Sakarya İli SARS-CoV-2 Olgularında İnme Sıklığının Araştırılması

Aim: The aim of this study is to identify the frequency of stroke among severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cases in Sakarya city, to find out the clinical characteristics of patients diagnosed with stroke and to contribute to the national database. Material and Methods: This retrospective study was carried out with 783 cases diagnosed with SARS-CoV-2 between April-June 2020 at the pandemic hospital in Sakarya city. Patients were compared in terms of age, National Institute of Health Stroke Scale (NIHSS), risk factors, radiological findings, inpatient treatment, intubation, and mortality rates. Results: Out of 26 cases of ischemic stroke, 11 (42.3%) were male and 15 (57.7%) were female. In terms of infarction localization, the cause was medial cerebral artery (MCA) in 4 (15.4%) patients, top of the basilar in 2 (7.7%) patients, basilar artery in 1 (3.8%) patient, lacunar in 9 (34.6%) patients and anterior system in 10 (38.5%) patients. There was no significant difference in terms of D-dimer and C-reactive protein (CRP) levels according to disease severity (both p=0.262). Three (0.38%) patients presented with stroke findings and were diagnosed with SARS-CoV-2. Cryptogenic stroke was detected in 8 (30.8%) of the SARS-CoV-2 cases. Stroke frequency was calculated as 3.3% among the SARS-CoV-2 cases in Sakarya city. Conclusion: This is the first study to identify the frequency of stroke among SARS-CoV-2 patients in Sakarya city and Turkey. Our study is important as it shows that preventing or treating ischemic stroke in SARS-CoV-2 cases contributes greatly to the reduction of mortality.Amaç: Bu çalışmanın amacı Sakarya ilindeki şiddetli akut solunum yolu sendromu koronavirüsü 2 (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2) olgularında inme sıklığını tespit etmek, inme tanısı almış olan hastaların klinik özelliklerini ortaya koyabilmek ve ulusal veri tabanına katkıda bulunmaktır. Gereç ve Yöntemler: Bu çalışma, Sakarya ilindeki pandemi hastanesinde Nisan-Haziran 2020 tarihleri arasında SARS-CoV-2 tanısı alan 783 olgu ile geriye dönük olarak yürütüldü. Hastalar, yaş, Ulusal Sağlık Enstitüleri İnme Skalası (National Institute of Health Stroke Scale, NIHSS), risk faktörleri, radyolojik bulgular, yatarak tedavi, entübe olma durumları ve mortalite oranları bakımından karşılaştırıldı. Bulgular: Yirmi altı iskemik inmeli olgunun 11 (%42,3)’i erkek ve 15 (%57,7)’i kadın idi. Enfarkt lokalizasyonu bakımından 26 hastanın 4 (%15,4)’ü orta serebral arter (medial cerebral artery, MCA), 2 (%7,7)’si baziller tepe, 1 (%3,8)’i baziller arter, 9 (%34,6)’u laküner, 10 (%38,5)’u arka sistemden kaynaklanmaktaydı. D-Dimer ve C-reaktif protein (C-reactive protein, CRP) düzeyleri bakımından hastalık şiddetine göre anlamlı bir farklılık yoktu (her iki p=0,262). Üç (%0,38) hasta inme bulgusuyla gelip SARS-CoV-2 tanısı almıştı. SARS-CoV-2 olgularının 8 (%30,8)’inde kriptojenik inme tespit edildi. Sakarya ilinde SARS-CoV-2 olgularında inme sıklığı %3,3 olarak hesaplandı. Sonuç: Bu çalışma SARS-CoV-2 hastalarında inme sıklığını tespit etmeye yönelik Sakarya ilinde ve Türkiye’de yapılmış ilk çalışmadır. Çalışmamız, SARS-CoV-2 olgularında iskemik inmenin önlenebilmesi ve tedavi edilebilmesinin mortalitenin azalmasına belirgin katkı sunduğunu göstermesi bakımından önemlidir

The evaluation of color stability of monolithic zirconia after storage in different beverages

Amaç: Bu çalışmanın amacı, günlük hayatta sıklıkla tüketilen farklı içeceklerin monolitik zirkonyanın renk stabilitesine etkisini değerlendirmektir. Materyal ve Metod: Disk şeklinde (10x1.2 mm) 40 adet monolitik zirkonya örnek hazırlandıktan sonra çay, kahve, kola ve suda bekletilmek üzere dört alt gruba (n=10) ayrıldı ve 37°C’de 24 saat, 7 gün, 15 gün ve 1 ay süreyle bekletildi. İçeceklerde bekletilmeden önce ve her bekletme süresinin sonunda renk ölçümleri spektrofotometre kullanılarak CIE-Lab sistemi ile yapıldı. Veriler ANOVA ve Duncan testi ile değerlendirildi. Bulgular: İçecek türünün zirkonya örneklerinin renk stabilitesine etkisinin önemli olduğu belirlendi (p <0.001; F: 32.908). Farklı içeceklerde bekletilen örneklerin ΔE değerleri incelendiğinde; en az renk değişiminin 24 saat çayda bekletilen örneklerde, en fazla renk değişiminin 30 gün kahvede bekletilen örneklerde olduğu tespit edildi. Tartışma: Monolitik zirkonyumun renk stabilitesi klinisyenler için önemli bir göstergedir. Test edilen materyallerle tedavi edilen hastalar renk değişimi konusunda uyarılmalıdır.Aim: The purpose of this study was to evaluate the color stability of monolithic zirconia upon exposure to different beverages which were highly consumed in daily life. Materials and methods: After the preparation of 40 monolithic zirconia samples in disc form (10×1.2 mm), they were divided into four subgroups (n=10). The samples in each group immersed in tea, coffee, cola and water at 37°C for 24 hours, 7 days, 15 days and 1 month. Color measurements were performed with the CIE-Lab system using by using spectrophotometer before and after each immersion period in beverages. The data were evaluated by ANOVA and Duncan tests. Results: It was determined that beverage type had significant effect on color stability of zirconia samples (p<0.001; F: 32.908). When examined the ΔE values for samples stored in different beverages, minimum color change were detected in the samples of tea left for 24 hours and maximum color change were detected in the samples of coffee left for 30 days. Conclusions: Color stability of monolithic zirconia is an important indicator for clinicians. The patients which had been treated with the tested materials must be warned about this discolaration

PTPN22 gene polymorphism in Takayasu's arteritis

Objective. Takayasu's arteritis (TA) is a chronic, rare granulomatous panarteritis of unknown aetiology involving mainly the aorta and its major branches. In this study, genetic susceptibility to TA has been investigated by screening the functional single nucleotide polymorphism (SNP) of PTPN22 gene encoding the lymphoid-specific protein tyrosine phosphatase. Methods. Totally, 181 patients with TA and 177 healthy controls are genotyped by PCR-RFLP method for the SNP rs2476601 (A/G) of PTPN22 gene. Polymorphic region was amplified by PCR and digested with Xcm I enzyme. Results. Detected frequencies of heterozygous genotype (AG) were 5.1% (9/177) in control group and 3.8% (7/181) in TA group (P = 0.61, odds ratio: 0.75, 95% CI: 0.3, 2.0). No association with angiographic type, vascular involvement or prognosis of TA was observed either. Conclusion. The distribution of PTPN22 polymorphism did not reveal any association with TA in Turkey. © The Author 2008. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved

diagnostic role of MPV in acute appendicitis

Amaç: Bu çalışmada, çocuklarda akut apandisit tanısında ortalama trombosit hacmi (MPV)’nin rolüolup olmadığının araştırılması amaçlandı. Yöntemler: Bu çalışmada hasta dosyaları retrospektif olarak tarandı. Klinik ve patolojik olarak akut apandisit tanısı alan 311 olgunun MPV değerleri, günübirlik operasyonlar için başvuran sağlıklı çocuklardan seçilen kontrol grubunun (n=314) MPV değerleri ile karşılaştırıldı. Çalışmada elde edilen verinin istatistiksel anlamda değerlendirilmesi amacıyla SPSS (IBM SPSS Statistics for Windows, Version 20.0. Armonk, NY: IBM Corp.) paket programı kullanılmıştır. Bulgular: Akut apandisitli çocukların 188’i (%60.5) erkek, yaş ortalaması 10.22±3.83 idi. Akut apandisiti olan (8.37±0.83fL) ve olmayan (10.55±0.83fL) çocukların MPV değerleri arasında istatistiksel olarak anlamlı fark tespit edildi (p<0,001). Sonuç: Çocuklarda MPV değerinin akut apandisit tanısında kullanılabilecek bir belirteç olduğu, ancak hastalığa spesifik olmadığı görülmüştür.Introduction: The aim of this study was to investigate the diagnostic role of mean platelet volume (MPV) for acute appendicitis. Methods: Patient files were retrospectively observed. MPV of 311 patients with pathological diagnosis of acute appendicitis were compared with the MPV of 314 healthy children (blood samples were taken for elective operations). SPSS (IBM SPSS Statistics for Windows, Version 20.0. Armonk, NY: IBM Corp.) was used to evaluate the results. Results: 188 of acute appendicitis were male (%60.5). Mean age of acute appendicitis group was 10.22±3.83. MPV of children with the diagnosis of acute appendicitis (8.37±0.83fL) and the control group (10.55±0.83fL). MPV values were statistically different between the acute appendicitis and control group (p<0,001). Conclusion: MPV may be used as a marker for the diagnosis of acute appendicitis, but it is not a specific biomarker for appendicitis

Poly(3,5-dithiophene-2-yldithieno[3,2-b;2',3'-d]thiophene-co-Ethylenedioxythiophene)/Glassy Carbon Electrode Formation and Electrochemical Impedance Spectroscopic Study

3,5-Dithiophene-2-yldithieno[3,2-b;2',3'-d]thiophene (Thy(2)DTT) and ethylenedioxythiophene (EDOT) were electro-copolymerized on glassy carbon electrode (GCE) in 0.1 M sodium perchlorate (NaClO4)/acetonitrile (ACN)/dichloromethane (CH2Cl2) (8:2) solution. Poly(Thy(2)DTT-co-EDOT)/GCE thin film was characterized by various techniques, such as Cyclic Voltammetry (CV), Fourier Transform Infrared Spectroscopy - Attenuated Transmittance Reflectance (FTIR-ATR), Scanning Electron Microscopy - Energy Dispersive X-ray analysis (SEM-EDX) and Electrochemical Impedance Spectroscopy (EIS). The effects of monomer mole fractions (mole fraction, X-Thy2DTT = n(Thy2DTT/nEDOT) + n(Thy2DTT)) (0.5, 0.66 and 0.83) during the preparation of modified electrodes were examined by EIS. Capacitive behaviors of the modified GCE were defined via Nyquist, Bode-magnitude, Bode-phase and Capacitance plots. The circuit model was used to fit the theoretical and experimental data through Kramers-Kronig Transform test. The lowest frequency capacitance (C-LF) value was obtained as C-LF = 0.89 mFcm(-2) for poly(Thy(2)DTT). However, the highest C-LF was obtained for the copolymer as C-LF = 1.11 mFcm(-2) for X-Thy2DTT = 0.66 and 0.83. Potential application of the copolymer could be energy-storage devices.Unsped Global LojistikWe thank to Serhat Tikiz (Afyon Kocatepe University, Technology and Research Center (TUAM), Afyon, Turkey) for recording the SEM-EDX analyzes. We thank Unsped Global Lojistik for financial support

DESIGN AND APPLICATION OF PIC CONTROLLED CONTROL UNIT FOR A FRICTION-WELDING MACHINE

In the present study, an easy programmable, low cost and high sensitively control unit has been designed and implemented for a friction welding machine. For this aim, a microcontroller has been used for design of control circuit. Parameters such as friction time, forge time and breaking time have been set up by using keypad. It has been observed from joint of the samples that the system works successfully