi\lambda_i have been determined. The time dependence is similar to that of the quintessence scalar field (having canonical kinetic energy) responsible for homogeneous inflation. Furthermore, the scaling relation and the obtained time dependence of the field ϕ\phi is used to determine the XX-dependence of the function F(X)F(X).Comment: 8 pages, 5 figures, Late

    Cosmological Parameters Degeneracies and Non-Gaussian Halo Bias

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    We study the impact of the cosmological parameters uncertainties on the measurements of primordial non-Gaussianity through the large-scale non-Gaussian halo bias effect. While this is not expected to be an issue for the standard LCDM model, it may not be the case for more general models that modify the large-scale shape of the power spectrum. We consider the so-called local non-Gaussianity model and forecasts from planned surveys, alone and combined with a Planck CMB prior. In particular, we consider EUCLID- and LSST-like surveys and forecast the correlations among fNLf_{\rm NL} and the running of the spectral index αs\alpha_s, the dark energy equation of state ww, the effective sound speed of dark energy perturbations cs2c^2_s, the total mass of massive neutrinos Mν=mνM_\nu=\sum m_\nu, and the number of extra relativistic degrees of freedom NνrelN_\nu^{rel}. Neglecting CMB information on fNLf_{\rm NL} and scales k>0.03hk > 0.03 h/Mpc, we find that, if NνrelN_\nu^{\rm rel} is assumed to be known, the uncertainty on cosmological parameters increases the error on fNLf_{\rm NL} by 10 to 30% depending on the survey. Thus the fNLf_{\rm NL} constraint is remarkable robust to cosmological model uncertainties. On the other hand, if NνrelN_\nu^{\rm rel} is simultaneously constrained from the data, the fNLf_{\rm NL} error increases by 80\sim 80%. Finally, future surveys which provide a large sample of galaxies or galaxy clusters over a volume comparable to the Hubble volume can measure primordial non-Gaussianity of the local form with a marginalized 1--σ\sigma error of the order ΔfNL25\Delta f_{\rm NL} \sim 2-5, after combination with CMB priors for the remaining cosmological parameters. These results are competitive with CMB bispectrum constraints achievable with an ideal CMB experiment.Comment: 17 pages, 1 figure added, typos corrected, comments added, matches the published versio

    Higher serum immunoglobulin G3 levels may predict the development of multiple sclerosis in individuals with Clinically Isolated Syndrome

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    Clinically isolated syndrome (CIS) is a first episode of neurological symptoms that may precede a diagnosis of multiple sclerosis (MS). Therefore, studying individuals with CIS may lead to breakthroughs in understanding the development and pathogenesis of MS. In this study, serum levels of immunoglobulin (Ig)G, IgA, IgM, and IgG1–4 were measured in 20 people with CIS and compared with those in 10 healthy controls (HC) and 8 people with MS. Serum Ig levels in individuals with CIS were compared with (a) the time to their conversion from CIS to MS, (b) serum levels of antibodies to Epstein–Barr virus, (c) frequencies of T regulatory (Treg), T follicular regulatory (Tfr), and B cell subsets, and (d) Treg/Tfr expression of Helios. Serum IgG, IgM, and IgG2 levels were significantly lower in people with CIS than HC, and IgG, IgM, and IgG1 levels were significantly lower in people with CIS than MS. After adjusting for age, sex, and serum 25(OH) vitamin D3 [25(OH)D] levels, CIS was associated with lower serum levels of IgG and IgG2 compared with HC (p = 0.001 and p < 0.001, respectively). People with MS had lower IgG2 levels (p < 0.001) and IgG2 proportions (%IgG; p = 0.007) compared with HC. After adjusting for age, sex, and 25(OH)D, these outcomes remained, in addition to lower serum IgA levels (p = 0.01) and increased IgG3 levels (p = 0.053) in people with MS compared with HC. Furthermore, serum from people with MS had increased proportions of IgG1 and IgG3 (p = 0.03 and p = 0.02, respectively), decreased proportions of IgG2 (p = 0.007), and greater ratios of “upstream” to “downstream” IgG subclasses (p = 0.001) compared with HC. Serum IgG3 proportions (%IgG) from people with CIS correlated with the frequency of plasmablasts in peripheral blood (p = 0.02). Expression of Helios by Treg and Tfr cell subsets from individuals with CIS correlated with levels of serum IgG2 and IgG4. IgG3 levels and proportions of IgG3 (%IgG) in serum at CIS diagnosis were inversely correlated with the time until conversion to MS (p = 0.018 and p < 0.001, respectively), suggesting they may be useful prognostic markers of individuals with CIS who rapidly convert to MS

    The structure of oppositionality: Response disposition and situational aspects

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    Background: The Amsterdam Scale of Oppositionality (ASO) is a recently developed self-report instrument to measure the full range of oppositionality. It was used to test the assumption that oppositionality can best be conceptualized as a combination of emotions and behaviors varying across contexts, i.e., with parents, peers and authority figures. Method: The sample consisted of 560 boys and 598 girls, aged 8 to 12 years. The thirty items of the ASO, grouped in item parcels, were analyzed using confirmatory factor analyses. Results: Results confirmed the main hypothesis. The best fitting models contained strongly related emotional and behavioral factors and three mutually related situational factors. Oppositionality appeared to be to a large extent situation-specific. Girls are more affected by the situation than boys and show less oppositionality only outside the family context. Conclusions: Results are discussed with respect to the concept of oppositionality, varying expectations for interpersonal consequences, and implications for clinical assessment and studies of inter-informant reliability
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