178 research outputs found

    Fatal poisoning by ingestion of a self‑prepared oleander leaf infusion

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    An unusual case of poisoning by the ingestion of oleander leaves is reported. A 71 year old male laboratory technician committed suicide at home in this unusual manner. At the death scene a steel pan and other paraphernalia, used for the extraction of oleandrin and other cardiac glycosides from the leaves of the Nerium oleander plant were found. Toxicological investigations for oleandrin, oleandrigenin, neritaloside, and odoroside were performed by LC–MS/MS on all biological samples (peripheral blood, vitreous humor, urine, liver, gastric contents) and on the yellow infusion found at the death scene. In all samples, toxic levels of oleandrin were detected (blood 37.5 ng/mL, vitreous humor 12.6 ng/mL, urine 83.8 ng/mL, liver 205 ng/mg, gastric content 31.2 ”g/mL, infusion 38.5 ”g/mL). Qualitative results for oleandrigenin, neritaloside, and odoroside were obtained. Oleandrigenin was present in all tissue samples whereas neritaloside and odoroside were absent in the blood and vitreous humor but present in urine, liver, gastric content, and in the leaf brew. The purpose of this study was the identifcation of oleandrin and its congener oleandrigenin, detected in the vitreous humor. The blood/vitreous humor ratio was also calculated in order to assess of the likely time interval from ingestion to death. According to the toxicological results death was attributed to fatal arrhythmia due to oleander intoxication. The manner of death was classifed as suicide through the ingestion of the infusion

    Fatal poisoning by ingestion of a self-prepared oleander leaf infusion

    Get PDF
    An unusual case of poisoning by the ingestion of oleander leaves is reported. A 71 year old male laboratory technician committed suicide at home in this unusual manner. At the death scene a steel pan and other paraphernalia, used for the extraction of oleandrin and other cardiac glycosides from the leaves of the Nerium oleander plant were found. Toxicological investigations for oleandrin, oleandrigenin, neritaloside, and odoroside were performed by LC–MS/MS on all biological samples (peripheral blood, vitreous humor, urine, liver, gastric contents) and on the yellow infusion found at the death scene. In all samples, toxic levels of oleandrin were detected (blood 37.5 ng/mL, vitreous humor 12.6 ng/mL, urine 83.8 ng/mL, liver 205 ng/mg, gastric content 31.2 ÎŒg/mL, infusion 38.5 ÎŒg/mL). Qualitative results for oleandrigenin, neritaloside, and odoroside were obtained. Oleandrigenin was present in all tissue samples whereas neritaloside and odoroside were absent in the blood and vitreous humor but present in urine, liver, gastric content, and in the leaf brew. The purpose of this study was the identification of oleandrin and its congener oleandrigenin, detected in the vitreous humor. The blood/vitreous humor ratio was also calculated in order to assess of the likely time interval from ingestion to death. According to the toxicological results death was attributed to fatal arrhythmia due to oleander intoxication. The manner of deathwas classified as suicide through the ingestion of the infusion

    Early gut microbiota signature of aGvHD in children given allogeneic hematopoietic cell transplantation for hematological disorders

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    The onset of acute Graft-versus-Host Disease (aGvHD) has been correlated with the gut microbiota (GM) composition, but experimental observations are still few, mainly involving cohorts of adult patients. In the current scenario where fecal microbiota transplantation has been used as a pioneer therapeutic approach to treat steroid-refractory aGvHD, there is an urgent need to expand existing observational studies of the GM dynamics in Hematopoietic Stem Cell Transplantation (HSCT). Aim of the present study is to explore the GM trajectory in 36 pediatric HSCT recipients in relation to aGvHD onset

    Creazione di una stazione di previsione degli eventi di Marrobbio da installare nel porto peschereccio di Mazara del Vallo

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    Il presente rapporto riporta le attivitĂ  svolte ed i risultati ottenuti in seno al Progetto “Creazione di una stazione di previsione degli eventi di Marrobbio da installare nel porto peschereccio di Mazara del Vallo” (Progetto cod. 1999.IT.16.1.PO.011/4.17b/8.3.7/0082 sottomisura 4.17 b POR Sicilia 2000-2006 Asse 4 – Sistemi Locali di Sviluppo) approvato e finanziato dall’Assessorato Regionale alla Cooperazione, Commercio, Artigianato e Pesca.Grazie a tale Progetto Ăš stato realizzato un sistema di monitoraggio del livello del mare e della pressione atmosferica proprio per verificare le ipotesi sul meccanismo di generazione del fenomeno “Marrobbio”, formulate da studi precedenti. Il fenomeno del Marrobbio si manifesta nell’area di Mazara del Vallo attraverso una veloce variazione del livello del mare che in taluni episodi puĂČ raggiungere circa 1.5 m di escursione. Lo studio condotto ha permesso di verificare l’ipotesi che il Marrobbio possa essere generato da salti di pressione in moto veloce in atmosfera

    Results from the first use of low radioactivity argon in a dark matter search

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    Liquid argon is a bright scintillator with potent particle identification properties, making it an attractive target for direct-detection dark matter searches. The DarkSide-50 dark matter search here reports the first WIMP search results obtained using a target of low-radioactivity argon. DarkSide-50 is a dark matter detector, using two-phase liquid argon time projection chamber, located at the Laboratori Nazionali del Gran Sasso. The underground argon is shown to contain Ar-39 at a level reduced by a factor (1.4 +- 0.2) x 10^3 relative to atmospheric argon. We report a background-free null result from (2616 +- 43) kg d of data, accumulated over 70.9 live-days. When combined with our previous search using an atmospheric argon, the 90 % C.L. upper limit on the WIMP-nucleon spin-independent cross section based on zero events found in the WIMP search regions, is 2.0 x 10^-44 cm^2 (8.6 x 10^-44 cm^2, 8.0 x 10^-43 cm^2) for a WIMP mass of 100 GeV/c^2 (1 TeV/c^2 , 10 TeV/c^2).Comment: Accepted by Phys. Rev.

    FRCSyn Challenge at WACV 2024:Face Recognition Challenge in the Era of Synthetic Data

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    Despite the widespread adoption of face recognition technology around the world, and its remarkable performance on current benchmarks, there are still several challenges that must be covered in more detail. This paper offers an overview of the Face Recognition Challenge in the Era of Synthetic Data (FRCSyn) organized at WACV 2024. This is the first international challenge aiming to explore the use of synthetic data in face recognition to address existing limitations in the technology. Specifically, the FRCSyn Challenge targets concerns related to data privacy issues, demographic biases, generalization to unseen scenarios, and performance limitations in challenging scenarios, including significant age disparities between enrollment and testing, pose variations, and occlusions. The results achieved in the FRCSyn Challenge, together with the proposed benchmark, contribute significantly to the application of synthetic data to improve face recognition technology.Comment: 10 pages, 1 figure, WACV 2024 Workshop
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