10 research outputs found
Man and Society In The Works of Georges Duhamel
- Author
- Publication venue
- XULA Digital Commons
- Publication date
- 01/05/1958
- Field of study
Man and the circumstances influencing his activities have always interested Georges Duhamel. This concern developed from a profound desire to aid, to improve, and to cure the ills of mankind. Having become a physician, he was able to fulfill his wishes, particularly in his surgical experiences on the battle front where he treated thousands for all types of human miseries. [...] The aim of this study is to show the extent of Duhamel\u27s understanding of the society of his time considering man as the active participant in its formatio
Prolonged Application of High Fluid Shear to Chondrocytes Recapitulates Gene Expression Profiles Associated with Osteoarthritis
- Author
- AC Lin
- AI Saeed
- AM Valdes
- AR Amin
- C Karlsson
- C Su
- CH Kim
- CP Bramlage
- CR Scanzello
- CS Haas
- CT Appleton
- D Pfander
- DR Carter
- DR Carter
- F Al-Shahrour
- F Al-Shahrour
- F Zhu
- F Zhu
- Fei Zhu
- G Tardif
- H Greim
- H Yokota
- HA Kim
- HC Siow
- IB Hansen
- ID Welch
- J Meng
- JA Buckwalter
- JA Martin
- JP Abulencia
- JT Backman
- JY Liou
- K Ali
- Konstantinos Konstantopoulos
- LA Joosten
- M Kobayashi
- M Mohtai
- MA Pattoli
- Mary B. Goldring
- MB Goldring
- MB Goldring
- MB Goldring
- ML Tiku
- MS Lee
- MS Lee
- N Fukui
- N Jung
- N Yatsugi
- N Zayed
- NH Moritani
- Norman H. Lee
- O Ullrich
- OC Trifan
- P Wang
- P Wang
- PE Scherer
- Pu Wang
- Q Zhang
- R Gobezie
- S Dunn
- S Mahr
- S Mahr
- S Yamane
- SI Hu
- SM Dai
- SR Kim
- Sudha Agarwal
- T Aigner
- T Aigner
- T Aigner
- T Kitamura
- UC Nzeako
- WZ Wang
- YS Hsieh
- ZR Healy
- ZR Healy
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2010
- Field of study
BACKGROUND: Excessive mechanical loading of articular cartilage producing hydrostatic stress, tensile strain and fluid flow leads to irreversible cartilage erosion and osteoarthritic (OA) disease. Since application of high fluid shear to chondrocytes recapitulates some of the earmarks of OA, we aimed to screen the gene expression profiles of shear-activated chondrocytes and assess potential similarities with OA chondrocytes. METHODOLOGY/PRINCIPAL FINDINGS: Using a cDNA microarray technology, we screened the differentially-regulated genes in human T/C-28a2 chondrocytes subjected to high fluid shear (20 dyn/cm(2)) for 48 h and 72 h relative to static controls. Confirmation of the expression patterns of select genes was obtained by qRT-PCR. Using significance analysis of microarrays with a 5% false discovery rate, 71 and 60 non-redundant transcripts were identified to be ≥2-fold up-regulated and ≤0.6-fold down-regulated, respectively, in sheared chondrocytes. Published data sets indicate that 42 of these genes, which are related to extracellular matrix/degradation, cell proliferation/differentiation, inflammation and cell survival/death, are differentially-regulated in OA chondrocytes. In view of the pivotal role of cyclooxygenase-2 (COX-2) in the pathogenesis and/or progression of OA in vivo and regulation of shear-induced inflammation and apoptosis in vitro, we identified a collection of genes that are either up- or down-regulated by shear-induced COX-2. COX-2 and L-prostaglandin D synthase (L-PGDS) induce reactive oxygen species production, and negatively regulate genes of the histone and cell cycle families, which may play a critical role in chondrocyte death. CONCLUSIONS/SIGNIFICANCE: Prolonged application of high fluid shear stress to chondrocytes recapitulates gene expression profiles associated with osteoarthritis. Our data suggest a potential link between exposure of chondrocytes/cartilage to abnormal mechanical loading and the pathogenesis/progression of OA
Differential expression of the inflammation marker IL12p40 in the at-risk mental state for psychosis: a predictor of transition to psychotic disorder?
- Author
- A Stojanovic
- AP Morrison
- AS Brown
- B Oppmann
- BJ Miller
- C Pantelis
- CN Serhan
- CS Carter
- CS Gama
- D Baumeister
- David R. Cotter
- E Duvallet
- E Fernandez-Egea
- E Hjorth
- E O’Callaghan
- G. Paul Amminger
- GM Khandaker
- GP Amminger
- GP Amminger
- GP Amminger
- I Kelleher
- I Kelleher
- J Addington
- JR Hibbeln
- JW Carter
- L Witte de
- LJ Phillips
- LN Hayes
- Lorna M. Lopez
- M Cannon
- M Cannon
- M Ding
- M Haack
- Mary Cannon
- Melanie Föcking
- Miriam R. Schäfer
- MO Huttunen
- N Mossaheb
- Patrick D. McGorry
- Patrick Dicker
- PC Sham
- PD McGorry
- RA Kastelein
- RC Drexhage
- S Jazayeri
- SA Mednick
- SG Fillman
- SG Fillman
- SL Buka
- SR Clark
- Stefan Smesny
- TD Cannon
- TK Larsen
- U Ratnayake
- V Bergink
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Comparative growth rates of cultured marine dinoflagellates in the genus Symbiodinium and the effects of temperature and light
- Author
- A Jones
- A Jones
- A Klueter
- A Prieto
- A Solimeno
- AC Baker
- AF Little
- AM Wood
- Anke Klueter
- B Viswanath
- BP Carlin
- C Granados-Cifuentes
- CJS Bolch
- D Tchernov
- D Thornhill
- Dee A. Carter
- DJ Thornhill
- DL Spector
- DM Anderson
- E Diaz-Almeyda
- E Garces
- EM Sampayo
- ES McGinty
- Frederick I. Archer
- G De'ath
- H Freudenthal
- HJ Jeong
- HJ Jeong
- J Beardall
- JD Hackett
- JE Parkinson
- JE Parkinson
- Jennifer Trapani
- JM Hilbe
- KB Ritchie
- KE Fabricius
- L Tonk
- LE Graham
- LF Whitehead
- M Lesser
- M Stat
- M Stat
- M Takabayashi
- MA Coffroth
- Mary Alice Coffroth
- MD Johnson
- MR Nitschke
- N Atkinson
- NE Cantin
- NW Beckon
- O Hoegh-Guldberg
- P Bongaerts
- PR Frade
- R Berkelmans
- R Cunning
- R Cunning
- R Cunning
- R Cunning
- R Cunning
- R Guillard
- R Hill
- R Iglesias-Prieto
- R Rowan
- RA Kinzie
- RE Rodriguez-Martinez
- RI Figueroa
- S Hennige
- SA Fay
- SA Murray
- SA Wooldridge
- SA Wooldridge
- Shelby E. McIlroy
- SR Santos
- SR Santos
- ST Dyhrman
- SY Lee
- SY Lee
- TC LaJeunesse
- TC LaJeunesse
- TC LaJeunesse
- TC LaJeunesse
- TC LaJeunesse
- TC LaJeunesse
- TC LaJeunesse
- TF Cooper
- TJ Smayda
- W Karim
- W Leggat
- W Leggat
- WKW Loh
- WW Toller
- X Pochon
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
THERAPIES FOR CROHN'S DISEASE: a clinical update
- Author
- Afif W
- Akobeng AK
- Alfadhli AA
- Annese V
- Arora S
- Beaugerie L
- Benchimol EI
- Bernstein CN
- Best WR
- Borgaonkar M
- Camma C
- Carlos Walter SOBRADO
- Carter MJ
- Colombel JF
- Colombel JF
- Colombel JF
- Dignass A
- Feagan BG
- Feagan BG
- Ferguson A
- Fidder HH
- Flores C
- Hanauer SB
- Hanauer SB
- Hanauer SB
- Leal RF
- Lucas Faraco SOBRADO
- Lémann M
- Malchow H
- Mary JY
- Messori A
- Modigliani R
- O'Regan K
- Ordás I
- Otley A
- Oussalah A
- Panés J
- Pearson DC
- Podolsky DK
- Raquel Franco LEAL
- Rutgeerts P
- Sandborn WJ
- Sandborn WJ
- Sandborn WJ
- Sands BE
- Schnitzler F
- Seow CH
- Singleton JW
- Steinhart AH
- Steinhart AH
- Steinhart AH
- Summers RW
- Sutherland LR
- Targan SR
- Teixeira FV
- Thomsen O
- Ursing B
- Yajnik V
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Standing Dead Trees are a Conduit for the Atmospheric Flux of CH4 and CO2 from Wetlands
- Author
- A Hietala
- A Newton
- AA Raghoebarsing
- AE Zanne
- AH Sallenger Jr
- AM Helton
- AR McLeod
- Ashley M. Helton
- B Lehner
- CM Litton
- CM Poindexter
- CW Woodall
- D Bastviken
- DD Hook
- DD Hook
- DD Hook
- DI Sebacher
- DT Shindell
- E Matthews
- E McInerney
- EH Stanley
- EJW Visser
- F Keppler
- G Myhre
- GP Livingston
- H Brix
- H Rusch
- H Schütz
- I Vigano
- J Hansen
- JG Titus
- JG Zeikus
- JHC Cornelissen
- JL Morse
- Joseph C. White
- JP Chanton
- JWH Dacey
- K Lenhart
- K Machacova
- K Machacova
- K Terazawa
- KM Walter
- KN Garnet
- KR Covey
- KR Covey
- LJ Carter
- LK Smith
- M Ardón
- M Ardón
- M Saunois
- Mary Jane Carmichael
- MD Mattson
- ME Harmon
- ME Hauer
- MJ Carmichael
- MJ Carmichael
- R Needham
- RO Teskey
- S Gilbert
- S Kirschke
- S Pitz
- S Schwietzke
- S Vogel
- SR Pangala
- SR Pangala
- SW Pacala
- T DelSontro
- TT Kozlowski
- TT Yates
- V Gauci
- WE Clements
- WH Schlesinger
- William K. Smith
- Y Pan
- Z-P Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Changes in Exposure to Neighborhood Characteristics are Associated with Sexual Network Characteristics in a Cohort of Adults Relocating from Public Housing
- Author
- A Bickford
- A Neaigus
- A Nunn
- A Zuberi
- AA Adimora
- AA Adimora
- AA Adimora
- AA Adimora
- AA Adimora
- AA Adimora
- AA Adimora
- AA Adimora
- AA Al-Tayyib
- Adaora Adimora
- AE Rudolph
- AM Curley
- AS Johnson
- BP Stoner
- C Cubbin
- C Williams
- CA Latkin
- CA Latkin
- Carlos del Rio
- CD Pilcher
- CL Mattson
- CM Fichtenberg
- Conny Chen Karnes
- D Cohen
- D Massey
- D Massey
- D Oakley
- DA Cohen
- DA Wagstaff
- Danielle F. Haley
- DC Jarlais
- DD Bohl
- DD Hallfors
- DK Smith
- E Digenis-Bury
- EG Goetz
- Emily F. Dauria
- EO Laumann
- ER Pouget
- EW Fiebig
- FL Sonenstein
- G Kline
- GC Galster
- Gina Wingood
- Hannah L. F. Cooper
- HL Cooper
- HL Cooper
- HL Cooper
- HW Chesson
- IA Doherty
- J Kling
- JA Bauermeister
- JA Hoffman
- JC Thomas
- JC Thomas
- JC Thomas
- JC Thomas
- JDWJB Singer
- JE Rosenbaum
- JL Ford
- JL Ford
- JM Ellen
- JM Jennings
- JM Jennings
- Josalin Hunter-Jones
- K Tanfer
- KB Biello
- KH Reilly
- KJ Sikkema
- KJ Sikkema
- KP Theall
- Kristen K. Renneker
- L Keating
- L Ku
- L Orr
- LB Finer
- LH Spence
- LM Friedman
- Loida E. Bonney
- M Davey-Rothwell
- M Guttentag
- M Javanbakht
- M Morris
- Mary E. Kelley
- MH Schill
- MH Schill
- MJ Wawer
- MR Khan
- MS Kaplan
- MT Fullilove
- N Denton
- N Krieger
- P Du
- P Seth
- R Crosby
- R Dembo
- R Rothenberg
- RA Crosby
- RC Fauth
- RC Fauth
- RC Neblett
- Richard Rothenberg
- RJ Sampson
- RM Gindi
- S Clampet-Lundquist
- S Galea
- S Greenbaum
- S Popkin
- S Popkin
- S Popkin
- S Popkin
- S Popkin
- S Zierler
- Sabriya Linton
- SM Grieb
- SM Rogers
- SM Rogers
- SR Friedman
- SR Friedman
- SR Friedman
- T Leventhal
- T Rhodes
- TC Green
- TE Perlis
- TL Osypuk
- WH Carter
- YO Ferguson
- YP Springer
- Z Gant
- Zev Ross
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Ecologic and cross-sectional multilevel analyses suggest that characteristics of the places where people live influence their vulnerability to HIV and other sexually-transmitted infections (STIs). Using data from a predominately substance-misusing cohort of African-American adults relocating from US public housing complexes, this multilevel longitudinal study tested the hypothesis that participants who experienced greater post-relocation improvements in economic disadvantage, violent crime, and male:female sex ratios would experience greater reductions in perceived partner risk and in the odds of having a partner who had another partner (i.e., indirect concurrency). Baseline data were collected from 172 public housing residents before relocations occurred; three waves of post-relocation data were collected every nine months. Participants who experienced greater improvements in community violence and in economic conditions experienced greater reductions in partner risk. Reduced community violence was associated with reduced indirect concurrency. Structural interventions that decrease exposure to violence and economic disadvantage may reduce vulnerability to HIV/STIs
Coordinated dysregulation of cancer progression by the HER family and p21-activated kinases
- Author
- A Berger
- A Chatterjee
- A Nagelkerke
- AE Gururaj
- AH Brunner
- AL Schechter
- Aswathy Mary Paul
- B Linggi
- B Rafn
- B Sánchez-Solana
- Bijesh George
- BL Parker
- C Curtis
- C Haslekås
- C Holm
- C Montero-Conde
- C Ndubaku
- C Sweeney
- C-F Tsai
- CC Ong
- CH Kugel 3rd
- CJ Barnes
- CR King
- D Araiza-Olivera
- D Li
- D Matthaios
- D Yeo
- D-J Kim
- D-Q Li
- DF Stern
- DJ Slamon
- DM Brix
- E Cerami
- E Manser
- EA Pérez-Yépez
- EL Bradshaw-Pierce
- F Li
- FE Jones
- G Abril-Rodriguez
- G Carpenter
- G Carpenter
- G Millan-Zambrano
- G Pines
- G Zhu
- GB Mills
- GD Plowman
- GD Plowman
- H Brustmann
- H Qing
- H Waterman
- HS Earp 3rd
- HS Wiley
- J Baselga
- J Baulida
- J Chen
- J Gan
- J Gao
- J Mendelsohn
- J Mendelsohn
- J Mendelsohn
- J Roig
- J Rudolph
- J Zhu
- J-L Thomas
- JG Paez
- JP Robichaux
- K Ohshiro
- K Semba
- K Walsh
- K Wang
- K Zhang
- KD Carey
- KM Ferguson
- L Adam
- L Adam
- L Adam
- L Fattore
- LA Puto
- LE Arias-Romero
- LE Arias-Romero
- LM Heiser
- M Babagana
- M Kaneko
- M Motwani
- M Pietilä
- M Zhang
- M-H Park
- M-K Chen
- M. Radhakrishna Pillai
- MC Hung
- MG Callow
- MH Kraus
- MJ van de Vijver
- MJ Van de Vijver
- MKY Siu
- ML Galisteo
- MM Morrison
- N Huynh
- N Li
- NM Pedersen
- O Villamar Cruz
- OA Sedelnikova
- OV Cruz
- P Carter
- P Oladimeji
- P Oladimeji
- P Peschard
- PR Molli
- PR Molli
- Q Ding
- Q Meng
- R Bagheri-Yarmand
- R Bagheri-Yarmand
- R Goldman
- R Herr
- R Kumar
- R Kumar
- R Kumar
- R Kumar
- R Kumar
- R Kumar
- R Kumar
- R Kumar
- R Kumar
- R Kumar
- R Kumar
- R Kumar
- R Kumar
- R Lupu
- R Tharakan
- R-A Wang
- R-A Wang
- R-A Wang
- Rakesh Kumar
- Ravikumar Amjesh
- RB Jones
- RK Vadlamudi
- RK Vadlamudi
- RK Vadlamudi
- RK Vadlamudi
- RR Singh
- S Balasenthil
- S Bekri
- S Cohen
- S Cohen
- S Cotteret
- S Ghosh
- S He
- S Wang
- S-U Moon
- SE Wang
- SJ Advani
- SK Rayala
- SK Rayala
- SP Kennedy
- SR Lee
- T Chen
- T Kawamoto
- T Wada
- V Korobeynikov
- VC Jordan
- W Gong
- W Long
- W Zhou
- WX Schulze
- X Li
- Y Chang
- Y Jiang
- Y Li
- Y Liu
- Y Shrestha
- Y Ueda
- Z Wang
- Z Yang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Mapping the human genetic architecture of COVID-19
- Author
- Abdelrazik M
- Abdullah T
- Abe R
- Abe S
- Abecasis GR
- Abel L
- Abernathy C
- Abraheem A
- Abul-Husn NS
- Acosta-Herrera M
- Acquilini D
- Acquilini D
- Adachi T
- Adachi Y
- Adams C
- Adams K
- Adanini O
- Adeleye O
- Adeniji K
- Adra D
- Afifi N
- Afilalo J
- Afilalo M
- Afolabi D
- Afrasiabi Z
- Afset JE
- Agasou A
- Aghemo A
- Agranoff D
- Agrawal S
- Aguirre LA
- Agwuh K
- Ahmad HF
- Ahmad N
- Ahmed A
- Ahmed C
- Ahmed KA
- Ai M
- Ail D
- Akeroyd L
- Akhtar MN
- Akhtar S
- Akinkugbe O
- Aksentijevich A
- Al Thani A
- Al-Muftah W
- Al-Sarraj Y
- Alarcon C
- Alarcon-Riquelme ME
- Alasdair F
- Alaverdian D
- Alavere H
- Albertos R
- Albillos A
- Albrecht W
- Albrich W
- Albrich WC
- Aldera EL
- Aldridge J
- Alegria A
- Alex B
- Alexander P
- Alfonso J
- Algera AG
- Ali A
- Ali IMA
- Ali S
- Aliberti S
- Allan A
- Allan E
- Allan J
- Alldis Z
- Allen L
- Allen S
- Allibone S
- Allison KS
- Allos R
- Ally SM
- Almaden-Boyle C
- Altabaibeh A
- Altmueller J
- Alvaro A
- Amar D
- Amin V
- Amitrano S
- Amiya S
- Ampuero J
- Anan R
- Anania S
- Anastasescu E
- Anderson F
- Anderson J
- Anderson M
- Anderson P
- Anderson S
- Anderson S
- Anderson T
- Ando A
- Andolfo I
- Andrade V
- Andretta F
- Andreucci E
- Andreucci E
- Andrew A
- Andrew B
- Andrew G
- Andrews E
- Andrews SJ
- Andrews SJ
- Andrews SJ
- Andrews SJ
- Andrikopoulos P
- Anedda F
- Aneli S
- Anemoli V
- Angelini C
- Angus B
- Annis A
- Antcliffe D
- Antinori A
- Antoni MD
- Anumakonda V
- Anwar M
- Anzai T
- Apetri E
- Arai D
- Arana E
- Arbane G
- Archer K
- Arciero E
- Arden T
- Arias SS
- Arif S
- Arimura K
- Armstrong J
- Armstrong JA
- Armstrong L
- Armstrong R
- Arning N
- Arnold S
- Arora J
- Artuso R
- Arumugam P
- Asakura T
- Asano K
- Aschard H
- Ascolillo S
- Ashish A
- Ashley E
- Ashraf S
- Ashraf S
- Ashton L
- Ashworth M
- Asiimwe IG
- Aslibekyan S
- Asselta R
- Atanasovska B
- Atkinson D
- Atkinson EG
- Attwood B
- Aucella F
- Augustin M
- Auld D
- Auld F
- Austin K
- Austin P
- Auton A
- Auton A
- Avendano-Ortiz J
- Awano N
- Ayers A
- Azarzar S
- Aziz F
- Azuma M
- Azuure C
- Azzolini E
- Baba R
- Baba T
- Bach B
- Bacher P
- Bachetti T
- Badalamenti S
- Badia JR
- Badji RM
- Bahmer T
- Baikady RR
- Baillie JK
- Baillie JK
- Baillie JK
- Baillie JK
- Baines B
- Baines D
- Baines K
- Baird T
- Baird Y
- Bakshi S
- Bakthavatsalam D
- Balaconis MK
- Baldassarri M
- Baldini M
- Ball CA
- Bals R
- Baltzell AH
- Bamford A
- Bamford P
- Banach D
- Banagan J
- Banales JM
- Bancroft H
- Band G
- Bandera A
- Bandini M
- Bandla N
- Bano S
- Baptista D
- Barada O
- Baras A
- Baratti S
- Barber R
- Barbieri C
- Barbieri C
- Barbour A
- Barclay L
- Barclay WS
- Barda B
- Bargagli E
- Bari S
- Barker J
- Barlow G
- Barlow SL
- Barnass S
- Barnes KC
- Baroni S
- Baroni S
- Barreira A
- Barrett F
- Barrett KMS
- Barrett N
- Barron A
- Barry P
- Bartels M
- Bartley S
- Baruah R
- Baselli G
- Bashyal A
- Basikolo C
- Bassetti M
- Bassford C
- Basso MEF
- Bastion V
- Basude S
- Bates H
- Bates M
- Battle C
- Bauchmuller K
- Bax D
- Baxter D
- Baxter N
- Baya N
- Bayo L-A
- Beadle J
- Beadsworth M
- Beale R
- Bean S
- Beaumont K
- Beavis S
- Beck A
- Beckmann ND
- Beech E
- Beech V
- Beekes M
- Beesley K
- Begg C
- Beguin Y
- Behan T
- Beith CM
- Belagodu Z
- Belbin GM
- Belfield H
- Belhaj Y
- Beligni G
- Belisle A
- Bell D
- Bell G
- Bell M
- Bellamy M
- Belli MA
- Bellinghausen C
- Bellini A
- Bellwood R
- Below JE
- Bemand T
- Benetti E
- Benham L
- Bennet D
- Bennett S
- Bentley M
- Benyon S
- Beppu S
- Beranova E
- Bercades G
- Bergan J
- Bergantini L
- Berger MM
- Bergomi M
- Bergomi P
- Berkowitz N
- Bernardo D
- Bernasconi A
- Bernatoniene J
- Berridge J
- Bertrand A
- Best N
- Bettini LR
- Beudel M
- Bevan E
- Bewley J
- Bhardwaj N
- Bhatia N
- Bhatterjee R
- Bhuie P
- Bi R
- Bianchi F
- Bianco C
- Bibert S
- Bibert S
- Bibi F
- Biddle J
- Biesecker L
- Biggs H
- Biondi A
- Birch J
- Birch J
- Birch S
- Birchall K
- Birchall K
- Bird S
- Birkinshaw I
- Birney E
- Birt M
- Biscarini F
- Black E
- Black K
- Blackledge B
- Blackledge B
- Blackman H
- Blakemore H
- Blanco-Grau A
- Blasi F
- Blay N
- Blay N
- Blow S
- Blunt M
- Boada M
- Board S
- Bocciardi R
- Bocciolone M
- Bochud M
- Bochud P-Y
- Bochud PY
- Bochud PY
- Bochud PY
- Bociek A
- Boer C
- Boezen M
- Bogaard HJ
- Bogaert D
- Boillat N
- Boillat-Blanco N
- Bokhari M
- Bolton M
- Bolton R
- Bolze A
- Bombace S
- Bomers M
- Bonfanti P
- Bonner S
- Bonta PI
- Booker L
- Booth L
- Booth S
- Borislavova B
- Borra C
- Bos L
- Bosari S
- Bosio G
- Bosse Y
- Botello A
- Bothma P
- Botta G
- Botta M
- Boua PR
- Bouab M
- Bough L
- Boughton AP
- Boujemla B
- Bouras K
- Boutros P
- Bouysran Y
- Bowes A
- Bowles R
- Boyle P
- Boyle R
- Boz C
- Bradford Y
- Bradley C
- Bradley P
- Bradley-Potts J
- Bradshaw Z
- Brady A
- Brady M
- Brady R
- Brahier T
- Brandwood C
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- Wilson JF
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- Winnard S
- Winter-Goodwin B
- Wiselka M
- Wittig M
- Witzke O
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- Wolford B
- Wolford B
- Wolterman RA
- Wolverson A
- Wong J
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- Wood H-L
- Wood S
- Wood T
- Woodford C
- Woodruff M
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- Woodyatt W
- Woolley AE
- Wooton DG
- Working UCLAHATLASDM
- Workman A
- Worner R
- Worsley L
- Wouters D
- Wozniak H
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- Wright J
- Wright M
- Wrobel N
- Wrobel N
- Wu Y
- Wulandari R
- Wyllie DH
- Wynter I
- Xavier K
- Xue X
- Yadav A
- Yagi K
- Yamada M
- Yamada Y
- Yamagata K
- Yamasaki M
- Yang G
- Yang J
- Yang Z
- Yaspan B
- Yasui Y
- Yates B
- Yates B
- Yatomi M
- Ye C
- Yengo L
- Yermakovich D
- Yi X
- Yonekawa A
- Yoon H
- Yoon KJ
- Yoshida K
- Yoshida S
- Yoshida S
- Yoshida T
- Yoshihara T
- Yoshiya K
- Yoshiyama T
- Youlton N
- Younes SE
- Young P
- Yun N
- Zak A
- Zaki A
- Zambon M
- Zamikula J
- Zanella A
- Zanella I
- Zanelli G
- Zara F
- Zara F
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- Zarate R
- Zborowski AC
- Zeberg H
- Zechner M
- Zechner M
- Zguro K
- Zhai R
- Zhang JE
- Zhang M
- Zhao JH
- Zhen J
- Zheng C
- Zheng T
- Zhou W
- Zhou W
- Zhu W
- Zitter L
- Zlatopolsky M
- Zoller H
- Zollner S
- Zongo O
- zu Bentrup FM
- Zucchi P
- Zwinderman AHK
- Zyndorf M
- Publication venue
- Publication date
- 01/01/2021
- Field of study
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3,4,5,6,7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease
EphA3 biology and cancer
- Author
- Adams RH
- Adams RH
- Andrew M. Scott
- Aoki M
- Arruga F
- Ashton JM
- Balakrishnan A
- Bao B
- Barcellos-de-Souza P
- Bardelli A
- Bea S
- Bianco P
- Binda E
- Birgbauer E
- Bonifaci N
- Bosco MC
- Boyd AW
- Boyd AW
- Brantley-Sieders DM
- Brantley-Sieders DM
- Brennaman LH
- Bush JO
- Caivano A
- Carter N
- Casey J
- Castellani CA
- Chang L-C
- Charmsaz S
- Chen J
- Chen J
- Cheng HJ
- Chiappalupi S
- Chiari R
- Choi Y
- Christopher I. Slape
- Clifford N
- Connor RJ
- Cooke JE
- Corbo V
- Cortina C
- Davies H
- Davis S
- Davis TL
- Day B
- Day BW
- Day BW
- Ding L
- Ding L
- Dobrzanski P
- Dottori M
- Durbin L
- Easty DJ
- Easty DJ
- Elowe S
- Fawcett JP
- Finger C
- Foo SS
- Fournier MV
- Fox BP
- Frieden LA
- Gallarda BW
- Gerety SS
- Gerety SS
- Greene AC
- Guan M
- Hattori M
- Herath NI
- Hess AR
- Himanen JP
- Himanen JP
- Himanen JP
- Hinoue T
- Holland SJ
- Holmberg J
- Hou F
- Hu T
- Huang J
- Huang X
- Iacobucci I
- Iwamasa H
- Janes PW
- Janes PW
- Janes PW
- Janes PW
- Jorgensen C
- Julien SG
- Kahn J
- Kalluri R
- Keane N
- Kilpatrick TJ
- Kilpinen S
- Kullander K
- Kumar SR
- Lackmann M
- Lackmann M
- Lackmann M
- Lakmali Atapattu
- Lawrenson ID
- Leone M
- Li W
- Lisabeth EM
- Lu C
- Mani SA
- Marie-Egyptienne DT
- Mary E. Vail
- Medici D
- Nievergall E
- Nievergall E
- Noren NK
- Noren NK
- Oates AC
- Ogawa K
- Palath V
- Park IH
- Pasquale EB
- Pasquale EB
- Peter W. Janes
- Poliakov A
- Polyak K
- Puente XS
- Qin H
- Rae H. Farnsworth
- Reiss K
- Ross JS
- Ruiz JC
- Salaita K
- Seiradake E
- Shintani T
- Singh AP
- Sjoblom T
- Smith FM
- Smith LM
- Solanas G
- Soverini S
- Stapleton D
- Stein E
- Stein E
- Stephen LJ
- Stubbs J
- Talks KL
- Ting MJ
- Tognolini M
- Tsai CC
- Tsai CC
- Vail ME
- Valsesia A
- Vearing C
- Vecchi M
- Vindis C
- Walker BA
- Wang HU
- Welch JS
- Wiesner S
- Wimmer-Kleikamp SH
- Wimmer-Kleikamp SH
- Wood LD
- Wu Q
- Wybenga-Groot LE
- Xi H-Q
- Xi H-Q
- Yuan W
- Zeisberg EM
- Zelinski DP
- Zhao H
- Zhong TP
- Zhuang G
- Zhuang G
- Ziebarth JD
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study