Molecular-dynamics studies on the shock-induced phase transition of a MgF2 crystal

金沢大学理工研究域数物科学系The shock-induced phase transition of a MgF2 crystal with the rutile structure was simulated by means of a molecular-dynamics (MD) calculation, where the simplified interatomic potential function was applied. We found that the rutile structure of a MgF2 crystal is transformed to the cubic fluorite structure in several femtoseconds through both the static and the biaxial shock-compression processes of the MD calculation, in which the transition pressure at room temperature was successfully reproduced. Moreover, we revealed explicitly that the mechanism of the rutile-cubic phase transition is mainly due to the rotational motion of F- ions surrounding the Mg2+ ion in the crystal. © 1995 The American Physical Society

Electrical structure beneath the northern MELT line on the East Pacific Rise at 15°45′S

Author Posting. © American Geophysical Union, 2006. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Geophysical Research Letters 33 (2006): L22301, doi:10.1029/2006GL027528.The electrical structure of the upper mantle beneath the East Pacific Rise (EPR) at 15°45′S is imaged by inverting seafloor magnetotelluric data obtained during the Mantle ELectromagnetic and Tomography (MELT) experiment. The electrical conductivity model shows no evidence for a conductive region immediately beneath the ridge, in contrast to the model previously obtained beneath the EPR at 17°S. This observation can be explained by differences in current melt production along the ridge, consistent with other observations. The mantle to the east of the ridge at 60 –100 km depth is anisotropic, with higher conductivity in the spreading direction compared to the along-strike direction, similar to the 17°S region. The high conductivity in the spreading direction can be explained by a hydrated mantle with strain-induced lattice preferred orientation of olivine or by partial melt preferentially connected in the spreading direction.This work was supported by NSF grant OCE0118254

Behavior of ACRBP-deficient mouse sperm in the female reproductive tract

Gene-knockout mice lacking ACRBP, a proacrosin-binding protein localized in the acrosome of sperm, have been shown to exhibit male subfertility, owing to abnormal formation of the acrosome. In this study, to elucidate the mechanism contributing to the subfertility phenotype, we examined the behavior of ACRBP-deficient mouse sperm in the female reproductive tract. When sperm that had migrated into the uterus and oviduct after mating were counted, the number of ACRBP-deficient sperm was noticeably smaller in the oviduct of mice post mating. However, ACRBP-deficient sperm recovered from the oviduct possessed morphologically normal head shape and retained normal motility. Importantly, ACRBP-deficient sperm displayed a marked reduction in the ability to successfully gain access to unfertilized oocytes. These data suggest that male subfertility of ACRBP-deficient mice may be attributed to incompleteness of the acrosome reaction rather than impairment in sperm migration from the uterus to the oviduct

Interleukin-10-Producing Plasmablasts Exert Regulatory Function in Autoimmune Inflammation

SummaryB cells can suppress autoimmunity by secreting interleukin-10 (IL-10). Although subpopulations of splenic B lineage cells are reported to express IL-10 in vitro, the identity of IL-10-producing B cells with regulatory function in vivo remains unknown. By using IL-10 reporter mice, we found that plasmablasts in the draining lymph nodes (dLNs), but not splenic B lineage cells, predominantly expressed IL-10 during experimental autoimmune encephalomyelitis (EAE). These plasmablasts were generated only during EAE inflammation. Mice lacking plasmablasts by genetic ablation of the transcription factors Blimp1 or IRF4 in B lineage cells developed an exacerbated EAE. Furthermore, IRF4 positively regulated IL-10 production that can inhibit dendritic cell functions to generate pathogenic T cells. Our data demonstrate that plasmablasts in the dLNs serve as IL-10 producers to limit autoimmune inflammation and emphasize the importance of plasmablasts as IL-10-producing regulatory B cells

Correction of seafloor magnetotelluric data for topographic effects during inversion

Author Posting. © American Geophysical Union, 2005. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research 110 (2005): B12105, doi:10.1029/2004JB003463.The large contrast in electrical conductivity between seawater and the underlying seafloor accumulates boundary electric charges which can severely distort observed electric and magnetic fields. For marine magnetotelluric (MT) studies, correcting this topographic effect is critical to obtaining accurate conductivity models for the mantle. Previously, correction for topography was based on the thin sheet approximation which breaks down at periods under ∼1000 s in the deep ocean. This paper introduces an analysis method for seafloor MT data which combines removal of three-dimensional (3-D) topographic effects with inversion of the data for 2-D structure. The observed MT impedance is first corrected to a flat-lying seafloor datum using the observed bathymetry without invoking the thin sheet approximation. The corrected MT response is then inverted in a flat seafloor model space. Because of coupling between topographic effects and deeper structure, the correction and inversion steps are iterated until changes in each become small. The procedure is verified using synthetic and real data. Tests for synthetic 3-D topography over a half-space show that the method closely recovers the true half-space model after a few iterations. The procedure is also applied to real data collected in the Mantle Electromagnetic and Tomography (MELT) experiment on the East Pacific Rise at 17°S.This work was supported by NSF grants OCE9402324 and OCE0118254 and Research Program on Mantle Core Dynamics, Institute for Research on Earth Evolution (IFREE), Japan Agency for Marine-Earth Science and Technology (JAMSTEC)

A Case of Granulocyte-Colony Stimulating Factor-Producing Hepatocellular Carcinoma Confirmed by Immunohistochemistry

Granulocyte-colony stimulating factor (G-CSF) is a naturally occurring glycoprotein that stimulates the proliferation and maturation of precursor cells in the bone marrow into fully differentiated neutrophils. Several reports of G-CSF-producing malignant tumors have been published, but scarcely any in the hepatobiliary system, such as in hepatocellular carcinoma (HCC). Here, we encountered a 69-yr-old man with a hepatic tumor who had received right hepatic resection. He showed leukocytosis of 25,450/µL along with elevated serum G-CSF. Histological examination of surgical samples demonstrated immunohistochemical staining for G-CSF, but not for G-CSF receptor. The patient survived without recurrence for four years, but ultimately passed away with multiple bone metastases. In light of the above, clinicians may consider G-CSF-producing HCC when encountering patients with leukocytosis and a hepatic tumor. More cases are needed to clarify the clinical picture of G-CSF-producing HCC