SiL: An Approach for Adjusting Applications to Heterogeneous Systems Under Perturbations

Scientific applications consist of large and computationally-intensive loops. Dynamic loop scheduling (DLS) techniques are used to load balance the execution of such applications. Load imbalance can be caused by variations in loop iteration execution times due to problem, algorithmic, or systemic characteristics (also, perturbations). The following question motivates this work: "Given an application, a high-performance computing (HPC) system, and both their characteristics and interplay, which DLS technique will achieve improved performance under unpredictable perturbations?" Existing work only considers perturbations caused by variations in the HPC system delivered computational speeds. However, perturbations in available network bandwidth or latency are inevitable on production HPC systems. Simulator in the loop (SiL) is introduced, herein, as a new control-theoretic inspired approach to dynamically select DLS techniques that improve the performance of applications on heterogeneous HPC systems under perturbations. The present work examines the performance of six applications on a heterogeneous system under all above system perturbations. The SiL proof of concept is evaluated using simulation. The performance results confirm the initial hypothesis that no single DLS technique can deliver best performance in all scenarios, while the SiL-based DLS selection delivered improved application performance in most experiments

Reaction rate for S31(p,)32Cl and its influence on the SiP cycle in hot stellar hydrogen burning

The excitation energies of the proton unbound states in Cl32 have been measured in the S32(3He,t)32Cl charge exchange reaction with high accuracy. The partial widths of the unbound levels have been calculated to derive the resonance strengths of these states in the S31(p,)32Cl reaction channel. The reaction rate for the S31(p,)32Cl reaction has been calculated and is compared with previous estimates. The role of this reaction for the closure of the SiP cycle is discussed in terms of the temperature and density conditions in hot stellar hydrogen burning

Quantum walks: a comprehensive review

Quantum walks, the quantum mechanical counterpart of classical random walks, is an advanced tool for building quantum algorithms that has been recently shown to constitute a universal model of quantum computation. Quantum walks is now a solid field of research of quantum computation full of exciting open problems for physicists, computer scientists, mathematicians and engineers. In this paper we review theoretical advances on the foundations of both discrete- and continuous-time quantum walks, together with the role that randomness plays in quantum walks, the connections between the mathematical models of coined discrete quantum walks and continuous quantum walks, the quantumness of quantum walks, a summary of papers published on discrete quantum walks and entanglement as well as a succinct review of experimental proposals and realizations of discrete-time quantum walks. Furthermore, we have reviewed several algorithms based on both discrete- and continuous-time quantum walks as well as a most important result: the computational universality of both continuous- and discrete- time quantum walks.Comment: Paper accepted for publication in Quantum Information Processing Journa

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362