Respon Lima Varietas Jagung (Zea Mays L.) Pada Aplikasi Pyraclostrobin

Aktivitas nitrat reduktase dapat ditingkatkan oleh pyraclostrobin. Penyerapan nitrogen pada tanaman dipengaruhi oleh aktivitas nitrat reduktase. Tujuan dari penelitian ini ialah untuk mempelajari respon lima varietas jagung pada aplikasi pyraclostrobin. Penelitian dilaksanakan di kebun percobaan Fakultas Pertanian Universitas Brawijaya yang berlokasi di Desa Jatikerto, Kecamatan Kromengan, Kabupaten Malang. Penelitian dilaksanakan pada bulan Juni 2011 sampai Oktober 2011. Bahan tanam yang digunakan ialah benih jagung varietas NK-22, NK-6326, P-21, BISI-2, dan BISI-816 dan pyraclostrobin 400 ppm berfungsi sebagai perlakuan. Hasil yang diperoleh menunjukkan Pyraclostrobin tidak memberikan pengaruh pada pertumbuhan dan hasil tanaman jagung. Lima varietas uji menunjukkan perbedaan pertumbuhan dan hasil karena pengaruh genetik masing-masing varietas. Interaksi perlakuan pyraclostrobin dan beberapa varietas mempengaruhi pertumbuhan tanaman pada tinggi tanaman umur 8 minggu setelah tanam, jumlah daun umur 5 minggu setelah tanam, dan umur muncul bunga betina

Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine

[This corrects the article DOI: 10.1186/s13054-016-1208-6.]

Bending Strength Of Lignocellulosic Materials In Softening Condition

This research aimed to understand the softening behaviour and viscoelastic property of wood, rattan, and bamboo as lignocellulosic materials. Nine years-old Fast growing teak wood [Tectona grandis L.f.], rattan [Calamus sp.], and 3 years-old andong bamboo [Gigantochloa pseudoarundinaceae (Steud.) Widjaja] were used for the experiments. The samples were taken from the bottom, middle and upper parts for wood and rattan, and that for bamboo were cut from the 1st to 20th internodes. Static bending tests were carried out in fresh (green) as control samples, air-dried, and softened by microwave heating (MW) for 1 min to determine modulus of rupture (MOR) and modulus of elasticity (MOE). The results showed that the MOR and MOE values of wood, rattan, and bamboo increased from fresh to air-dried condition, and decreased by MW. When compared at the same density, drastic increase was observed for the normalized MOR value in air-dried of rattan, i.e. 2.5 fold. However, the decreasing of all the normalized MOR values were almost the same, i.e. 0.5 fold when they were softened by MW. Remarkably increase was also appeared for the normalized MOE value in air-dried of rattan, i.e. 3.0 fold and decreased to almost zero by MW. These results indicated that rattan was more easily bent, followed by bamboo and then wood. Hydrothermal properties of chemical components significantly affected the changes of strength (MOR) and elastic properties (MOE). However, the differences in bending strength of wood, rattan, and bamboo were more likely due to differences in their anatomical structures

Safety and Activity of Immune Checkpoint Inhibitors in People Living With HIV and Cancer: A Real-World Report From the Cancer Therapy Using Checkpoint Inhibitors in People Living With HIV-International (CATCH-IT) Consortium

Purpose: Compared with people living without HIV (PWOH), people living with HIV (PWH) and cancer have traditionally been excluded from immune checkpoint inhibitor (ICI) trials. Furthermore, there is a paucity of real-world data on the use of ICIs in PWH and cancer. Methods: This retrospective study included PWH treated with anti-PD-1- or anti-PD-L1-based therapies for advanced cancers. Kaplan-Meier method was used to estimate overall survival (OS) and progression-free survival (PFS). Objective response rates (ORRs) were measured per RECIST 1.1 or other tumor-specific criteria, whenever feasible. Restricted mean survival time (RMST) was used to compare OS and PFS between matched PWH and PWOH with metastatic NSCLC (mNSCLC). Results: Among 390 PWH, median age was 58 years, 85% (n = 331) were males, 36% (n = 138) were Black; 70% (n = 274) received anti-PD-1/anti-PD-L1 monotherapy. Most common cancers were NSCLC (28%, n = 111), hepatocellular carcinoma ([HCC]; 11%, n = 44), and head and neck squamous cell carcinoma (HNSCC; 10%, n = 39). Seventy percent (152/216) had CD4+ T cell counts ≥200 cells/µL, and 94% (179/190) had HIV viral load <400 copies/mL. Twenty percent (79/390) had any grade immune-related adverse events (irAEs) and 7.7% (30/390) had grade ≥3 irAEs. ORRs were 69% (nonmelanoma skin cancer), 31% (NSCLC), 16% (HCC), and 11% (HNSCC). In the matched mNSCLC cohort (61 PWH v 110 PWOH), 20% (12/61) PWH and 22% (24/110) PWOH had irAEs. Adjusted 42-month RMST difference was -0.06 months (95% CI, -5.49 to 5.37; P = .98) for PFS and 2.23 months (95% CI, -4.02 to 8.48; P = .48) for OS. Conclusion: Among PWH, ICIs demonstrated differential activity across cancer types with no excess toxicity. Safety and activity of ICIs were similar between matched cohorts of PWH and PWOH with mNSCLC

The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study

AimThe SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery.MethodsThis was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4 weeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin.ResultsOverall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4 weeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, P = 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, P ConclusionOne in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease