Federated Space-Time Query for Earth Science Data Using OpenSearch Conventions

This slide presentation reviews a Space-time query system that has been developed to assist the user in finding Earth science data that fulfills the researchers needs. It reviews the reasons why finding Earth science data can be so difficult, and explains the workings of the Space-Time Query with OpenSearch and how this system can assist researchers in finding the required data, It also reviews the developments with client server systems

Religion as practices of attachment and materiality: the making of Buddhism in contemporary London

This article aims to explore Buddhism’s often-overlooked presence on London’s urban landscape, showing how its quietness and subtlety of approach has allowed the faith to grow largely beneath the radar. It argues that Buddhism makes claims to urban space in much the same way as it produces its faith, being as much about the practices performed and the spaces where they are enacted as it is about faith or beliefs. The research across a number of Buddhist sites in London reveals that number of people declaring themselves as Buddhists has indeed risen in recent years, following the rise of other non-traditional religions in the UK; however, this research suggests that Buddhism differs from these in several ways. Drawing on Baumann’s (2002) distinction between traditionalist and modernist approaches to Buddhism, our research reveals a growth in each of these. Nevertheless, Buddhism remains largely invisible in the urban and suburban landscape of London, adapting buildings that are already in place, with little material impact on the built environment, and has thus been less subject to contestation than other religious movements and traditions. This research contributes to a growing literature which foregrounds the importance of religion in making contemporary urban and social worlds

Earth Science Markup Language: A Solution for Generic Access to Heterogeneous Data Sets

The Earth Science community is processing and analyzing a large amount and variety of data. These data are generally stored in different data formats, which forces the scientists to spend a significant amount of time in writing specialized, data format specific readers. However, this preprocessing burden can by alleviated by using the Earth Science Markup Language (ESML). ESML is a specialized markup language for Earth Science metadata. Based on the eXtensible Markup Language (XMLTM), ESML allows data descriptions to be written in a standard fashion

Earth Science Markup Language: A Solution for Generic Access to Heterogeneous Data Sets

The Earth Science community is processing and analyzing a large amount and variety of data. These data are generally stored in different data formats, which forces the scientists to spend a significant amount of time in writing specialized, data format specific readers. However, this preprocessing burden can by alleviated by using the Earth Science Markup Language (ESML). ESML is a specialized markup language for Earth Science metadata. Based on the eXtensible Markup Language (XMLTM), ESML allows data descriptions to be written in a standard fashion

A whole-grain cereal-rich diet increases plasma betaine, and tends to decrease total and LDL-cholesterol compared with a refined-grain diet in healthy subjects

Epidemiological studies have repeatedly found that whole-grain (WG) cereal foods reduce the risk of several lifestyle-related diseases, though consistent clinical outcomes and mechanisms are elusive. To compare the effects of a WG-rich diet with a matched refined-grain (RG) diet on plasma biomarkers and bowel health parameters, seventeen healthy subjects (eleven females and six males) completed an exploratory cross-over study with a 2-week intervention diet based on either WG- or RG-based foods, separated by a washout of at least 5 weeks. Both diets were the same except for the use of WG (150g/d) or RG foods. Subjects undertook a 4h postprandial challenge on day 8 of each intervention diet. After 2 weeks, the WG diet tended to decrease plasma total and LDL-cholesterol (both P=0·09), but did not change plasma HDL-cholesterol, fasting glucose, C-reactive protein or homocysteine compared with the RG diet. Plasma betaine and alkylresorcinol concentrations were elevated after 1 week of the WG diet (P=0·01 and P<0·0001, respectively). Clostridium leptum populations in faeces were increased after the WG diet, along with a trend for decreased faecal water pH (P=0·096) and increased stool frequency (P<0·0001) compared with the RG diet. A short controlled intervention trial with a variety of commercially available WG-based products tended to improve biomarkers of CVD compared with a RG diet. Changes in faecal microbiota related to increased fibre fermentation and increased plasma betaine concentrations point to both fibre and phytochemical components of WG being important in mediating any potential health effect

EARTH SCIENCE MARKUP LANGUAGE

The Earth Science community is the processing and analyzing large amount and variety of data from space and ground-based observations and from models. These data are generally stored in physical media with different data formats. This large variety of data formats forces the scientists to spend significant amount of time in writing specialized data format specific, readers before their analysis can even begin. Formats for Earth Science data can be as simple as ASCII and binary formats or be as complex as Hierarchical Data Format (HDF) and HDF Earth Observing System (HDF-EOS) formats. In this paper, we introduce the Earth Science Markup Language (ESML), being currently developed at the Information Technology and Systems Center at the University of Alabama in Huntsville. ESML would make applications independent of data formats and facilitate easier searches for data via internet search engine. Primary purpose of this paper is to bring ESML to the attention of data consumers and producers, and invite comments and suggestions

EARTH SCIENCE MARKUP LANGUAGE

The Earth Science community is the processing and analyzing large amount and variety of data from space and ground-based observations and from models. These data are generally stored in physical media with different data formats. This large variety of data formats forces the scientists to spend significant amount of time in writing specialized data format specific, readers before their analysis can even begin. Formats for Earth Science data can be as simple as ASCII and binary formats or be as complex as Hierarchical Data Format (HDF) and HDF Earth Observing System (HDF-EOS) formats. In this paper, we introduce the Earth Science Markup Language (ESML), being currently developed at the Information Technology and Systems Center at the University of Alabama in Huntsville. ESML would make applications independent of data formats and facilitate easier searches for data via internet search engine. Primary purpose of this paper is to bring ESML to the attention of data consumers and producers, and invite comments and suggestions

Human Recombinant Alkaline Phosphatase (Ilofotase Alfa) Protects Against Kidney Ischemia-Reperfusion Injury in Mice and Rats Through Adenosine Receptors

Adenosine triphosphate (ATP) released from injured or dying cells is a potent pro-inflammatory “danger” signal. Alkaline phosphatase (AP), an endogenous enzyme that de-phosphorylates extracellular ATP, likely plays an anti-inflammatory role in immune responses. We hypothesized that ilofotase alfa, a human recombinant AP, protects kidneys from ischemia-reperfusion injury (IRI), a model of acute kidney injury (AKI), by metabolizing extracellular ATP to adenosine, which is known to activate adenosine receptors. Ilofotase alfa (iv) with or without ZM241,385 (sc), a selective adenosine A2A receptor (A2AR) antagonist, was administered 1 h before bilateral IRI in WT, A2AR KO (Adora2a–/–) or CD73–/– mice. In additional studies recombinant alkaline phosphatase was given after IRI. In an AKI-on-chronic kidney disease (CKD) ischemic rat model, ilofotase alfa was given after the three instances of IRI and rats were followed for 56 days. Ilofotase alfa in a dose dependent manner decreased IRI in WT mice, an effect prevented by ZM241,385 and partially prevented in Adora2a–/– mice. Enzymatically inactive ilofotase alfa was not protective. Ilofotase alfa rescued CD73–/– mice, which lack a 5′-ectonucleotidase that dephosphorylates AMP to adenosine; ZM241,385 inhibited that protection. In both rats and mice ilofotase alfa ameliorated IRI when administered after injury, thus providing relevance for therapeutic dosing of ilofotase alfa following established AKI. In an AKI-on-CKD ischemic rat model, ilofotase alfa given after the third instance of IRI reduced injury. These results suggest that ilofotase alfa promotes production of adenosine from liberated ATP in injured kidney tissue, thereby amplifying endogenous mechanisms that can reverse tissue injury, in part through A2AR-and non-A2AR-dependent signaling pathways

Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration

The duration of pregnancy is influenced by fetal and maternal genetic and non-genetic factors. Here we report a fetal genome-wide association meta-analysis of gestational duration, and early preterm, preterm, and postterm birth in 84,689 infants. One locus on chromosome 2q13 is associated with gestational duration; the association is replicated in 9,291 additional infants (combined P= 3.96 x 10(-14)). Analysis of 15,588 mother-child pairs shows that the association is driven by fetal rather than maternal genotype. Functional experiments show that the lead SNP, rs7594852, alters the binding of the HIC1 transcriptional repressor. Genes at the locus include several interleukin 1 family members with roles in pro-inflammatory pathways that are central to the process of parturition. Further understanding of the underlying mechanisms will be of great public health importance, since giving birth either before or after the window of term gestation is associated with increased morbidity and mortality.Peer reviewe